{"id":"https://openalex.org/W2960509302","doi":"https://doi.org/10.24355/dbbs.084-201711021223","title":"Control of immunological synapse formation in regulatory T cells","display_name":"Control of immunological synapse formation in regulatory T cells","publication_year":2017,"publication_date":"2017-11-02","ids":{"openalex":"https://openalex.org/W2960509302","doi":"https://doi.org/10.24355/dbbs.084-201711021223","mag":"2960509302"},"language":"en","primary_location":{"id":"pmh:oai:https://leopard.tu-braunschweig.de/:dbbs_mods_00065265","doi":null,"is_oa":true,"landing_page_url":"http://uri.gbv.de/document/gvk:ppn:1011856433","pdf_url":"https://nbn-resolving.org/urn:nbn:de:gbv:084-2017110212269","source":{"id":"https://openalex.org/S4306402617","display_name":"Digitale Bibliothek Braunschweig (Verbundzentrale G\u00f6ttingen (VZG))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149878","host_organization_name":"Verbundzentrale des GBV","host_organization_lineage":["https://openalex.org/I4210149878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nbn-resolving.org/urn:nbn:de:gbv:084-2017110212269","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016720960","display_name":"Jana Niemz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Niemz, Jana","raw_affiliation_strings":["Helmholtz-Zentrum f\u00fcr Infektionsforschung (HZI)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz-Zentrum f\u00fcr Infektionsforschung (HZI)","institution_ids":["https://openalex.org/I4210124929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016720960"],"corresponding_institution_ids":["https://openalex.org/I4210124929"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9909999966621399},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8740000128746033},{"id":"https://openalex.org/keywords/themis","display_name":"THEMIS","score":0.671999990940094},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.7229999899864197},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.7149999737739563},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.8410000205039978},{"id":"https://openalex.org/keywords/treg-activation","display_name":"Treg activation","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.7653273344039917},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6719756722450256},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6368861198425293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5857061743736267},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.5715734958648682},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5127597451210022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48409998416900635},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.46372219920158386},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4292532205581665},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4205668270587921},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4155486226081848},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.394822895526886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3589800000190735},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3512458801269531},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14538565278053284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09057053923606873}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:https://leopard.tu-braunschweig.de/:dbbs_mods_00065265","doi":null,"is_oa":true,"landing_page_url":"http://uri.gbv.de/document/gvk:ppn:1011856433","pdf_url":"https://nbn-resolving.org/urn:nbn:de:gbv:084-2017110212269","source":{"id":"https://openalex.org/S4306402617","display_name":"Digitale Bibliothek Braunschweig (Verbundzentrale G\u00f6ttingen (VZG))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149878","host_organization_name":"Verbundzentrale des GBV","host_organization_lineage":["https://openalex.org/I4210149878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dissertation"},{"id":"pmh:oai:publikationsserver.tu-braunschweig.de:dbbs_mods_00065265","doi":null,"is_oa":false,"landing_page_url":"https://publikationsserver.tu-braunschweig.de/receive/dbbs_mods_00065265","pdf_url":null,"source":{"id":"https://openalex.org/S4306402617","display_name":"Digitale Bibliothek Braunschweig (Verbundzentrale G\u00f6ttingen (VZG))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149878","host_organization_name":"Verbundzentrale des GBV","host_organization_lineage":["https://openalex.org/I4210149878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dissertation"},{"id":"doi:10.24355/dbbs.084-201711021223","doi":"https://doi.org/10.24355/dbbs.084-201711021223","is_oa":true,"landing_page_url":"https://doi.org/10.24355/dbbs.084-201711021223","pdf_url":null,"source":{"id":"https://openalex.org/S7407052991","display_name":"LeoPARD - TU Braunschweig Publications And Research Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:2960509302","doi":null,"is_oa":false,"landing_page_url":"https://publikationsserver.tu-braunschweig.de/receive/dbbs_mods_00065265","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:https://leopard.tu-braunschweig.de/:dbbs_mods_00065265","doi":null,"is_oa":true,"landing_page_url":"http://uri.gbv.de/document/gvk:ppn:1011856433","pdf_url":"https://nbn-resolving.org/urn:nbn:de:gbv:084-2017110212269","source":{"id":"https://openalex.org/S4306402617","display_name":"Digitale Bibliothek Braunschweig (Verbundzentrale G\u00f6ttingen (VZG))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149878","host_organization_name":"Verbundzentrale des GBV","host_organization_lineage":["https://openalex.org/I4210149878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2960509302.pdf","grobid_xml":"https://content.openalex.org/works/W2960509302.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1524676684","https://openalex.org/W1817755743","https://openalex.org/W1965673490","https://openalex.org/W1977709885","https://openalex.org/W2067580785","https://openalex.org/W2070528611","https://openalex.org/W2075089210","https://openalex.org/W2108491944","https://openalex.org/W2116015828","https://openalex.org/W2126464081","https://openalex.org/W2476524461"],"related_works":["https://openalex.org/W2773085551","https://openalex.org/W2750210373","https://openalex.org/W3208757825","https://openalex.org/W2272278257","https://openalex.org/W2727210048","https://openalex.org/W2048809303","https://openalex.org/W2902462632","https://openalex.org/W2968730953","https://openalex.org/W3028449645","https://openalex.org/W1984109590","https://openalex.org/W2259408979","https://openalex.org/W3025622075","https://openalex.org/W3168980228","https://openalex.org/W1575998452","https://openalex.org/W2033025341","https://openalex.org/W2407962908","https://openalex.org/W2017243926","https://openalex.org/W3017827940","https://openalex.org/W2126545845","https://openalex.org/W2729802091"],"abstract_inverted_index":{"Regulatory":[0],"T":[1,7,53,60,82,140],"cells":[2,83],"(Tregs)":[3],"are":[4],"a":[5,122,203],"CD4+":[6],"cell":[8,54,61,141,290],"subset,":[9],"which":[10,114,165,221],"maintains":[11],"tolerance":[12],"towards":[13],"self":[14],"and":[15,19,63,87,105,112,131,188,213,229,239,284],"harmless":[16],"foreign":[17],"antigens":[18],"is":[20,57,65,71,166,270],"characterized":[21],"by":[22,251],"expression":[23],"of":[24,89,98,110,125,152,163,193,202,209,233,241,249,273],"the":[25,52,90,96,138,160,225,231,234,254,267,271,282,293],"master":[26],"transcription":[27],"factor":[28,219],"Foxp3.":[29],"Besides":[30],"this":[31],"well":[32],"studied":[33],"Treg-specific":[34],"feature,":[35],"several":[36],"effector":[37],"molecules":[38],"have":[39],"been":[40],"identified":[41,132,223],"as":[42,76,127,146,259],"preferentially":[43],"but":[44],"not":[45],"exclusively":[46],"expressed":[47],"in":[48,74,118,169,176,186],"Tregs.":[49],"Activation":[50],"via":[51,224],"receptor":[55],"(TCR)":[56],"crucial":[58],"for":[59,149,171,237],"functionality,":[62],"there":[64],"accumulating":[66],"evidence":[67],"that":[68],"TCR":[69,184],"signaling":[70,185,255,280,288],"differentially":[72,133],"organized":[73],"Tregs":[75,104,111,126,187,242,250],"compared":[77,128],"to":[78,129,178,265,277,285],"their":[79,172],"counterparts,":[80],"conventional":[81],"(Tconv).":[84],"Accordingly,":[85],"formation":[86],"composition":[88],"immunological":[91],"synapse":[92],"(IS),":[93],"built":[94],"at":[95,207,253,281,292],"interface":[97],"interacting":[99],"immune":[100],"cells,":[101],"differs":[102],"between":[103,137],"Tconv.":[106],"Quantitative":[107],"phosphopeptide":[108],"sequencing":[109],"Tconv,":[113,189],"was":[115,222,243],"recently":[116],"performed":[117],"our":[119],"laboratory,":[120],"revealed":[121],"pre-activated":[123],"phenotype":[124],"Tconv":[130],"regulated":[134,215],"phosphorylation":[135,191,205],"sites":[136,195],"two":[139],"subsets.":[142],"Those":[143],"might":[144,257],"serve":[145,258],"promising":[147,260],"candidates":[148],"targeted":[150],"intervention":[151,252],"Treg":[153],"activation.":[154],"The":[155,199],"present":[156],"study":[157],"(i)":[158],"addressed":[159],"functional":[161,200],"role":[162,232],"Themis,":[164],"strongly":[167],"under-represented":[168],"Tregs,":[170],"suppressive":[173],"capacity.":[174],"Furthermore,":[175],"order":[177],"expand":[179],"current":[180],"knowledge":[181],"about":[182],"differential":[183],"(ii)":[190],"kinetics":[192],"selected":[194,287],"were":[196],"performed.":[197],"(iii)":[198],"impact":[201],"novel":[204],"site":[206],"Y523":[208],"CalDAG":[210],"GEFI":[211],"(Calcium":[212],"DAG":[214],"guanine":[216],"nucleotide":[217],"exchange":[218],"I),":[220],"aforementioned":[226],"phosphoproteomic":[227],"approach,":[228],"(iv)":[230],"protein":[235],"itself":[236],"development":[238],"function":[240],"investigated.":[244],"In":[245],"summary,":[246],"selective":[247],"targeting":[248],"level":[256],"future":[261],"therapeutic":[262],"strategy.":[263],"Up":[264],"date,":[266],"major":[268],"obstacle":[269],"lack":[272],"specific":[274],"tools,":[275],"both":[276],"investigate":[278],"intracellular":[279],"bench":[283],"target":[286],"processes":[289],"subset-specifically":[291],"bedside.":[294]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2025-10-10T00:00:00"}
