{"id":"https://openalex.org/W2960418263","doi":"https://doi.org/10.3390/cancers11070959","title":"Methylation Dynamics of RASSF1A and Its Impact on Cancer","display_name":"Methylation Dynamics of RASSF1A and Its Impact on Cancer","publication_year":2019,"publication_date":"2019-07-09","ids":{"openalex":"https://openalex.org/W2960418263","doi":"https://doi.org/10.3390/cancers11070959","mag":"2960418263","pmid":"https://pubmed.ncbi.nlm.nih.gov/31323949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6678546"},"language":"en","primary_location":{"id":"doi:10.3390/cancers11070959","doi":"https://doi.org/10.3390/cancers11070959","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11070959","pdf_url":"https://www.mdpi.com/2072-6694/11/7/959/pdf?version=1563461129","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/11/7/959/pdf?version=1563461129","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022596417","display_name":"Giorgio Malpeli","orcid":"https://orcid.org/0000-0002-2996-2903","observed_orcids":["https://orcid.org/0000-0002-2996-2903"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giorgio Malpeli","raw_affiliation_strings":["Department of Diagnostics and Public Health, Section of Anatomic Pathology, University of Verona, 37134 Verona, Italy","Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2996-2903","affiliations":[{"raw_affiliation_string":"Department of Diagnostics and Public Health, Section of Anatomic Pathology, University of Verona, 37134 Verona, Italy","institution_ids":["https://openalex.org/I119439378"]},{"raw_affiliation_string":"Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037768686","display_name":"Giulio Innamorati","orcid":"https://orcid.org/0000-0003-0123-8777","observed_orcids":["https://orcid.org/0000-0003-0123-8777"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Innamorati","raw_affiliation_strings":["Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023437649","display_name":"Ilaria Decimo","orcid":"https://orcid.org/0000-0002-6627-1263","observed_orcids":["https://orcid.org/0000-0002-6627-1263"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Decimo","raw_affiliation_strings":["Department of Medicine, Section of Pharmacology, University of Verona, 37134 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Pharmacology, University of Verona, 37134 Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001941833","display_name":"Maria Bencivenga","orcid":"https://orcid.org/0000-0003-1338-6160","observed_orcids":["https://orcid.org/0000-0003-1338-6160"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Bencivenga","raw_affiliation_strings":["Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040839479","display_name":"Armel Herv\u00e9 Nwabo Kamdje","orcid":"https://orcid.org/0000-0002-6943-7628","observed_orcids":["https://orcid.org/0000-0002-6943-7628"]},"institutions":[{"id":"https://openalex.org/I59196294","display_name":"University of Ngaound\u00e9r\u00e9","ror":"https://ror.org/03gq1d339","country_code":"CM","type":"education","lineage":["https://openalex.org/I59196294"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Armel Herve Nwabo Kamdje","raw_affiliation_strings":["Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere 454, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere 454, Cameroon","institution_ids":["https://openalex.org/I59196294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043991877","display_name":"Roberto Perris","orcid":"https://orcid.org/0000-0001-5626-5233","observed_orcids":["https://orcid.org/0000-0001-5626-5233"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Perris","raw_affiliation_strings":["Department of Biosciences, COMT-Centre for Molecular and Translational Oncology, University of Parma, 43124 Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, COMT-Centre for Molecular and Translational Oncology, University of Parma, 43124 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107837866","display_name":"Claudio Bassi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Bassi","raw_affiliation_strings":["Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022596417"],"corresponding_institution_ids":["https://openalex.org/I119439378"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":0.8994,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.6904411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"7","first_page":"959","last_page":"959"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rassf1a","display_name":"RASSF1A","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.8659999966621399},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.6669999957084656},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.722000002861023},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.734000027179718},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.720561683177948},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7082756161689758},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6852227449417114},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5186194777488708},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4867143929004669},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4518336057662964},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4299122095108032},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38322126865386963},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.374329149723053},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32485127449035645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32383495569229126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2845759987831116}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers11070959","doi":"https://doi.org/10.3390/cancers11070959","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11070959","pdf_url":"https://www.mdpi.com/2072-6694/11/7/959/pdf?version=1563461129","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5648698","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6678546","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31323949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31323949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6678546","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6678546/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5a23fcab50b24c748cfcd635d69052d9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5a23fcab50b24c748cfcd635d69052d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 11, Iss 7, p 959 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers11070959","doi":"https://doi.org/10.3390/cancers11070959","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11070959","pdf_url":"https://www.mdpi.com/2072-6694/11/7/959/pdf?version=1563461129","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6827062231","display_name":null,"funder_award_id":"IG17132","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2960418263.pdf","grobid_xml":"https://content.openalex.org/works/W2960418263.grobid-xml"},"referenced_works_count":136,"referenced_works":["https://openalex.org/W1504197144","https://openalex.org/W1505937832","https://openalex.org/W1524266803","https://openalex.org/W1573991640","https://openalex.org/W1598690774","https://openalex.org/W1603787733","https://openalex.org/W1646424808","https://openalex.org/W1757788795","https://openalex.org/W1763011611","https://openalex.org/W1797326032","https://openalex.org/W1905924310","https://openalex.org/W1945576905","https://openalex.org/W1953337176","https://openalex.org/W1963567108","https://openalex.org/W1963822977","https://openalex.org/W1966598245","https://openalex.org/W1967841068","https://openalex.org/W1969670934","https://openalex.org/W1975559410","https://openalex.org/W1978620346","https://openalex.org/W1979659697","https://openalex.org/W1985542606","https://openalex.org/W1989578834","https://openalex.org/W1990396479","https://openalex.org/W1990916340","https://openalex.org/W1990998965","https://openalex.org/W1991102078","https://openalex.org/W1991961196","https://openalex.org/W1992213480","https://openalex.org/W1994465394","https://openalex.org/W1995114552","https://openalex.org/W2004063027","https://openalex.org/W2005531525","https://openalex.org/W2006024173","https://openalex.org/W2008933729","https://openalex.org/W2011672248","https://openalex.org/W2015347426","https://openalex.org/W2021527895","https://openalex.org/W2032053235","https://openalex.org/W2033162367","https://openalex.org/W2034059681","https://openalex.org/W2037160755","https://openalex.org/W2040875973","https://openalex.org/W2041686632","https://openalex.org/W2049195493","https://openalex.org/W2049850518","https://openalex.org/W2050474151","https://openalex.org/W2052333525","https://openalex.org/W2058988392","https://openalex.org/W2059099579","https://openalex.org/W2060446375","https://openalex.org/W2064397865","https://openalex.org/W2065402899","https://openalex.org/W2066430857","https://openalex.org/W2070788773","https://openalex.org/W2074332692","https://openalex.org/W2076154138","https://openalex.org/W2077359776","https://openalex.org/W2083522244","https://openalex.org/W2085628515","https://openalex.org/W2088985926","https://openalex.org/W2090379876","https://openalex.org/W2091001933","https://openalex.org/W2095607598","https://openalex.org/W2096217287","https://openalex.org/W2097222531","https://openalex.org/W2099149369","https://openalex.org/W2103007980","https://openalex.org/W2106626074","https://openalex.org/W2107038650","https://openalex.org/W2108005060","https://openalex.org/W2112357729","https://openalex.org/W2113633164","https://openalex.org/W2116168071","https://openalex.org/W2117904693","https://openalex.org/W2121417064","https://openalex.org/W2122994808","https://openalex.org/W2125805216","https://openalex.org/W2128146359","https://openalex.org/W2131136248","https://openalex.org/W2139526606","https://openalex.org/W2140701693","https://openalex.org/W2141285625","https://openalex.org/W2141862600","https://openalex.org/W2145272757","https://openalex.org/W2148521032","https://openalex.org/W2150596811","https://openalex.org/W2153464229","https://openalex.org/W2153943205","https://openalex.org/W2160232849","https://openalex.org/W2160392555","https://openalex.org/W2166670116","https://openalex.org/W2167996825","https://openalex.org/W2178944583","https://openalex.org/W2181892250","https://openalex.org/W2219064517","https://openalex.org/W2233552477","https://openalex.org/W2238390617","https://openalex.org/W2301486587","https://openalex.org/W2308566229","https://openalex.org/W2346690872","https://openalex.org/W2381786691","https://openalex.org/W2411039126","https://openalex.org/W2414449891","https://openalex.org/W2417387999","https://openalex.org/W2507741532","https://openalex.org/W2508495626","https://openalex.org/W2546877500","https://openalex.org/W2550788914","https://openalex.org/W2588397568","https://openalex.org/W2588517583","https://openalex.org/W2611325260","https://openalex.org/W2761602928","https://openalex.org/W2762502577","https://openalex.org/W2766704091","https://openalex.org/W2766738567","https://openalex.org/W2767589262","https://openalex.org/W2770066606","https://openalex.org/W2787611996","https://openalex.org/W2789727733","https://openalex.org/W2791632970","https://openalex.org/W2794821911","https://openalex.org/W2800289222","https://openalex.org/W2810143528","https://openalex.org/W2898281911","https://openalex.org/W2998175746","https://openalex.org/W3000401679","https://openalex.org/W3011043971","https://openalex.org/W6631626130","https://openalex.org/W6635802794","https://openalex.org/W6636939961","https://openalex.org/W6637747103","https://openalex.org/W6637977764","https://openalex.org/W6639974313","https://openalex.org/W6704833617","https://openalex.org/W6745860079"],"related_works":["https://openalex.org/W2149432374","https://openalex.org/W7155077854","https://openalex.org/W2411039126","https://openalex.org/W2016926578","https://openalex.org/W2114656575","https://openalex.org/W2367336861","https://openalex.org/W2088985926","https://openalex.org/W7096095736","https://openalex.org/W1966598245","https://openalex.org/W2382722934"],"abstract_inverted_index":{"5-methyl":[0],"cytosine":[1],"(5mC)":[2],"is":[3,45,66,123,141,194],"a":[4,24,38,67,197,222,234],"key":[5],"epigenetic":[6,145,171],"mark":[7],"entwined":[8],"with":[9,74],"gene":[10,21,64,218],"expression":[11,160,179],"and":[12,57,69,81,91,93,98,128,159,189,204,217,220],"the":[13,48,52,55,75,95,105,170,177,181,187,210,226,229],"specification":[14],"of":[15,43,104,157,173,180,191,201,228,236],"cellular":[16],"phenotypes.":[17],"Its":[18],"distribution":[19],"around":[20],"promoters":[22],"sets":[23],"barrier":[25],"for":[26,196],"transcriptional":[27],"enhancers":[28],"or":[29],"inhibitor":[30],"proteins":[31],"binding":[32],"to":[33,47,54,113,162],"their":[34],"target":[35],"sequences.":[36],"As":[37],"result,":[39],"an":[40,131,144,154],"additional":[41],"level":[42],"regulation":[44],"added":[46],"signals":[49],"that":[50,169],"organize":[51],"access":[53],"chromatin":[56],"its":[58,114,202],"structural":[59],"components.":[60],"The":[61,207],"tumor":[62],"suppressor":[63],"RASSF1A":[65,84,106,121,139,174,192,215,230],"microtubule-associated":[68],"multitasking":[70],"scaffold":[71],"protein":[72],"communicating":[73],"RAS":[76],"pathway,":[77],"estrogen":[78],"receptor":[79],"signaling,":[80],"Hippo":[82],"pathway.":[83],"action":[85],"stimulates":[86],"mitotic":[87],"arrest,":[88],"DNA":[89],"repair":[90],"apoptosis,":[92],"controls":[94],"cell":[96,99,136],"cycle":[97],"migration.":[100],"De":[101],"novo":[102],"methylation":[103,122,140,158,193,216,231],"promoter":[107],"has":[108],"received":[109],"much":[110],"attention":[111],"due":[112],"increased":[115],"frequency":[116],"in":[117,135,148,214,233],"most":[118],"cancer":[119,150,238],"types.":[120,239],"preceded":[124],"by":[125],"histones":[126],"modifications":[127],"could":[129],"represent":[130],"early":[132],"molecular":[133,211],"event":[134],"transformation.":[137],"Accordingly,":[138],"proposed":[142],"as":[143],"candidate":[146],"marker":[147],"many":[149],"types,":[151],"even":[152],"though":[153],"inverse":[155],"correlation":[156],"remains":[161],"be":[163],"fully":[164],"ascertained.":[165],"Some":[166],"findings":[167],"indicate":[168],"abrogation":[172],"can":[175],"promote":[176],"alternative":[178],"putative":[182],"oncogenic":[183],"isoform":[184],"RASSF1C.":[185],"Understanding":[186],"complexity":[188],"significance":[190,227],"instrumental":[195],"more":[198],"accurate":[199],"determination":[200],"biological":[203],"clinical":[205],"role.":[206],"review":[208],"covers":[209],"events":[212],"implicated":[213],"silencing":[219],"provides":[221],"deeper":[223],"view":[224],"into":[225],"patterns":[232],"number":[235],"gastrointestinal":[237]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-07-23T00:00:00"}