{"id":"https://openalex.org/W29603845","doi":null,"title":"Inhibition of choriocapillaris regeneration with genistein.","display_name":"Inhibition of choriocapillaris regeneration with genistein.","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W29603845","mag":"29603845","pmid":"https://pubmed.ncbi.nlm.nih.gov/10359330"},"language":"en","primary_location":{"id":"pmid:10359330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10359330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109834814","display_name":"Ajit Babu Majji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Majji","raw_affiliation_strings":["Wilmer Ophthalmological Institute, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmer Ophthalmological Institute, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069794663","display_name":"Atsushi Hayashi","orcid":"https://orcid.org/0000-0003-2885-1141","observed_orcids":["https://orcid.org/0000-0003-2885-1141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108731639","display_name":"Hyung Chan Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H C Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007965549","display_name":"Rhonda R. Grebe","orcid":"https://orcid.org/0000-0003-1841-9777","observed_orcids":["https://orcid.org/0000-0003-1841-9777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R R Grebe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112738330","display_name":"E. de Juan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E de Juan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8009,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82153991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"40","issue":"7","first_page":"1477","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8999999761581421},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.7540000081062317},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.8999729156494141},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5436484217643738},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4993128776550293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48170119524002075},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.44823381304740906},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4246165454387665},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.4132079780101776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.337123841047287},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3341643214225769},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3299415707588196},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.310504674911499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2421865463256836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24070122838020325},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.23495545983314514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12037080526351929},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0847434401512146},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003646","descriptor_name":"Debridement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005654","descriptor_name":"Fundus Oculi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016319","descriptor_name":"Corrosion Casting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:10359330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10359330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.1246","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.1246","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/40/7/1477.full.pdf","raw_type":"text"},{"id":"mag:29603845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10359330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099805002","https://openalex.org/W2407780705","https://openalex.org/W2088943983","https://openalex.org/W2020323601","https://openalex.org/W2371493808","https://openalex.org/W857722337","https://openalex.org/W2096789199","https://openalex.org/W2352119423","https://openalex.org/W2031709968","https://openalex.org/W4411537947"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"test":[2],"the":[3,22,68,80,96,99,111,134,138,151,168,183,199,207,251],"effects":[4],"of":[5,27,31,35,55,63,79,95,98,121,133,155,219,227,253],"genistein":[6,159,220,242],"on":[7,233],"choriocapillaris":[8,100,156,228],"regeneration":[9,143,229],"and":[10,67,71,77,89,102,110],"retinal":[11],"pigment":[12],"epithelial":[13],"(RPE)":[14],"wound":[15,140,208,235],"healing":[16],"in":[17,21,57,150,182,213,250],"a":[18,32,124,177,247],"surgical":[19,53],"model":[20],"rabbit.":[23],"METHODS:":[24],"Intravitreal":[25,217],"injections":[26],"either":[28],"0.1":[29],"ml":[30],"90-microM":[33],"concentration":[34],"genistein,":[36],"dimethyl":[37],"sulfoxide":[38],"(DMSO;":[39],"negative":[40,170],"control),":[41],"or":[42],"2":[43],"microg":[44],"cycloheximide":[45],"(positive":[46],"control)":[47],"were":[48,83,113],"given":[49],"24":[50],"hours":[51],"before":[52],"debridement":[54],"RPE":[56,69,103,122,139,205,234],"rabbits.":[58],"Scanning":[59],"electron":[60],"microscopy":[61,76],"(EM)":[62],"choroidal":[64,254],"vascular":[65],"casts":[66],"wounds":[70],"histologic":[72],"evaluation":[73],"by":[74,106,115,129,147,158,210],"light":[75],"EM":[78],"disturbed":[81],"areas":[82],"performed":[84,105],"at":[85,162,194],"days":[86],"1,":[87],"7,":[88],"30":[90,149,164],"after":[91],"surgery.":[92],"Quantitative":[93],"analysis":[94],"area":[97,209],"bed":[101],"was":[104,160,176,221],"automated":[107],"image":[108],"analysis,":[109],"results":[112],"analyzed":[114],"paired":[116],"Student's":[117],"t-test.":[118],"RESULTS:":[119],"Loss":[120],"caused":[123],"rapid":[125],"initial":[126],"atrophy":[127],"followed":[128],"slower":[130],"subsequent":[131],"revascularization":[132,157],"choriocapillaris,":[135],"which":[136,191],"paralleled":[137],"healing.":[141,236],"Choriocapillaris":[142],"appeared":[144],"nearly":[145],"normal":[146],"day":[148,163,195,211],"DMSO":[152,200],"group.":[153],"Inhibition":[154],"significant":[161,225],"when":[165],"compared":[166,197],"with":[167,198],"DMSO-treated":[169],"control":[171,186],"(P":[172,188,202],"=":[173,189,203],"0.013).":[174],"There":[175],"strong":[178],"trend":[179],"toward":[180],"inhibition":[181,226],"cycloheximide-treated":[184],"positive":[185],"group":[187,201],"0.062),":[190],"reached":[192],"significance":[193],"7":[196,212],"0.02).":[204],"covered":[206],"all":[214],"groups.":[215],"CONCLUSIONS:":[216],"injection":[218],"found":[222],"to":[223],"cause":[224],"without":[230],"apparent":[231],"effect":[232],"Tyrosine":[237],"kinase":[238],"inhibitors":[239],"such":[240],"as":[241,246],"may":[243],"be":[244],"useful":[245],"pharmacologic":[248],"approach":[249],"treatment":[252],"neovascularization.":[255]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
