{"id":"https://openalex.org/W2960294704","doi":null,"title":"Telomere Length and Senescence in a Long-lived Fish (Ictiobus cyprinellus)","display_name":"Telomere Length and Senescence in a Long-lived Fish (Ictiobus cyprinellus)","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2960294704","mag":"2960294704"},"language":"en","primary_location":{"id":"pmh:oai:library.ndsu.edu:10365/29782","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10365/29782","pdf_url":"https://hdl.handle.net/10365/29782","source":{"id":"https://openalex.org/S4306401374","display_name":"NDSU Repository (North Dakota State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57328836","host_organization_name":"North Dakota State University","host_organization_lineage":["https://openalex.org/I57328836"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10365/29782","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044999004","display_name":"Derek J. Sauer","orcid":"https://orcid.org/0000-0002-3350-1632","observed_orcids":["https://orcid.org/0000-0002-3350-1632"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Derek J. Sauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3350-1632","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044999004"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bigmouth-buffalo","display_name":"bigmouth buffalo","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ictiobus-cyprinellus","display_name":"Ictiobus cyprinellus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6520000100135803},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.6740000247955322},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9509999752044678},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.5059999823570251},{"id":"https://openalex.org/keywords/long-lived-fish","display_name":"long-lived fish","score":0.6899999976158142},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.6179999709129333},{"id":"https://openalex.org/keywords/negligible-senescence","display_name":"negligible senescence","score":0.6370000243186951},{"id":"https://openalex.org/keywords/catostomidae","display_name":"Catostomidae","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9688693881034851},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.809485673904419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7477023005485535},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.6554826498031616},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.604689359664917},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47811001539230347},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4545546770095825},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.44742587208747864},{"id":"https://openalex.org/C3020391436","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte subsets","level":4,"score":0.4100651443004608},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37522590160369873},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.36887580156326294},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.29577115178108215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21383550763130188},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.11389905214309692},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:library.ndsu.edu:10365/29782","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10365/29782","pdf_url":"https://hdl.handle.net/10365/29782","source":{"id":"https://openalex.org/S4306401374","display_name":"NDSU Repository (North Dakota State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57328836","host_organization_name":"North Dakota State University","host_organization_lineage":["https://openalex.org/I57328836"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2960294704","doi":null,"is_oa":false,"landing_page_url":"https://library.ndsu.edu/ir/bitstream/10365/29782/1/Sauer_ndsu_0157N_12293.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:library.ndsu.edu:10365/29782","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10365/29782","pdf_url":"https://hdl.handle.net/10365/29782","source":{"id":"https://openalex.org/S4306401374","display_name":"NDSU Repository (North Dakota State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57328836","host_organization_name":"North Dakota State University","host_organization_lineage":["https://openalex.org/I57328836"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2960294704.pdf","grobid_xml":"https://content.openalex.org/works/W2960294704.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W73308801","https://openalex.org/W167981432","https://openalex.org/W839424108","https://openalex.org/W1486360339","https://openalex.org/W1519233253","https://openalex.org/W1524525825","https://openalex.org/W1959307403","https://openalex.org/W1964386146","https://openalex.org/W1970139105","https://openalex.org/W1970891016","https://openalex.org/W1975000733","https://openalex.org/W1975594217","https://openalex.org/W1977698433","https://openalex.org/W1981335415","https://openalex.org/W1981392889","https://openalex.org/W1983673827","https://openalex.org/W1986231293","https://openalex.org/W1988910648","https://openalex.org/W1992582037","https://openalex.org/W1992729444","https://openalex.org/W1995424845","https://openalex.org/W2000417322","https://openalex.org/W2006954669","https://openalex.org/W2009675362","https://openalex.org/W2013852236","https://openalex.org/W2014231393","https://openalex.org/W2016313075","https://openalex.org/W2019202249","https://openalex.org/W2025524824","https://openalex.org/W2026053675","https://openalex.org/W2026654007","https://openalex.org/W2036331658","https://openalex.org/W2036432055","https://openalex.org/W2047457477","https://openalex.org/W2054684152","https://openalex.org/W2055451491","https://openalex.org/W2065173659","https://openalex.org/W2079282402","https://openalex.org/W2081527689","https://openalex.org/W2082376311","https://openalex.org/W2085491621","https://openalex.org/W2097075017","https://openalex.org/W2097529540","https://openalex.org/W2109625473","https://openalex.org/W2110245017","https://openalex.org/W2122252259","https://openalex.org/W2134718821","https://openalex.org/W2135821619","https://openalex.org/W2138700466","https://openalex.org/W2139793739","https://openalex.org/W2144439991","https://openalex.org/W2164321086","https://openalex.org/W2164808240","https://openalex.org/W2166432839","https://openalex.org/W2168901136","https://openalex.org/W2175659544","https://openalex.org/W2233660390","https://openalex.org/W2336501432","https://openalex.org/W2470219606"],"related_works":["https://openalex.org/W3159120185","https://openalex.org/W1967708893","https://openalex.org/W2435104299","https://openalex.org/W4365597368","https://openalex.org/W2004740296","https://openalex.org/W6958345558","https://openalex.org/W2000310814","https://openalex.org/W4403033519","https://openalex.org/W7098790531","https://openalex.org/W2596935654"],"abstract_inverted_index":{"The":[0],"pattern":[1],"of":[2,35,48,53,92,132,135,144],"shorter":[3],"telomere":[4,40,62,136],"lengths":[5],"in":[6,20,45,55,68,77,84,113,121,147],"older":[7,114,122],"individuals":[8],"has":[9,16],"been":[10,18],"observed":[11],"across":[12],"many":[13],"vertebrates,":[14,36],"but":[15],"not":[17,100],"well-documented":[19],"bony":[21,75],"fishes.":[22],"Bony":[23],"fish":[24,76],"(i.e.,":[25],"Class":[26],"Osteichthyes)":[27],"represent":[28],"the":[29,49,78,108,142],"most":[30],"speciose":[31],"and":[32,37,51,66,86,116,138],"oldest":[33],"group":[34],"understanding":[38,47],"their":[39],"dynamics":[41],"can":[42],"fill":[43],"gaps":[44],"our":[46],"process":[50],"evolution":[52],"aging":[54],"vertebrates.":[56,149],"In":[57],"this":[58],"study":[59],"we":[60],"quantified":[61],"length,":[63],"immune":[64,117],"function,":[65],"stress":[67],"bigmouth":[69,127],"buffalo":[70,128],"(Ictiobus":[71],"cyrpinellus),":[72],"a":[73],"long-lived":[74],"family":[79],"Catostomidae,":[80],"to":[81,102],"characterize":[82],"variation":[83],"telomeres":[85,93],"condition.":[87],"We":[88,104],"found":[89,106],"that":[90,107],"length":[91],"extracted":[94],"from":[95],"red":[96],"blood":[97],"cells":[98],"was":[99,111,119],"related":[101],"age.":[103],"also":[105],"neutrophil/lymphocyte":[109],"ratio":[110],"lower":[112],"individuals,":[115],"function":[118],"greater":[120],"individuals.":[123],"Our":[124],"findings":[125],"suggest":[126],"may":[129],"be":[130],"capable":[131],"intrinsic":[133],"regulation":[134],"shortening":[137],"provide":[139],"support":[140],"for":[141],"existence":[143],"negligible":[145],"senescence":[146],"some":[148]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2019-07-23T00:00:00"}