{"id":"https://openalex.org/W2960136981","doi":"https://doi.org/10.1111/tra.12677","title":"Conformational regulation of AP1 and AP2 clathrin adaptor complexes","display_name":"Conformational regulation of AP1 and AP2 clathrin adaptor complexes","publication_year":2019,"publication_date":"2019-07-17","ids":{"openalex":"https://openalex.org/W2960136981","doi":"https://doi.org/10.1111/tra.12677","mag":"2960136981","pmid":"https://pubmed.ncbi.nlm.nih.gov/31313456","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6774827"},"language":"en","primary_location":{"id":"doi:10.1111/tra.12677","doi":"https://doi.org/10.1111/tra.12677","is_oa":false,"landing_page_url":"https://doi.org/10.1111/tra.12677","pdf_url":null,"source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6774827","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064983507","display_name":"Gwendolyn M. Beacham","orcid":"https://orcid.org/0000-0001-7158-6887","observed_orcids":["https://orcid.org/0000-0001-7158-6887"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gwendolyn M. Beacham","raw_affiliation_strings":["Department of Molecular Medicine, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028859518","display_name":"Edward A. Partlow","orcid":"https://orcid.org/0000-0001-5513-088X","observed_orcids":["https://orcid.org/0000-0001-5513-088X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A. Partlow","raw_affiliation_strings":["Department of Molecular Medicine, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027595235","display_name":"Gunther Hollopeter","orcid":"https://orcid.org/0000-0002-6409-0530","observed_orcids":["https://orcid.org/0000-0002-6409-0530"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gunther Hollopeter","raw_affiliation_strings":["Department of Molecular Medicine, Cornell University, Ithaca, New York"],"raw_orcid":"https://orcid.org/0000-0002-6409-0530","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027595235"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":0.5483,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.45552785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"20","issue":"10","first_page":"741","last_page":"751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clathrin-adaptor-proteins","display_name":"clathrin adaptor proteins","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ap2","display_name":"AP-2","score":1.0},{"id":"https://openalex.org/keywords/conformational-control","display_name":"conformational control","score":0.9319999814033508},{"id":"https://openalex.org/keywords/coated-vesicle-formation","display_name":"coated vesicle formation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-phosphate","display_name":"phosphatidylinositol 4-phosphate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.996999979019165},{"id":"https://openalex.org/keywords/trans-golgi-network","display_name":"trans-Golgi network","score":0.6729999780654907},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.8240000009536743},{"id":"https://openalex.org/keywords/arf1","display_name":"Arf1","score":0.703000009059906},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/clathrin-triskelion","display_name":"clathrin triskelion","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cargo-recruitment","display_name":"cargo recruitment","score":0.7170000076293945},{"id":"https://openalex.org/keywords/viral-evasion-of-host-defense","display_name":"viral evasion of host defense","score":0.6629999876022339},{"id":"https://openalex.org/keywords/membrane-trafficking","display_name":"membrane trafficking","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8439348340034485},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.8255664110183716},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.8010022640228271},{"id":"https://openalex.org/C102280478","wikidata":"https://www.wikidata.org/wiki/Q3270441","display_name":"AP-1 transcription factor","level":4,"score":0.7390413284301758},{"id":"https://openalex.org/C33410366","wikidata":"https://www.wikidata.org/wiki/Q21106379","display_name":"Clathrin adaptor proteins","level":5,"score":0.6193617582321167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5926382541656494},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2711092233657837},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22640478610992432},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.2170741856098175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15810224413871765},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15101349353790283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12093481421470642}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002966","descriptor_name":"Clathrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002966","descriptor_name":"Clathrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033961","descriptor_name":"Adaptor Protein Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033961","descriptor_name":"Adaptor Protein Complex 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D033962","descriptor_name":"Adaptor Protein Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033962","descriptor_name":"Adaptor Protein Complex 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/tra.12677","doi":"https://doi.org/10.1111/tra.12677","is_oa":false,"landing_page_url":"https://doi.org/10.1111/tra.12677","pdf_url":null,"source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},{"id":"pmid:31313456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31313456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic (Copenhagen, Denmark)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6774827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6774827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Traffic","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6774827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6774827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Traffic","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2964512417","display_name":"Predoctoral Training in Cellular and Molecular Biology","funder_award_id":"T32GM007273","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4935328766","display_name":"Molecular regulation of the AP2 clathrin adaptor complex","funder_award_id":"R01GM127548","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7040166047","display_name":null,"funder_award_id":"GM007273\u201043","funder_id":"https://openalex.org/F4320337368","funder_display_name":"Division of Graduate Education"},{"id":"https://openalex.org/G8229174675","display_name":null,"funder_award_id":"DGE-165-0441","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W49587981","https://openalex.org/W215944638","https://openalex.org/W1494503629","https://openalex.org/W1586410827","https://openalex.org/W1654155636","https://openalex.org/W1826847771","https://openalex.org/W1967637720","https://openalex.org/W1968971638","https://openalex.org/W1972665490","https://openalex.org/W1975428752","https://openalex.org/W1979815209","https://openalex.org/W1982116050","https://openalex.org/W1985097347","https://openalex.org/W1986805207","https://openalex.org/W1987672004","https://openalex.org/W1992968802","https://openalex.org/W1993054972","https://openalex.org/W1997347495","https://openalex.org/W1999819298","https://openalex.org/W2004344365","https://openalex.org/W2004435513","https://openalex.org/W2004972894","https://openalex.org/W2008511010","https://openalex.org/W2009942743","https://openalex.org/W2010458160","https://openalex.org/W2012848672","https://openalex.org/W2015749520","https://openalex.org/W2017430826","https://openalex.org/W2019196882","https://openalex.org/W2020459053","https://openalex.org/W2023119588","https://openalex.org/W2026790970","https://openalex.org/W2037403702","https://openalex.org/W2040010587","https://openalex.org/W2040207361","https://openalex.org/W2040816352","https://openalex.org/W2041848251","https://openalex.org/W2042195196","https://openalex.org/W2045437791","https://openalex.org/W2048451267","https://openalex.org/W2049484730","https://openalex.org/W2050222635","https://openalex.org/W2050251450","https://openalex.org/W2056701485","https://openalex.org/W2058582949","https://openalex.org/W2058706417","https://openalex.org/W2058819983","https://openalex.org/W2077084337","https://openalex.org/W2088144068","https://openalex.org/W2092303195","https://openalex.org/W2094882170","https://openalex.org/W2096154351","https://openalex.org/W2097244362","https://openalex.org/W2100278600","https://openalex.org/W2104927620","https://openalex.org/W2105308973","https://openalex.org/W2106947004","https://openalex.org/W2107853353","https://openalex.org/W2108328973","https://openalex.org/W2114410573","https://openalex.org/W2115994196","https://openalex.org/W2117679566","https://openalex.org/W2119260049","https://openalex.org/W2119575179","https://openalex.org/W2124897859","https://openalex.org/W2126002974","https://openalex.org/W2126126419","https://openalex.org/W2129896183","https://openalex.org/W2136114088","https://openalex.org/W2137089508","https://openalex.org/W2140194302","https://openalex.org/W2145410464","https://openalex.org/W2155657795","https://openalex.org/W2156041055","https://openalex.org/W2156136078","https://openalex.org/W2158131682","https://openalex.org/W2158168091","https://openalex.org/W2158907019","https://openalex.org/W2159803769","https://openalex.org/W2160997906","https://openalex.org/W2163597027","https://openalex.org/W2167020534","https://openalex.org/W2173675591","https://openalex.org/W2264619615","https://openalex.org/W2297102350","https://openalex.org/W2399726023","https://openalex.org/W2400526229","https://openalex.org/W2415709290","https://openalex.org/W2568848023","https://openalex.org/W2604905743","https://openalex.org/W2620484568","https://openalex.org/W2626951342","https://openalex.org/W2760253866","https://openalex.org/W2793567263","https://openalex.org/W2800413193","https://openalex.org/W2884498378","https://openalex.org/W4231046242"],"related_works":["https://openalex.org/W2045175038","https://openalex.org/W7135457686","https://openalex.org/W2117679566","https://openalex.org/W1997347495","https://openalex.org/W2946252778","https://openalex.org/W2158907019","https://openalex.org/W4243960924","https://openalex.org/W2235569879","https://openalex.org/W1972665490","https://openalex.org/W1523957574"],"abstract_inverted_index":{"Heterotetrameric":[0],"clathrin":[1,59,93],"adaptor":[2],"protein":[3,56,132],"complexes":[4],"(APs)":[5],"orchestrate":[6],"the":[7,17,29,40,51,121,158,172],"formation":[8],"of":[9,16,39,54,144,160,171],"coated":[10],"vesicles":[11],"for":[12,24],"transport":[13],"among":[14],"organelles":[15],"cell":[18],"periphery.":[19],"AP1":[20,47,177],"binds":[21],"membranes":[22],"enriched":[23],"phosphatidylinositol":[25,37],"4-phosphate,":[26],"such":[27,107],"as":[28,108],"trans":[30],"Golgi":[31],"network,":[32],"while":[33],"AP2":[34,49,179],"associates":[35],"with":[36],"4,5-bisphosphate":[38],"plasma":[41],"membrane.":[42],"At":[43],"their":[44],"respective":[45],"membranes,":[46],"and":[48,58,70,80,92,110,130,178,183],"bind":[50],"cytoplasmic":[52],"tails":[53],"transmembrane":[55],"cargo":[57,63,91],"triskelions,":[60],"thereby":[61],"coupling":[62],"recruitment":[64],"to":[65,83,97,120,152,180],"coat":[66],"polymerization.":[67],"Structural,":[68],"biochemical":[69],"genetic":[71],"studies":[72],"have":[73,94,148],"revealed":[74],"that":[75,104,175],"APs":[76,116],"undergo":[77],"conformational":[78],"rearrangements":[79],"reversible":[81],"phosphorylation":[82,129],"cycle":[84],"between":[85],"different":[86],"activity":[87],"states.":[88],"While":[89],"membrane,":[90],"been":[95],"demonstrated":[96],"promote":[98],"AP":[99],"activation,":[100],"growing":[101],"evidence":[102],"supports":[103],"membrane-associated":[105],"proteins":[106],"Arf1":[109],"FCHo":[111],"also":[112],"stimulate":[113,176],"this":[114],"transition.":[115],"may":[117],"be":[118],"returned":[119],"inactive":[122],"state":[123],"via":[124],"a":[125,131],"regulated":[126],"process":[127],"involving":[128],"called":[133],"NECAP.":[134],"Finally,":[135],"because":[136],"antiviral":[137],"mechanisms":[138],"often":[139],"rely":[140],"on":[141],"appropriate":[142],"trafficking":[143],"membrane":[145],"proteins,":[146],"viruses":[147],"evolved":[149],"novel":[150],"strategies":[151],"evade":[153],"host":[154],"defenses":[155],"by":[156],"influencing":[157],"conformation":[159],"APs.":[161],"This":[162],"review":[163],"will":[164],"cover":[165],"recent":[166],"advances":[167],"in":[168],"our":[169],"understanding":[170],"molecular":[173],"inputs":[174],"adopt":[181],"structurally":[182],"functionally":[184],"distinct":[185],"configurations.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-23T00:00:00"}