{"id":"https://openalex.org/W2959907886","doi":"https://doi.org/10.1109/isbi.2019.8759409","title":"Physician-Level Aggregated Classifier for Genetic Muscle Disorders","display_name":"Physician-Level Aggregated Classifier for Genetic Muscle Disorders","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2959907886","doi":"https://doi.org/10.1109/isbi.2019.8759409","mag":"2959907886"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759409","doi":"https://doi.org/10.1109/isbi.2019.8759409","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759409","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"IEEE International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062362584","display_name":"Yoshinori Kabeya","orcid":"https://orcid.org/0000-0001-5843-4889","observed_orcids":["https://orcid.org/0000-0001-5843-4889"]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Kabeya","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067290048","display_name":"Toshiya Iwamori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiya Iwamori","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024443006","display_name":"Sho Yonezawa","orcid":"https://orcid.org/0000-0002-9846-7092","observed_orcids":["https://orcid.org/0000-0002-9846-7092"]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Yonezawa","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101662176","display_name":"Yusuke Takeuchi","orcid":"https://orcid.org/0000-0003-2491-9524","observed_orcids":["https://orcid.org/0000-0003-2491-9524"]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Takeuchi","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686841","display_name":"Hiroki Nakano","orcid":"https://orcid.org/0000-0001-9978-7007","observed_orcids":["https://orcid.org/0000-0001-9978-7007"]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Nakano","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053069627","display_name":"Yuhe Nagisa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuhe Nagisa","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066713182","display_name":"Mariko Okubo","orcid":"https://orcid.org/0000-0002-7564-4463","observed_orcids":["https://orcid.org/0000-0002-7564-4463"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Okubo","raw_affiliation_strings":["National Center of Neurology and Psychiatry (NCNP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Neurology and Psychiatry (NCNP)","institution_ids":["https://openalex.org/I4210103779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061142650","display_name":"Michio Inoue","orcid":"https://orcid.org/0000-0003-2757-3266","observed_orcids":["https://orcid.org/0000-0003-2757-3266"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Inoue","raw_affiliation_strings":["National Center of Neurology and Psychiatry (NCNP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Neurology and Psychiatry (NCNP)","institution_ids":["https://openalex.org/I4210103779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001631245","display_name":"Reitaro Tokumasu","orcid":"https://orcid.org/0000-0002-2611-241X","observed_orcids":["https://orcid.org/0000-0002-2611-241X"]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reitaro Tokumasu","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035641736","display_name":"Issei Ozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Issei Ozawa","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Atsushi Takano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264400","display_name":"IBM Japan, Ltd. (Japan)","ror":"https://ror.org/01t8cbh24","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Takano","raw_affiliation_strings":["IBM Japan Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM Japan Ltd","institution_ids":["https://openalex.org/I4405264400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071478982","display_name":"Ichizo Nishino","orcid":"https://orcid.org/0000-0001-9452-112X","observed_orcids":["https://orcid.org/0000-0001-9452-112X"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichizo Nishino","raw_affiliation_strings":["National Center of Neurology and Psychiatry (NCNP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Neurology and Psychiatry (NCNP)","institution_ids":["https://openalex.org/I4210103779"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0956,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32708716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":null,"first_page":"1850","last_page":"1854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.43869999051094055,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.43869999051094055,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-muscle-disorders","display_name":"genetic muscle disorders","score":0.9279999732971191},{"id":"https://openalex.org/keywords/muscle-pathology","display_name":"muscle pathology","score":0.9190000295639038},{"id":"https://openalex.org/keywords/computer-aided-diagnosis","display_name":"computer-aided diagnosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.6430000066757202},{"id":"https://openalex.org/keywords/dystrophinopathy","display_name":"dystrophinopathy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/limb-girdle-muscular-dystrophy","display_name":"limb-girdle muscular dystrophy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ullrich-congenital-muscular-dystrophy","display_name":"Ullrich congenital muscular dystrophy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fukuyama-type-congenital-muscular-dystrophy","display_name":"Fukuyama-type congenital muscular dystrophy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/h-e-staining","display_name":"H&E staining","score":0.9049999713897705},{"id":"https://openalex.org/keywords/multiclass-classification","display_name":"multi-class classification","score":0.7749999761581421},{"id":"https://openalex.org/keywords/physician-comparison","display_name":"physician comparison","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5682026743888855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5454651713371277},{"id":"https://openalex.org/C2909765735","wikidata":"https://www.wikidata.org/wiki/Q4116663","display_name":"Muscle disorder","level":2,"score":0.452716201543808},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4461558163166046},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35100579261779785},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.336750328540802},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3302929401397705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22505232691764832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20708316564559937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12536853551864624}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2019.8759409","doi":"https://doi.org/10.1109/isbi.2019.8759409","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759409","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"IEEE International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2183341477","https://openalex.org/W2332886223","https://openalex.org/W2504150216","https://openalex.org/W2557738935","https://openalex.org/W2581082771","https://openalex.org/W2592929672","https://openalex.org/W2760946358","https://openalex.org/W2770241596","https://openalex.org/W2889510460","https://openalex.org/W2963446712"],"related_works":["https://openalex.org/W4247398530","https://openalex.org/W2976234930","https://openalex.org/W3143670628","https://openalex.org/W3203852240","https://openalex.org/W2395436027","https://openalex.org/W4415978749","https://openalex.org/W4412197484","https://openalex.org/W4299402848","https://openalex.org/W7162720081","https://openalex.org/W4392450124"],"abstract_inverted_index":{"Muscle":[0],"histopathology":[1,164],"is":[2,20],"the":[3,6,12,35,126,131,151],"one":[4],"of":[5,14,30,41,134],"most":[7],"important":[8],"diagnostic":[9,55],"methods":[10],"in":[11,34,45,61],"diagnosis":[13],"muscle":[15,77,84,163],"diseases":[16],"[1].":[17],"Nevertheless,":[18],"it":[19],"a":[21,27,53,69,120],"highly":[22],"specialized":[23],"field":[24],"and":[25,103,111],"only":[26,150,179],"limited":[28],"number":[29,40],"experts":[31],"are":[32,43],"available":[33],"world.":[36],"Not":[37],"surprisingly,":[38],"significant":[39],"cases":[42],"undiagnosed":[44],"underserved":[46],"areas.":[47],"We":[48,80,118],"therefore":[49],"intended":[50],"to":[51,67,113,137],"establish":[52],"computer-aided":[54,76],"system":[56],"which":[57,123],"should":[58],"be":[59,176],"helpful":[60],"this":[62],"domain.":[63],"This":[64,168],"study":[65],"aims":[66],"develop":[68],"multi-class":[70],"classifier":[71,143,153],"with":[72,139],"deep":[73],"learning":[74],"for":[75,162,165],"histopathological":[78,140],"diagnosis.":[79],"chose":[81],"five":[82],"genetic":[83,186],"disease":[85],"categories":[86],"(dystrophinopathy,":[87],"limb-girdle":[88,93],"muscular":[89,94,100,106],"dystrophy":[90,95,101,107],"2A":[91],"(LGMD2A),":[92],"2B":[96],"(LGMD2B),":[97],"Ullrich":[98],"congenital":[99,105],"(UCMD),":[102],"Fukuyama-type":[104],"(FCMD))":[108],"as":[109],"targets":[110],"aimed":[112],"distinguish":[114],"between":[115],"these":[116],"diseases.":[117],"developed":[119],"new":[121],"classifier,":[122,128],"we":[124],"call":[125],"aggregated":[127],"that":[129,171],"improves":[130],"classification":[132,146],"accuracy":[133,147],"existing":[135,152],"classifiers":[136],"deal":[138],"images.":[141],"The":[142],"achieved":[144],"better":[145],"than":[148],"not":[149],"but":[154],"also":[155],"eight":[156],"physicians":[157],"who":[158],"have":[159],"been":[160],"trained":[161],"variable":[166],"duration.":[167],"result":[169],"suggests":[170],"causative":[172],"genes":[173],"may":[174],"possibly":[175],"precisely":[177],"predicted":[178],"by":[180],"hematoxylin-eosin":[181],"(H&E)":[182],"stained":[183],"images":[184],"without":[185],"testing.":[187]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-07-23T00:00:00"}