{"id":"https://openalex.org/W2959593232","doi":"https://doi.org/10.15537/smj.2019.7.24302","title":"The evaluation of leukocyte-platelet rich fibrin as an anti-inflammatory autologous biological additive: A novel in vitro study","display_name":"The evaluation of leukocyte-platelet rich fibrin as an anti-inflammatory autologous biological additive: A novel in vitro study","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2959593232","doi":"https://doi.org/10.15537/smj.2019.7.24302","mag":"2959593232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31287125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6757208"},"language":"en","primary_location":{"id":"doi:10.15537/smj.2019.7.24302","doi":"https://doi.org/10.15537/smj.2019.7.24302","is_oa":true,"landing_page_url":"https://doi.org/10.15537/smj.2019.7.24302","pdf_url":null,"source":{"id":"https://openalex.org/S73848604","display_name":"Saudi Medical Journal","issn_l":"0379-5284","issn":["0379-5284","1658-3175"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319313","host_organization_name":"Ministry of Defence and Aviation","host_organization_lineage":["https://openalex.org/P4310319313"],"host_organization_lineage_names":["Ministry of Defence and Aviation"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.15537/smj.2019.7.24302","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025858801","display_name":"Mahmoud Mudalal","orcid":"https://orcid.org/0000-0001-5551-6053","observed_orcids":["https://orcid.org/0000-0001-5551-6053"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mahmoud Mudalal","raw_affiliation_strings":["Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China. E-mail. modalla10@hotmail.com","From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China. E-mail. modalla10@hotmail.com","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102003506","display_name":"Xiaolin Sun","orcid":"https://orcid.org/0000-0003-2659-2537","observed_orcids":["https://orcid.org/0000-0003-2659-2537"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolin Sun","raw_affiliation_strings":["From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101900335","display_name":"Xue Li","orcid":"https://orcid.org/0000-0003-2485-4812","observed_orcids":["https://orcid.org/0000-0003-2485-4812","https://orcid.org/0000-0002-2304-292X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Li","raw_affiliation_strings":["From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018071543","display_name":"Yanmin Zhou","orcid":"https://orcid.org/0000-0002-4173-6765","observed_orcids":["https://orcid.org/0000-0002-4173-6765"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanmin Zhou","raw_affiliation_strings":["From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018071543"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":null,"apc_paid":null,"fwci":1.9518,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.82810095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"40","issue":"7","first_page":"657","last_page":"668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukocyte-and-platelet-rich-fibrin","display_name":"L-PRF","score":0.9789999723434448},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5429999828338623},{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9800000190734863},{"id":"https://openalex.org/keywords/gingival-fibroblasts","display_name":"gingival fibroblasts","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8930000066757202},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9480000138282776},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7039721608161926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6815980076789856},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.681152880191803},{"id":"https://openalex.org/C2777560349","wikidata":"https://www.wikidata.org/wiki/Q18388934","display_name":"Platelet-rich fibrin","level":3,"score":0.6750359535217285},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.604364275932312},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.5596033334732056},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.5253388285636902},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.499561071395874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45232659578323364},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4427807331085205},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.44274190068244934},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.43779414892196655},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40010759234428406},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3856351375579834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2536658048629761},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.23497086763381958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19085460901260376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17488688230514526},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1465410590171814},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.11073896288871765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073183","descriptor_name":"Platelet-Rich Fibrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013280","descriptor_name":"Stomatitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.15537/smj.2019.7.24302","doi":"https://doi.org/10.15537/smj.2019.7.24302","is_oa":true,"landing_page_url":"https://doi.org/10.15537/smj.2019.7.24302","pdf_url":null,"source":{"id":"https://openalex.org/S73848604","display_name":"Saudi Medical Journal","issn_l":"0379-5284","issn":["0379-5284","1658-3175"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319313","host_organization_name":"Ministry of Defence and Aviation","host_organization_lineage":["https://openalex.org/P4310319313"],"host_organization_lineage_names":["Ministry of Defence and Aviation"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6757208","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6757208/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6757208/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Med J","raw_type":"Text"},{"id":"pmid:31287125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31287125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi medical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.15537/smj.2019.7.24302","doi":"https://doi.org/10.15537/smj.2019.7.24302","is_oa":true,"landing_page_url":"https://doi.org/10.15537/smj.2019.7.24302","pdf_url":null,"source":{"id":"https://openalex.org/S73848604","display_name":"Saudi Medical Journal","issn_l":"0379-5284","issn":["0379-5284","1658-3175"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319313","host_organization_name":"Ministry of Defence and Aviation","host_organization_lineage":["https://openalex.org/P4310319313"],"host_organization_lineage_names":["Ministry of Defence and Aviation"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2959593232.pdf","grobid_xml":"https://content.openalex.org/works/W2959593232.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W128665603","https://openalex.org/W312292106","https://openalex.org/W1585494570","https://openalex.org/W1653496340","https://openalex.org/W1842508430","https://openalex.org/W1963993157","https://openalex.org/W1966135833","https://openalex.org/W1973688632","https://openalex.org/W1974783559","https://openalex.org/W1990612828","https://openalex.org/W1992667806","https://openalex.org/W1995438382","https://openalex.org/W1996587784","https://openalex.org/W2005769688","https://openalex.org/W2027682383","https://openalex.org/W2030322516","https://openalex.org/W2044242789","https://openalex.org/W2044456093","https://openalex.org/W2046563190","https://openalex.org/W2047431133","https://openalex.org/W2064442032","https://openalex.org/W2074259284","https://openalex.org/W2081080799","https://openalex.org/W2098200347","https://openalex.org/W2101582557","https://openalex.org/W2114783134","https://openalex.org/W2114918609","https://openalex.org/W2115801781","https://openalex.org/W2125427361","https://openalex.org/W2148023279","https://openalex.org/W2150464834","https://openalex.org/W2161632831","https://openalex.org/W2329434588","https://openalex.org/W2514713760","https://openalex.org/W2518046346","https://openalex.org/W2620034449","https://openalex.org/W2756917037","https://openalex.org/W2768994249","https://openalex.org/W2945704790"],"related_works":["https://openalex.org/W3188686673","https://openalex.org/W2761627508","https://openalex.org/W3017275732","https://openalex.org/W4399670582","https://openalex.org/W1993217596","https://openalex.org/W1966761404","https://openalex.org/W2363718755","https://openalex.org/W2548976418","https://openalex.org/W2908688971","https://openalex.org/W2948302724"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"investigate":[2],"the":[3,11,26,66,81,122,131,141,165,170,177,207,211,214],"use":[4],"of":[5,16,30,101,124,140,160,180,200,206,213,217],"leukocyte-platelet":[6],"rich":[7],"fibrin":[8,191],"on":[9],"suppressing":[10],"porphyromonas":[12],"gingivalis":[13],"(PG-LPS)-induced":[14],"secretion":[15],"proinflammatory":[17],"cytokines.":[18],"Methods:This":[19],"quantitative":[20,95],"experimental":[21],"study":[22,195],"was":[23,45,84,112,130,147,182],"conducted":[24],"at":[25,77,108,150],"School":[27],"and":[28,39,57,80,92,105,152,169,189,203],"Hospital":[29],"Stomatology,":[31],"Jilin":[32],"University,":[33],"Changchun,":[34],"China,":[35],"between":[36],"September":[37],"2017":[38],"January":[40],"2019.":[41],"A":[42],"modified":[43,119],"technique":[44,120],"used":[46],"to":[47,64,86,134],"obtain":[48],"human":[49],"gingival":[50,70],"fibroblast":[51,71,136,178],"cells":[52,72],"(HGFCs).":[53],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[54],"bromide":[55],"(MTT)":[56],"Cell":[58],"Counting":[59],"Kit-8":[60],"tests":[61],"were":[62,73],"established":[63,117],"determine":[65],"proliferation":[67],"rate.":[68],"Human":[69],"treated":[74],"by":[75],"PG-LPS":[76,129],"different":[78],"periods":[79],"isolated":[82],"mRNA":[83],"subjected":[85],"reverse":[87],"transcription":[88],"polymerase":[89,96],"chain":[90,97],"reaction":[91],"real":[93],"time":[94,110],"reaction.":[98],"The":[99,138,157],"release":[100,159],"platelet-derived":[102],"growth":[103,161],"factor":[104],"transforming-growth":[106],"factor-\u03b21":[107],"various":[109],"intervals":[111],"observed.":[113],"Results:":[114],"We":[115],"successfully":[116],"a":[118,197],"for":[121,173],"production":[123,171],"HGFCs":[125,202],"culture.":[126],"One":[127],"\u00b5g/mL":[128],"recommended":[132],"concentration":[133],"inhibit":[135],"proliferation.":[137],"expression":[139,179],"pro-inflammatory":[142],"cytokines":[143,181],"messenger":[144],"ribnucleic":[145],"acid":[146],"notably":[148],"raised":[149],"3":[151],"6":[153],"hours":[154,168],"post-PG-LPS":[155],"treatment.":[156],"cumulative":[158],"factors":[162],"peaked":[163],"during":[164],"first":[166],"24":[167],"continued":[172],"10":[174],"days.":[175],"However,":[176],"significantly":[183],"suppressed":[184],"after":[185],"treatment":[186],"with":[187],"leucocyte-":[188],"platelet-rich":[190],"(L-PRF).":[192],"Conclusion:":[193],"This":[194],"provided":[196],"novel":[198],"way":[199],"obtaining":[201],"greater":[204],"understanding":[205],"clinical":[208],"impacts":[209],"through":[210],"assessment":[212],"anti-inflammatory":[215],"properties":[216],"L-PRF":[218],"in":[219],"vitro.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2019-07-23T00:00:00"}