{"id":"https://openalex.org/W2410237123","doi":"https://doi.org/10.1016/j.nicl.2015.10.013","title":"Relating multi-sequence longitudinal intensity profiles and clinical covariates in incident multiple sclerosis lesions","display_name":"Relating multi-sequence longitudinal intensity profiles and clinical covariates in incident multiple sclerosis lesions","publication_year":2015,"publication_date":"2015-11-11","ids":{"openalex":"https://openalex.org/W2410237123","doi":"https://doi.org/10.1016/j.nicl.2015.10.013","mag":"2410237123","pmid":"https://pubmed.ncbi.nlm.nih.gov/26693397","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4660378"},"language":"en","primary_location":{"id":"doi:10.1016/j.nicl.2015.10.013","doi":"https://doi.org/10.1016/j.nicl.2015.10.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nicl.2015.10.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213158215300139/pdf","source":{"id":"https://openalex.org/S2898194095","display_name":"NeuroImage Clinical","issn_l":"2213-1582","issn":["2213-1582"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage: Clinical","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["arxiv","crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2213158215300139/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024618722","display_name":"Elizabeth M. Sweeney","orcid":"https://orcid.org/0000-0002-4094-7421","observed_orcids":["https://orcid.org/0000-0002-4094-7421","https://orcid.org/0000-0002-2555-5497"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth M. Sweeney","raw_affiliation_strings":["Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States ; Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States","Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States"],"raw_orcid":"https://orcid.org/0000-0002-2555-5497","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States ; Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037974362","display_name":"Russell Taki Shinohara","orcid":"https://orcid.org/0000-0001-8627-8203","observed_orcids":["https://orcid.org/0000-0001-8627-8203"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell T. Shinohara","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044628433","display_name":"Blake E. Dewey","orcid":"https://orcid.org/0000-0003-4554-5058","observed_orcids":["https://orcid.org/0000-0003-4554-5058"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake E. Dewey","raw_affiliation_strings":["Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044579001","display_name":"Matthew K. Schindler","orcid":"https://orcid.org/0000-0003-0157-5669","observed_orcids":["https://orcid.org/0000-0003-0157-5669"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Schindler","raw_affiliation_strings":["Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087393296","display_name":"John Muschelli","orcid":"https://orcid.org/0000-0001-6469-1750","observed_orcids":["https://orcid.org/0000-0001-6469-1750"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Muschelli","raw_affiliation_strings":["Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024904743","display_name":"Daniel S. Reich","orcid":"https://orcid.org/0000-0002-2628-4334","observed_orcids":["https://orcid.org/0000-0002-2628-4334"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Reich","raw_affiliation_strings":["Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States ; Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States","Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States ; Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disease and Stroke, National Institute of Health, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089030792","display_name":"Ciprian M. Crainiceanu","orcid":"https://orcid.org/0000-0001-6601-3881","observed_orcids":["https://orcid.org/0000-0001-6601-3881"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciprian M. Crainiceanu","raw_affiliation_strings":["Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080505451","display_name":"Ani Eloyan","orcid":"https://orcid.org/0000-0002-8110-7680","observed_orcids":["https://orcid.org/0000-0002-8110-7680"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ani Eloyan","raw_affiliation_strings":["Department of Biostatistics, Brown University School of Public Health, RI 02912, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Brown University School of Public Health, RI 02912, United States","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024618722"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I4210110767"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":2.1781,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.86535869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/lesion-formation","display_name":"lesion formation","score":0.5130000114440918},{"id":"https://openalex.org/keywords/lesion-repair","display_name":"lesion repair","score":0.5740000009536743},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"principal component analysis","score":0.5920000076293945},{"id":"https://openalex.org/keywords/function-on-scalar-regression","display_name":"function-on-scalar regression","score":0.9959999918937683},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.5559999942779541},{"id":"https://openalex.org/keywords/treatment-response-assessment","display_name":"treatment response assessment","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.7441827058792114},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6881794929504395},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.6432032585144043},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6134222149848938},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.43566659092903137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42155787348747253},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.26751673221588135},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20280146598815918},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16102227568626404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1578269600868225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10081315040588379},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09351742267608643},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06516081094741821},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1016/j.nicl.2015.10.013","doi":"https://doi.org/10.1016/j.nicl.2015.10.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nicl.2015.10.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213158215300139/pdf","source":{"id":"https://openalex.org/S2898194095","display_name":"NeuroImage Clinical","issn_l":"2213-1582","issn":["2213-1582"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage: Clinical","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3659954","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4660378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4660378","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4660378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroimage Clin","raw_type":"Text"},{"id":"pmid:26693397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26693397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage. Clinical","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:1509.08359","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1509.08359","pdf_url":"https://arxiv.org/pdf/1509.08359","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2959103409","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/pdf/1509.08359.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"pmh:oai:doaj.org/article:d627075779af43c4823555a1d1eab203","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d627075779af43c4823555a1d1eab203","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage: Clinical, Vol 10, Iss C, Pp 1-17 (2016)","raw_type":"article"},{"id":"doi:10.48550/arxiv.1509.08359","doi":"https://doi.org/10.48550/arxiv.1509.08359","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1509.08359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1016/j.nicl.2015.10.013","doi":"https://doi.org/10.1016/j.nicl.2015.10.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nicl.2015.10.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213158215300139/pdf","source":{"id":"https://openalex.org/S2898194095","display_name":"NeuroImage Clinical","issn_l":"2213-1582","issn":["2213-1582"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage: Clinical","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1154439375","display_name":null,"funder_award_id":"T32AG021334","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1306429619","display_name":"Statistical methods for large n and p problems","funder_award_id":"R01EB012547","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G1519573612","display_name":null,"funder_award_id":"RO1MH095836","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1960095986","display_name":"Statistical methods for large and complex databases of ultra-high-dimensional","funder_award_id":"R01NS085211","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2344887565","display_name":null,"funder_award_id":"RO1 MH095836","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2965369434","display_name":null,"funder_award_id":"RO1NS085211","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3801258567","display_name":"Statistical Methods for Mapping Human Brain Development","funder_award_id":"R01MH095836","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G472242964","display_name":null,"funder_award_id":"RO1 EB012547","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4820200227","display_name":"Statistical methods for biosignals with varying domains","funder_award_id":"R01HL123407","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4961852482","display_name":null,"funder_award_id":"NS060910","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6681234998","display_name":null,"funder_award_id":"RO1 NS060910","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7571719231","display_name":null,"funder_award_id":"NS085211","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000891644","display_name":"Epidemiology and Biostatistics of Aging","funder_award_id":"T32AG000247","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000915968","display_name":"Statistical Methods for Multilevel Multivariate Functional Studies","funder_award_id":"R01NS060910","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000917273","display_name":"Older Americans Independence Center","funder_award_id":"P30AG021334","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2410237123.pdf","grobid_xml":"https://content.openalex.org/works/W2410237123.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W59540123","https://openalex.org/W1884697066","https://openalex.org/W1991463855","https://openalex.org/W2000278813","https://openalex.org/W2011598139","https://openalex.org/W2025009638","https://openalex.org/W2029817323","https://openalex.org/W2046748764","https://openalex.org/W2047440597","https://openalex.org/W2050468619","https://openalex.org/W2051588049","https://openalex.org/W2066319437","https://openalex.org/W2068354891","https://openalex.org/W2071415177","https://openalex.org/W2086900658","https://openalex.org/W2096609500","https://openalex.org/W2102865756","https://openalex.org/W2116832207","https://openalex.org/W2119516839","https://openalex.org/W2122545833","https://openalex.org/W2137077530","https://openalex.org/W2141845152","https://openalex.org/W2142577589","https://openalex.org/W2146531642","https://openalex.org/W2166068224","https://openalex.org/W2166219471","https://openalex.org/W2582743722","https://openalex.org/W2797563284","https://openalex.org/W2905399339","https://openalex.org/W4249888275"],"related_works":["https://openalex.org/W2959103409","https://openalex.org/W3016356434","https://openalex.org/W4324077605","https://openalex.org/W4247348586","https://openalex.org/W2066319437","https://openalex.org/W1928338241","https://openalex.org/W2046432781","https://openalex.org/W1888496801","https://openalex.org/W97484841","https://openalex.org/W1489284139"],"abstract_inverted_index":{"The":[0,128,248,296],"formation":[1],"of":[2,20,150,173,187,223,235,245,255,309,319],"multiple":[3],"sclerosis":[4],"(MS)":[5],"lesions":[6,54],"is":[7,136],"a":[8,62,113,145,148,169,184,202,236,284],"complex":[9],"process":[10,85],"involving":[11],"inflammation,":[12],"tissue":[13,16,126,310],"damage,":[14],"and":[15,30,58,67,70,119,144,178,217,275,314],"repair":[17,84],"-":[18],"all":[19,231],"which":[21,261],"are":[22,230,264],"visible":[23],"on":[24,86,107,165],"structural":[25,49,89],"magnetic":[26],"resonance":[27],"imaging":[28],"(MRI)":[29],"potentially":[31],"modifiable":[32],"by":[33,138],"pharmacological":[34],"therapy.":[35],"In":[36,269],"this":[37,301],"paper,":[38],"we":[39,78,104],"introduce":[40],"two":[41,139,297],"statistical":[42],"models":[43,298],"for":[44,116,253,305,315,321],"relating":[45],"voxel-level,":[46],"longitudinal,":[47,87],"multi-sequence":[48,88],"MRI":[50,90],"intensities":[51,291],"within":[52,124],"MS":[53,93,313],"to":[55,111,132,152,197,220,238,243,277,282],"clinical":[56,199,325],"information":[57,200],"therapeutic":[59],"interventions:":[60],"(1)":[61],"principal":[63],"component":[64],"analysis":[65],"(PCA)":[66],"regression":[68,73,102,250],"model":[69,204,251],"(2)":[71],"function-on-scalar":[72,249,271],"models.":[74],"To":[75],"do":[76],"so,":[77],"first":[79,167],"characterize":[80],"the":[81,100,108,157,160,163,166,179,182,195,198,221,256,262,267,270,278,289,307,317,322],"post-lesion":[82],"incidence":[83],"from":[91],"34":[92],"patients":[94],"as":[95],"voxel-level":[96,114],"intensity":[97,109,122,226,240],"profiles.":[98,268],"For":[99],"PCA":[101,106],"model,":[103],"perform":[105],"profiles":[110],"develop":[112],"biomarker":[115,196],"identifying":[117],"slow":[118],"persistent,":[120],"long-term":[121],"changes":[123],"lesion":[125,290],"voxels.":[127],"proposed":[129],"biomarker's":[130],"ability":[131],"identify":[133],"such":[134],"effects":[135],"validated":[137],"experienced":[140],"clinicians":[141],"(a":[142],"neuroradiologist":[143,161],"neurologist).":[146],"On":[147],"scale":[149],"1":[151],"4,":[153],"with":[154,207,233,266,288],"4":[155,174],"being":[156,218],"highest":[158],"quality,":[159],"gave":[162,181],"score":[164,183],"PC":[168],"median":[170,185],"quality":[171],"rating":[172,186],"(95%":[175,189],"CI:":[176,190],"[4,4]),":[177],"neurologist":[180],"3":[188],"[3,3]).":[191],"We":[192],"then":[193],"relate":[194],"in":[201,300,312,324],"mixed":[203],"framework.":[205],"Treatment":[206],"disease-modifying":[208],"therapies":[209],"(p":[210,214,227],"<":[211,215,228],"0.01),":[212,216],"steroids":[213],"closer":[219,242],"boundary":[222,279],"abnormal":[224],"signal":[225],"0.01)":[229],"associated":[232,265],"return":[234],"voxel":[237],"an":[239],"value":[241],"that":[244],"normal-appearing":[246],"tissue.":[247],"allows":[252],"assessment":[254],"post-incidence":[257],"time":[258,294],"points":[259],"at":[260,292],"covariates":[263],"regression,":[272],"both":[273],"age":[274],"distance":[276],"were":[280],"found":[281],"have":[283],"statistically":[285],"significant":[286],"association":[287],"some":[293],"point.":[295],"presented":[299],"article":[302],"show":[303],"promise":[304],"understanding":[306],"mechanisms":[308],"damage":[311],"evaluating":[316],"impact":[318],"treatments":[320],"disease":[323],"trials.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
