{"id":"https://openalex.org/W2958926595","doi":"https://doi.org/10.3389/fncel.2019.00335","title":"GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model","display_name":"GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model","publication_year":2019,"publication_date":"2019-07-23","ids":{"openalex":"https://openalex.org/W2958926595","doi":"https://doi.org/10.3389/fncel.2019.00335","mag":"2958926595","pmid":"https://pubmed.ncbi.nlm.nih.gov/31396055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6664076"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2019.00335","doi":"https://doi.org/10.3389/fncel.2019.00335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2019.00335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2019.00335/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncel.2019.00335/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044091027","display_name":"Junxiu Liu","orcid":"https://orcid.org/0000-0002-9790-1571","observed_orcids":["https://orcid.org/0000-0002-9790-1571","https://orcid.org/0009-0007-5949-7735"]},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]},{"id":"https://openalex.org/I4405260289","display_name":"Ulster University, Derry-Londonderry Campus","ror":"https://ror.org/03hab3x36","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Junxiu Liu","raw_affiliation_strings":["School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom","institution_ids":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035500696","display_name":"Liam J. Mcdaid","orcid":"https://orcid.org/0000-0002-1197-4375","observed_orcids":["https://orcid.org/0000-0002-1197-4375"]},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]},{"id":"https://openalex.org/I4405260289","display_name":"Ulster University, Derry-Londonderry Campus","ror":"https://ror.org/03hab3x36","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Liam McDaid","raw_affiliation_strings":["School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom","institution_ids":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064949079","display_name":"Alfonso Araque","orcid":"https://orcid.org/0000-0003-3840-1144","observed_orcids":["https://orcid.org/0000-0003-3840-1144"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfonso Araque","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050402624","display_name":"John Joseph Wade","orcid":"https://orcid.org/0000-0003-1300-9429","observed_orcids":["https://orcid.org/0000-0003-1300-9429"]},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]},{"id":"https://openalex.org/I4405260289","display_name":"Ulster University, Derry-Londonderry Campus","ror":"https://ror.org/03hab3x36","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Wade","raw_affiliation_strings":["School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom","institution_ids":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059141312","display_name":"Jim Harkin","orcid":"https://orcid.org/0000-0001-7484-8205","observed_orcids":["https://orcid.org/0000-0001-7484-8205"]},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]},{"id":"https://openalex.org/I4405260289","display_name":"Ulster University, Derry-Londonderry Campus","ror":"https://ror.org/03hab3x36","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jim Harkin","raw_affiliation_strings":["School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom","institution_ids":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039683485","display_name":"Shvan Karim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]},{"id":"https://openalex.org/I4405260289","display_name":"Ulster University, Derry-Londonderry Campus","ror":"https://ror.org/03hab3x36","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shvan Karim","raw_affiliation_strings":["School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, Engineering and Intelligent Systems, Ulster University, Derry, United Kingdom","institution_ids":["https://openalex.org/I138801177","https://openalex.org/I4405260289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002978004","display_name":"David Clifford Henshall","orcid":"https://orcid.org/0000-0001-6237-9632","observed_orcids":["https://orcid.org/0000-0001-6237-9632"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"David C. Henshall","raw_affiliation_strings":["Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland","FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006157798","display_name":"Niamh M. C. Connolly","orcid":"https://orcid.org/0000-0002-6005-1307","observed_orcids":["https://orcid.org/0000-0002-6005-1307"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Niamh M. C. Connolly","raw_affiliation_strings":["Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012947651","display_name":"Anju P. Johnson","orcid":"https://orcid.org/0000-0002-7017-1644","observed_orcids":["https://orcid.org/0000-0002-7017-1644"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anju P. Johnson","raw_affiliation_strings":["Department of Electronic Engineering, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048789717","display_name":"Andy M. Tyrrell","orcid":"https://orcid.org/0000-0002-8533-2404","observed_orcids":["https://orcid.org/0000-0002-8533-2404"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andy M. Tyrrell","raw_affiliation_strings":["Department of Electronic Engineering, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080582720","display_name":"Jon Timmis","orcid":"https://orcid.org/0000-0003-1055-0471","observed_orcids":["https://orcid.org/0000-0003-1055-0471"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon Timmis","raw_affiliation_strings":["Department of Electronic Engineering, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031341828","display_name":"Alan G. Millard","orcid":"https://orcid.org/0000-0002-4424-5953","observed_orcids":["https://orcid.org/0000-0002-4424-5953"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan G. Millard","raw_affiliation_strings":["Department of Electronic Engineering, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015048030","display_name":"James A. Hilder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Hilder","raw_affiliation_strings":["Department of Electronic Engineering, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026981278","display_name":"David M. Halliday","orcid":"https://orcid.org/0000-0001-9957-0983","observed_orcids":["https://orcid.org/0000-0001-9957-0983"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David M. Halliday","raw_affiliation_strings":["Department of Electronic Engineering, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044091027"],"corresponding_institution_ids":["https://openalex.org/I138801177","https://openalex.org/I4405260289"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5071,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56725435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":null,"first_page":"335","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gabaergic-interneurons","display_name":"GABAergic interneurons","score":0.843999981880188},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gliotransmission","display_name":"gliotransmission","score":0.8569999933242798},{"id":"https://openalex.org/keywords/burst-firing","display_name":"burst firing","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7400000095367432},{"id":"https://openalex.org/keywords/ip3-signaling","display_name":"IP3 signaling","score":0.675000011920929},{"id":"https://openalex.org/keywords/er-calcium-release","display_name":"endoplasmic reticulum calcium release","score":0.890999972820282},{"id":"https://openalex.org/keywords/2-arachidonoylglycerol","display_name":"2-arachidonoylglycerol","score":0.8669999837875366},{"id":"https://openalex.org/keywords/synaptic-potentiation","display_name":"synaptic potentiation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neuronal-synchronization","display_name":"neuronal synchronization","score":0.8100000023841858},{"id":"https://openalex.org/keywords/seizure-like-activity","display_name":"seizure-like activity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/biophysical-modeling","display_name":"biophysical model","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8021934032440186},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7350269556045532},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.596375048160553},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.571475625038147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3496786952018738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2747920751571655},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.10543304681777954}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3389/fncel.2019.00335","doi":"https://doi.org/10.3389/fncel.2019.00335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2019.00335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2019.00335/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6664076","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6664076","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmid:31396055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31396055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:149644","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/id/eprint/149644/1/fncel_13_00335.pdf","pdf_url":"https://eprints.whiterose.ac.uk/id/eprint/149644/1/fncel_13_00335.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:sure.sunderland.ac.uk:11851","doi":null,"is_oa":false,"landing_page_url":"http://sure.sunderland.ac.uk/view/creators/Liu=3AJunxiu=3A=3A.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306402295","display_name":"Sunderland Repository (University of Sunderland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5728261","host_organization_name":"University of Sunderland","host_organization_lineage":["https://openalex.org/I5728261"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:e0851bf144f54bb9ab2f26f216072450","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e0851bf144f54bb9ab2f26f216072450","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 13 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/19097363","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/GABA_regulation_of_burst_firing_in_hippocampal_astrocyte_neural_circuit_a_biophysical_model/19097363","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/44154c05-0aca-4c5a-9788-a082a6cb8e50","doi":null,"is_oa":true,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/44154c05-0aca-4c5a-9788-a082a6cb8e50","pdf_url":null,"source":{"id":"https://openalex.org/S4306402454","display_name":"Ulster University Research Portal (Ulster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138801177","host_organization_name":"University of Ulster","host_organization_lineage":["https://openalex.org/I138801177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liu, J, McDaid, L, Araque, A, Wade, J, Harkin, J, Haji Karim, S, Henshall, D, Connolly, N, Johnson, A P, Tyrrell, A, Timmis, J, Millard, A G, Hilder, J & Halliday, D M 2019, 'GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model', Frontiers in Cellular Neuroscience, vol. 13, 335, pp. 1-14. https://doi.org/10.3389/fncel.2019.00335","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fncel.2019.00335","doi":"https://doi.org/10.3389/fncel.2019.00335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2019.00335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2019.00335/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2832425221","display_name":"Mitochondrial G Protein signaling in astrocytes: a new player in the tripartite synapse","funder_award_id":"RGP0036/2014","funder_id":"https://openalex.org/F4320307846","funder_display_name":"Human Frontier Science Program"},{"id":"https://openalex.org/G6679357188","display_name":null,"funder_award_id":"EP/N007141X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7970336994","display_name":"Self-repairing Hardware Paradigms based on Astrocyte-neuron Models","funder_award_id":"EP/N007050/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307846","display_name":"Human Frontier Science Program","ror":"https://ror.org/02ebx7v45"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2958926595.pdf","grobid_xml":"https://content.openalex.org/works/W2958926595.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1486852018","https://openalex.org/W1733248925","https://openalex.org/W1837351149","https://openalex.org/W1978111097","https://openalex.org/W1978408389","https://openalex.org/W1992838140","https://openalex.org/W1993507604","https://openalex.org/W2006338283","https://openalex.org/W2011563038","https://openalex.org/W2025559018","https://openalex.org/W2032730787","https://openalex.org/W2034466321","https://openalex.org/W2040109036","https://openalex.org/W2044730840","https://openalex.org/W2051435374","https://openalex.org/W2066261176","https://openalex.org/W2071036343","https://openalex.org/W2072233684","https://openalex.org/W2076646500","https://openalex.org/W2079785767","https://openalex.org/W2083710925","https://openalex.org/W2090930028","https://openalex.org/W2095456641","https://openalex.org/W2123452424","https://openalex.org/W2123716335","https://openalex.org/W2124953936","https://openalex.org/W2127283052","https://openalex.org/W2129896258","https://openalex.org/W2130459697","https://openalex.org/W2136668808","https://openalex.org/W2146535241","https://openalex.org/W2158567876","https://openalex.org/W2164653071","https://openalex.org/W2461148724","https://openalex.org/W2562109833","https://openalex.org/W2569493629","https://openalex.org/W2591982720","https://openalex.org/W2741917766","https://openalex.org/W2743995715","https://openalex.org/W2751092582","https://openalex.org/W2754770663","https://openalex.org/W2786310594","https://openalex.org/W2791063489","https://openalex.org/W2799844935","https://openalex.org/W2804386241","https://openalex.org/W2806752067","https://openalex.org/W2914858039","https://openalex.org/W4238614602","https://openalex.org/W4301172471","https://openalex.org/W6983794798"],"related_works":["https://openalex.org/W3086570168","https://openalex.org/W2537558553","https://openalex.org/W2092225093","https://openalex.org/W1586815960","https://openalex.org/W2620558082","https://openalex.org/W3002370256","https://openalex.org/W1988518240","https://openalex.org/W126592111","https://openalex.org/W2113504399","https://openalex.org/W4401444237"],"abstract_inverted_index":{"It":[0],"is":[1,137,150],"now":[2],"widely":[3],"accepted":[4],"that":[5,30,120,148,170],"glia":[6],"cells":[7],"and":[8,17,22,41,86,109,115,176],"gamma-aminobutyric":[9],"acidergic":[10],"(GABA)":[11],"interneurons":[12],"dynamically":[13],"regulate":[14],"synaptic":[15],"transmission":[16,79],"neuronal":[18,92,177],"activity":[19,175],"in":[20,52,73,90],"time":[21],"space.":[23],"This":[24,71],"paper":[25,118],"presents":[26],"a":[27,38,48,87,151,165],"biophysical":[28],"model":[29,145,163],"captures":[31],"the":[32,54,60,64,77,100,110,144],"interaction":[33,122],"between":[34,103],"an":[35,128],"astrocyte":[36],"cell,":[37],"GABA":[39,45,49,108],"interneuron":[40,50],"pre/postsynaptic":[42],"neurons.":[43],"Specifically,":[44],"released":[46],"from":[47,59,106],"triggers":[51],"astrocytes":[53],"release":[55],"of":[56],"calcium":[57],"(Ca^(2+))":[58],"endoplasmic":[61],"reticulum":[62],"via":[63],"inositol":[65],"1,":[66],"4,":[67],"5-trisphosphate":[68],"(IP_3)":[69],"pathway.":[70],"results":[72],"gliotransmission":[74],"which":[75,94,156],"elevates":[76],"presynaptic":[78,152],"probability":[80],"rate":[81],"(PR)":[82],"causing":[83],"weight":[84,130],"potentiation":[85,131],"gradual":[88],"increase":[89],"postsynaptic":[91,140],"firing,":[93],"eventually":[95],"stabilises.":[96],"However,":[97],"by":[98,139],"capturing":[99],"complex":[101],"interactions":[102],"IP_3,":[104],"generated":[105],"both":[107,173],"2-arachidonyl":[111],"glycerol":[112],"(2-AG)":[113],"pathway,":[114],"PR,":[116],"this":[117,121,135],"shows":[119],"not":[123],"only":[124],"gives":[125],"rise":[126],"to":[127],"initial":[129],"phase":[132,136],"but":[133],"also":[134],"followed":[138],"bursting":[141],"behaviour.":[142],"Moreover,":[143],"will":[146],"show":[147],"there":[149],"frequency":[153],"range":[154],"over":[155],"burst":[157],"firing":[158],"can":[159],"occur.":[160],"The":[161],"proposed":[162],"offers":[164],"novel":[166],"cellular":[167],"level":[168],"mechanism":[169],"may":[171],"underpin":[172],"seizure-like":[174],"synchrony":[178],"across":[179],"different":[180],"brain":[181],"regions.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-07-23T00:00:00"}