{"id":"https://openalex.org/W2957960403","doi":null,"title":"[White adipose tissue, inflammation and atherosclerosis].","display_name":"[White adipose tissue, inflammation and atherosclerosis].","publication_year":2008,"publication_date":"2008-02-25","ids":{"openalex":"https://openalex.org/W2957960403","mag":"2957960403","pmid":"https://pubmed.ncbi.nlm.nih.gov/18225444"},"language":"en","primary_location":{"id":"pmid:18225444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin de l'Academie nationale de medecine","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004008262","display_name":"Christoph Andreas Meier","orcid":"https://orcid.org/0000-0002-2974-1422","observed_orcids":["https://orcid.org/0000-0002-2974-1422"]},"institutions":[{"id":"https://openalex.org/I2799963127","display_name":"Triemli Hospital","ror":"https://ror.org/03kpdys72","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799963127","https://openalex.org/I4405256532"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christoph A Meier","raw_affiliation_strings":["D\u00e9partment de M\u00e9decine Interne, Triemli H\u00f4pital, Birmensdorferstrasse 497, CH-8063 Z\u00fcrich, Suisse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partment de M\u00e9decine Interne, Triemli H\u00f4pital, Birmensdorferstrasse 497, CH-8063 Z\u00fcrich, Suisse","institution_ids":["https://openalex.org/I2799963127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000399238","display_name":"S\u00e9bastien Thalmann","orcid":"https://orcid.org/0009-0003-9310-7041","observed_orcids":["https://orcid.org/0009-0003-9310-7041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Thalmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.311,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.82093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"191","issue":"4-5","first_page":"897","last_page":"908; discussion 908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8500000238418579},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9490000009536743},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8169999718666077},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9769999980926514},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/perivascular-adipose-tissue","display_name":"perivascular adipose tissue","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neoangiogenesis","display_name":"neoangiogenesis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.6320100426673889},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6148017644882202},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6130679845809937},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5874742269515991},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5303818583488464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5219606757164001},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4518220126628876},{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.43707603216171265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3657955825328827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35339945554733276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3252906799316406},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.31847333908081055},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.30284735560417175},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1451839804649353}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18225444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin de l'Academie nationale de medecine","raw_type":"Comparative Study"},{"id":"mag:2957960403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4300000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000639850","https://openalex.org/W2187010577","https://openalex.org/W130785158","https://openalex.org/W2339543741","https://openalex.org/W2954488321","https://openalex.org/W2111648036","https://openalex.org/W2520870178","https://openalex.org/W2306112551","https://openalex.org/W2605829102","https://openalex.org/W1972150170","https://openalex.org/W2766389802","https://openalex.org/W2384174176","https://openalex.org/W2139304924","https://openalex.org/W2144291938","https://openalex.org/W88066218","https://openalex.org/W2754866689","https://openalex.org/W3029810013","https://openalex.org/W2793705639","https://openalex.org/W2620596469","https://openalex.org/W2803348067"],"abstract_inverted_index":{"Our":[0],"view":[1],"of":[2,109,159,179],"white":[3],"adipose":[4],"tissue":[5,18],"(WAT)":[6],"has":[7],"changed":[8],"over":[9],"the":[10,85,118,157,171,177],"last":[11],"decade,":[12],"from":[13],"an":[14],"inert":[15],"triglyceride":[16],"storage":[17],"to":[19,76,91,156],"a":[20,95],"highly":[21],"active":[22],"metabolic":[23],"organ.":[24],"Indeed,":[25],"WAT":[26,78,124,138],"secretes":[27,140],"proinflammatory":[28],"cytokines":[29,132,142],"such":[30,43,63,116],"TNF-a,":[31],"interleukin-1":[32,34],"(IL-1),":[33],"receptor":[35],"antagonist":[36],"(IL-1Ra),":[37],"and":[38,41,58,67,81,100,103,121,133,143,145,151,166],"interleukin-6":[39],"(IL-6),":[40],"chemokines":[42,144],"as":[44,64,117],"monocyte":[45],"chemoattractant":[46],"protein-1":[47],"(MCP-1),":[48],"interferon":[49],"gamma":[50],"inducible":[51],"protein":[52],"10":[53],"(IP-10),":[54],"interleukin-8":[55],"(IL-8),":[56],"RANTES,":[57],"peptides":[59],"with":[60],"hormone-like":[61],"actions":[62,72],"adiponectin,":[65],"leptin":[66],"resistin.":[68],"Through":[69],"their":[70],"paracrine":[71],"these":[73],"factors":[74],"contribute":[75,90,155],"local":[77],"inflammation,":[79],"neoangiogenesis":[80],"differentiation.":[82],"On":[83],"entering":[84],"systemic":[86,96],"circulation":[87],"they":[88],"can":[89,104,125],"creating":[92],"or":[93],"maintaining":[94],"inflammatory":[97,164],"state,":[98],"hypertension":[99],"insulin":[101],"resistance,":[102],"also":[105],"affect":[106,127],"central":[107],"control":[108],"food":[110],"intake.":[111],"When":[112],"located":[113],"around":[114,149],"organs":[115],"kidney,":[119],"heart":[120],"blood":[122],"vessels,":[123],"adversely":[126],"organ":[128],"function":[129],"by":[130,162],"secreting":[131],"chemokines.":[134],"For":[135],"example,":[136],"perivascular":[137],"which":[139,146,175],"proatherogenic":[141],"is":[147,176],"present":[148],"large":[150],"medium-sized":[152],"arteries,":[153],"could":[154],"development":[158],"atherosclerotic":[160],"lesions":[161],"attracting":[163],"cells":[165],"stimulating":[167],"neoangiogenesis,":[168],"thereby":[169],"amplifying":[170],"chronic":[172],"vascular":[173],"inflammation":[174],"hallmark":[178],"atherosclerosis.":[180]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}