{"id":"https://openalex.org/W2957137166","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.7558","title":"Afatinib monotherapy in patients with metastatic squamous cell carcinoma of the lung progressing after erlotinib/gefitinib (E/G) and chemotherapy: Interim subset analysis from a phase III trial.","display_name":"Afatinib monotherapy in patients with metastatic squamous cell carcinoma of the lung progressing after erlotinib/gefitinib (E/G) and chemotherapy: Interim subset analysis from a phase III trial.","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W2957137166","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.7558","mag":"2957137166"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.30.15_suppl.7558","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.7558","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.7558","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005188570","display_name":"Joo-Hang Kim","orcid":"https://orcid.org/0000-0003-0408-8997","observed_orcids":["https://orcid.org/0000-0003-0408-8997"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo-Hang Kim","raw_affiliation_strings":["Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4405258038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032477448","display_name":"Francesco Grossi","orcid":"https://orcid.org/0000-0001-8412-3136","observed_orcids":["https://orcid.org/0000-0001-8412-3136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Grossi","raw_affiliation_strings":["Lung Cancer Unit, National Institute for Cancer Research, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Cancer Unit, National Institute for Cancer Research, Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003664573","display_name":"Filippo de Marinis","orcid":"https://orcid.org/0000-0002-1118-5536","observed_orcids":["https://orcid.org/0000-0002-1118-5536"]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo De Marinis","raw_affiliation_strings":["San Camillo and Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Camillo and Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027946288","display_name":"Manuel Cobo","orcid":"https://orcid.org/0000-0003-3402-1144","observed_orcids":["https://orcid.org/0000-0003-3402-1144"]},"institutions":[{"id":"https://openalex.org/I4210108548","display_name":"Hospital Regional Universitario de M\u00e1laga","ror":"https://ror.org/01mqsmm97","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210108548"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Cobo","raw_affiliation_strings":["Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain","institution_ids":["https://openalex.org/I4210108548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"James Chih-Hsin Yang","raw_affiliation_strings":["National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081716197","display_name":"Yu. \u0410. Ragulin","orcid":"https://orcid.org/0000-0001-5352-9248","observed_orcids":["https://orcid.org/0000-0001-5352-9248"]},"institutions":[{"id":"https://openalex.org/I4210117327","display_name":"Medical Radiological Research Center","ror":"https://ror.org/02dr19631","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117327"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yury Ragulin","raw_affiliation_strings":["Medical Radiological Research Center, Obninsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Radiological Research Center, Obninsk, Russia","institution_ids":["https://openalex.org/I4210117327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019547742","display_name":"Igor Bondarenko","orcid":"https://orcid.org/0000-0002-7071-2471","observed_orcids":["https://orcid.org/0000-0002-7071-2471"]},"institutions":[{"id":"https://openalex.org/I905458539","display_name":"Dnipro State Medical University","ror":"https://ror.org/0469ncz24","country_code":"UA","type":"healthcare","lineage":["https://openalex.org/I905458539"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Igor N. Bondarenko","raw_affiliation_strings":["Dnipropetrovsk State Medical Academy, Dnipropetrovsk, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dnipropetrovsk State Medical Academy, Dnipropetrovsk, Ukraine","institution_ids":["https://openalex.org/I905458539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063821551","display_name":"Vikram K. Chand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram K. Chand","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086847475","display_name":"Bushi Wang","orcid":"https://orcid.org/0000-0001-8916-9416","observed_orcids":["https://orcid.org/0000-0001-8916-9416"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bushi Wang","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062197116","display_name":"Edith Gracien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edith Gracien","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036507802","display_name":"Martin Sch\u00fcler","orcid":"https://orcid.org/0000-0002-2166-3394","observed_orcids":["https://orcid.org/0000-0002-2166-3394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin H. Schuler","raw_affiliation_strings":["Department of Medical Oncology, West German Cancer Center, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, West German Cancer Center, Essen, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"15_suppl","first_page":"7558","last_page":"7558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/afatinib","display_name":"afatinib","score":0.9810000061988831},{"id":"https://openalex.org/keywords/metastatic-squamous-cell-carcinoma","display_name":"metastatic squamous cell carcinoma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7620000243186951},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.7200000286102295},{"id":"https://openalex.org/keywords/paclitaxel-combination-therapy","display_name":"paclitaxel combination therapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/interim-analysis","display_name":"interim analysis","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C2780586478","wikidata":"https://www.wikidata.org/wiki/Q4688818","display_name":"Afatinib","level":5,"score":0.9387826919555664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9122076034545898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.690615713596344},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.6684156060218811},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5678876638412476},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.5672105550765991},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.545220673084259},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5106685757637024},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5071730613708496},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.46730470657348633},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31288009881973267},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2823198437690735},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.16955125331878662}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2012.30.15_suppl.7558","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.7558","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.7558","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3194900622","https://openalex.org/W2600898673","https://openalex.org/W2693468451","https://openalex.org/W2137043950","https://openalex.org/W2607223419","https://openalex.org/W2981714860","https://openalex.org/W2183001075","https://openalex.org/W2569874961","https://openalex.org/W3095546119","https://openalex.org/W3120007840"],"abstract_inverted_index":{"7558":[0],"Background:":[1],"Patients":[2],"with":[3,47,64,80,107,248,253,312],"squamous":[4,65,168,203,290,313],"NSCLC":[5,49,84,310],"have":[6],"limited":[7],"treatment":[8],"options.":[9],"For":[10],"those":[11,63],"deriving":[12],"benefit":[13,26,109],"from":[14,155],"EGFR":[15,36],"TKIs,":[16],"it":[17],"is":[18],"unclear":[19],"whether":[20],"sustained":[21],"ErbB":[22],"family":[23],"blockade":[24],"offers":[25],"upon":[27],"progression.":[28,105],"We":[29],"evaluated":[30],"afatinib,":[31],"an":[32,134,136],"irreversible":[33],"blocker":[34],"of":[35,62,89,139,217,239],"(ErbB1),":[37],"HER2":[38],"(ErbB2)":[39],"and":[40,54,92,171,175,226,232,241,282],"ErbB4":[41],"receptor":[42],"tyrosine":[43],"kinases,":[44],"in":[45,67,201,276,288,308],"patients":[46,79,97,222,234,247,311],"metastatic":[48,83],"who":[50,112],"had":[51,167,173,210,215,235],"failed":[52],"chemotherapy":[53,91,124],"E/G.":[55,93],"Here":[56],"we":[57],"describe":[58],"a":[59],"pre-specified":[60],"analysis":[61,138],"histology":[66,204,291,314],"Part":[68,95,140,152,277],"A.":[69],"Methods:":[70],"This":[71],"randomized":[72],"Phase":[73],"III,":[74],"open-label,":[75],"multi-center":[76],"trial":[77],"enrolled":[78],"pathologically":[81],"confirmed":[82,259],"after":[85],"failing":[86],"\u22651":[87],"line":[88],"cytotoxic":[90],"In":[94,220],"A,":[96],"received":[98],"oral":[99],"afatinib":[100,118,146,197],"50":[101],"mg":[102],"until":[103],"disease":[104,260],"Those":[106],"clinical":[108],"(\u226512":[110],"wks)":[111],"progressed":[113],"were":[114,189,192,229,279],"eligible":[115],"to":[116,144,158,295],"receive":[117],"plus":[119],"paclitaxel":[120],"or":[121],"investigator\u2019s":[122],"choice":[123],"(Part":[125],"B).":[126],"Primary":[127],"endpoint":[128],"was":[129,142,154,185,198,293],"PFS":[130,195,211,216],"(RECIST":[131],"1.1).":[132],"Following":[133],"amendment,":[135],"interim":[137],"A":[141,153,278],"performed":[143],"assess":[145],"monotherapy.":[147],"Results:":[148],"Patient":[149],"enrolment":[150],"into":[151],"April":[156],"2010":[157],"May":[159],"2011.":[160],"Of":[161,206,244],"1154":[162],"afatinib-treated":[163],"patients,":[164,208],"91":[165,207],"(8%)":[166],"histology;":[169],"18/91":[170],"40/91":[172],"CR/PR":[174],"SD":[176,240],"on":[177,196,250,266],"prior":[178,251],"E/G,":[179],"respectively":[180],"(by":[181],"investigator).":[182],"Median":[183,194],"age":[184],"63":[186],"yrs,":[187],"71%":[188],"male,":[190],"76%":[191],"current/ex-smokers.":[193],"3.7":[199],"mths":[200],"the":[202,245,289,299],"subset.":[205],"42":[209],"\u22653":[212],"mths;":[213],"13":[214],"\u22656":[218],"mths.":[219],"evaluable":[221],"(n=77),":[223],"1":[224],"CR":[225],"3":[227],"PRs":[228],"confirmed;":[230],"51":[231],"22":[233],"best":[236],"overall":[237],"response":[238],"PD,":[242],"respectively.":[243],"31":[246],"PD":[249],"E/G":[252],"no":[254],"intervening":[255],"chemotherapy,":[256],"10":[257],"achieved":[258],"control":[261],"(2":[262],"PR;":[263],"8":[264],"SD)":[265],"afatinib.":[267],"Most":[268],"commonly":[269],"reported":[270],"grade":[271],"3/4":[272],"adverse":[273],"events":[274],"(AEs)":[275],"diarrhea":[280],"(13%)":[281],"rash/acne":[283],"(12%).":[284],"The":[285],"safety":[286],"profile":[287],"subset":[292],"similar":[294],"that":[296,315],"observed":[297],"for":[298],"whole":[300],"trial.":[301],"Conclusions:":[302],"Afatinib":[303],"monotherapy":[304],"demonstrated":[305],"encouraging":[306],"activity":[307],"treatment-refractory":[309],"merits":[316],"further":[317],"evaluation.":[318]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-07-23T00:00:00"}