{"id":"https://openalex.org/W2956964192","doi":"https://doi.org/10.1373/clinchem.2018.289371","title":"Role of BNP vs NT-proBNP Testing in the Age of New Drug Therapies: Sacubitril-Valsartan","display_name":"Role of BNP vs NT-proBNP Testing in the Age of New Drug Therapies: Sacubitril-Valsartan","publication_year":2019,"publication_date":"2019-07-18","ids":{"openalex":"https://openalex.org/W2956964192","doi":"https://doi.org/10.1373/clinchem.2018.289371","mag":"2956964192","pmid":"https://pubmed.ncbi.nlm.nih.gov/31320381"},"language":"en","primary_location":{"id":"doi:10.1373/clinchem.2018.289371","doi":"https://doi.org/10.1373/clinchem.2018.289371","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2018.289371","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068500647","display_name":"Fred S. Apple","orcid":"https://orcid.org/0000-0002-5920-6498","observed_orcids":["https://orcid.org/0000-0002-5920-6498"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]},{"id":"https://openalex.org/I4210152469","display_name":"Hennepin Healthcare Research Institute","ror":"https://ror.org/05v1amx46","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210152469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred S Apple","raw_affiliation_strings":["Cardiac Biomarkers Trials Laboratory, Hennepin Healthcare Research Institute, Minneapolis, MN","Co-Director, Clinical & Forensic Toxicology Laboratory, Hennepin Healthcare/Hennepin County Medical Center, Minneapolis, MN","Professor, Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Biomarkers Trials Laboratory, Hennepin Healthcare Research Institute, Minneapolis, MN","institution_ids":["https://openalex.org/I4210152469"]},{"raw_affiliation_string":"Co-Director, Clinical & Forensic Toxicology Laboratory, Hennepin Healthcare/Hennepin County Medical Center, Minneapolis, MN","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"Professor, Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048308230","display_name":"Lori B. Daniels","orcid":"https://orcid.org/0000-0002-4841-9922","observed_orcids":["https://orcid.org/0000-0002-4841-9922"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori B Daniels","raw_affiliation_strings":["Professor of Medicine, Division of Cardiovascular Medicine; Director, Cardiovascular Intensive Care Unit, University of California, San Diego, CA","Professor of Medicine, Division of Cardiovascular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine, Division of Cardiovascular Medicine; Director, Cardiovascular Intensive Care Unit, University of California, San Diego, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Professor of Medicine, Division of Cardiovascular Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112353553","display_name":"James L. Januzzi","orcid":"https://orcid.org/0000-0002-8338-1798","observed_orcids":["https://orcid.org/0000-0002-8338-1798"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210111520","display_name":"Baim Institute for Clinical Research","ror":"https://ror.org/01va8fr66","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111520"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Januzzi","raw_affiliation_strings":["Cardiometabolic Trials and Trial Design, Baim Institute for Clinical Research, Brookline, MA","Hutter Family Professor of Medicine, Harvard Medical School, Boston, MA","Physician, Cardiology Division, Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiometabolic Trials and Trial Design, Baim Institute for Clinical Research, Brookline, MA","institution_ids":["https://openalex.org/I4210111520"]},{"raw_affiliation_string":"Hutter Family Professor of Medicine, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Physician, Cardiology Division, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063218674","display_name":"Torbj\u00f8rn Omland","orcid":"https://orcid.org/0000-0002-6452-0369","observed_orcids":["https://orcid.org/0000-0002-6452-0369"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I2800192669","display_name":"Akershus University Hospital","ror":"https://ror.org/0331wat71","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800192669"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Torbj\u00f8rn Omland","raw_affiliation_strings":["Associate Editor, Circulation","Head, Cardio-Thoracic Research Group, Division of Medicine, Akershus University Hospital, Oslo, Norway","Professor of Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Editor, Circulation","institution_ids":[]},{"raw_affiliation_string":"Head, Cardio-Thoracic Research Group, Division of Medicine, Akershus University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I2800192669"]},{"raw_affiliation_string":"Professor of Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058557146","display_name":"Jordi Ord\u00f3\u00f1ez\u2010Llanos","orcid":"https://orcid.org/0000-0003-4896-5832","observed_orcids":["https://orcid.org/0000-0003-4896-5832"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Ordonez-Llanos","raw_affiliation_strings":["Professor, Clinical Biochemistry, Universitat Aut\u00f2noma, Barcelona, Spain","Senior Consultant, Hospital de Sant Pau, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Clinical Biochemistry, Universitat Aut\u00f2noma, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Senior Consultant, Hospital de Sant Pau, Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075187080","display_name":"Allan S. Jaffe","orcid":"https://orcid.org/0000-0003-1183-3959","observed_orcids":["https://orcid.org/0000-0003-1183-3959"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan Jaffe","raw_affiliation_strings":["Chair, CCLS Division, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","Professor of Medicine/Cardiology and Professor of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair, CCLS Division, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Professor of Medicine/Cardiology and Professor of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5068500647"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015","https://openalex.org/I4210152469"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":0.1764,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56398096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"65","issue":"9","first_page":"1076","last_page":"1083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.9679999947547913},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9290000200271606},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.9319999814033508},{"id":"https://openalex.org/keywords/angiotensin-receptor-neprilysin-inhibitors","display_name":"angiotensin receptor-neprilysin inhibitors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.5759999752044678},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2776754050","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril","level":4,"score":0.9227735996246338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8150384426116943},{"id":"https://openalex.org/C2775999527","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril, Valsartan","level":4,"score":0.7681488990783691},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6874617338180542},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.6871840953826904},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.6721804141998291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6583902835845947},{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.6430546045303345},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5983426570892334},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5774462819099426},{"id":"https://openalex.org/C104826730","wikidata":"https://www.wikidata.org/wiki/Q414232","display_name":"Neprilysin","level":3,"score":0.5468229651451111},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5336376428604126},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3987267315387726},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.1461830735206604},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09710687398910522},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000613","descriptor_name":"Aminobutyrates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1373/clinchem.2018.289371","doi":"https://doi.org/10.1373/clinchem.2018.289371","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2018.289371","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:31320381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31320381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Interview"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320307779","display_name":"Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320322923","display_name":"Siemens","ror":"https://ror.org/059mq0909"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2962575762","https://openalex.org/W2968076584","https://openalex.org/W3087430082","https://openalex.org/W2918599246","https://openalex.org/W2439855811","https://openalex.org/W4385343045","https://openalex.org/W2793667706","https://openalex.org/W2238377800","https://openalex.org/W4311737300","https://openalex.org/W2955136116"],"abstract_inverted_index":{"Sacubitril-valsartan":[0],"(Entresto),":[1],"a":[2,55,138],"new":[3],"dual":[4],"drug":[5,65],"therapy":[6],"that":[7],"includes":[8],"an":[9,128],"angiotensin":[10],"receptor":[11],"neprilysin":[12],"(NEP)15":[13],"inhibitor":[14],"(sacubitril),":[15],"is":[16,140],"directed":[17],"at":[18],"reducing":[19],"the":[20,51,68,81,103,132,151],"risk":[21],"of":[22,53,70,80,105],"cardiovascular":[23],"death":[24],"and":[25,42,94,108,124,153],"hospitalization":[26],"for":[27,50],"heart":[28],"failure":[29],"(HF)":[30],"in":[31,112,121],"patients":[32],"with":[33,63,89],"chronic":[34],"HF":[35],"(New":[36],"York":[37],"Heart":[38],"Association":[39],"classes":[40],"II\u2013IV)":[41],"reduced":[43],"ejection":[44],"fraction":[45],"(HFrEF).":[46],"Since":[47],"its":[48],"approval":[49],"treatment":[52,62],"HFrEF,":[54],"commonly":[56],"raised":[57],"question":[58],"has":[59],"been":[60,118],"whether":[61],"this":[64,98,146,159],"can":[66],"complicate":[67],"interpretation":[69],"B-type":[71],"natriuretic":[72],"peptide":[73],"(BNP)":[74],"testing":[75],"results":[76],"compared":[77],"to":[78,126,135],"those":[79],"N-terminal":[82],"proBNP":[83],"assay":[84],"because":[85],"Entresto":[86,142],"may":[87],"interfere":[88],"BNP":[90,107],"clearance.":[91],"The":[92],"clinical":[93,113,122],"analytical":[95],"studies":[96,125],"addressing":[97],"issue":[99],"are":[100,143],"limited.":[101],"Furthermore,":[102],"diversity":[104],"both":[106],"NT-proBNP":[109],"assays":[110,134],"used":[111],"laboratory":[114],"practice":[115],"have":[116],"not":[117],"adequately":[119],"evaluated":[120],"trials,":[123],"provide":[127,155],"evidence-based":[129],"conclusion":[130],"regarding":[131,158],"appropriate":[133],"use":[136],"when":[137],"patient":[139],"on":[141],"lacking.":[144],"In":[145],"article,":[147],"5":[148],"experts":[149],"from":[150],"US":[152],"Europe":[154],"their":[156],"views":[157],"issue.":[160]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-23T00:00:00"}