{"id":"https://openalex.org/W2956880640","doi":"https://doi.org/10.1016/bs.pmbts.2019.07.002","title":"In search of pathogenic amyloid \u03b2-peptide in familial Alzheimer's disease","display_name":"In search of pathogenic amyloid \u03b2-peptide in familial Alzheimer's disease","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2956880640","doi":"https://doi.org/10.1016/bs.pmbts.2019.07.002","mag":"2956880640","pmid":"https://pubmed.ncbi.nlm.nih.gov/31699328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7523514"},"language":"en","primary_location":{"id":"doi:10.1016/bs.pmbts.2019.07.002","doi":"https://doi.org/10.1016/bs.pmbts.2019.07.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.pmbts.2019.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S2506244597","display_name":"Progress in molecular biology and translational science","issn_l":"1877-1173","issn":["1877-1173","1878-0814"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Molecular Biology and Translational Science","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4234312301","display_name":"Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part A"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7523514","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070207434","display_name":"Michael S. Wolfe","orcid":"https://orcid.org/0000-0002-5721-9092","observed_orcids":["https://orcid.org/0000-0002-5721-9092"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Wolfe","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States. Electronic address: mswolfe@ku.edu","Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States. Electronic address: mswolfe@ku.edu","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070207434"],"corresponding_institution_ids":["https://openalex.org/I146416000"],"apc_list":null,"apc_paid":null,"fwci":5.3749,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.97312023,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"168","issue":null,"first_page":"71","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-familial-alzheimer-s-disease","display_name":"early-onset familial Alzheimer's disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8690000176429749},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8539999723434448},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.6299999952316284},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.7061328291893005},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6649132966995239},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.593113362789154},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5404139757156372},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5403085350990295},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5401142835617065},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.5241178274154663},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.44691002368927},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.42481040954589844},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.4181840419769287},{"id":"https://openalex.org/C151484617","wikidata":"https://www.wikidata.org/wiki/Q4834493","display_name":"BACE1-AS","level":5,"score":0.4152674674987793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4124670624732971},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.386656254529953},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3710028827190399},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3458343744277954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2571973204612732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23283711075782776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19033190608024597}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/bs.pmbts.2019.07.002","doi":"https://doi.org/10.1016/bs.pmbts.2019.07.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.pmbts.2019.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S2506244597","display_name":"Progress in molecular biology and translational science","issn_l":"1877-1173","issn":["1877-1173","1878-0814"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Molecular Biology and Translational Science","raw_type":"book-chapter"},{"id":"pmid:31699328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31699328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in molecular biology and translational science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7523514","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7523514","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Prog Mol Biol Transl Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7523514","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7523514","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Prog Mol Biol Transl Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6002711780","display_name":"Membrane-anchored amyloid peptides in Alzheimer's disease","funder_award_id":"R21AG052751","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1572225000","https://openalex.org/W1675105744","https://openalex.org/W1979432217","https://openalex.org/W1991435932","https://openalex.org/W1993571512","https://openalex.org/W1995434077","https://openalex.org/W1997801717","https://openalex.org/W2005681172","https://openalex.org/W2036288989","https://openalex.org/W2049451196","https://openalex.org/W2050529442","https://openalex.org/W2057709960","https://openalex.org/W2071953900","https://openalex.org/W2080225612","https://openalex.org/W2084972185","https://openalex.org/W2086163393","https://openalex.org/W2088989293","https://openalex.org/W2102496493","https://openalex.org/W2104132043","https://openalex.org/W2112395233","https://openalex.org/W2113166966","https://openalex.org/W2131819352","https://openalex.org/W2150999725","https://openalex.org/W2158707059","https://openalex.org/W2162588539","https://openalex.org/W2171250577","https://openalex.org/W2180506828","https://openalex.org/W2617930056","https://openalex.org/W2795424618","https://openalex.org/W2884933563","https://openalex.org/W2904723669","https://openalex.org/W2912215317","https://openalex.org/W2912754856","https://openalex.org/W2952068167","https://openalex.org/W4233829850","https://openalex.org/W4247759744"],"related_works":["https://openalex.org/W4297770704","https://openalex.org/W3119714211","https://openalex.org/W2471686248","https://openalex.org/W2462169856","https://openalex.org/W2315470265","https://openalex.org/W102325034","https://openalex.org/W2412446943","https://openalex.org/W4317538671","https://openalex.org/W2066223581","https://openalex.org/W2026563454"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-23T00:00:00"}