{"id":"https://openalex.org/W2956801792","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e18549","title":"Pyridoxine impact on patients with myelodysplastic syndromes with ring sideroblasts: Single institution retrospective study.","display_name":"Pyridoxine impact on patients with myelodysplastic syndromes with ring sideroblasts: Single institution retrospective study.","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2956801792","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e18549","mag":"2956801792"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.e18549","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e18549","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e18549","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032947311","display_name":"Darci Zblewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darci Zblewski","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013277990","display_name":"Phuong Nguyen","orcid":"https://orcid.org/0000-0002-1575-0395","observed_orcids":["https://orcid.org/0000-0002-1575-0395"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phuong L. Nguyen","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079731167","display_name":"Rong Lucy He","orcid":"https://orcid.org/0000-0001-6116-8163","observed_orcids":["https://orcid.org/0000-0001-6116-8163","https://orcid.org/0000-0002-6011-5964"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong He","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072775789","display_name":"Patricia Theresa Greipp","orcid":"https://orcid.org/0000-0002-5536-9011","observed_orcids":["https://orcid.org/0000-0002-5536-9011"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia T. Greipp","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080965667","display_name":"Kebede H. Begna","orcid":"https://orcid.org/0000-0003-2730-8593","observed_orcids":["https://orcid.org/0000-0003-2730-8593"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kebede Begna","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072463255","display_name":"Mrinal M. Patnaik","orcid":"https://orcid.org/0000-0001-6998-662X","observed_orcids":["https://orcid.org/0000-0001-6998-662X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinal Mahesh Patnaik","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002643270","display_name":"Naseema Gangat","orcid":"https://orcid.org/0000-0002-9104-6172","observed_orcids":["https://orcid.org/0000-0002-9104-6172"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naseema Gangat","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020872528","display_name":"Mithun Vinod Shah","orcid":"https://orcid.org/0000-0002-5359-336X","observed_orcids":["https://orcid.org/0000-0002-5359-336X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mithun Vinod Shah","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064856519","display_name":"Hassan B. Alkhateeb","orcid":"https://orcid.org/0000-0002-3609-8404","observed_orcids":["https://orcid.org/0000-0002-3609-8404"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hassan Alkhateeb","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Robert Litzow","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aref Al-Kali","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"e18549","last_page":"e18549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.13660000264644623,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.11190000176429749,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridoxine","display_name":"pyridoxine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.7620000243186951},{"id":"https://openalex.org/keywords/sideroblastic-anemia","display_name":"sideroblastic anemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vitamin-deficiency","display_name":"vitamin deficiency","score":0.7450000047683716},{"id":"https://openalex.org/keywords/anemia-treatment","display_name":"anemia treatment","score":0.656000018119812},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.828000009059906},{"id":"https://openalex.org/keywords/transfusion-dependence","display_name":"transfusion dependence","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hemoglobin-response","display_name":"hemoglobin response","score":0.6890000104904175},{"id":"https://openalex.org/keywords/vitamin-b6-supplementation","display_name":"vitamin B6 supplementation","score":0.3310000002384186},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5440000295639038},{"id":"https://openalex.org/keywords/irf2","display_name":"IRF2","score":0.38600000739097595},{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.42800000309944153},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.3930000066757202},{"id":"https://openalex.org/keywords/idh2","display_name":"IDH2","score":0.35600000619888306},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9176541566848755},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.699433445930481},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.6654016375541687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6285886764526367},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5895049571990967},{"id":"https://openalex.org/C2779188306","wikidata":"https://www.wikidata.org/wiki/Q2610084","display_name":"Sideroblastic anemia","level":3,"score":0.587890625},{"id":"https://openalex.org/C2780240888","wikidata":"https://www.wikidata.org/wiki/Q6052586","display_name":"International Prognostic Scoring System","level":4,"score":0.508463978767395},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47470229864120483},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.43520474433898926},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3484240770339966},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34224236011505127},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.11561208963394165}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.e18549","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e18549","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e18549","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2551132121","https://openalex.org/W1779113488","https://openalex.org/W4411855477","https://openalex.org/W3096236688","https://openalex.org/W3120602004","https://openalex.org/W2979336171","https://openalex.org/W3031819610","https://openalex.org/W2983268967","https://openalex.org/W3194418772","https://openalex.org/W2012844404"],"abstract_inverted_index":{"e18549":[0],"Background:":[1],"Many":[2],"vitamin":[3,20],"deficiencies":[4,21],"can":[5],"cause":[6],"anemia.":[7,34,45],"It":[8],"is":[9,369],"prudent":[10],"prior":[11],"to":[12,17,49,97,263,288,305,371],"diagnosing":[13],"a":[14,140,202,234,348],"myeloid":[15],"neoplasm,":[16],"check":[18],"for":[19],"and":[22,58,91,119,121,148,169,193,236,323],"correct":[23],"them.":[24],"Myelodysplastic":[25,74],"syndromes":[26],"with":[27,33,135,291],"ring":[28],"sideroblasts":[29],"(MDS-RS)":[30],"are":[31,256,268],"associated":[32],"Pyridoxine":[35],"(Vit":[36],"B6)":[37],"replacement":[38,60,286,295,308,320,333,356],"may":[39],"improve":[40],"anemia":[41],"found":[42],"in":[43,64,108,253,265,277,279,317,325,343,351,353,376],"sideroblastic":[44],"The":[46,179],"study":[47,368,372],"was":[48,55,86,94,105,124,146,185,190,195,259,274,321,339,347],"determine":[50],"how":[51],"frequently":[52],"Vit":[53,203,214,223,284,293,306,318,331,337,354,373],"B6":[54,204,215,224,285,294,307,319,332,338,355,374],"assessed,":[56],"replaced":[57],"impact":[59],"had":[61,139,157,172,201,222,228,233,239,283],"on":[62],"outcomes":[63],"MDS-RS.":[65,143,377],"Methods:":[66],"Study":[67],"subjects":[68],"were":[69,114,152,212,247],"from":[70],"the":[71,245,280,289],"Mayo":[72],"Clinic":[73],"syndrome":[75],"(MDS)":[76],"database":[77],"which":[78],"contains":[79],"1315":[80,133],"patients":[81],"(pts).":[82],"Appropriate":[83],"IRB":[84],"approval":[85],"obtained.":[87],"Diagnosis":[88],"of":[89,142,208,244],"MDS":[90],"its":[92],"sub-classification":[93],"done":[95,125],"according":[96],"World":[98],"Health":[99],"Organization":[100],"2016":[101],"criteria.":[102],"A":[103,365],"response":[104,235],"any":[106],"improvement":[107,276,350],"hemoglobin.":[109],"Overall":[110,251],"survival":[111,252],"(OS)":[112],"estimates":[113],"calculated":[115],"using":[116,126],"Kaplan-Meier":[117],"curves":[118],"univariate":[120],"multivariate":[122],"analysis":[123],"JMP":[127],"software":[128],"version":[129],"13.":[130],"Results:":[131],"Among":[132,217],"pts":[134,138,151,156,199,220,246,254,266],"MDS,":[136],"161":[137],"diagnosis":[141],"Median":[144],"age":[145],"73,":[147],"55":[149],"(34%)":[150],"females.":[153],"Thirty-nine":[154],"(36%)":[155],"very":[158,173],"low,":[159,162],"53":[160],"(50%)":[161,227],"9":[163],"(8%)":[164],"intermediate,":[165],"3":[166],"(3%)":[167,200],"high,":[168],"2":[170],"(1%)":[171],"high":[174],"revised":[175],"international":[176],"prognostic":[177],"score.":[178],"median":[180],"white":[181],"blood":[182],"cell":[183],"count":[184,189],"5.4":[186],"x109,":[187,192],"platelet":[188],"255":[191],"hemoglobin":[194],"9.9":[196],"gm/dL.":[197],"Five":[198],"levels":[205],"done;":[206],"out":[207],"whom,":[209],"4":[210,231],"(80%)":[211],"not":[213,310,329,340,362],"deficient.":[216],"42":[218],"(26%)":[219],"who":[221,255,267,327],"replacement,":[225],"21":[226],"no":[229,292],"response,":[230],"(10%)":[232],"17":[237],"(40%)":[238],"unknown":[240],"response.":[241],"103":[242],"(64%)":[243],"transfusion":[248,257],"independent":[249],"(TI).":[250],"dependent":[258],"68":[260,299],"months":[261,297],"compared":[262,287],"85":[264],"TI":[269],"(Wilcoxon":[270],"P":[271,302],"=.03).":[272],"There":[273,346],"an":[275],"OS":[278,312,352],"group":[281,290,357],"that":[282],"(92":[296],"vs":[298],"months,":[300],"Wilcoxon":[301],"=.07).":[303],"Response":[304,360],"did":[309,328,361],"show":[311],"benefit.":[313],"Acute":[314],"Leukemia":[315],"transformation":[316],"2%":[322],"6%":[324],"pts.":[326,345],"have":[330],"(P=":[334],".4).":[335],"Conclusions:":[336],"checked":[341],"often":[342],"MDS-RS":[344],"borderline":[349],"(p=":[358],".07).":[359],"affect":[363],"OS.":[364],"larger":[366],"prospective":[367],"needed":[370],"role":[375]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-07-23T00:00:00"}