{"id":"https://openalex.org/W2956680313","doi":"https://doi.org/10.1016/j.bpj.2019.07.007","title":"Interaction Between the a3 Region of Factor VIII and the TIL\u2019E\u2019 Domains of the von Willebrand Factor","display_name":"Interaction Between the a3 Region of Factor VIII and the TIL\u2019E\u2019 Domains of the von Willebrand Factor","publication_year":2019,"publication_date":"2019-07-11","ids":{"openalex":"https://openalex.org/W2956680313","doi":"https://doi.org/10.1016/j.bpj.2019.07.007","mag":"2956680313","pmid":"https://pubmed.ncbi.nlm.nih.gov/31349985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6697466"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2019.07.007","doi":"https://doi.org/10.1016/j.bpj.2019.07.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2019.07.007","pdf_url":"http://www.cell.com/article/S0006349519305636/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S0006349519305636/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079803664","display_name":"Lisbeth Dagil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]},{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Lisbeth Dagil","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom; Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom","Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom; Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075877789","display_name":"Kathrin R. Troelsen","orcid":"https://orcid.org/0000-0002-8734-533X","observed_orcids":["https://orcid.org/0000-0002-8734-533X"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kathrin S. Troelsen","raw_affiliation_strings":["Department of Chemistry, Technical University of Denmark, Kongens Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Technical University of Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060448502","display_name":"Gert R. Bolt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Gert Bolt","raw_affiliation_strings":["Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111689575","display_name":"Lars Thim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars Thim","raw_affiliation_strings":["Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bo Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo Wu","raw_affiliation_strings":["Novo Nordisk Research Center China, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center China, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031973958","display_name":"Xin Zhao","orcid":"https://orcid.org/0000-0001-6071-4433","observed_orcids":["https://orcid.org/0000-0001-6071-4433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Zhao","raw_affiliation_strings":["Novo Nordisk Research Center China, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center China, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029562668","display_name":"Edward G. D. Tuddenham","orcid":"https://orcid.org/0000-0001-8955-2909","observed_orcids":["https://orcid.org/0000-0001-8955-2909"]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]},{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edward G.D. Tuddenham","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom; Katharine Dormandy, Haemophilia Centre and Thrombosis Unit, Royal Free Hospital NHS Trust, London, United Kingdom","Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom","Katharine Dormandy, Haemophilia Centre and Thrombosis Unit, Royal Free Hospital NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom; Katharine Dormandy, Haemophilia Centre and Thrombosis Unit, Royal Free Hospital NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I169248724","https://openalex.org/I2801138448","https://openalex.org/I4210157240","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Katharine Dormandy, Haemophilia Centre and Thrombosis Unit, Royal Free Hospital NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043122653","display_name":"Thomas E. Nielsen","orcid":"https://orcid.org/0000-0001-8700-1951","observed_orcids":["https://orcid.org/0000-0001-8700-1951"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thomas E. Nielsen","raw_affiliation_strings":["Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012538389","display_name":"David Tanner","orcid":"https://orcid.org/0000-0002-0156-3863","observed_orcids":["https://orcid.org/0000-0002-0156-3863"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"David A. Tanner","raw_affiliation_strings":["Department of Chemistry, Technical University of Denmark, Kongens Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Technical University of Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083685180","display_name":"Johan H. Faber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Johan H. Faber","raw_affiliation_strings":["Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113870933","display_name":"Jens Breinholt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jens Breinholt","raw_affiliation_strings":["Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100852702","display_name":"Jakob Ewald Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Jakob E. Rasmussen","raw_affiliation_strings":["Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark. Electronic address: jaor@novonordisk.com","Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark. Electronic address: jaor@novonordisk.com","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S, Novo Nordisk Park, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003139041","display_name":"D. Flemming Hansen","orcid":"https://orcid.org/0000-0003-0891-220X","observed_orcids":["https://orcid.org/0000-0003-0891-220X"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D. Flemming Hansen","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom. Electronic address: d.hansen@ucl.ac.uk","Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom. Electronic address: d.hansen@ucl.ac.uk","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003139041","https://openalex.org/A5100852702"],"corresponding_institution_ids":["https://openalex.org/I189090001","https://openalex.org/I4210157240","https://openalex.org/I45129253"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2198,"currency":"EUR","value_usd":2370},"fwci":1.8261,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85625363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"117","issue":"3","first_page":"479","last_page":"489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/high-affinity-binding","display_name":"high-affinity binding","score":0.8659999966621399},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.6140000224113464},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.8619999885559082},{"id":"https://openalex.org/keywords/protein-complex-structure","display_name":"protein complex structure","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.9010818004608154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6606270670890808},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.6292725801467896},{"id":"https://openalex.org/C2778780528","wikidata":"https://www.wikidata.org/wiki/Q709360","display_name":"Von Willebrand disease","level":4,"score":0.5706007480621338},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5250641703605652},{"id":"https://openalex.org/C193125475","wikidata":"https://www.wikidata.org/wiki/Q17029192","display_name":"Heteronuclear single quantum coherence spectroscopy","level":3,"score":0.483236163854599},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4498051702976227},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.4327995181083679},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.40005266666412354},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3871699869632721},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3593079447746277},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2339164912700653},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22704145312309265},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.21211087703704834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18553191423416138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14810192584991455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14234188199043274},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14228102564811707},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09772616624832153}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.bpj.2019.07.007","doi":"https://doi.org/10.1016/j.bpj.2019.07.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2019.07.007","pdf_url":"http://www.cell.com/article/S0006349519305636/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5828172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6697466","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6697466","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6697466","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:31349985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31349985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10079361","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10079361/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biophysical Journal , 117 (3) pp. 479-489. (2019)","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:publications/83a76c47-7b96-446b-8f62-55cdb52053fa","doi":null,"is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/83a76c47-7b96-446b-8f62-55cdb52053fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dagil , L , Troelsen , K S , Bolt , G , Thim , L , Wu , B , Zhao , X , Tuddenham , E G D , Nielsen , T E , Tanner , D A , Faber , J H , Breinholt , J , Rasmussen , J E & Hansen , D F 2019 , ' Interaction Between the a3 Region of Factor VIII and the TIL'E' Domains of the von Willebrand Factor ' , Biophysical Journal , vol. 117 , no. 3 , pp. 479-489 . https://doi.org/10.1016/j.bpj.2019.07.007","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2019.07.007","doi":"https://doi.org/10.1016/j.bpj.2019.07.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2019.07.007","pdf_url":"http://www.cell.com/article/S0006349519305636/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2423823566","display_name":null,"funder_award_id":"FC001029","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3416286394","display_name":"The UCL Integrated NMR Centre:Bridging fine-scale analysis of macromolecules and cell physiology with high-throughput population scale metabolomics, drug target validation and biomarker development .","funder_award_id":"101569/Z/13/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6088487555","display_name":"Characterising structure, interactions and dynamics of large molecular machines and intrinsically disordered proteins using novel carbon-detected NMR","funder_award_id":"BB/R000255/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6560794314","display_name":null,"funder_award_id":"RPG-2016-268","funder_id":"https://openalex.org/F4320319993","funder_display_name":"Leverhulme Trust"},{"id":"https://openalex.org/G7055296076","display_name":null,"funder_award_id":"FC001029","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G7944063001","display_name":null,"funder_award_id":"10029","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319993","display_name":"Leverhulme Trust","ror":"https://ror.org/012mzw131"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2956680313.pdf","grobid_xml":"https://content.openalex.org/works/W2956680313.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W97948080","https://openalex.org/W118880679","https://openalex.org/W120923871","https://openalex.org/W172098433","https://openalex.org/W174752904","https://openalex.org/W211967407","https://openalex.org/W262805330","https://openalex.org/W1482422136","https://openalex.org/W1512481003","https://openalex.org/W1539663343","https://openalex.org/W1542837635","https://openalex.org/W1543530742","https://openalex.org/W1554853279","https://openalex.org/W1555294060","https://openalex.org/W1578168675","https://openalex.org/W1582407961","https://openalex.org/W1625938724","https://openalex.org/W1896702999","https://openalex.org/W1956677504","https://openalex.org/W1978820185","https://openalex.org/W1980884659","https://openalex.org/W1986322598","https://openalex.org/W2005268147","https://openalex.org/W2011694089","https://openalex.org/W2017312554","https://openalex.org/W2021283345","https://openalex.org/W2026381834","https://openalex.org/W2027217170","https://openalex.org/W2027228214","https://openalex.org/W2032735275","https://openalex.org/W2036307682","https://openalex.org/W2039852043","https://openalex.org/W2047498280","https://openalex.org/W2049786448","https://openalex.org/W2052126236","https://openalex.org/W2054616813","https://openalex.org/W2055557864","https://openalex.org/W2060842498","https://openalex.org/W2074856155","https://openalex.org/W2078892740","https://openalex.org/W2091153742","https://openalex.org/W2117195560","https://openalex.org/W2130314959","https://openalex.org/W2169707043","https://openalex.org/W2169821755","https://openalex.org/W2293930120","https://openalex.org/W2330411027","https://openalex.org/W2337186576","https://openalex.org/W2395581362","https://openalex.org/W2462127403","https://openalex.org/W2569325116","https://openalex.org/W2910496356","https://openalex.org/W2935159162"],"related_works":["https://openalex.org/W3128422450","https://openalex.org/W3204058823","https://openalex.org/W2091153742","https://openalex.org/W2495607021","https://openalex.org/W2059314532","https://openalex.org/W1582407961","https://openalex.org/W2509144358","https://openalex.org/W1976462890","https://openalex.org/W2888909627","https://openalex.org/W1535088401"],"abstract_inverted_index":{"The":[0],"von":[1,50],"Willebrand":[2,51],"factor":[3,7],"(VWF)":[4],"and":[5,21,30,42,49,63,92,100,126,138,170,181,223,225],"coagulation":[6],"VIII":[8],"(FVIII)":[9],"are":[10],"intricately":[11],"involved":[12],"in":[13,28],"hemostasis.":[14],"A":[15,48],"tight,":[16],"noncovalent":[17],"complex":[18,35,60,219],"between":[19,61,98,133,179,221],"VWF":[20,62,99,139,222],"FVIII":[22,27,41,64,101,125,135,163,180,214,224,237],"prolongs":[23],"the":[24,59,74,77,96,109,118,121,127,134,158,177,192,195,204,211,213,226,240,243],"half-life":[25],"of":[26,40,81,95,108,124,130,160,187,194,198,229],"plasma,":[29],"failure":[31],"to":[32,37,153,175,233],"form":[33],"this":[34,250],"leads":[36],"rapid":[38],"clearance":[39],"bleeding":[43],"diatheses":[44],"such":[45],"as":[46,183,185],"hemophilia":[47],"disease":[52],"(VWD)":[53],"type":[54],"2N.":[55],"High-resolution":[56],"insight":[57,209],"into":[58,210,249],"has":[65],"so":[66],"far":[67],"been":[68,113],"strikingly":[69],"lacking.":[70],"This":[71],"is":[72,84,102,231],"particularly":[73],"case":[75],"for":[76,86,116,200,218,236,245],"flexible":[78],"a3":[79,122,136,164,215],"region":[80,123,137,165,197,216,228],"FVIII,":[82],"which":[83,189],"imperative":[85,251],"high-affinity":[87,201],"binding.":[88,166,202,238],"Here,":[89],"a":[90],"structural":[91],"biophysical":[93],"characterization":[94],"interaction":[97,178],"presented":[103,206],"with":[104],"focus":[105],"on":[106,157],"two":[107,154],"domains":[110,129],"that":[111],"have":[112],"proven":[114],"pivotal":[115],"mediating":[117],"interaction,":[119],"namely":[120],"TIL'E'":[128,140,161,182,199,230],"VWF.":[131],"Binding":[132],"was":[141],"here":[142],"observed":[143],"using":[144],"NMR":[145,171],"spectroscopy,":[146],"where":[147],"chemical":[148],"shift":[149],"changes":[150],"were":[151,173],"localized":[152],"\u03b2-sheet":[155,196,227],"regions":[156],"edge":[159],"upon":[162],"Isothermal":[167],"titration":[168],"calorimetry":[169],"spectroscopy":[172],"used":[174],"characterize":[176],"well":[184],"mutants":[186],"TIL'E',":[188],"further":[190,246],"highlights":[191],"importance":[193],"Overall,":[203],"results":[205,241],"provide":[207],"new":[208],"role":[212],"plays":[217],"formation":[220],"shown":[232],"be":[234],"important":[235],"Thus,":[239],"pave":[242],"way":[244],"high-resolution":[247],"insights":[248],"complex.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-23T00:00:00"}