{"id":"https://openalex.org/W295657281","doi":"https://doi.org/10.1089/vim.2013.0090","title":"Neural Stem/Progenitor Cells Induce Conversion of Encephalitogenic T Cells into CD4 + -CD25 + - FOXP3 + Regulatory T cells","display_name":"Neural Stem/Progenitor Cells Induce Conversion of Encephalitogenic T Cells into CD4 + -CD25 + - FOXP3 + Regulatory T cells","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W295657281","doi":"https://doi.org/10.1089/vim.2013.0090","mag":"295657281","pmid":"https://pubmed.ncbi.nlm.nih.gov/24605788"},"language":"en","primary_location":{"id":"doi:10.1089/vim.2013.0090","doi":"https://doi.org/10.1089/vim.2013.0090","is_oa":false,"landing_page_url":"https://doi.org/10.1089/vim.2013.0090","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061475630","display_name":"Arshed Nazmi","orcid":"https://orcid.org/0000-0002-5073-2061","observed_orcids":["https://orcid.org/0000-0002-5073-2061"]},"institutions":[{"id":"https://openalex.org/I85332549","display_name":"National Brain Research Centre","ror":"https://ror.org/022swbj46","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I85332549"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arshed Nazmi","raw_affiliation_strings":["National Brain Research Centre, Manesar, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Brain Research Centre, Manesar, Haryana, India","institution_ids":["https://openalex.org/I85332549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Iqbal Mohamed Arif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85332549","display_name":"National Brain Research Centre","ror":"https://ror.org/022swbj46","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I85332549"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Iqbal Mohamed Arif","raw_affiliation_strings":["National Brain Research Centre, Manesar, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Brain Research Centre, Manesar, Haryana, India","institution_ids":["https://openalex.org/I85332549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074937652","display_name":"Kallol Dutta","orcid":"https://orcid.org/0000-0001-6402-1300","observed_orcids":["https://orcid.org/0000-0001-6402-1300"]},"institutions":[{"id":"https://openalex.org/I85332549","display_name":"National Brain Research Centre","ror":"https://ror.org/022swbj46","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I85332549"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kallol Dutta","raw_affiliation_strings":["National Brain Research Centre, Manesar, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Brain Research Centre, Manesar, Haryana, India","institution_ids":["https://openalex.org/I85332549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057011524","display_name":"Kiran Kundu","orcid":"https://orcid.org/0000-0001-7586-4696","observed_orcids":["https://orcid.org/0000-0001-7586-4696"]},"institutions":[{"id":"https://openalex.org/I85332549","display_name":"National Brain Research Centre","ror":"https://ror.org/022swbj46","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I85332549"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kiran Kundu","raw_affiliation_strings":["National Brain Research Centre, Manesar, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Brain Research Centre, Manesar, Haryana, India","institution_ids":["https://openalex.org/I85332549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075526464","display_name":"Anirban Basu","orcid":"https://orcid.org/0000-0002-5200-2054","observed_orcids":["https://orcid.org/0000-0002-5200-2054"]},"institutions":[{"id":"https://openalex.org/I85332549","display_name":"National Brain Research Centre","ror":"https://ror.org/022swbj46","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I85332549"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anirban Basu","raw_affiliation_strings":["National Brain Research Centre, Manesar, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Brain Research Centre, Manesar, Haryana, India","institution_ids":["https://openalex.org/I85332549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I85332549"],"apc_list":null,"apc_paid":null,"fwci":1.0623,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73438307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"27","issue":"2","first_page":"48","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-progenitor-cells","display_name":"neural stem/progenitor cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8100000023841858},{"id":"https://openalex.org/keywords/encephalitogenic-t-cells","display_name":"encephalitogenic T cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/japanese-encephalitis-virus","display_name":"Japanese encephalitis virus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/viral-encephalitis","display_name":"viral encephalitis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.6629999876022339},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.8270000219345093},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.875},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.6890000104904175},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.7447506189346313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5865799784660339},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5632979273796082},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5518739819526672},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5015120506286621},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49713996052742004},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4716937839984894},{"id":"https://openalex.org/C131665280","wikidata":"https://www.wikidata.org/wiki/Q14866169","display_name":"Interleukin 3","level":5,"score":0.46247828006744385},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3702460825443268},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34845656156539917},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3444553017616272},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34434181451797485}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004664","descriptor_name":"Encephalitis Virus, Japanese","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004671","descriptor_name":"Encephalitis, Arbovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018177","descriptor_name":"Flavivirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/vim.2013.0090","doi":"https://doi.org/10.1089/vim.2013.0090","is_oa":false,"landing_page_url":"https://doi.org/10.1089/vim.2013.0090","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},{"id":"pmid:24605788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24605788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1590965838","https://openalex.org/W1785015986","https://openalex.org/W1868578788","https://openalex.org/W1903439047","https://openalex.org/W1965009960","https://openalex.org/W1969696108","https://openalex.org/W1971052491","https://openalex.org/W1972066347","https://openalex.org/W1975380933","https://openalex.org/W1985273119","https://openalex.org/W1986628684","https://openalex.org/W1987270591","https://openalex.org/W1990384244","https://openalex.org/W1993764727","https://openalex.org/W2000586928","https://openalex.org/W2002381210","https://openalex.org/W2011851462","https://openalex.org/W2022329534","https://openalex.org/W2026657037","https://openalex.org/W2030679062","https://openalex.org/W2031472162","https://openalex.org/W2034340892","https://openalex.org/W2040603262","https://openalex.org/W2045798092","https://openalex.org/W2048237213","https://openalex.org/W2058756509","https://openalex.org/W2064573340","https://openalex.org/W2074274817","https://openalex.org/W2074640200","https://openalex.org/W2076478752","https://openalex.org/W2082549804","https://openalex.org/W2089929836","https://openalex.org/W2094613247","https://openalex.org/W2110087602","https://openalex.org/W2120010406","https://openalex.org/W2132924600","https://openalex.org/W2146835532","https://openalex.org/W2150902623","https://openalex.org/W2154022519"],"related_works":["https://openalex.org/W2154022519","https://openalex.org/W4366603663","https://openalex.org/W2052233080","https://openalex.org/W2062521126","https://openalex.org/W7095266157","https://openalex.org/W2046424934","https://openalex.org/W2325968474","https://openalex.org/W4313381485","https://openalex.org/W815720553","https://openalex.org/W2441138583"],"abstract_inverted_index":{"An":[0],"immune":[1],"role":[2],"of":[3,71,99,110,123,148,178,194],"neural":[4],"stem/progenitor":[5],"cells":[6,37,42,48,78,95,113,126,171,181],"(NSPCs)":[7],"has":[8],"been":[9],"proposed":[10],"in":[11,68,103,156,192,197],"many":[12],"recent":[13],"studies;":[14],"however":[15],"much":[16],"still":[17],"remains":[18],"to":[19,33,87],"be":[20,88],"elucidated.":[21],"In":[22],"the":[23,31,69,165,198],"current":[24],"investigation,":[25],"we":[26],"report":[27],"that":[28],"NSPCs":[29,128,144,173,188],"possess":[30],"ability":[32],"convert":[34],"encephalitogenic":[35,76,111,169,179],"T":[36,41,47,77,94,112,125,170,180],"into":[38,114,164,182],"CD4(+)-CD25(+)-FOXP3(+)":[39,183],"regulatory":[40],"(T(reg)).":[43],"Encephalitogenic":[44],"and":[45,52,96,101,120,127,131,139,151,172],"nonencephalitogenic":[46],"isolated":[49],"from":[50,75],"sham":[51],"Japanese":[53],"encephalitis":[54],"virus":[55],"(JEV)":[56],"infected":[57],"animals":[58],"were":[59,141,153],"co-cultured":[60,79],"with":[61,80,187],"mouse":[62],"NSPCs.":[63,81,97,157],"Post":[64],"co-culture,":[65],"significant":[66],"increase":[67],"number":[70],"T(regs)":[72,184],"was":[73,85],"observed":[74],"This":[82,158],"increased":[83,108,142,155],"conversion":[84,109],"found":[86],"dependent":[89],"on":[90,143],"direct":[91],"contact":[92],"between":[93,167],"Neutralization":[98],"TGF-\u03b2":[100],"IFN-\u03b3":[102],"NSPC":[104],"cultures":[105],"abrogated":[106],"this":[107],"T(regs).":[115],"Flow":[116],"cytometric,":[117],"quantitative":[118],"RT-PCR,":[119],"immunoblot":[121],"analysis":[122],"both":[124],"revealed":[129],"surface":[130],"intracellular":[132],"changes":[133],"post":[134,145],"co-culture.":[135],"Co-stimulatory":[136],"molecules":[137],"(B7)":[138],"ICAM-1":[140],"co-culture;":[146],"levels":[147],"TGF\u03b2,":[149],"IFN\u03b3,":[150],"TGF\u03b2R1":[152],"also":[154],"study":[159],"provides":[160],"a":[161],"basic":[162],"insight":[163],"interaction":[166,186],"CNS-infiltrating":[168],"during":[174],"viral":[175],"encephalitis.":[176],"Conversion":[177],"through":[185],"indicates":[189],"an":[190],"attempt":[191],"regulation":[193],"excessive":[195],"inflammation":[196],"CNS.":[199]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}