{"id":"https://openalex.org/W2956427550","doi":"https://doi.org/10.18632/oncotarget.26995","title":"Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining","display_name":"Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining","publication_year":2019,"publication_date":"2019-06-11","ids":{"openalex":"https://openalex.org/W2956427550","doi":"https://doi.org/10.18632/oncotarget.26995","mag":"2956427550","pmid":"https://pubmed.ncbi.nlm.nih.gov/31231467","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6570467"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.26995","doi":"https://doi.org/10.18632/oncotarget.26995","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.26995","pdf_url":"https://www.oncotarget.com/article/26995/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/26995/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051330408","display_name":"Dinesh Kumar Barupal","orcid":"https://orcid.org/0000-0002-9954-8628","observed_orcids":["https://orcid.org/0000-0002-9954-8628"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dinesh Kumar Barupal","raw_affiliation_strings":["West Coast Metabolomics Center, University of California, Davis, CA, 95616","West Coast Metabolomics Center, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Coast Metabolomics Center, University of California, Davis, CA, 95616","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"West Coast Metabolomics Center, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056546567","display_name":"Bei Gao","orcid":"https://orcid.org/0000-0002-3321-2339","observed_orcids":["https://orcid.org/0000-0002-3321-2339"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bei Gao","raw_affiliation_strings":["West Coast Metabolomics Center, University of California, Davis, CA, 95616","West Coast Metabolomics Center, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Coast Metabolomics Center, University of California, Davis, CA, 95616","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"West Coast Metabolomics Center, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089035898","display_name":"Jan Budczies","orcid":"https://orcid.org/0000-0002-6668-5327","observed_orcids":["https://orcid.org/0000-0002-6668-5327"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Budczies","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9 University Hospital, Berlin","Institute of Pathology, Charit\u00e9 University Hospital, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 University Hospital, Berlin","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 University Hospital, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084209996","display_name":"Brett S. Phinney","orcid":"https://orcid.org/0000-0003-3870-3302","observed_orcids":["https://orcid.org/0000-0003-3870-3302"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett S. Phinney","raw_affiliation_strings":["UC Davis Genome Center, University of California, Davis, CA, 95616","UC Davis Genome Center, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Davis Genome Center, University of California, Davis, CA, 95616","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"UC Davis Genome Center, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033428030","display_name":"Bertrand Perroud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bertrand Perroud","raw_affiliation_strings":["UC Davis Genome Center, University of California, Davis, CA, 95616","UC Davis Genome Center, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Davis Genome Center, University of California, Davis, CA, 95616","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"UC Davis Genome Center, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033698551","display_name":"Carsten Denkert","orcid":"https://orcid.org/0000-0002-2249-0982","observed_orcids":["https://orcid.org/0000-0002-2249-0982"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten Denkert","raw_affiliation_strings":["German Institute of Pathology, Philipps-University Marburg, Germany","Institute of Pathology, Charit\u00e9 University Hospital, Berlin","German Institute of Pathology, Philipps-University Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Institute of Pathology, Philipps-University Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 University Hospital, Berlin","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"raw_affiliation_string":"German Institute of Pathology, Philipps-University Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087349635","display_name":"Oliver Fiehn","orcid":"https://orcid.org/0000-0002-6261-8928","observed_orcids":["https://orcid.org/0000-0002-6261-8928"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oliver Fiehn","raw_affiliation_strings":["West Coast Metabolomics Center, University of California, Davis, CA, 95616","West Coast Metabolomics Center, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Coast Metabolomics Center, University of California, Davis, CA, 95616","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"West Coast Metabolomics Center, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087349635"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":0.7325,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.65430748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"39","first_page":"3894","last_page":"3909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0917000025510788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/metabolic-genes","display_name":"metabolic genes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8960000276565552},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8240000009536743},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7480000257492065},{"id":"https://openalex.org/keywords/nucleotide-biosynthesis","display_name":"nucleotide synthesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/amino-acid-biosynthesis","display_name":"amino acid biosynthesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pfkp","display_name":"PFKP","score":0.7279999852180481},{"id":"https://openalex.org/keywords/glycinamide-ribonucleotide-transformylase","display_name":"GART","score":0.9300000071525574},{"id":"https://openalex.org/keywords/plod1","display_name":"PLOD1","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ass1","display_name":"ASS1","score":0.972000002861023},{"id":"https://openalex.org/keywords/sorbitol-dehydrogenase","display_name":"sorbitol dehydrogenase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/reactome-pathway-analysis","display_name":"Reactome pathway analysis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gene-prioritization","display_name":"gene prioritization","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7014542818069458},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6348888874053955},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.5909373760223389},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5758796334266663},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.529458224773407},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4965978264808655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4956444501876831},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4493761360645294},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3425060510635376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3393966555595398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3255586624145508},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16466593742370605},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1440022885799408}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.18632/oncotarget.26995","doi":"https://doi.org/10.18632/oncotarget.26995","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.26995","pdf_url":"https://www.oncotarget.com/article/26995/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"doi:10.1101/515403","doi":"https://doi.org/10.1101/515403","is_oa":true,"landing_page_url":"https://doi.org/10.1101/515403","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/01/09/515403.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:5555548","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6570467","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6570467","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6570467","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:31231467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31231467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2wr121nd","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2wr121nd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, vol 10, iss 39","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.26995","doi":"https://doi.org/10.18632/oncotarget.26995","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.26995","pdf_url":"https://www.oncotarget.com/article/26995/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2374061958","display_name":"Identification and validation of new breast cancer biomarkers based on integrated metabolomics","funder_award_id":"200327","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5950577451","display_name":null,"funder_award_id":"NIH U54","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7146956810","display_name":"West Coast Metabolomics Center for Compound Identification","funder_award_id":"U2CES030158","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8526486059","display_name":"Center for Solutions for ME/CFS","funder_award_id":"U54AI138370","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000919024","display_name":"Longevity Consortium","funder_award_id":"U19AG023122","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2956427550.pdf","grobid_xml":"https://content.openalex.org/works/W2956427550.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1896429920","https://openalex.org/W1964007537","https://openalex.org/W1980151620","https://openalex.org/W1989277387","https://openalex.org/W1996822667","https://openalex.org/W2007227595","https://openalex.org/W2010434645","https://openalex.org/W2016806296","https://openalex.org/W2019581322","https://openalex.org/W2023747218","https://openalex.org/W2023947368","https://openalex.org/W2041334056","https://openalex.org/W2042081254","https://openalex.org/W2046336448","https://openalex.org/W2060081607","https://openalex.org/W2071146934","https://openalex.org/W2072816950","https://openalex.org/W2085934079","https://openalex.org/W2089094422","https://openalex.org/W2099451866","https://openalex.org/W2101239722","https://openalex.org/W2112963260","https://openalex.org/W2116586864","https://openalex.org/W2120742047","https://openalex.org/W2125997801","https://openalex.org/W2131253478","https://openalex.org/W2137426380","https://openalex.org/W2139467064","https://openalex.org/W2139593382","https://openalex.org/W2147458973","https://openalex.org/W2150473997","https://openalex.org/W2154686512","https://openalex.org/W2164050296","https://openalex.org/W2168014041","https://openalex.org/W2203717837","https://openalex.org/W2341128841","https://openalex.org/W2344840591","https://openalex.org/W2466672339","https://openalex.org/W2476542314","https://openalex.org/W2480418441","https://openalex.org/W2491348399","https://openalex.org/W2517829629","https://openalex.org/W2561101222","https://openalex.org/W2565535622","https://openalex.org/W2766501219","https://openalex.org/W2766792020","https://openalex.org/W2793323277","https://openalex.org/W2896968374","https://openalex.org/W4233698560"],"related_works":["https://openalex.org/W4286296424","https://openalex.org/W7118724956","https://openalex.org/W4401904760","https://openalex.org/W2395828723","https://openalex.org/W4200316232","https://openalex.org/W2589313592","https://openalex.org/W6926966444","https://openalex.org/W3191278981","https://openalex.org/W4281608768","https://openalex.org/W4385283150"],"abstract_inverted_index":{"//":[0],"Dinesh":[1],"Kumar":[2],"Barupal":[3],"1":[4,10,35,36],",":[5,7,11,13,17,22,26,30],"*":[6,12,76],"Bei":[8],"Gao":[9],"Jan":[14],"Budczies":[15],"2":[16,29,47],"Brett":[18],"S.":[19],"Phinney":[20],"4":[21,25,65],"Bertrand":[23],"Perroud":[24],"Carsten":[27],"Denkert":[28],"3":[31,56],"and":[32,79,136,148,163,180,191,242,248,263,284,301,316],"Oliver":[33,87],"Fiehn":[34],"West":[37],"Coast":[38],"Metabolomics":[39],"Center,":[40,69],"University":[41,52,70],"of":[42,49,59,71,142,166,175,204,217,235,244,298,313],"California,":[43,72],"Davis,":[44,73],"CA,":[45,74],"USA":[46,75],"Institute":[48,58],"Pathology,":[50,60],"Charit\u00e9":[51],"Hospital,":[53],"Berlin,":[54],"Germany":[55,64],"German":[57],"Philipps-University":[61],"Marburg,":[62,63],"UC":[66],"Davis":[67],"Genome":[68],"Co-first":[77],"authors":[78],"contributed":[80],"equally":[81],"to":[82,215,269],"this":[83],"work":[84],"Correspondence":[85],"to:":[86],"Fiehn,":[88],"email:":[89],"ofiehn@ucdavis.edu":[90],"Keywords:":[91],"set-enrichment;":[92],"ChemRICH;":[93],"multi-omics;":[94],"metabolic":[95,167,219,261],"networks;":[96],"candidate":[97],"gene":[98],"prioritization":[99],"Received:":[100],"March":[101],"12,":[102],"2019":[103,107,111],"Accepted:":[104],"May":[105],"13,":[106],"Published:":[108],"June":[109],"11,":[110],"ABSTRACT":[112],"Estrogen-receptor":[113],"negative":[114],"(ERneg)":[115],"breast":[116,121,144,193],"cancer":[117,122,343],"is":[118],"an":[119],"aggressive":[120],"subtype":[123],"in":[124,323,342],"the":[125,170,196,218,229],"need":[126],"for":[127,139,318,339,353],"new":[128],"therapeutic":[129],"options.":[130],"We":[131],"have":[132,265],"analyzed":[133],"metabolomics,":[134,299],"proteomics":[135,300],"transcriptomics":[137,151,199,230,302],"data":[138],"a":[140,173],"cohort":[141],"276":[143],"tumors":[145,291],"(MetaCancer":[146],"study)":[147],"nine":[149,197],"public":[150,198],"datasets":[152],"using":[153],"univariate":[154],"statistics,":[155],"meta-analysis,":[156],"Reactome":[157,232],"pathway":[158,233],"analysis,":[159],"biochemical":[160],"network":[161],"mapping":[162],"text":[164,331],"mining":[165,256,332],"genes.":[168],"In":[169,195],"MetaCancer":[171],"cohort,":[172],"total":[174],"29%":[176],"metabolites,":[177],"21%":[178],"proteins":[179],"33%":[181],"transcripts":[182],"were":[183,207,221,250,292,321,328],"significantly":[184,208,222],"different":[185,209,223],"(raw":[186,210],"p":[187,211,226],"<0.05)":[188,227],"between":[189],"ERneg":[190,253,290,324],"ERpos":[192],"tumors.":[194,325],"datasets,":[200],"on":[201],"average":[202],"23%":[203],"all":[205,236],"genes":[206,220,262,327],"<0.05).":[212],"Specifically,":[213],"up":[214],"60%":[216],"(meta-analysis":[224],"raw":[225],"across":[228],"datasets.":[231],"analysis":[234,297],"omics":[237],"showed":[238],"that":[239,258,307],"energy":[240],"metabolism,":[241],"biosynthesis":[243],"nucleotides,":[245],"amino":[246],"acids,":[247],"lipids":[249,315],"associated":[251,288],"with":[252,289],"status.":[254],"Text":[255],"revealed":[257,329],"several":[259],"significant":[260],"enzymes":[264],"been":[266],"rarely":[267],"reported":[268],"date,":[270],"including":[271],"PFKP,":[272],"GART,":[273],"PLOD1,":[274],"ASS1,":[275],"NUDT12,":[276],"FAR1,":[277],"PDE7A,":[278],"FAHD1,":[279],"ITPK1,":[280],"SORD,":[281],"HACD3,":[282],"CDS2":[283],"PDSS1.":[285],"Metabolic":[286],"processes":[287],"identified":[293],"by":[294,330],"multi-omics":[295],"integration":[296],"data.":[303],"Overall":[304],"results":[305],"suggested":[306],"TCA":[308],"anaplerosis,":[309],"proline":[310],"biosynthesis,":[311],"synthesis":[312],"complex":[314],"mechanisms":[317],"recycling":[319],"substrates":[320],"activated":[322],"Under-reported":[326],"which":[333],"may":[334],"serve":[335],"as":[336],"novel":[337],"candidates":[338],"drug":[340],"targets":[341],"therapies.":[344],"The":[345],"workflow":[346],"presented":[347],"here":[348],"can":[349],"also":[350],"be":[351],"used":[352],"other":[354],"tumor":[355],"types.":[356]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-07-23T00:00:00"}
