{"id":"https://openalex.org/W2956396333","doi":null,"title":"Actin regulation in dendritic spines: From synaptic plasticity to animal behavior and human neurodevelopmental disorders","display_name":"Actin regulation in dendritic spines: From synaptic plasticity to animal behavior and human neurodevelopmental disorders","publication_year":2019,"publication_date":"2019-08-16","ids":{"openalex":"https://openalex.org/W2956396333","mag":"2956396333"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/303934","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/303934","pdf_url":"http://hdl.handle.net/10138/303934","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/303934","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058725647","display_name":"Iryna Hlushchenko","orcid":"https://orcid.org/0000-0002-7162-3024","observed_orcids":["https://orcid.org/0000-0002-7162-3024"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Iryna Hlushchenko","raw_affiliation_strings":["University of Helsinki"],"raw_orcid":"https://orcid.org/0000-0002-7162-3024","affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058725647"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.8709999918937683},{"id":"https://openalex.org/keywords/actin-regulation","display_name":"actin regulation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/actin-binding-proteins","display_name":"actin-binding proteins","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gelsolin","display_name":"gelsolin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.8410000205039978},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mim","display_name":"MIM","score":0.6639999747276306},{"id":"https://openalex.org/keywords/purkinje-cells","display_name":"Purkinje cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.7580000162124634},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.6549999713897705},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.38499999046325684},{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":0.824999988079071},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.7879999876022339},{"id":"https://openalex.org/keywords/de-novo-missense-variant","display_name":"de novo missense variant","score":0.8769999742507935},{"id":"https://openalex.org/keywords/actn4","display_name":"ACTN4","score":0.9129999876022339},{"id":"https://openalex.org/keywords/swap-70","display_name":"SWAP-70","score":0.9850000143051147},{"id":"https://openalex.org/keywords/myosin-iib","display_name":"myosin IIB","score":0.9940000176429749},{"id":"https://openalex.org/keywords/inhibitory-synapses","display_name":"inhibitory synapses","score":0.9200000166893005},{"id":"https://openalex.org/keywords/spine-morphology","display_name":"dendritic spine morphology","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.8307497501373291},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6302096247673035},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5838981866836548},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.47341614961624146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35585886240005493},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/303934","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/303934","pdf_url":"http://hdl.handle.net/10138/303934","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:2956396333","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/handle/10138/303934","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/303934","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/303934","pdf_url":"http://hdl.handle.net/10138/303934","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2956396333.pdf","grobid_xml":"https://content.openalex.org/works/W2956396333.grobid-xml"},"referenced_works_count":572,"referenced_works":["https://openalex.org/W120728491","https://openalex.org/W152466120","https://openalex.org/W153260337","https://openalex.org/W170774084","https://openalex.org/W236699799","https://openalex.org/W238668910","https://openalex.org/W313547275","https://openalex.org/W323582779","https://openalex.org/W598525099","https://openalex.org/W1409125172","https://openalex.org/W1479801386","https://openalex.org/W1480721347","https://openalex.org/W1481473039","https://openalex.org/W1484036769","https://openalex.org/W1484186367","https://openalex.org/W1529872769","https://openalex.org/W1533942137","https://openalex.org/W1535714951","https://openalex.org/W1538903611","https://openalex.org/W1539659593","https://openalex.org/W1544359545","https://openalex.org/W1544740042","https://openalex.org/W1548684779","https://openalex.org/W1562676004","https://openalex.org/W1573788550","https://openalex.org/W1581590351","https://openalex.org/W1593008823","https://openalex.org/W1594932835","https://openalex.org/W1595124760","https://openalex.org/W1597565122","https://openalex.org/W1602160127","https://openalex.org/W1606934131","https://openalex.org/W1607765379","https://openalex.org/W1636205509","https://openalex.org/W1798211820","https://openalex.org/W1829663576","https://openalex.org/W1843374414","https://openalex.org/W1870318548","https://openalex.org/W1895171560","https://openalex.org/W1904987459","https://openalex.org/W1907953875","https://openalex.org/W1910192533","https://openalex.org/W1913875977","https://openalex.org/W1920303762","https://openalex.org/W1920899731","https://openalex.org/W1926261341","https://openalex.org/W1936208266","https://openalex.org/W1958284284","https://openalex.org/W1963797629","https://openalex.org/W1964065290","https://openalex.org/W1964185512","https://openalex.org/W1964368217","https://openalex.org/W1964802927","https://openalex.org/W1964895626","https://openalex.org/W1965117896","https://openalex.org/W1965561480","https://openalex.org/W1965702739","https://openalex.org/W1965751809","https://openalex.org/W1965833261","https://openalex.org/W1966680360","https://openalex.org/W1966760515","https://openalex.org/W1966775465","https://openalex.org/W1967479320","https://openalex.org/W1967554899","https://openalex.org/W1967581926","https://openalex.org/W1967963412","https://openalex.org/W1969318131","https://openalex.org/W1969353942","https://openalex.org/W1969558225","https://openalex.org/W1969646198","https://openalex.org/W1970369207","https://openalex.org/W1970818983","https://openalex.org/W1970852339","https://openalex.org/W1971569193","https://openalex.org/W1972328472","https://openalex.org/W1972387603","https://openalex.org/W1973335462","https://openalex.org/W1974903257","https://openalex.org/W1975792077","https://openalex.org/W1976886432","https://openalex.org/W1978626885","https://openalex.org/W1978740755","https://openalex.org/W1979771234","https://openalex.org/W1979993594","https://openalex.org/W1980444612","https://openalex.org/W1980479546","https://openalex.org/W1980991473","https://openalex.org/W1981005523","https://openalex.org/W1981120831","https://openalex.org/W1981122661","https://openalex.org/W1981190999","https://openalex.org/W1981239255","https://openalex.org/W1981779311","https://openalex.org/W1984223780","https://openalex.org/W1985117013","https://openalex.org/W1986393839","https://openalex.org/W1987122345","https://openalex.org/W1987378600","https://openalex.org/W1988329060","https://openalex.org/W1988743517","https://openalex.org/W1989239923","https://openalex.org/W1990014844","https://openalex.org/W1990985007","https://openalex.org/W1991384037","https://openalex.org/W1992116689","https://openalex.org/W1992314523","https://openalex.org/W1993790910","https://openalex.org/W1994975196","https://openalex.org/W1995633792","https://openalex.org/W1996081658","https://openalex.org/W1996873526","https://openalex.org/W1997073961","https://openalex.org/W1997932830","https://openalex.org/W1998537522","https://openalex.org/W1999187348","https://openalex.org/W1999919528","https://openalex.org/W2000097985","https://openalex.org/W2000440562","https://openalex.org/W2001092468","https://openalex.org/W2001145951","https://openalex.org/W2002040433","https://openalex.org/W2002993299","https://openalex.org/W2003086579","https://openalex.org/W2003092661","https://openalex.org/W2003615344","https://openalex.org/W2004722643","https://openalex.org/W2005191830","https://openalex.org/W2005725366","https://openalex.org/W2005998843","https://openalex.org/W2009358750","https://openalex.org/W2009765246","https://openalex.org/W2010360110","https://openalex.org/W2010589159","https://openalex.org/W2010920434","https://openalex.org/W2011171974","https://openalex.org/W2011389479","https://openalex.org/W2014691022","https://openalex.org/W2015997269","https://openalex.org/W2016474170","https://openalex.org/W2016646330","https://openalex.org/W2017452923","https://openalex.org/W2018314000","https://openalex.org/W2018526667","https://openalex.org/W2019607817","https://openalex.org/W2019983262","https://openalex.org/W2020016182","https://openalex.org/W2020142016","https://openalex.org/W2020980399","https://openalex.org/W2021511985","https://openalex.org/W2022586187","https://openalex.org/W2023007803","https://openalex.org/W2023033037","https://openalex.org/W2023084443","https://openalex.org/W2023372666","https://openalex.org/W2023529196","https://openalex.org/W2024012275","https://openalex.org/W2024344376","https://openalex.org/W2025015073","https://openalex.org/W2025314114","https://openalex.org/W2025609063","https://openalex.org/W2025670719","https://openalex.org/W2026794525","https://openalex.org/W2027764308","https://openalex.org/W2027879081","https://openalex.org/W2028597602","https://openalex.org/W2029483640","https://openalex.org/W2029595320","https://openalex.org/W2029662381","https://openalex.org/W2030585597","https://openalex.org/W2031422006","https://openalex.org/W2031579870","https://openalex.org/W2031765671","https://openalex.org/W2033763182","https://openalex.org/W2035517592","https://openalex.org/W2036236740","https://openalex.org/W2037068261","https://openalex.org/W2037260832","https://openalex.org/W2038963685","https://openalex.org/W2039359938","https://openalex.org/W2039898366","https://openalex.org/W2040190863","https://openalex.org/W2041467022","https://openalex.org/W2042031939","https://openalex.org/W2043008521","https://openalex.org/W2043781338","https://openalex.org/W2043899383","https://openalex.org/W2044433401","https://openalex.org/W2045479207","https://openalex.org/W2046153261","https://openalex.org/W2046281870","https://openalex.org/W2046792469","https://openalex.org/W2046959912","https://openalex.org/W2047783882","https://openalex.org/W2047883646","https://openalex.org/W2048754663","https://openalex.org/W2049299149","https://openalex.org/W2049338406","https://openalex.org/W2049718819","https://openalex.org/W2050480410","https://openalex.org/W2050527162","https://openalex.org/W2052235822","https://openalex.org/W2053188090","https://openalex.org/W2053453318","https://openalex.org/W2053755159","https://openalex.org/W2054002753","https://openalex.org/W2054048431","https://openalex.org/W2056104397","https://openalex.org/W2056334127","https://openalex.org/W2056579761","https://openalex.org/W2058837236","https://openalex.org/W2059108639","https://openalex.org/W2060697677","https://openalex.org/W2060731979","https://openalex.org/W2060907567","https://openalex.org/W2061289636","https://openalex.org/W2061856741","https://openalex.org/W2061909175","https://openalex.org/W2062219112","https://openalex.org/W2062376760","https://openalex.org/W2063593696","https://openalex.org/W2065597225","https://openalex.org/W2066680323","https://openalex.org/W2068994547","https://openalex.org/W2069220645","https://openalex.org/W2069790213","https://openalex.org/W2071132560","https://openalex.org/W2071966593","https://openalex.org/W2072518443","https://openalex.org/W2073052893","https://openalex.org/W2073397208","https://openalex.org/W2073618702","https://openalex.org/W2073883348","https://openalex.org/W2074304498","https://openalex.org/W2075406774","https://openalex.org/W2075951378","https://openalex.org/W2076273397","https://openalex.org/W2076717597","https://openalex.org/W2076766181","https://openalex.org/W2077120161","https://openalex.org/W2077369044","https://openalex.org/W2078581066","https://openalex.org/W2079750277","https://openalex.org/W2079957854","https://openalex.org/W2080600841","https://openalex.org/W2080832433","https://openalex.org/W2080902960","https://openalex.org/W2082421800","https://openalex.org/W2082947145","https://openalex.org/W2084085285","https://openalex.org/W2085690892","https://openalex.org/W2086548243","https://openalex.org/W2087762539","https://openalex.org/W2088600148","https://openalex.org/W2088624336","https://openalex.org/W2089043633","https://openalex.org/W2092015913","https://openalex.org/W2093580533","https://openalex.org/W2094109313","https://openalex.org/W2094141932","https://openalex.org/W2094162828","https://openalex.org/W2094323986","https://openalex.org/W2095656207","https://openalex.org/W2096716094","https://openalex.org/W2098962936","https://openalex.org/W2099424211","https://openalex.org/W2099771077","https://openalex.org/W2101315894","https://openalex.org/W2101439617","https://openalex.org/W2103406187","https://openalex.org/W2103548575","https://openalex.org/W2103982053","https://openalex.org/W2104082168","https://openalex.org/W2104085290","https://openalex.org/W2104093114","https://openalex.org/W2105213416","https://openalex.org/W2105363294","https://openalex.org/W2106365164","https://openalex.org/W2106663346","https://openalex.org/W2107153119","https://openalex.org/W2107283868","https://openalex.org/W2107480474","https://openalex.org/W2107888750","https://openalex.org/W2109491705","https://openalex.org/W2109541355","https://openalex.org/W2110239433","https://openalex.org/W2110664940","https://openalex.org/W2110876246","https://openalex.org/W2111058018","https://openalex.org/W2111184801","https://openalex.org/W2111842257","https://openalex.org/W2111918646","https://openalex.org/W2112595718","https://openalex.org/W2113080377","https://openalex.org/W2113154361","https://openalex.org/W2113784410","https://openalex.org/W2114104545","https://openalex.org/W2114980230","https://openalex.org/W2116362436","https://openalex.org/W2116614564","https://openalex.org/W2116654331","https://openalex.org/W2116970128","https://openalex.org/W2117172772","https://openalex.org/W2117822816","https://openalex.org/W2118411078","https://openalex.org/W2118958304","https://openalex.org/W2120437617","https://openalex.org/W2121619780","https://openalex.org/W2122097157","https://openalex.org/W2122354255","https://openalex.org/W2122444834","https://openalex.org/W2122992925","https://openalex.org/W2123848615","https://openalex.org/W2125678888","https://openalex.org/W2126703107","https://openalex.org/W2126982762","https://openalex.org/W2127063269","https://openalex.org/W2128016314","https://openalex.org/W2128335879","https://openalex.org/W2128490578","https://openalex.org/W2129757655","https://openalex.org/W2129890422","https://openalex.org/W2130510785","https://openalex.org/W2131841237","https://openalex.org/W2131971625","https://openalex.org/W2132039396","https://openalex.org/W2132297623","https://openalex.org/W2133106209","https://openalex.org/W2133183695","https://openalex.org/W2133539678","https://openalex.org/W2133616332","https://openalex.org/W2135122652","https://openalex.org/W2135518377","https://openalex.org/W2136326352","https://openalex.org/W2136420476","https://openalex.org/W2136890225","https://openalex.org/W2136963255","https://openalex.org/W2137100593","https://openalex.org/W2137214353","https://openalex.org/W2138261897","https://openalex.org/W2138271749","https://openalex.org/W2138614694","https://openalex.org/W2138664009","https://openalex.org/W2139064671","https://openalex.org/W2139768136","https://openalex.org/W2139852278","https://openalex.org/W2140124881","https://openalex.org/W2140551998","https://openalex.org/W2140908395","https://openalex.org/W2141024484","https://openalex.org/W2141175327","https://openalex.org/W2142046859","https://openalex.org/W2142514031","https://openalex.org/W2142521574","https://openalex.org/W2142609451","https://openalex.org/W2142681605","https://openalex.org/W2142686356","https://openalex.org/W2143017332","https://openalex.org/W2143263348","https://openalex.org/W2143506157","https://openalex.org/W2143752982","https://openalex.org/W2144177856","https://openalex.org/W2144436995","https://openalex.org/W2144815950","https://openalex.org/W2145609497","https://openalex.org/W2147088778","https://openalex.org/W2147212130","https://openalex.org/W2147615829","https://openalex.org/W2148422519","https://openalex.org/W2148733280","https://openalex.org/W2149166037","https://openalex.org/W2149566020","https://openalex.org/W2149698717","https://openalex.org/W2150455956","https://openalex.org/W2150583786","https://openalex.org/W2151269016","https://openalex.org/W2151386071","https://openalex.org/W2152724294","https://openalex.org/W2152951302","https://openalex.org/W2153589742","https://openalex.org/W2154693681","https://openalex.org/W2155237566","https://openalex.org/W2155496693","https://openalex.org/W2155808081","https://openalex.org/W2156714600","https://openalex.org/W2157371077","https://openalex.org/W2157685284","https://openalex.org/W2158255028","https://openalex.org/W2158597684","https://openalex.org/W2158955103","https://openalex.org/W2159154806","https://openalex.org/W2159632272","https://openalex.org/W2159833574","https://openalex.org/W2160524628","https://openalex.org/W2161890956","https://openalex.org/W2161998322","https://openalex.org/W2162638563","https://openalex.org/W2162802689","https://openalex.org/W2162960013","https://openalex.org/W2165677013","https://openalex.org/W2166018854","https://openalex.org/W2166379725","https://openalex.org/W2167315449","https://openalex.org/W2167439117","https://openalex.org/W2168397823","https://openalex.org/W2168681512","https://openalex.org/W2170178908","https://openalex.org/W2170994084","https://openalex.org/W2171589158","https://openalex.org/W2171692026","https://openalex.org/W2175605995","https://openalex.org/W2178247063","https://openalex.org/W2184824469","https://openalex.org/W2210053200","https://openalex.org/W2213640235","https://openalex.org/W2227157632","https://openalex.org/W2237408380","https://openalex.org/W2256043227","https://openalex.org/W2273375894","https://openalex.org/W2280757066","https://openalex.org/W2284317439","https://openalex.org/W2288611291","https://openalex.org/W2290189795","https://openalex.org/W2290950904","https://openalex.org/W2293757680","https://openalex.org/W2296375360","https://openalex.org/W2297334215","https://openalex.org/W2299367339","https://openalex.org/W2302285143","https://openalex.org/W2303043072","https://openalex.org/W2314742145","https://openalex.org/W2316386130","https://openalex.org/W2316569153","https://openalex.org/W2320909684","https://openalex.org/W2322532875","https://openalex.org/W2331694814","https://openalex.org/W2335208378","https://openalex.org/W2335683749","https://openalex.org/W2340829607","https://openalex.org/W2343607850","https://openalex.org/W2344208563","https://openalex.org/W2344729420","https://openalex.org/W2345797678","https://openalex.org/W2396071392","https://openalex.org/W2401811918","https://openalex.org/W2403124237","https://openalex.org/W2406396923","https://openalex.org/W2410121959","https://openalex.org/W2411556531","https://openalex.org/W2413273374","https://openalex.org/W2418120661","https://openalex.org/W2419464083","https://openalex.org/W2420202036","https://openalex.org/W2420567905","https://openalex.org/W2429408914","https://openalex.org/W2434261529","https://openalex.org/W2441084609","https://openalex.org/W2461183258","https://openalex.org/W2462896723","https://openalex.org/W2469213152","https://openalex.org/W2470593319","https://openalex.org/W2478298964","https://openalex.org/W2486951052","https://openalex.org/W2490829779","https://openalex.org/W2492077070","https://openalex.org/W2493873986","https://openalex.org/W2504732151","https://openalex.org/W2512829047","https://openalex.org/W2518302135","https://openalex.org/W2522439778","https://openalex.org/W2526509935","https://openalex.org/W2527438532","https://openalex.org/W2527853957","https://openalex.org/W2533790763","https://openalex.org/W2547705394","https://openalex.org/W2555264382","https://openalex.org/W2555460132","https://openalex.org/W2559028527","https://openalex.org/W2560036924","https://openalex.org/W2569741216","https://openalex.org/W2573152477","https://openalex.org/W2577356249","https://openalex.org/W2579417391","https://openalex.org/W2581629846","https://openalex.org/W2582743722","https://openalex.org/W2584469054","https://openalex.org/W2586630391","https://openalex.org/W2588964575","https://openalex.org/W2594538327","https://openalex.org/W2598151303","https://openalex.org/W2604242421","https://openalex.org/W2607246766","https://openalex.org/W2609876203","https://openalex.org/W2610540773","https://openalex.org/W2610887355","https://openalex.org/W2610903912","https://openalex.org/W2618601620","https://openalex.org/W2622249265","https://openalex.org/W2626497039","https://openalex.org/W2626606138","https://openalex.org/W2626724458","https://openalex.org/W2669144980","https://openalex.org/W2715694363","https://openalex.org/W2725988230","https://openalex.org/W2726312558","https://openalex.org/W2734771078","https://openalex.org/W2744208468","https://openalex.org/W2755073646","https://openalex.org/W2762464447","https://openalex.org/W2763875663","https://openalex.org/W2765372369","https://openalex.org/W2765645082","https://openalex.org/W2765690812","https://openalex.org/W2766141193","https://openalex.org/W2766463108","https://openalex.org/W2767736920","https://openalex.org/W2768722765","https://openalex.org/W2769729552","https://openalex.org/W2769890966","https://openalex.org/W2770316874","https://openalex.org/W2770376747","https://openalex.org/W2773508782","https://openalex.org/W2777147486","https://openalex.org/W2777674083","https://openalex.org/W2787037265","https://openalex.org/W2789706525","https://openalex.org/W2789794538","https://openalex.org/W2790400126","https://openalex.org/W2792291055","https://openalex.org/W2793804433","https://openalex.org/W2794938555","https://openalex.org/W2796099474","https://openalex.org/W2796224317","https://openalex.org/W2799484515","https://openalex.org/W2801758612","https://openalex.org/W2803271184","https://openalex.org/W2803689123","https://openalex.org/W2804457587","https://openalex.org/W2805681834","https://openalex.org/W2808608645","https://openalex.org/W2808844109","https://openalex.org/W2809751444","https://openalex.org/W2810288019","https://openalex.org/W2883757632","https://openalex.org/W2885003027","https://openalex.org/W2886259079","https://openalex.org/W2888249333","https://openalex.org/W2890039732","https://openalex.org/W2891146013","https://openalex.org/W2892519957","https://openalex.org/W2895486342","https://openalex.org/W2895782917","https://openalex.org/W2898900138","https://openalex.org/W2898960554","https://openalex.org/W2899140256","https://openalex.org/W2899461667","https://openalex.org/W2900534496","https://openalex.org/W2905567470","https://openalex.org/W2906059448","https://openalex.org/W2911079132","https://openalex.org/W2915113581","https://openalex.org/W2915402738","https://openalex.org/W2916118800","https://openalex.org/W2917595702","https://openalex.org/W2939189769","https://openalex.org/W2944851672","https://openalex.org/W2963740442","https://openalex.org/W2981208788","https://openalex.org/W3029661147","https://openalex.org/W3041284877","https://openalex.org/W4238079920","https://openalex.org/W4295682055","https://openalex.org/W4298665600"],"related_works":["https://openalex.org/W1546353979","https://openalex.org/W7101092838","https://openalex.org/W2148846435","https://openalex.org/W2101176534","https://openalex.org/W2114129553","https://openalex.org/W2100621375","https://openalex.org/W2908649987","https://openalex.org/W3198931206","https://openalex.org/W7096965677","https://openalex.org/W2045035263"],"abstract_inverted_index":{"This":[0],"thesis":[1],"explores":[2],"the":[3,10,25,73,97,110,118,158,184,250,272,321,330,360],"role":[4],"of":[5,12,106,112,120,162,200,252,332,362,369],"several":[6],"actin-binding":[7],"proteins":[8,234,274],"in":[9,42,132,147,154,157,169,175,188,220,242,249,283,316,320,324,348,365,382],"regulation":[11,127],"brain":[13,205],"physiology":[14],"with":[15,51,302,346],"a":[16,197,280,339],"focus":[17],"on":[18],"dendritic":[19,80,123,148,152,202,258,269,284,305,325],"spines.":[20,124,270,312,334,366],"Dendritic":[21],"spines":[22,81],"are":[23,47,61],"considered":[24],"plausible":[26,95],"physical":[27],"substrate":[28],"for":[29,37,130,261],"learning":[30,60,131,171],"and":[31,45,65,151,172,178,182,191,207,235,260,263,292,351,355,376],"memory,":[32],"as":[33],"their":[34],"morphology":[35,46,286,307,327],"allows":[36],"modulating":[38],"incoming":[39],"signals.":[40],"Disruptions":[41],"spine":[43,126,149,285,290,295,306,326,344],"density":[44,199,291,331,345],"also":[48],"often":[49,218],"associated":[50,301],"neuropsychiatric":[52,221],"disorders.":[53],"The":[54,367],"two":[55],"cellular":[56],"processes":[57],"representing":[58],"neuronal":[59,91],"long-term":[62,66],"potentiation":[63],"(LTP)":[64],"depression":[67],"(LTD).":[68],"Here,":[69],"I":[70],"show":[71],"that":[72,96,216,299],"actin-severing":[74],"protein":[75],"gelsolin":[76,113,121],"transiently":[77],"relocates":[78],"to":[79,114,122,144,257,268,310],"upon":[82],"LTD":[83],"induction,":[84],"but":[85,100],"not":[86],"LTP":[87],"induction":[88],"or":[89],"spontaneous":[90],"activity.":[92],"It":[93],"is":[94,128,136],"modest":[98],"\u2013":[99,103],"relatively":[101],"long-lasting":[102],"LTD-induced":[104],"elevation":[105],"Ca2+":[107],"concentration":[108],"increases":[109],"affinity":[111],"F-actin,":[115],"thus":[116],"inducing":[117],"relocalization":[119],"Proper":[125],"crucial":[129],"live":[133],"animals.":[134],"MIM":[135,163],"an":[137],"I-BAR":[138],"containing":[139],"membrane":[140],"curving":[141],"protein,":[142],"shown":[143],"be":[145],"involved":[146],"initiation":[150],"branching":[153],"Purkinje":[155],"cells":[156],"cerebellum.":[159],"Behavioral":[160],"analysis":[161],"knock-out":[164],"(KO)":[165],"mice":[166],"revealed":[167],"defects":[168],"both":[170],"reverse-learning,":[173],"alterations":[174],"anxiety":[176],"levels":[177],"reduced":[179],"dominant":[180],"behavior,":[181],"confirmed":[183],"previously":[185],"described":[186],"deficiency":[187],"motor":[189],"coordination":[190],"pre-pulse":[192],"inhibition.":[193],"Anatomically,":[194],"we":[195,337],"observed":[196,338],"decreased":[198,208],"thin":[201,294,311,333,343],"protrusions,":[203],"enlarged":[204],"ventricles":[206],"cortical":[209],"volume.":[210],"Genetic":[211],"studies":[212],"have":[213],"pointed":[214],"out":[215],"genes":[217,230],"disturbed":[219],"disorders":[222],"encode":[223],"synaptic":[224],"actin":[225],"regulators.":[226],"We":[227,297],"selected":[228],"five":[229],"encoding":[231],"different":[232],"actin-regulating":[233],"induced":[236,247,379],"ASD-associated":[237],"de":[238],"novo":[239],"missense":[240],"mutations":[241,246,300,347],"these":[243],"proteins.":[244],"These":[245],"changes":[248,381],"localization":[251],"\u03b1-actinin-4,":[253],"which":[254,265],"localized":[255,266],"less":[256],"spines,":[259],"SWAP-70":[262,377],"SrGAP3,":[264],"more":[267],"Among":[271],"wild-type":[273],"studied,":[275],"only":[276],"\u03b1-actinin-4":[277,317],"expression":[278,358,368],"caused":[279],"significant":[281],"change":[282],"by":[287,328],"increasing":[288,329],"mushroom":[289,309],"decreasing":[293],"density.":[296],"hypothesized":[298],"ASD":[303],"shift":[304,323],"from":[308],"An":[313],"M554V":[314],"mutation":[315],"(ACTN4)":[318],"resulted":[319],"expected":[322],"In":[335],"addition,":[336],"trend":[340],"toward":[341],"higher":[342],"myosin":[349,356,371],"IXb":[350,357],"SWAP-70.":[352],"Myosin":[353],"IIb":[354,372],"increased":[359],"proportion":[361],"inhibitory":[363,383],"synapses":[364],"mutated":[370],"(Y265C),":[373],"SrGAP3":[374],"(E469K),":[375],"(L544F)":[378],"variable":[380],"synapses.":[384]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-23T00:00:00"}
