{"id":"https://openalex.org/W2956133703","doi":"https://doi.org/10.23866/brnrev:2018-0018","title":"Genetic Risk for Developing Chronic Obstructive Pulmonary Disease","display_name":"Genetic Risk for Developing Chronic Obstructive Pulmonary Disease","publication_year":2019,"publication_date":"2019-06-27","ids":{"openalex":"https://openalex.org/W2956133703","doi":"https://doi.org/10.23866/brnrev:2018-0018","mag":"2956133703"},"language":"en","primary_location":{"id":"doi:10.23866/brnrev:2018-0018","doi":"https://doi.org/10.23866/brnrev:2018-0018","is_oa":true,"landing_page_url":"https://doi.org/10.23866/brnrev:2018-0018","pdf_url":"https://www.brnreviews.com/files/brn_2019_5_3_154-168.pdf","source":{"id":"https://openalex.org/S4210170412","display_name":"Barcelona Respiratory Network","issn_l":"2385-7110","issn":["2385-7110","2462-3172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Barcelona Respiratory Network","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.brnreviews.com/files/brn_2019_5_3_154-168.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064433832","display_name":"Ronald G. Crystal","orcid":"https://orcid.org/0000-0001-6177-6839","observed_orcids":["https://orcid.org/0000-0001-6177-6839"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald G. Crystal","raw_affiliation_strings":["Department of Genetic Medicine Weill Cornell Medical College 1300 York Avenue , Box 164 New York , New York 10065","Department of Genetic Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine Weill Cornell Medical College 1300 York Avenue , Box 164 New York , New York 10065","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Genetic Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048309975","display_name":"Sarah L. O\u2019Beirne","orcid":"https://orcid.org/0000-0003-2876-0258","observed_orcids":["https://orcid.org/0000-0003-2876-0258"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara L. O'Beirne","raw_affiliation_strings":["Department of Genetic Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College New York, New York","REVIEW BRN Reviews","Department of Genetic Medicine Weill Cornell Medical College 1300 York Avenue, Box 164 New York, New York 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"REVIEW BRN Reviews","institution_ids":[]},{"raw_affiliation_string":"Department of Genetic Medicine Weill Cornell Medical College 1300 York Avenue, Box 164 New York, New York 10065","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10727732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.906000018119812},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.6119999885559082},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7400000095367432},{"id":"https://openalex.org/keywords/missing-heritability","display_name":"missing heritability","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.8187198042869568},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5731766223907471},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3875613212585449},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3366572856903076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3285689949989319}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23866/brnrev:2018-0018","doi":"https://doi.org/10.23866/brnrev:2018-0018","is_oa":true,"landing_page_url":"https://doi.org/10.23866/brnrev:2018-0018","pdf_url":"https://www.brnreviews.com/files/brn_2019_5_3_154-168.pdf","source":{"id":"https://openalex.org/S4210170412","display_name":"Barcelona Respiratory Network","issn_l":"2385-7110","issn":["2385-7110","2462-3172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Barcelona Respiratory Network","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.23866/brnrev:2018-0018","doi":"https://doi.org/10.23866/brnrev:2018-0018","is_oa":true,"landing_page_url":"https://doi.org/10.23866/brnrev:2018-0018","pdf_url":"https://www.brnreviews.com/files/brn_2019_5_3_154-168.pdf","source":{"id":"https://openalex.org/S4210170412","display_name":"Barcelona Respiratory Network","issn_l":"2385-7110","issn":["2385-7110","2462-3172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Barcelona Respiratory Network","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2956133703.pdf","grobid_xml":"https://content.openalex.org/works/W2956133703.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1460422212","https://openalex.org/W1866342749","https://openalex.org/W1968225213","https://openalex.org/W1968611355","https://openalex.org/W1971000546","https://openalex.org/W1972020976","https://openalex.org/W1985715054","https://openalex.org/W1995467463","https://openalex.org/W2000200706","https://openalex.org/W2004719527","https://openalex.org/W2005623173","https://openalex.org/W2006720016","https://openalex.org/W2019305446","https://openalex.org/W2021085462","https://openalex.org/W2022912717","https://openalex.org/W2024612440","https://openalex.org/W2035673201","https://openalex.org/W2037621565","https://openalex.org/W2038979515","https://openalex.org/W2040421689","https://openalex.org/W2064786372","https://openalex.org/W2068679706","https://openalex.org/W2086569637","https://openalex.org/W2089703171","https://openalex.org/W2099598799","https://openalex.org/W2099676542","https://openalex.org/W2100074859","https://openalex.org/W2100511558","https://openalex.org/W2101612379","https://openalex.org/W2102417402","https://openalex.org/W2102487178","https://openalex.org/W2103465143","https://openalex.org/W2104704131","https://openalex.org/W2106506181","https://openalex.org/W2107766358","https://openalex.org/W2110846909","https://openalex.org/W2111344085","https://openalex.org/W2111469008","https://openalex.org/W2112348866","https://openalex.org/W2112503036","https://openalex.org/W2122791877","https://openalex.org/W2126981568","https://openalex.org/W2130894454","https://openalex.org/W2131423215","https://openalex.org/W2137128941","https://openalex.org/W2138271981","https://openalex.org/W2148970730","https://openalex.org/W2149200222","https://openalex.org/W2150283886","https://openalex.org/W2151850247","https://openalex.org/W2154453846","https://openalex.org/W2154952302","https://openalex.org/W2158180397","https://openalex.org/W2158615286","https://openalex.org/W2168850818","https://openalex.org/W2226675184","https://openalex.org/W2226781705","https://openalex.org/W2232970380","https://openalex.org/W2277205211","https://openalex.org/W2286396527","https://openalex.org/W2318517963","https://openalex.org/W2343999743","https://openalex.org/W2510773831","https://openalex.org/W2512932385","https://openalex.org/W2513564350","https://openalex.org/W2514610798","https://openalex.org/W2526344756","https://openalex.org/W2552966078","https://openalex.org/W2558208069","https://openalex.org/W2573109541","https://openalex.org/W2583265473","https://openalex.org/W2583564626","https://openalex.org/W2605149571","https://openalex.org/W2746473595","https://openalex.org/W2752097721","https://openalex.org/W2775253580","https://openalex.org/W2776895565","https://openalex.org/W2783065045","https://openalex.org/W2796615944","https://openalex.org/W2803873254","https://openalex.org/W2810967747","https://openalex.org/W2884715813","https://openalex.org/W2901119117","https://openalex.org/W4254612232","https://openalex.org/W4406411448","https://openalex.org/W7075675439"],"related_works":["https://openalex.org/W2318517963","https://openalex.org/W1606707126","https://openalex.org/W2155071789","https://openalex.org/W6887911201","https://openalex.org/W4223546717","https://openalex.org/W2591924740","https://openalex.org/W218678414","https://openalex.org/W2037666254","https://openalex.org/W2518913076","https://openalex.org/W7216770929"],"abstract_inverted_index":{"Chronic":[0],"obstructive":[1],"pulmonary":[2],"disease":[3,67,102],"(COPD),":[4],"a":[5,99],"disorder":[6],"characterised":[7],"by":[8],"chronic":[9],"airway":[10],"inflammation":[11],"and":[12,23,37,41,49,57,69,88,108,112,117],"the":[13,71,79,81,113,135],"development":[14],"of":[15,59,84,101,115,123,128,137],"emphysema,":[16],"results":[17],"from":[18],"complex":[19],"interaction":[20],"between":[21],"genetic":[22,82],"environmental":[24],"factors,":[25],"most":[26],"importantly":[27],"cigarette":[28],"smoke.Linkage":[29],"analysis,":[30],"candidate":[31],"gene":[32],"studies,":[33,36],"genome-wide":[34],"association":[35],"more":[38],"recently":[39],"exome":[40,106],"whole":[42,109],"genome":[43,110],"sequencing":[44,107],"have":[45,93],"identified":[46],"numerous":[47],"genes":[48],"variants":[50],"linked":[51],"to":[52,64,73,133,142],"COPD":[53,85],"susceptibility,":[54],"smoking":[55],"behaviour":[56],"determinants":[58],"lung":[60],"function.This":[61],"has":[62,70],"led":[63],"insights":[65],"into":[66],"pathogenesis":[68],"potential":[72],"result":[74],"in":[75,139],"novel":[76],"therapies":[77],"for":[78],"condition.However,":[80],"architecture":[83],"is":[86],"complex,":[87],"though":[89],"many":[90],"susceptibility":[91,141],"loci":[92],"been":[94],"identified,":[95],"they":[96],"only":[97],"explain":[98],"fraction":[100],"heritability.Newer":[103],"methodologies":[104],"including":[105],"sequencing,":[111],"study":[114],"epigenetic":[116],"gene-by-environment":[118],"interactions":[119],"may":[120],"uncover":[121],"some":[122],"this":[124,129],"missing":[125],"heritability.The":[126],"focus":[127],"review":[130],"will":[131],"be":[132],"assess":[134],"role":[136],"genetics":[138],"individual":[140],"COPD.(BRN":[143],"Rev.":[144],"2019;5(3):154-68)":[145]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-12T00:00:00"}
