{"id":"https://openalex.org/W2956110533","doi":"https://doi.org/10.1101/690057","title":"Intestinal mucus and gut-vascular barrier: FxR-modulated entry sites for pathological bacterial translocation in liver cirrhosis","display_name":"Intestinal mucus and gut-vascular barrier: FxR-modulated entry sites for pathological bacterial translocation in liver cirrhosis","publication_year":2019,"publication_date":"2019-07-08","ids":{"openalex":"https://openalex.org/W2956110533","doi":"https://doi.org/10.1101/690057","mag":"2956110533"},"language":"en","primary_location":{"id":"doi:10.1101/690057","doi":"https://doi.org/10.1101/690057","is_oa":true,"landing_page_url":"https://doi.org/10.1101/690057","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/08/690057.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/08/690057.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080993348","display_name":"Marcel Sorribas","orcid":"https://orcid.org/0000-0003-2833-7193","observed_orcids":["https://orcid.org/0000-0003-2833-7193"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Sorribas","raw_affiliation_strings":["Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. O. Jakob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. O. Jakob","raw_affiliation_strings":["Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Yilmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B. Yilmaz","raw_affiliation_strings":["Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H. Li","raw_affiliation_strings":["Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Stutz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. Stutz","raw_affiliation_strings":["Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Noser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Y. Noser","raw_affiliation_strings":["Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064451267","display_name":"Andrea De Gottardi","orcid":"https://orcid.org/0000-0002-4401-2340","observed_orcids":["https://orcid.org/0000-0002-4401-2340"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A. de Gottardi","raw_affiliation_strings":["Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080488079","display_name":"Sheida Moghadamrad","orcid":"https://orcid.org/0000-0001-7322-4759","observed_orcids":["https://orcid.org/0000-0001-7322-4759"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S. Moghadamrad","raw_affiliation_strings":["Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Hassan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Hassan","raw_affiliation_strings":["Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Albillos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Albillos","raw_affiliation_strings":["Department of Gastroenterology, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032816072","display_name":"Rub\u00e9n Franc\u00e9s","orcid":"https://orcid.org/0000-0001-5105-1201","observed_orcids":["https://orcid.org/0000-0001-5105-1201"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Franc\u00e9s","raw_affiliation_strings":["Hepatic and Intestinal Immunobiology Group, Universidad Miguel Hern\u00e1ndez-CIBERehd, San Juan, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatic and Intestinal Immunobiology Group, Universidad Miguel Hern\u00e1ndez-CIBERehd, San Juan, Spain","institution_ids":["https://openalex.org/I111262870","https://openalex.org/I4210132431"]}]},{"author_position":"middle","author":{"id":null,"display_name":"O. Juanola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"O. Juanola","raw_affiliation_strings":["Hepatic and Intestinal Immunobiology Group, Universidad Miguel Hern\u00e1ndez-CIBERehd, San Juan, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatic and Intestinal Immunobiology Group, Universidad Miguel Hern\u00e1ndez-CIBERehd, San Juan, Spain","institution_ids":["https://openalex.org/I111262870","https://openalex.org/I4210132431"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Spadoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I. Spadoni","raw_affiliation_strings":["Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele, MI, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele, MI, Italy","institution_ids":["https://openalex.org/I1339471597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085944050","display_name":"Mar\u00eda Rescigno","orcid":"https://orcid.org/0000-0002-6464-509X","observed_orcids":["https://orcid.org/0000-0002-6464-509X"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Rescigno","raw_affiliation_strings":["Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, MI, Italy","Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele, MI, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, MI, Italy","institution_ids":[]},{"raw_affiliation_string":"Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele, MI, Italy","institution_ids":["https://openalex.org/I1339471597"]}]},{"author_position":"last","author":{"id":null,"display_name":"R. Wiest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"R. Wiest","raw_affiliation_strings":["Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland","Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Maurice M\u00fcller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intestinal-mucus-layer","display_name":"intestinal mucus layer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/gut-vascular-barrier","display_name":"gut-vascular barrier","score":0.925000011920929},{"id":"https://openalex.org/keywords/farnesoid-x-receptor-agonist","display_name":"farnesoid X receptor agonist","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.7770000100135803},{"id":"https://openalex.org/keywords/portal-hypertension","display_name":"portal hypertension","score":0.7120000123977661},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ccl4-induced-cirrhosis","display_name":"CCl4-induced cirrhosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.8109999895095825},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.859000027179718},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8014000058174133},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6651999950408936},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6585000157356262},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.5327000021934509},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.5175999999046326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42089998722076416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41449999809265137},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.41019999980926514},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.40540000796318054},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3928000032901764},{"id":"https://openalex.org/C3018975166","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Bacterial translocation","level":4,"score":0.3716999888420105},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.3619999885559082},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.3528999984264374},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.35010001063346863},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34929999709129333},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3391999900341034},{"id":"https://openalex.org/C2910129844","wikidata":"https://www.wikidata.org/wiki/Q1271831","display_name":"Bacterial overgrowth","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2554999887943268}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/690057","doi":"https://doi.org/10.1101/690057","is_oa":true,"landing_page_url":"https://doi.org/10.1101/690057","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/08/690057.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/690057","doi":"https://doi.org/10.1101/690057","is_oa":true,"landing_page_url":"https://doi.org/10.1101/690057","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/08/690057.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5203161775","display_name":"The microbial-dependent hemodynamic response to partial portal vein ligation is regulated by the microbiota via mucosa-derived angiogenic factors.","funder_award_id":"163143","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7479191985","display_name":"Splanchnic sympathetic hyperactivity and alterations in mucus barrier and gut-associated lymphatic tissue in mice with experimental portal hypertension: role for pathological bacterial translocation","funder_award_id":"152805","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320310992","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2956110533.pdf","grobid_xml":"https://content.openalex.org/works/W2956110533.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W199832027","https://openalex.org/W1967217097","https://openalex.org/W1968070105","https://openalex.org/W1973763077","https://openalex.org/W1974556922","https://openalex.org/W1974616640","https://openalex.org/W1974787234","https://openalex.org/W1976611079","https://openalex.org/W1976666264","https://openalex.org/W1978195655","https://openalex.org/W1992449311","https://openalex.org/W2005879027","https://openalex.org/W2011337131","https://openalex.org/W2014956339","https://openalex.org/W2021920348","https://openalex.org/W2023250239","https://openalex.org/W2024485888","https://openalex.org/W2030364983","https://openalex.org/W2044195919","https://openalex.org/W2045455672","https://openalex.org/W2047711197","https://openalex.org/W2049515100","https://openalex.org/W2055788999","https://openalex.org/W2063951813","https://openalex.org/W2067719505","https://openalex.org/W2074432560","https://openalex.org/W2082732215","https://openalex.org/W2093795546","https://openalex.org/W2103108588","https://openalex.org/W2104582722","https://openalex.org/W2107051699","https://openalex.org/W2107239589","https://openalex.org/W2124347139","https://openalex.org/W2127690112","https://openalex.org/W2131655174","https://openalex.org/W2132551814","https://openalex.org/W2134059673","https://openalex.org/W2136211803","https://openalex.org/W2136919496","https://openalex.org/W2153223490","https://openalex.org/W2155741939","https://openalex.org/W2162119791","https://openalex.org/W2162888435","https://openalex.org/W2163205192","https://openalex.org/W2169619812","https://openalex.org/W2172107868","https://openalex.org/W2172687959","https://openalex.org/W2189724811","https://openalex.org/W2253934566","https://openalex.org/W2254397565","https://openalex.org/W2274550287","https://openalex.org/W2412282056","https://openalex.org/W2462023038","https://openalex.org/W2549269050","https://openalex.org/W2565993381","https://openalex.org/W2606348958","https://openalex.org/W2616858715","https://openalex.org/W2681223455","https://openalex.org/W2758170246","https://openalex.org/W2761145411","https://openalex.org/W2761437180","https://openalex.org/W2771673520","https://openalex.org/W2791786910"],"related_works":["https://openalex.org/W2957171936","https://openalex.org/W2935906959","https://openalex.org/W1822961287","https://openalex.org/W2093795546","https://openalex.org/W4416331906","https://openalex.org/W3187309090","https://openalex.org/W1230918098","https://openalex.org/W2805379007","https://openalex.org/W1994306054","https://openalex.org/W3120104941"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,95,104,118,143,145,160,176,194,238],"aims":[3],"Pathological":[4],"bacterial":[5,17,154],"translocation":[6,55,101,124,162],"(PBT)":[7],"in":[8,28,49,78,137,147,156,174,188,196,206],"liver":[9,114],"cirrhosis":[10,227],"(LC)":[11],"is":[12,60,76,126,135,171],"the":[13,40,69,87,109,113,167,214,236,244,256],"hallmark":[14],"for":[15,56,90],"spontaneous":[16],"infections":[18],"increasing":[19],"mortality":[20],"several-fold.":[21],"Factors":[22],"known":[23],"to":[24,26,62,83,112,243],"contribute":[25],"PBT":[27,242,254],"LC":[29],"are":[30],"among":[31],"others":[32],"an":[33,201],"increased":[34,84],"intestinal":[35,58,207],"permeability":[36,193],"of":[37,54,86,102,141,163,181,204,221],"which":[38,125],"however,":[39],"mucus":[41,158],"layer":[42,134,159],"has":[43],"not":[44,127,150,211,229],"been":[45],"addressed":[46],"so":[47],"far":[48],"detail.":[50],"A":[51],"clear":[52],"route":[53],"luminal":[57],"bacteria":[59],"yet":[61],"be":[63],"defined":[64],"but":[65,149,185,210,228],"we":[66],"hypothesize":[67],"that":[68],"recently":[70],"described":[71],"gut":[72],"vascular":[73,88],"barrier":[74],"(GVB)":[75],"impaired":[77],"experimental":[79],"portal":[80,230],"hypertension":[81,231],"leading":[82],"accessibility":[85,195],"compartment":[89],"translocating":[91],"bacteria.":[92],"Results":[93],"Healthy":[94],"pre-hepatic":[96],"portal-hypertensive":[97],"(PPVL)":[98],"mice":[99,121,198],"lack":[100],"FITC-dextran":[103],"GFP-":[105,164,222],"Escherichia":[106],"coli":[107],"from":[108],"small":[110],"intestine":[111],"whereas":[115,216],"bile-duct-ligated":[116],"(BDL)":[117],"CCl4-induced":[119],"cirrhotic":[120,148,197],"demonstrate":[122],"pathological":[123,161,191],"altered":[128,173],"by":[129],"prior":[130],"thoracic-duct":[131],"ligation.":[132],"Mucus":[133],"reduced":[136],"thickness":[138],"with":[139,153,178,200,251],"loss":[140],"goblet-cells":[142],"Muc2-staining":[144],"expression":[146,203],"PPVL-mice":[151],"associated":[152],"overgrowth":[155],"inner":[157],"E.coli":[165,223],"through":[166],"ileal":[168],"epithelium.":[169],"GVB":[170,215],"profoundly":[172],"BDL":[175],"CCl4-mice":[177],"Ileal":[179],"extravasation":[180],"large-sized":[182],"150":[183],"kDa-FITC-dextran":[184],"only":[186],"minor":[187],"PPVL-mice.":[189],"This":[190],"endothelial":[192,237],"associates":[199],"augmented":[202],"PV1":[205],"vessels.":[208],"OCA":[209],"fexaramine":[212],"stabilizes":[213],"both":[217],"FXR-agonists":[218],"ameliorate":[219],"gut-liver-translocation":[220],".":[224],"Conclusions":[225],"Liver":[226],"per":[232],"se":[233],"grossly":[234],"impairs":[235],"muco-epithelial":[239],"barriers":[240,248],"promoting":[241],"portal-venous":[245,257],"circulation.":[246],"Both":[247],"appear":[249],"FXR-modulated":[250],"\u2013agonists":[252],"reducing":[253],"via":[255],"route.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2019-07-12T00:00:00"}
