{"id":"https://openalex.org/W2956073868","doi":"https://doi.org/10.1158/1538-7445.sabcs18-864","title":"Abstract 864: Mutant IDH1 is essential for chondrosarcoma growth","display_name":"Abstract 864: Mutant IDH1 is essential for chondrosarcoma growth","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2956073868","doi":"https://doi.org/10.1158/1538-7445.sabcs18-864","mag":"2956073868"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-864","doi":"https://doi.org/10.1158/1538-7445.sabcs18-864","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-864","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018163640","display_name":"Luyuan Li","orcid":"https://orcid.org/0000-0002-3144-1306","observed_orcids":["https://orcid.org/0000-0002-3144-1306"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luyuan Li","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039694919","display_name":"Xiaoyu Hu","orcid":"https://orcid.org/0000-0003-1384-5005","observed_orcids":["https://orcid.org/0000-0003-1384-5005"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Hu","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073102787","display_name":"Josiane E. Eid","orcid":"https://orcid.org/0000-0003-2379-8927","observed_orcids":["https://orcid.org/0000-0003-2379-8927"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josiane E. Eid","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003652550","display_name":"Joanna DeSalvo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna DeSalvo","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004418792","display_name":"Jonathan C. Trent","orcid":"https://orcid.org/0000-0001-6169-5238","observed_orcids":["https://orcid.org/0000-0001-6169-5238"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Trent","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"864","last_page":"864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/2-hydroxyglutarate","display_name":"2-hydroxyglutarate","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oncometabolites","display_name":"oncometabolites","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.5339999794960022},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/murine-xenografts","display_name":"murine xenografts","score":0.6809999942779541},{"id":"https://openalex.org/keywords/bone-tumors","display_name":"bone tumors","score":0.5870000123977661},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6293190717697144},{"id":"https://openalex.org/C2776302905","wikidata":"https://www.wikidata.org/wiki/Q1076087","display_name":"Chondrosarcoma","level":2,"score":0.5836942195892334},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.5010323524475098},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39646175503730774},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3654538094997406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3091880679130554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3080977499485016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1910891830921173},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12164568901062012},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08526363968849182}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-864","doi":"https://doi.org/10.1158/1538-7445.sabcs18-864","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-864","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2967174676","https://openalex.org/W2998275831","https://openalex.org/W7097565639","https://openalex.org/W3094196636","https://openalex.org/W2209736027","https://openalex.org/W4313061833","https://openalex.org/W1934866169","https://openalex.org/W2968896536","https://openalex.org/W4282984373","https://openalex.org/W3199751654"],"abstract_inverted_index":{"Chondrosarcomas":[0],"are":[1,30],"malignant":[2],"bone":[3],"tumors":[4],"that":[5,70,127,178,258,275],"produce":[6],"cartilaginous":[7],"matrix.":[8],"Mutations":[9],"in":[10,18,26,99,172,189,201,221,232,241,282,293],"isocitrate":[11,44],"dehydrogenase":[12],"enzymes":[13],"(IDH1/2)":[14],"were":[15,144],"recently":[16],"described":[17],"several":[19],"cancers,":[20],"including":[21],"chondrosarcomas.":[22],"IDH":[23,41,132,291],"mutations":[24,35,98,292],"detected":[25],"human":[27,103,120],"cancers":[28],"invariably":[29],"heterozygous":[31],"missense":[32],"substitutions.":[33],"These":[34],"lead":[36],"to":[37,42,58,88,92,264,300],"the":[38,59,94,100,164,202,222,227,236,288,294,302,334],"inability":[39],"of":[40,73,96,102,166,180,208,229,260,268,290,296,333],"convert":[43],"into":[45,52],"\u03b1-ketoglutarate":[46],"(\u03b1-KG).":[47],"Instead,":[48],"\u03b1-KG":[49],"is":[50,325],"reduced":[51,186],"2-hydroxyglutarate":[53],"(D-2HG),":[54],"an":[55],"oncometabolite.":[56],"Due":[57],"structural":[60],"similarity":[61],"between":[62],"D-2HG":[63,74,142,187,214],"and":[64,83,111,125,141,157,216,244,251],"\u03b1-KG,":[65],"it":[66],"has":[67],"been":[68],"reported":[69],"high":[71],"levels":[72,143],"competitively":[75],"inhibit":[76],"\u03b1-KG-dependent":[77],"dioxygenases":[78],"such":[79],"as":[80],"TET,":[81],"JHDM":[82],"PHD":[84],"enzymes,":[85],"thus":[86],"contributing":[87],"tumorigenesis.":[89],"We":[90,162,176],"sought":[91],"determine":[93],"role":[95,281,289],"IDH1":[97,108,130,151,168,182,195,210,262,277,324],"tumorigenesis":[101],"chondrosarcomas":[104],"by":[105,137,146],"inactivating":[106],"mutant":[107,167,181,194,209,237,261,276],"using":[109],"pharmacological":[110],"genetic":[112,206],"approaches.":[113],"In":[114,192,253],"our":[115],"study,":[116],"we":[117,234,256,298],"employed":[118],"two":[119],"chondrosarcoma":[121,170,190,223,269,283,328],"cell":[122],"lines,":[123],"JJ012":[124],"HT1080,":[126],"carry":[128],"endogenous":[129],"mutations.":[131],"mutation":[133],"analysis":[134],"was":[135,152],"performed":[136],"PCR-based":[138],"DNA":[139],"sequencing,":[140],"measured":[145],"tandem":[147],"mass":[148],"spectrometry.":[149],"Mutant":[150,323],"knocked":[153,158],"down":[154],"via":[155,160,183],"siRNA":[156,184],"out":[159],"CRISPR/Cas9.":[161],"analyzed":[163],"effect":[165],"on":[169],"growth":[171,329],"murine":[173],"xenograft":[174],"models.":[175],"found":[177],"knockdown":[179,196],"significantly":[185,217],"production":[188,215],"cells.":[191,204,224],"addition,":[193],"dramatically":[197],"inhibited":[198,218],"colony":[199,219],"formation":[200,220],"sarcoma":[203],"Consistently,":[205],"knockout":[207,239],"almost":[211],"completely":[212],"depleted":[213],"To":[225],"assess":[226],"significance":[228],"these":[230,254],"results":[231],"vivo,":[233],"implanted":[235],"IDH1-":[238],"cells":[240],"nude":[242],"mice":[243],"studied":[245],"their":[246],"capacity":[247],"for":[248,327,337],"tumor":[249,284],"initiation":[250],"growth.":[252],"models,":[255],"observed":[257],"loss":[259],"led":[263],"a":[265,279],"marked":[266],"attenuation":[267],"formation.":[270,285],"Our":[271],"findings":[272],"clearly":[273],"demonstrate":[274],"plays":[278],"vital":[280],"By":[286],"investigating":[287],"pathogenesis":[295],"chondrosarcomas,":[297],"aim":[299],"uncover":[301],"potential":[303],"therapeutic":[304],"targets":[305],"against":[306],"this":[307],"aggressive":[308],"cancer.Citation":[309],"Format:":[310],"Luyuan":[311],"Li,":[312],"Xiaoyu":[313],"Hu,":[314],"Josiane":[315],"E.":[316],"Eid,":[317],"Joanna":[318],"DeSalvo,":[319],"Jonathan":[320],"C.":[321],"Trent.":[322],"essential":[326],"[abstract].":[330],"In:":[331],"Proceedings":[332],"American":[335],"Association":[336],"Cancer":[338,352],"Research":[339],"Annual":[340],"Meeting":[341],"2019;":[342],"2019":[343],"Mar":[344],"29-Apr":[345],"3;":[346],"Atlanta,":[347],"GA.":[348],"Philadelphia":[349],"(PA):":[350],"AACR;":[351],"Res":[353],"2019;79(13":[354],"Suppl):Abstract":[355],"nr":[356],"864.":[357]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-07-12T00:00:00"}