{"id":"https://openalex.org/W2955815296","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2739","title":"Abstract 2739: EZH2 promotes breast cancer bone metastasis","display_name":"Abstract 2739: EZH2 promotes breast cancer bone metastasis","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2955815296","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2739","mag":"2955815296"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-2739","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2739","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2739","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1538-7445.sabcs18-2739","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042120900","display_name":"Jingkun Qu","orcid":"https://orcid.org/0000-0002-5064-2832","observed_orcids":["https://orcid.org/0000-0002-5064-2832"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingkun Qu","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351921","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0003-1634-3780","observed_orcids":["https://orcid.org/0000-0003-1634-3780"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089604106","display_name":"Zhifen Zhou","orcid":"https://orcid.org/0000-0003-2737-6764","observed_orcids":["https://orcid.org/0000-0003-2737-6764"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhifen Zhou","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040450464","display_name":"Dihua Yu","orcid":"https://orcid.org/0000-0001-6231-9381","observed_orcids":["https://orcid.org/0000-0001-6231-9381"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dihua Yu","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2739","last_page":"2739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.4503999948501587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.4503999948501587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.24120000004768372,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-bone-metastasis","display_name":"breast cancer bone metastasis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9020000100135803},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/osteolysis","display_name":"osteolysis","score":0.75},{"id":"https://openalex.org/keywords/parathyroid-hormone-related-protein","display_name":"parathyroid hormone-related protein","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7910000085830688},{"id":"https://openalex.org/keywords/bone-destruction","display_name":"bone destruction","score":0.5289999842643738},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/metastasis-free-survival","display_name":"metastasis-free survival","score":0.6650000214576721},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6885702610015869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6879521012306213},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.6493525505065918},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6266422271728516},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.5852402448654175},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5305079817771912},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.516685962677002},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.477251261472702},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42998093366622925}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-2739","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2739","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2739","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1158/1538-7445.sabcs18-2739","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2739","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2739","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3083308528","https://openalex.org/W4229446476","https://openalex.org/W4282922697","https://openalex.org/W2238030165","https://openalex.org/W2475386015","https://openalex.org/W341991839","https://openalex.org/W1967417054","https://openalex.org/W2588822073","https://openalex.org/W2316026215","https://openalex.org/W3083153937"],"abstract_inverted_index":{"Metastasis":[0],"causes":[1],"about":[2],"90%":[3],"of":[4,10,23,46,49,69,90,101,148,158,214,232,244,254,259,292,356],"cancer":[5,12,77,115,191,204,304,320,350],"deaths":[6],"and":[7,79,171,189,235,262],"approximately":[8],"55%":[9],"breast":[11,24,76,85,114,190,203,303,319,349],"patients":[13,40],"develop":[14,36],"bone":[15,29,42,50,93,104,140,160,181,209,260,293,296,305,324,336,351],"metastases.":[16],"Although":[17],"significant":[18],"advances":[19],"in":[20,84,103,207,273,278,295,318],"the":[21,88,99,133,145,155,208,241,251,289,357],"cure":[22],"cancer,":[25,86],"effective":[26],"therapies":[27,38],"targeted":[28],"metastases":[30],"are":[31,311],"still":[32],"not":[33],"available.":[34],"To":[35,97,150],"novel":[37,330],"for":[39,202,335,360],"with":[41,136,168],"metastasis,":[43,105,161],"better":[44],"understanding":[45],"underlying":[47,156],"mechanisms":[48],"metastasis":[51,94,182,261,306,352],"is":[52,55,72,80,95,200],"critical.":[53],"EZH2":[54,71,91,102,120,126,301,315,347],"a":[56,75,122,230,256,263],"classic":[57],"histone":[58],"methyl":[59],"transferase":[60],"that":[61,132,250,277],"generally":[62],"suppresses":[63],"downstream":[64,265],"target":[65],"genes":[66],"through":[67,307],"tri-methylation":[68],"H3K27.":[70],"considered":[73],"as":[74,225],"oncogene":[78],"frequently":[81],"over":[82],"expressed":[83,268],"but":[87],"effect":[89],"on":[92,154],"unknown.":[96],"explore":[98],"function":[100],"we":[106,162,248,310],"intracardially":[107],"injected":[108,135],"into":[109],"nude":[110],"mice":[111,134],"control":[112,146],"MDA.MB.231":[113,123,164,215,236,274],"cells":[116,165,237,275,280,321],"expressing":[117],"readily":[118],"detectable":[119],"or":[121,166],"subline":[124],"having":[125],"knocked":[127],"out":[128],"(231.EZH2.ko).":[129],"We":[130,185],"found":[131,249],"231.EZH2.ko":[137,167,245,279],"had":[138],"prolonged":[139],"metastasis-free":[141],"survival":[142],"compared":[143],"to":[144,179,222,287,322],"group":[147],"mice.":[149],"gain":[151],"initial":[152],"insight":[153],"mechanism":[157],"EZH2-mediated":[159],"co-cultured":[163],"pre-osteoclasts":[169,219],"(RAW264.7)":[170],"osteoblasts":[172],"(MC3T3)":[173],"under":[174,281],"TGF-\u03b2":[175,264,282],"treatment":[176],"(triple":[177],"co-culture)":[178],"mimic":[180],"tumor":[183],"microenvironment.":[184],"examined":[186],"osteoclast":[187],"maturation":[188],"cell":[192,205],"proliferation":[193],"because":[194],"osteolysis":[195],"induced":[196],"by":[197,227],"mature":[198,223,233],"osteoclasts":[199],"critical":[201],"growth":[206],"metastasis.":[210,297,325],"In":[211],"triple":[212,242],"co-culture":[213,243],"cells,":[216],"more":[217],"RAW264.7":[218],"were":[220],"differentiated":[221],"osteoclasts,":[224,234],"measured":[226],"TRAP+":[228],"staining,":[229],"marker":[231],"grew":[238],"faster":[239],"than":[240,276],"cells.":[246],"Furthermore,":[247],"mRNA":[252],"level":[253,272],"PTHrP,":[255],"master":[257],"regulator":[258],"cytokine,":[266],"was":[267,285],"at":[269],"significantly":[270],"higher":[271],"stimulation.":[283],"PTHrP":[284,317],"known":[286],"promote":[288,323],"\u201cvicious":[290],"cycle\u201d":[291],"destruction":[294],"The":[298],"data":[299],"suggests":[300],"promotes":[302,348],"PTHrP.":[308],"Currently,":[309],"further":[312],"exploring":[313],"how":[314],"regulates":[316],"Our":[326],"studies":[327],"may":[328],"reveal":[329],"biomarkers":[331],"and/or":[332],"therapeutic":[333],"targets":[334],"metastasis.Citation":[337],"Format:":[338],"Jingkun":[339],"Qu,":[340],"Lin":[341],"Zhang,":[342],"Zhifen":[343],"Zhou,":[344],"Dihua":[345],"Yu.":[346],"[abstract].":[353],"In:":[354],"Proceedings":[355],"American":[358],"Association":[359],"Cancer":[361,375],"Research":[362],"Annual":[363],"Meeting":[364],"2019;":[365],"2019":[366],"Mar":[367],"29-Apr":[368],"3;":[369],"Atlanta,":[370],"GA.":[371],"Philadelphia":[372],"(PA):":[373],"AACR;":[374],"Res":[376],"2019;79(13":[377],"Suppl):Abstract":[378],"nr":[379],"2739.":[380]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-07-12T00:00:00"}
