{"id":"https://openalex.org/W2955812592","doi":"https://doi.org/10.1158/1538-7445.am2019-1560","title":"Abstract 1560: Selection of a bispecific trivalent HER2 x CD137 TRIDENT format providing optimal tumor-anchored immune co-stimulation","display_name":"Abstract 1560: Selection of a bispecific trivalent HER2 x CD137 TRIDENT format providing optimal tumor-anchored immune co-stimulation","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2955812592","doi":"https://doi.org/10.1158/1538-7445.am2019-1560","mag":"2955812592"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-1560","doi":"https://doi.org/10.1158/1538-7445.am2019-1560","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-1560","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005053576","display_name":"Liqin Liu","orcid":"https://orcid.org/0000-0001-7158-6772","observed_orcids":["https://orcid.org/0000-0001-7158-6772","https://orcid.org/0000-0001-5436-1790","https://orcid.org/0009-0004-2886-3905"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liqin Liu","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074604187","display_name":"Chia\u2010Ying K. Lam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chia-Ying K. Lam","raw_affiliation_strings":["2MacroGenics, Inc., Brisbane, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MacroGenics, Inc., Brisbane, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110185766","display_name":"Ralph F. Alderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Alderson","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041233681","display_name":"Vatana Long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vatana Long","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118788581","display_name":"Yinhua Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinhua Yang","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090039285","display_name":"Robert Burns","orcid":"https://orcid.org/0000-0001-5334-3486","observed_orcids":["https://orcid.org/0000-0001-5334-3486"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Burns","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074909322","display_name":"Lusiana Widjaja","orcid":"https://orcid.org/0000-0002-6379-1415","observed_orcids":["https://orcid.org/0000-0002-6379-1415"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lusiana Widjaja","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jonathan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Li","raw_affiliation_strings":["2MacroGenics, Inc., Brisbane, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MacroGenics, Inc., Brisbane, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christina Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Wolf","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061388073","display_name":"Valentina C. Ciccarone","orcid":"https://orcid.org/0000-0001-5530-7112","observed_orcids":["https://orcid.org/0000-0001-5530-7112"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentina Ciccarone","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016101772","display_name":"James K. Tamura","orcid":"https://orcid.org/0000-0002-0463-2932","observed_orcids":["https://orcid.org/0000-0002-0463-2932"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Tamura","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003749078","display_name":"Gundo Diedrich","orcid":"https://orcid.org/0000-0001-5109-0307","observed_orcids":["https://orcid.org/0000-0001-5109-0307"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gundo Diedrich","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009027578","display_name":"Ezio Bonvini","orcid":"https://orcid.org/0000-0001-9054-3137","observed_orcids":["https://orcid.org/0000-0001-9054-3137"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ezio Bonvini","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031117799","display_name":"Syd Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syd Johnson","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023294934","display_name":"Paul A. Moore","orcid":"https://orcid.org/0000-0001-6057-7539","observed_orcids":["https://orcid.org/0000-0001-6057-7539"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Moore","raw_affiliation_strings":["1MacroGenics, Inc., Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MacroGenics, Inc., Rockville, MD;","institution_ids":["https://openalex.org/I4210106297"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"1560","last_page":"1560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.5519999861717224},{"id":"https://openalex.org/keywords/margetuximab","display_name":"margetuximab","score":0.7850000262260437},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.777999997138977},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.6039999723434448},{"id":"https://openalex.org/keywords/her2-positive-gastric-cancer","display_name":"HER2-positive gastric cancer","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2780249625","wikidata":"https://www.wikidata.org/wiki/Q14913226","display_name":"CD137","level":4,"score":0.9802148342132568},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5452398061752319},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5209078192710876},{"id":"https://openalex.org/C2780405999","wikidata":"https://www.wikidata.org/wiki/Q3483597","display_name":"Co-stimulation","level":5,"score":0.5174751281738281},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49449917674064636},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4219900071620941},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.38904139399528503},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3382551372051239},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23865118622779846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2284495234489441},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22294339537620544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09905144572257996},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-1560","doi":"https://doi.org/10.1158/1538-7445.am2019-1560","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-1560","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4251372154","https://openalex.org/W2741361137","https://openalex.org/W2405402424","https://openalex.org/W2490035279","https://openalex.org/W2157150174","https://openalex.org/W2400398928","https://openalex.org/W2327409939","https://openalex.org/W1561552618","https://openalex.org/W2598704149","https://openalex.org/W2547318564"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"CD137":[2,21,42,53,68,82,118,171,181,185,221,234,251,265,284,300,326,331,347,357,375,434],"(4-1BB)":[3],"signaling":[4,137],"provides":[5,48],"co-stimulation":[6,22,83,139,186,441],"of":[7,64,115,146,192,228,273,297,428,445],"CD8":[8,305],"or":[9,14,35,102,126,144],"NK":[10],"cells":[11,148,211,306],"following":[12],"antigen":[13],"Fc\u03b3R":[15],"engagement,":[16],"respectively.":[17],"Efforts":[18],"to":[19,44,51,55,76,111,302],"leverage":[20],"via":[23],"agonistic":[24],"monoclonal":[25],"antibodies":[26],"(mAbs)":[27],"have":[28,378],"been":[29],"thwarted":[30],"by":[31,243],"limited":[32],"clinical":[33],"efficacy":[34],"unacceptable":[36],"toxicity.":[37],"Bispecific":[38],"targeting":[39],"strategies":[40],"linking":[41],"activation":[43,54,222,332],"a":[45,62,85,105,113,275,310,334,341,363,368,383,429],"tumor-targeting":[46],"moiety":[47],"an":[49,245],"approach":[50],"localize":[52],"the":[56,78,142,190,226,269,295,446],"tumor":[57,147,210,230,311],"microenvironment.":[58],"Here":[59],"we":[60],"evaluate":[61],"panel":[63],"Fc-bearing":[65],"HER2":[66,116,174,193,198,202,232,263,298,324,350,355,373,432],"x":[67,117,233,264,277,299,325,356,374,433],"bispecific":[69,119,266,279,314,327,371,430],"molecules":[70,120,132,168,267,301,377],"incorporating":[71,387],"different":[72],"valency":[73],"and":[74,104,123,138,157,172,206,212,239,316,348,367,381],"geometry":[75],"define":[77],"format":[79,328,436],"providing":[80,329,437],"optimal":[81,177,323,438],"in":[84,121,135,141,155,158,225,270,290,333],"tumor-cell":[86,179],"anchor-dependent":[87],"manner.":[88],"Methods:":[89],"An":[90,322],"anti-HER2":[91,247],"mAb":[92,108,248,366],"specificity":[93],"that":[94,249,282],"does":[95],"not":[96],"cross":[97],"compete":[98],"with":[99,163,189,197,215,256,309,354,361],"margetuximab,":[100,244],"trastuzumab":[101],"pertuzumab":[103],"proprietary":[106],"anti-CD137":[107],"were":[109,133,153],"utilized":[110],"assemble":[112],"set":[114],"bivalent":[122,170,346],"tetravalent":[124],"DART\u00ae":[125],"trivalent":[127,342,431],"TRIDENTTM":[128],"configurations.":[129],"The":[130],"resulting":[131],"compared":[134],"binding,":[136],"assays":[140],"presence":[143],"absence":[145,227],"expressing":[149],"HER2.":[150],"Combination":[151],"studies":[152,293],"performed":[154],"vitro":[156,271],"immune":[159,182,440],"deficient":[160],"mice":[161],"reconstituted":[162],"human":[164],"PBMCs.":[165],"Results:":[166],"TRIDENT":[167,343,376,435],"bearing":[169,345],"monovalent":[173,349],"binding":[175],"achieve":[176],"HER2-dependent":[178],"anchored":[180],"cell":[183,218],"co-stimulation.":[184],"increases":[187],"proportionally":[188],"level":[191],"expression":[194,252],"as":[195,340],"observed":[196,224,360],"1+":[199],"(MCF7":[200],"breast),":[201],"2+":[203],"(JIMT1":[204],"breast)":[205],"3+":[207],"(N87":[208],"gastric)":[209],"was":[213,338,359],"paralleled":[214],"increased":[216],"HER2+/CD137+":[217],"association.":[219],"No":[220],"is":[223],"HER2-expressing":[229],"cells.":[231,261],"bispecifics":[235,358],"enhance":[236,318],"NK-cell":[237],"proliferation":[238],"IFN-\u03b3":[240],"release":[241],"induced":[242],"Fc-optimized":[246],"up-regulates":[250,283],"on":[253],"NK-cells":[254],"concomitant":[255],"enhanced":[257,268],"ADCC":[258],"against":[259],"HER2-positive":[260],"Similarly,":[262],"activity":[272,353],"orlotamab,":[274],"B7-H3":[276],"CD3":[278,313],"DART":[280],"molecule":[281,315,344],"during":[285],"T-cell":[286],"redirected":[287],"killing.":[288],"Finally,":[289],"vivo":[291],"mouse":[292],"demonstrate":[294],"ability":[296],"expand":[303],"tumor-associated":[304],"when":[307],"co-administered":[308],"targeted":[312],"support":[317],"anti-tumor":[319],"activity.":[320],"Conclusion:":[321],"maximal":[330],"HER2-":[335],"dependent":[336],"manner":[337],"identified":[339],"binding.":[351],"Combinatorial":[352],"both":[362],"HER2-directed":[364],"therapeutic":[365,379],"CD3-engaging":[369],"tumor-targeted":[370],"molecule.":[372],"potential":[380],"provide":[382],"structural":[384],"template":[385],"for":[386,449],"alternate":[388],"tumor-":[389],"and/or":[390],"co-stimulatory-targeting":[391],"arms.":[392],"Citation":[393],"Format:":[394],"Liqin":[395],"Liu,":[396],"Chia-Ying":[397],"K.":[398],"Lam,":[399],"Ralph":[400],"Alderson,":[401],"Vatana":[402],"Long,":[403],"Yinhua":[404],"Yang,":[405],"Robert":[406],"Burns,":[407],"Lusiana":[408],"Widjaja,":[409],"Jonathan":[410],"Li,":[411],"Christina":[412],"Wolf,":[413],"Valentina":[414],"Ciccarone,":[415],"James":[416],"Tamura,":[417],"Gundo":[418],"Diedrich,":[419],"Ezio":[420],"Bonvini,":[421],"Syd":[422],"Johnson,":[423],"Paul":[424],"A.":[425],"Moore.":[426],"Selection":[427],"tumor-anchored":[439],"[abstract].":[442],"In:":[443],"Proceedings":[444],"American":[447],"Association":[448],"Cancer":[450,464],"Research":[451],"Annual":[452],"Meeting":[453],"2019;":[454],"2019":[455],"Mar":[456],"29-Apr":[457],"3;":[458],"Atlanta,":[459],"GA.":[460],"Philadelphia":[461],"(PA):":[462],"AACR;":[463],"Res":[465],"2019;79(13":[466],"Suppl):Abstract":[467],"nr":[468],"1560.":[469]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2019-07-12T00:00:00"}