{"id":"https://openalex.org/W2955722147","doi":"https://doi.org/10.1158/1538-7445.am2019-1448","title":"Abstract 1448: Lymphangiogenesis-inducing whole-cell vaccine against melanoma promotes broad tumor-specific T cell immunity and effective tumor control","display_name":"Abstract 1448: Lymphangiogenesis-inducing whole-cell vaccine against melanoma promotes broad tumor-specific T cell immunity and effective tumor control","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2955722147","doi":"https://doi.org/10.1158/1538-7445.am2019-1448","mag":"2955722147"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-1448","doi":"https://doi.org/10.1158/1538-7445.am2019-1448","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-1448","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016088495","display_name":"Maria Stella Sasso","orcid":"https://orcid.org/0000-0002-4625-9486","observed_orcids":["https://orcid.org/0000-0002-4625-9486"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Stella Sasso","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047054145","display_name":"Sylvie Hauert","orcid":"https://orcid.org/0000-0002-7066-0050","observed_orcids":["https://orcid.org/0000-0002-7066-0050"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvie Hauert","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057771838","display_name":"Priscilla S. Briquez","orcid":"https://orcid.org/0000-0002-4680-9636","observed_orcids":["https://orcid.org/0000-0002-4680-9636"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priscilla S. Briquez","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yue Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084172811","display_name":"Jun Ishihara","orcid":"https://orcid.org/0000-0002-9083-9859","observed_orcids":["https://orcid.org/0000-0002-9083-9859"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Ishihara","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031517705","display_name":"Jeffrey A. Hubbell","orcid":"https://orcid.org/0000-0003-0276-5456","observed_orcids":["https://orcid.org/0000-0003-0276-5456"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Hubbell","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088767177","display_name":"Melody A. Swartz","orcid":"https://orcid.org/0000-0001-5484-1903","observed_orcids":["https://orcid.org/0000-0001-5484-1903"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melody A. Swartz","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"1448","last_page":"1448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.2890999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/vegf-c","display_name":"VEGF-C","score":0.9089999794960022},{"id":"https://openalex.org/keywords/whole-cell-vaccine","display_name":"whole-cell vaccine","score":0.878000020980835},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tumor-specific-t-cell-immunity","display_name":"tumor-specific T cell immunity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ccl21","display_name":"CCL21","score":0.7429999709129333},{"id":"https://openalex.org/keywords/draining-lymph-nodes","display_name":"draining lymph nodes","score":0.6869999766349792},{"id":"https://openalex.org/keywords/prophylactic-vaccination","display_name":"prophylactic vaccination","score":0.753000020980835},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.7630000114440918},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6370000243186951},{"id":"https://openalex.org/keywords/metastasis-risk","display_name":"metastasis risk","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.940313458442688},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.6560342311859131},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5855497121810913},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.556517481803894},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5480301380157471},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5357033610343933},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.48136383295059204},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.47483211755752563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4478611648082733},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.44090506434440613},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4178589880466461},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4164566099643707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38283318281173706},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.32054251432418823},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2503049373626709},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.2211686372756958},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.19910931587219238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13827335834503174},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-1448","doi":"https://doi.org/10.1158/1538-7445.am2019-1448","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-1448","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3083481024","https://openalex.org/W2914399440","https://openalex.org/W3137286939","https://openalex.org/W2885287481","https://openalex.org/W4388083659","https://openalex.org/W6948402237","https://openalex.org/W2809887423","https://openalex.org/W4379984001","https://openalex.org/W1965423355","https://openalex.org/W4298027861"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"recently":[2],"reported":[3],"that":[4,121],"the":[5,16,27,58,64,81,89,106,113,123,176,180,208,275,333],"growth":[6,60,169],"of":[7,18,57,83,109,125,196,272,277,332],"lymphatic":[8,85,168,173],"vessels":[9,86],"(lymphangiogenesis)":[10],"in":[11,48,204,207,279],"mouse":[12,139,224],"melanomas":[13],"dramatically":[14],"enhances":[15],"efficacy":[17],"immunotherapy":[19],"by":[20,115,229],"promoting":[21],"immune":[22,155],"cell":[23,30,74,219,247,323],"infiltration":[24],"and":[25,76,104,150,158,170,193,234,249,282,325],"broadening":[26],"anti-tumor":[28],"T":[29,199,218,246,322],"repertoire":[31],"(Fankhauser":[32],"et":[33],"al,":[34],"Sci.":[35],"Trans.":[36],"Med.":[37],"2017).":[38],"Correlative":[39],"evidence":[40],"supporting":[41],"such":[42],"\u2018lymphangiogenic":[43],"potentiation\u2019":[44],"was":[45],"also":[46],"seen":[47],"human":[49],"melanoma":[50,140,225,318],"patients,":[51],"suggesting":[52],"a":[53,93,117,126,216,238,262,270,284],"possible":[54],"immunotherapeutic":[55],"use":[56,276],"pro-lymphangiogenic":[59],"factor":[61],"VEGFC.":[62],"On":[63],"other":[65],"hand,":[66],"tumor":[67,90,114,253,327],"lymphangiogenesis":[68],"is":[69],"known":[70],"to":[71,102,147,179,212,256],"promote":[72],"cancer":[73,97,119,280],"dissemination":[75],"metastasis,":[77],"raising":[78],"concerns":[79],"about":[80],"possibility":[82],"manipulating":[84],"directly":[87],"within":[88],"site":[91,178],"as":[92,227,259,261],"treatment":[94],"strategy":[95],"for":[96,274,291,336],"immunotherapy.":[98],"Here,":[99],"we":[100],"sought":[101],"manipulate":[103],"exploit":[105],"immune-promoting":[107],"functions":[108],"lymphatics":[110],"remotely":[111],"from":[112,175,252],"developing":[116],"lymphangiogenesis-inducing":[118,286],"vaccine":[120,177,209,240,287,316],"mimics":[122],"microenvironment":[124],"lymphangiogenic":[127],"tumor.":[128],"Whole-cell":[129],"vaccines":[130,281],"were":[131],"formulated":[132],"using":[133],"lethally":[134],"irradiated":[135],"B16F10":[136],"or":[137,144],"B16F10-OVA":[138],"cells,":[141,200],"either":[142],"mock-transduced":[143],"genetically":[145],"modified":[146],"overexpress":[148],"VEGFC,":[149],"combined":[151],"with":[152,185,289],"topically":[153],"retained":[154],"adjuvants":[156],"(ctrl-vax":[157],"VEGFC-vax,":[159],"respectively).":[160],"Upon":[161],"intradermal":[162],"injection,":[163],"VEGFC-vax":[164,214,242],"induced":[165,190,243],"extensive":[166],"local":[167,194],"stimulated":[171],"increased":[172],"transport":[174],"draining":[181],"lymph":[182],"nodes.":[183],"Consistently":[184],"our":[186],"previous":[187],"study,":[188],"VEGFC":[189,278],"CCL21":[191],"upregulation":[192],"recruitment":[195],"CCR7+":[197],"na\u00efve":[198],"which":[201],"could":[202],"undergo":[203],"situ":[205],"priming":[206],"site.":[210],"Compared":[211],"ctrl-vax,":[213],"elicited":[215],"robust":[217],"response":[220],"directed":[221],"against":[222,317],"multiple":[223],"antigens,":[226],"assessed":[228],"ex":[230],"vivo":[231],"antigen":[232],"stimulation":[233],"IFN\u03b3":[235],"ELISPOT.":[236],"In":[237],"prophylactic":[239],"setting,":[241],"stronger":[244],"tumor-specific":[245,321],"immunity":[248,324],"greater":[250],"protection":[251],"challenge":[254],"compared":[255],"both":[257],"ctrl-vax":[258],"well":[260],"GM-CSF-secreting":[263],"whole-cell":[264,285,315],"vaccine.":[265],"Overall":[266],"this":[267],"study":[268],"provides":[269],"proof":[271],"concept":[273],"characterizes":[283],"formulation":[288],"potential":[290],"clinical":[292],"translation.":[293],"Citation":[294],"Format:":[295],"Maria":[296],"Stella":[297],"Sasso,":[298],"Sylvie":[299],"Hauert,":[300],"Priscilla":[301],"S.":[302],"Briquez,":[303],"Yue":[304],"Wang,":[305],"Jun":[306],"Ishihara,":[307],"Jeffrey":[308],"A.":[309,312],"Hubbell,":[310],"Melody":[311],"Swartz.":[313],"Lymphangiogenesis-inducing":[314],"promotes":[319],"broad":[320],"effective":[326],"control":[328],"[abstract].":[329],"In:":[330],"Proceedings":[331],"American":[334],"Association":[335],"Cancer":[337,351],"Research":[338],"Annual":[339],"Meeting":[340],"2019;":[341],"2019":[342],"Mar":[343],"29-Apr":[344],"3;":[345],"Atlanta,":[346],"GA.":[347],"Philadelphia":[348],"(PA):":[349],"AACR;":[350],"Res":[352],"2019;79(13":[353],"Suppl):Abstract":[354],"nr":[355],"1448.":[356]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-07-12T00:00:00"}
