{"id":"https://openalex.org/W2955699346","doi":"https://doi.org/10.1158/1538-7445.sabcs18-375","title":"Abstract 375: Integrin \u03b24-targeted cancer immunotherapies","display_name":"Abstract 375: Integrin \u03b24-targeted cancer immunotherapies","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2955699346","doi":"https://doi.org/10.1158/1538-7445.sabcs18-375","mag":"2955699346"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-375","doi":"https://doi.org/10.1158/1538-7445.sabcs18-375","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-375","pdf_url":null,"source":{"id":"https://openalex.org/S4306510252","display_name":"Experimental and Molecular Therapeutics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Therapeutics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104113067","display_name":"Shasha Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shasha Ruan","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109542040","display_name":"Ming T. Lin","orcid":"https://orcid.org/0009-0000-7371-5996","observed_orcids":["https://orcid.org/0009-0000-7371-5996"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Lin","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101737578","display_name":"Yongshun Chen","orcid":"https://orcid.org/0000-0002-2544-6266","observed_orcids":["https://orcid.org/0000-0002-2544-6266"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongshun Chen","raw_affiliation_strings":["Renmin Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renmin Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031063483","display_name":"Elaine M. Hurt","orcid":"https://orcid.org/0009-0005-3801-9537","observed_orcids":["https://orcid.org/0009-0005-3801-9537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elaine Hurt","raw_affiliation_strings":["Medimmune LLC, Gaithersburg, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medimmune LLC, Gaithersburg, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104109531","display_name":"Alfred E. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred E. Chang","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max S. Wicha","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100393720","display_name":"Qiao Li","orcid":"https://orcid.org/0000-0003-4321-2647","observed_orcids":["https://orcid.org/0000-0003-4321-2647"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiao Li","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"375","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-beta-4","display_name":"ITGB4","score":0.871999979019165},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.843999981880188},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.890999972820282},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tumor-draining-lymph-nodes","display_name":"tumor-draining lymph nodes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.7760000228881836},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.5059999823570251},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.48399999737739563},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5591428875923157},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.48065483570098877},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4417833089828491},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4342110753059387},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4197550415992737},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40968939661979675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3603687882423401},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3566821217536926},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2972017526626587},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2135220766067505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15011554956436157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-375","doi":"https://doi.org/10.1158/1538-7445.sabcs18-375","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-375","pdf_url":null,"source":{"id":"https://openalex.org/S4306510252","display_name":"Experimental and Molecular Therapeutics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Therapeutics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2995510656","https://openalex.org/W3194944933","https://openalex.org/W4409689846","https://openalex.org/W2078721111","https://openalex.org/W2144060157","https://openalex.org/W1844826649","https://openalex.org/W2153601322","https://openalex.org/W7100102765","https://openalex.org/W2318353241","https://openalex.org/W2015611567"],"abstract_inverted_index":{"Integrins":[0],"are":[1],"heterodimeric":[2],"cell":[3,108,126,396],"surface":[4],"receptors":[5],"that":[6,151,203,275,324],"mediate":[7],"interaction":[8],"of":[9,27,34,50,59,257,265,349,385,426],"cells":[10,30,115,131,145,172,186,197,214,278,290,296,312,330],"with":[11,187,249,283,366],"extracellular":[12],"matrix":[13],"components.":[14],"Integrin":[15,419],"\u03b24":[16],"(ITGB4)":[17],"has":[18],"been":[19],"reported":[20,56],"by":[21,321],"other":[22,399],"investigators":[23],"as":[24,38,61,167,319,389],"a":[25,39,42,62,101,340],"marker":[26,63],"cancer":[28,52,88,109,421],"stem":[29],"(CSCs).":[31],"Immunological":[32],"targeting":[33,374],"CSCs":[35,66,137,238,351],"utilizing":[36],"ITGB4":[37,118,134,139,165,209,235],"biomarker":[40],"represnets":[41],"novel":[43,379],"therapeutic":[44,263,380],"opportunity":[45],"to":[46,64,93,111,169,174,194,301,357],"improve":[47],"the":[48,57,205,212,230,243,247,262,335,347,353,383,427],"efficacy":[49],"current":[51],"treatment.":[53],"We":[54,156,201],"previously":[55],"use":[58],"ALDH":[60],"isolate":[65],"from":[67,280],"multiple":[68],"tumor":[69,84,91,98,206,213,225,231,244,355],"types,":[70],"including":[71],"both":[72,223,266,342],"human":[73],"and":[74,96,105,124,227,297,327,331,393,398],"animal":[75],"tumors.":[76],"In":[77,128,304,359],"this":[78],"study,":[79],"we":[80],"used":[81],"two":[82,158],"murine":[83],"models:":[85],"triple-negative":[86],"breast":[87,390],"(TNBC)":[89],"4T1":[90,114,295,329],"syngeneic":[92,110],"Balb/c":[94],"mice":[95,281],"SCC7":[97,130,144,154,298,332],"which":[99,207,232],"is":[100,146],"spontaneously":[102],"arising":[103],"head":[104,392],"neck":[106,394],"squamous":[107,395],"C3H":[112],"mice.":[113],"highly":[116],"express":[117,133],"(about":[119],"90%)":[120],"in":[121,246,272,352],"unsorted,":[122],"ALDHhigh":[123,136,143,237,302,336,350],"ALDHlow":[125,153],"populations.":[127],"contrast,":[129],"preferentially":[132,233],"on":[135,142,152,210,236,252],"because":[138],"cell-surface":[140],"abundance":[141],"approximately":[147],"2-fold":[148],"higher":[149],"than":[150],"cells.":[155],"tested":[157],"different":[159],"approaches":[160,344],"for":[161,177,198,204,229,382,430],"ITGB4-targeted":[162,219,240,361],"immunotherapy:":[163],"using":[164],"protein":[166],"antigen":[168],"pulse":[170],"dendritic":[171],"(DC)":[173],"prepare":[175,195],"ITGB4-DC":[176,284,306],"vaccination,":[178],"or":[179,286,308,364],"coating":[180],"tumor-draining":[181],"lymph":[182],"node":[183],"(TDLN)":[184],"T":[185,277,289,311],"anti-CD3":[188],"x":[189],"anti-ITGB4":[190,316],"bispecific":[191],"antibody":[192],"(ITGB4BiAb)":[193],"ITGB4BiAb-T":[196],"adoptive":[199],"transfer.":[200],"found":[202],"expresses":[208,234],"all":[211],"at":[215],"high":[216],"level":[217],"(4T1),":[218],"immunotherapies":[220,241,362,422],"could":[221],"inhibit":[222],"local":[224,253],"growth":[226,245],"metastasis;":[228],"(SCC7),":[239],"inhibited":[242],"lung,":[248],"partial":[250],"effect":[251],"tumor.":[254],"Co-current":[255],"administration":[256],"anti-PD-L1":[258],"mAb":[259],"significantly":[260,345],"enhanced":[261],"effectiveness":[264],"approches.":[267],"Our":[268],"immune":[269],"monitoring":[270],"studies":[271],"vitro":[273],"revealed":[274],"splenetic":[276],"harvested":[279],"treated":[282],"vaccine":[285,307],"ITGB4BiAb":[287,309],"armed":[288,310],"mediated":[291],"significant":[292,314,370],"cytotoxicity":[293],"against":[294],"cells,":[299,333],"especially":[300,334],"CSCs.":[303,375],"addition,":[305],"conferred":[313],"host":[315],"humoral":[317],"immunity":[318,372],"evident":[320],"produced":[322],"antibodies":[323],"specifically":[325],"bind":[326],"kill":[328],"CSC":[337],"population.":[338],"As":[339],"result,":[341],"immunotherapeutic":[343],"reduced":[346],"number":[348],"residual":[354],"subjected":[356],"immunotherapies.":[358],"conclusion,":[360],"alone":[363],"combined":[365],"PD-L1":[367],"blockade":[368],"demonstrated":[369],"antitumor":[371],"via":[373],"This":[376],"may":[377],"provide":[378],"strategies":[381],"treatment":[384],"ITGB4-positive":[386],"cancers,":[387],"such":[388],"cancer,":[391],"carcinoma":[397],"soilid":[400],"tumors.Citation":[401],"Format:":[402],"Shasha":[403],"Ruan,":[404],"Ming":[405],"Lin,":[406],"Yongshun":[407],"Chen,":[408],"Elaine":[409],"Hurt,":[410],"Alfred":[411],"E.":[412],"Chang,":[413],"Max":[414],"S.":[415],"Wicha,":[416],"Qiao":[417],"Li.":[418],"\u03b24-targeted":[420],"[abstract].":[423],"In:":[424],"Proceedings":[425],"American":[428],"Association":[429],"Cancer":[431,445],"Research":[432],"Annual":[433],"Meeting":[434],"2019;":[435],"2019":[436],"Mar":[437],"29-Apr":[438],"3;":[439],"Atlanta,":[440],"GA.":[441],"Philadelphia":[442],"(PA):":[443],"AACR;":[444],"Res":[446],"2019;79(13":[447],"Suppl):Abstract":[448],"nr":[449],"375.":[450]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-07-12T00:00:00"}