{"id":"https://openalex.org/W2955469733","doi":null,"title":"Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.","display_name":"Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.","publication_year":2018,"publication_date":"2018-09-01","ids":{"openalex":"https://openalex.org/W2955469733","mag":"2955469733","pmid":"https://pubmed.ncbi.nlm.nih.gov/30235387"},"language":"en","primary_location":{"id":"pmid:30235387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30235387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Clinical Trial, Phase III"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085051271","display_name":"Angela Yen Moore","orcid":"https://orcid.org/0000-0002-5788-7445","observed_orcids":["https://orcid.org/0000-0002-5788-7445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela Moore","raw_affiliation_strings":["Arlington Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arlington Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090367295","display_name":"Lawrence J. Green","orcid":"https://orcid.org/0000-0002-1295-9249","observed_orcids":["https://orcid.org/0000-0002-1295-9249"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence J Green","raw_affiliation_strings":["(George Washington University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(George Washington University)","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056678869","display_name":"Suzanne Bruce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne Bruce","raw_affiliation_strings":["Suzanne Bruce and Associates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzanne Bruce and Associates","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088719380","display_name":"Neil S. Sadick","orcid":"https://orcid.org/0000-0002-9542-4097","observed_orcids":["https://orcid.org/0000-0002-9542-4097"]},"institutions":[{"id":"https://openalex.org/I4210147984","display_name":"Sadick Research Group","ror":"https://ror.org/05kw0cb16","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210147984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Sadick","raw_affiliation_strings":["Sadick Research Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sadick Research Group","institution_ids":["https://openalex.org/I4210147984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008914021","display_name":"Eduardo H. Tschen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126752","display_name":"Academic Dermatology Associates","ror":"https://ror.org/02x25m361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126752"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Tschen","raw_affiliation_strings":["Academic Dermatology Associates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Dermatology Associates","institution_ids":["https://openalex.org/I4210126752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108428454","display_name":"Philip Werschler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110215","display_name":"Premier Clinical Research (United States)","ror":"https://ror.org/020ea8709","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Werschler","raw_affiliation_strings":["Premier Clinical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Premier Clinical Research","institution_ids":["https://openalex.org/I4210110215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013708358","display_name":"Fran E. Cook-Bolden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109609","display_name":"Skin Specialty Dermatology (United States)","ror":"https://ror.org/0246w5s24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109609"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fran E Cook-Bolden","raw_affiliation_strings":["Skin Specialty Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skin Specialty Dermatology","institution_ids":["https://openalex.org/I4210109609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087638193","display_name":"Sunil Dhawan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunil S Dhawan","raw_affiliation_strings":["Center for Dermatology Clinical Research, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Dermatology Clinical Research, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071317805","display_name":"Douglass W. Forsha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097453","display_name":"Jordan Valley Dermatology","ror":"https://ror.org/00xp3qv26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210097453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglass Forsha","raw_affiliation_strings":["Jordan Valley Dermatology and Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jordan Valley Dermatology and Research Center","institution_ids":["https://openalex.org/I4210097453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032610869","display_name":"Michael H. Gold","orcid":"https://orcid.org/0000-0002-5183-5433","observed_orcids":["https://orcid.org/0000-0002-5183-5433"]},"institutions":[{"id":"https://openalex.org/I4210158012","display_name":"Tennessee Clinical Research Center","ror":"https://ror.org/05jsaxg97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210158012"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H Gold","raw_affiliation_strings":["Tennessee Clinical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tennessee Clinical Research Center","institution_ids":["https://openalex.org/I4210158012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025746305","display_name":"Scott Guenthner","orcid":"https://orcid.org/0000-0002-6660-2245","observed_orcids":["https://orcid.org/0000-0002-6660-2245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Guenthner","raw_affiliation_strings":["Dermatology Center of Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Center of Indiana","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112794056","display_name":"Steven E. Kempers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128048","display_name":"Associated Skin Care Specialists","ror":"https://ror.org/02c241b98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128048"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E Kempers","raw_affiliation_strings":["Associated Skin Care Specialists"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associated Skin Care Specialists","institution_ids":["https://openalex.org/I4210128048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058903008","display_name":"Leon Kircik","orcid":"https://orcid.org/0000-0002-0831-2151","observed_orcids":["https://orcid.org/0000-0002-0831-2151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leon H Kircik","raw_affiliation_strings":["PLLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PLLC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045484623","display_name":"Jennifer L. Parish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124462","display_name":"Parish Dermatology","ror":"https://ror.org/02v3jvj44","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124462"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L Parish","raw_affiliation_strings":["Parish Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parish Dermatology","institution_ids":["https://openalex.org/I4210124462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112774679","display_name":"Marta I. Rendon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta I Rendon","raw_affiliation_strings":["Rendon Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rendon Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087549040","display_name":"Phoebe A. Rich","orcid":"https://orcid.org/0000-0002-2294-9466","observed_orcids":["https://orcid.org/0000-0002-2294-9466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phoebe Rich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009976581","display_name":"Linda Stein\u2010Gold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Stein-Gold","raw_affiliation_strings":["Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000478173","display_name":"Stephen Keith Tyring","orcid":"https://orcid.org/0000-0002-3337-0580","observed_orcids":["https://orcid.org/0000-0002-3337-0580"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen K Tyring","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102833038","display_name":"Robert A. Weiss","orcid":"https://orcid.org/0000-0003-2720-353X","observed_orcids":["https://orcid.org/0000-0003-2720-353X"]},"institutions":[{"id":"https://openalex.org/I4210112392","display_name":"Maryland Dermatology Laser Skin and Vein Institute","ror":"https://ror.org/01vvgpy65","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210112392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Weiss","raw_affiliation_strings":["Laser Skin and Vein Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laser Skin and Vein Institute","institution_ids":["https://openalex.org/I4210112392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102880077","display_name":"Adnan Nasir","orcid":"https://orcid.org/0000-0001-5054-4557","observed_orcids":["https://orcid.org/0000-0001-5054-4557"]},"institutions":[{"id":"https://openalex.org/I4210102103","display_name":"Wake Research","ror":"https://ror.org/01954vf31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210102103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adnan Nasir","raw_affiliation_strings":["Wake Research Associates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Research Associates","institution_ids":["https://openalex.org/I4210102103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carsten Schmitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten Schmitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065651957","display_name":"Terry Boodhoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terry I Boodhoo","raw_affiliation_strings":["Allergan Inc;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan Inc;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003586451","display_name":"Alexandre Kaoukhov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre Kaoukhov","raw_affiliation_strings":["Allergan Inc;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan Inc;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109600467","display_name":"David R. Berk","orcid":"https://orcid.org/0009-0009-4852-0287","observed_orcids":["https://orcid.org/0009-0009-4852-0287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R Berk","raw_affiliation_strings":["Allergan Inc;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan Inc;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9639,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.98578776,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"9","first_page":"987","last_page":"996"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12116","display_name":"Dermatological diseases and infestations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarecycline","display_name":"sarecycline","score":0.9929999709129333},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.972000002861023},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.9679999947547913},{"id":"https://openalex.org/keywords/inflammatory-acne-lesions","display_name":"inflammatory acne lesions","score":0.6320000290870667},{"id":"https://openalex.org/keywords/investigator-s-global-assessment","display_name":"Investigator's Global Assessment","score":0.9229999780654907},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.531000018119812},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6949999928474426},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9248080253601074},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8706583976745605},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.7286004424095154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6002945303916931},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5973879098892212},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5597396492958069},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5268101692199707},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4948248267173767},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4598264694213867},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4307578206062317},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.23016390204429626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07369542121887207},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005148","descriptor_name":"Facial Dermatoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005148","descriptor_name":"Facial Dermatoses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:30235387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30235387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Clinical Trial, Phase III"},{"id":"mag:2955469733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30235387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2975900880","https://openalex.org/W7153774710","https://openalex.org/W2971936256","https://openalex.org/W4248673268","https://openalex.org/W7167456373","https://openalex.org/W3003158866","https://openalex.org/W4252479542","https://openalex.org/W3085213598","https://openalex.org/W4413787994","https://openalex.org/W4280580500"],"abstract_inverted_index":{"BACKGROUND:":[0],"Side":[1],"effects":[2,318],"may":[3],"limit":[4],"the":[5,15,138,203],"use":[6],"of":[7,19,131,157,173,178,210,261,316],"current":[8],"tetracycline-class":[9,25],"antibiotics":[10],"for":[11,69,175,267,308],"acne.":[12,31],"OBJECTIVE:":[13],"Evaluate":[14],"efficacy":[16,132,174],"and":[17,51,56,79,88,102,113,119,126,155,159,165,192,228,238,251,278,283,285,289,292,306],"safety":[18],"once-daily":[20],"sarecycline,":[21],"a":[22],"novel,":[23],"narrow-spectrum":[24,299],"antibiotic,":[26],"in":[27,72,133,147,153,186,195,233,258],"moderate":[28,37,309],"to":[29,38,63,310],"severe":[30,39,311],"METHODS:":[32],"Patients":[33],"9-45":[34],"years":[35],"with":[36,143,313,320],"facial":[40],"acne":[41],"(Investigator's":[42],"Global":[43],"Assessment":[44],"[IGA]":[45],"score":[46,103],"\u2265":[47,208],"3,":[48],"20-50":[49],"inflammatory":[50,134,148],"\u2264":[52,57,259],"100":[53],"noninflammatory":[54,179],"lesions,":[55],"2":[58],"nodules)":[59],"were":[60,111,216,243,269,295],"randomized":[61],"1:1":[62],"sarecycline":[64,212,262,268,301],"1.5":[65],"mg/kg/day":[66],"or":[67,106,213],"placebo":[68,86,92,214],"12":[70,152],"weeks":[71],"identically":[73],"designed":[74],"phase":[75],"3":[76],"studies":[77],"(SC1401":[78],"SC1402).":[80],"RESULTS:":[81],"In":[82,201],"SC1401":[83,154,187],"(sarecycline":[84,90],"n=483,":[85],"n=485)":[87],"SC1402":[89,156,196],"n=519,":[91],"n=515),":[93],"at":[94,150,183],"week":[95,151,184,193],"12,":[96],"IGA":[97],"success":[98],"(\u2265":[99],"2-grade":[100],"improvement":[101],"0":[104,279],"[clear]":[105],"1":[107],"[almost":[108],"clear])":[109],"rates":[110,266,294,315],"21.9%":[112],"22.6%":[114],"(sarecycline),":[115,161],"respectively,":[116,162],"versus":[117,163],"10.5%":[118],"15.3%":[120],"(placebo;":[121,167],"P":[122,127,168],"less":[123,169,189,198],"than":[124,170,190,199],"0.0001":[125],"equals":[128],"0.0038).":[129],"Onset":[130,172],"lesions":[135,149],"occurred":[136,182,257],"by":[137],"first":[139],"visit":[140],"(week":[141],"3),":[142],"mean":[144],"percentage":[145],"reduction":[146,177],"-51.8%":[158],"-49.9%":[160],"-35.1%":[164],"-35.4%":[166],"0.0001).":[171],"absolute":[176],"lesion":[180],"count":[181],"6":[185],"(P":[188,197],"0.05)":[191],"9":[194],"0.01).":[200],"SC1401,":[202],"most":[204],"common":[205,319],"TEAEs":[206,255],"(in":[207],"2%":[209],"either":[211],"group)":[215],"nausea":[217],"(4.6%":[218],"[sarecycline];":[219],"2.5%":[220],"[placebo]),":[221],"nasopharyngitis":[222,235],"(3.1%;":[223],"1.7%),":[224],"headache":[225,239],"(2.7%;":[226],"2.7%),":[227],"vomiting":[229],"(2.1%;":[230],"1.4%)":[231],"and,":[232],"SC1402,":[234],"(2.5%;":[236],"2.9%)":[237],"(2.9%;":[240],"4.9%).":[241],"Most":[242],"not":[244],"considered":[245],"treatment-related.":[246],"Vestibular":[247],"(dizziness,":[248],"tinnitus,":[249],"vertigo)":[250],"phototoxic":[252],"(sunburn,":[253],"photosensitivity)":[254],"both":[256],"1%":[260],"patients.":[263],"Gastrointestinal":[264],"TEAE":[265],"low.":[270,296],"Among":[271],"females,":[272],"vulvovaginal":[273],"candidiasis":[274],"(SC1401:":[275],"1.1%":[276],"[sarecycline]":[277],"[placebo];":[280],"SC1402:":[281],"0.3%":[282],"0)":[284,293],"mycotic":[286],"infection":[287],"(0.7%":[288],"0;":[290],"1.0%":[291],"CONCLUSION:":[297],"The":[298],"antibiotic":[300],"was":[302],"safe,":[303],"well":[304],"tolerated,":[305],"effective":[307],"acne,":[312],"low":[314],"side":[317],"tetracycline":[321],"antibiotics.":[322],"J":[323],"Drugs":[324],"Dermatol.":[325],"2018;17(9):987-996.":[326]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-07-12T00:00:00"}
