{"id":"https://openalex.org/W2955445519","doi":"https://doi.org/10.2174/1872210513666190702165556","title":"Study of 5-Fluorouracil Loaded Chitosan Nanoparticles for Treatment of Skin Cancer","display_name":"Study of 5-Fluorouracil Loaded Chitosan Nanoparticles for Treatment of Skin Cancer","publication_year":2019,"publication_date":"2019-07-03","ids":{"openalex":"https://openalex.org/W2955445519","doi":"https://doi.org/10.2174/1872210513666190702165556","mag":"2955445519","pmid":"https://pubmed.ncbi.nlm.nih.gov/31267881"},"language":"en","primary_location":{"id":"doi:10.2174/1872210513666190702165556","doi":"https://doi.org/10.2174/1872210513666190702165556","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1872210513666190702165556","pdf_url":null,"source":{"id":"https://openalex.org/S171866559","display_name":"Recent Patents on Nanotechnology","issn_l":"1872-2105","issn":["1872-2105","2212-4020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075738756","display_name":"Gayatri C. Patel","orcid":"https://orcid.org/0000-0002-2523-1281","observed_orcids":["https://orcid.org/0000-0002-2523-1281"]},"institutions":[{"id":"https://openalex.org/I33459947","display_name":"Charotar University of Science and Technology","ror":"https://ror.org/0442pkv24","country_code":"IN","type":"education","lineage":["https://openalex.org/I33459947"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Gayatri Patel","raw_affiliation_strings":["Department of Pharmaceutics & Pharmaceutical Technology, Charotar University of Science and Technology, Ramanbhai Patel College of Pharmacy, CHARUSAT Campus Changa, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics & Pharmaceutical Technology, Charotar University of Science and Technology, Ramanbhai Patel College of Pharmacy, CHARUSAT Campus Changa, Gujarat, India","institution_ids":["https://openalex.org/I33459947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070587027","display_name":"Bindu Kumari Yadav","orcid":"https://orcid.org/0000-0001-7899-9406","observed_orcids":["https://orcid.org/0000-0001-7899-9406"]},"institutions":[{"id":"https://openalex.org/I33459947","display_name":"Charotar University of Science and Technology","ror":"https://ror.org/0442pkv24","country_code":"IN","type":"education","lineage":["https://openalex.org/I33459947"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bindu K.N. Yadav","raw_affiliation_strings":["Department of Pharmaceutics & Pharmaceutical Technology, Charotar University of Science and Technology, Ramanbhai Patel College of Pharmacy, CHARUSAT Campus Changa, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics & Pharmaceutical Technology, Charotar University of Science and Technology, Ramanbhai Patel College of Pharmacy, CHARUSAT Campus Changa, Gujarat, India","institution_ids":["https://openalex.org/I33459947"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075738756"],"corresponding_institution_ids":["https://openalex.org/I33459947"],"apc_list":null,"apc_paid":null,"fwci":0.7663,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.60328515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"14","issue":"3","first_page":"210","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.07119999825954437,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chitosan-nanoparticles","display_name":"chitosan nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.7639999985694885},{"id":"https://openalex.org/keywords/ionic-gelation","display_name":"ionic gelation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sodium-tripolyphosphate","display_name":"sodium tripolyphosphate","score":0.9160000085830688},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/a375-cells","display_name":"A375 cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nanoparticle-formulation-optimization","display_name":"nanoparticle formulation optimization","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.7767210006713867},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7515332698822021},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.670339822769165},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6651164293289185},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.6510123610496521},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5901807546615601},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.4609757959842682},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4584263563156128},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4532131552696228},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40485942363739014},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.39014336466789246},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.375369668006897},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3257475793361664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3135735094547272},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25488370656967163},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.12961304187774658},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1115449070930481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07533088326454163},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06862038373947144},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011122","descriptor_name":"Polyphosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013818","descriptor_name":"Thermogravimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1872210513666190702165556","doi":"https://doi.org/10.2174/1872210513666190702165556","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1872210513666190702165556","pdf_url":null,"source":{"id":"https://openalex.org/S171866559","display_name":"Recent Patents on Nanotechnology","issn_l":"1872-2105","issn":["1872-2105","2212-4020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on Nanotechnology","raw_type":"journal-article"},{"id":"pmid:31267881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31267881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent patents on nanotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404053747","https://openalex.org/W7164384332","https://openalex.org/W4391885211","https://openalex.org/W3017019992","https://openalex.org/W4280543331","https://openalex.org/W2391193366","https://openalex.org/W2769133964","https://openalex.org/W4392710639","https://openalex.org/W2559715734","https://openalex.org/W2001433258"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,25,81,100,138],"purpose":[2],"of":[3,13,22,43,61,110,111,116,122,163,176,187,192,197],"this":[4],"study":[5,49,150],"was":[6,151],"to":[7,146,159,179],"formulate,":[8],"characterize":[9],"and":[10,38,63,69,74,95,119,127],"in-vitro":[11],"cytotoxicity":[12,165],"5-Fluorouracil":[14,102,178],"loaded":[15,103],"controlled":[16,143],"release":[17,97,140,144],"nanoparticles":[18,28,50,83],"for":[19,40,86,190],"the":[20,35,41,47,161,174,188],"treatment":[21,191],"skin":[23,180,198],"cancer.":[24,199],"patents":[26],"on":[27],"(US8414926B1),":[29],"(US61654404A),":[30],"(WO2007150075A3)":[31],"etc.":[32],"helped":[33],"in":[34],"selection":[36],"polymers":[37],"method":[39,57],"preparation":[42],"nanoparticles.":[44],"METHODS:":[45],"In":[46],"present":[48],"were":[51,72,84,105],"prepared":[52,82],"by":[53,166],"simple":[54],"ionic":[55],"gelation":[56],"using":[58,76,153],"various":[59],"concentrations":[60],"chitosan":[62],"sodium":[64],"tripolyphosphate":[65],"(TPP).":[66],"Several":[67],"process":[68],"formulation":[70,189],"parameters":[71],"screened":[73],"optimized":[75,101],"25-2":[77],"fractional":[78],"factorial":[79],"design.":[80],"evaluated":[85],"particle":[87,108],"size,":[88],"shape,":[89],"charge,":[90],"entrapment":[91,114],"efficiency,":[92],"crosslinking":[93],"mechanism":[94,162],"drug":[96],"study.":[98],"RESULTS:":[99],"nanoparticle":[104],"found":[106],"with":[107,135,181],"size":[109],"320\u00b12.1":[112],"nm,":[113],"efficiency":[115,184],"85.12%\u00b1":[117],"1.1%":[118],"Zeta":[120],"potential":[121],"29mv\u00b11mv.":[123],"Scanning":[124],"electron":[125],"microscopy":[126],"dynamic":[128],"light":[129],"scattering":[130],"technique":[131],"revealed":[132],"spherical":[133],"particles":[134],"uniform":[136],"size.":[137],"invitro":[139],"profile":[141],"showed":[142],"up":[145],"24":[147],"hr.":[148],"Further":[149],"carried":[152],"A375":[154],"basal":[155,193],"cell":[156,194],"carcinoma":[157,195],"cell-line":[158],"elucidate":[160],"its":[164],"MTT":[167],"assay.":[168],"CONCLUSION:":[169],"These":[170],"results":[171],"demonstrate":[172],"that":[173],"possibility":[175],"delivering":[177],"enhanced":[182],"encapsulation":[183],"indicating":[185],"effectiveness":[186],"type":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-12T00:00:00"}