{"id":"https://openalex.org/W2955182016","doi":null,"title":"The Role of Non-Motif Selectivity Determinants in PDZ Domain-Binding Interactions","display_name":"The Role of Non-Motif Selectivity Determinants in PDZ Domain-Binding Interactions","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2955182016","mag":"2955182016"},"language":"en","primary_location":{"id":"pmh:oai:cedar.wwu.edu:scholwk-1604","doi":null,"is_oa":false,"landing_page_url":"https://cedar.wwu.edu/scholwk/2019/2019_poster_presentations/79","pdf_url":null,"source":{"id":"https://openalex.org/S4377196384","display_name":"Western CEDAR (Western Washington University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52669646","host_organization_name":"Western Washington University","host_organization_lineage":["https://openalex.org/I52669646"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scholars Week","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064481407","display_name":"Melody Gao","orcid":"https://orcid.org/0000-0003-2902-7517","observed_orcids":["https://orcid.org/0000-0003-2902-7517"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melody Gao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2902-7517","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064481407"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.8880000114440918},{"id":"https://openalex.org/keywords/short-linear-motifs","display_name":"short linear motifs","score":0.9120000004768372},{"id":"https://openalex.org/keywords/peptide-binding","display_name":"peptide binding","score":0.3880000114440918},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hpv16-e6","display_name":"HPV16 E6","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.8870000243186951},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.8539999723434448},{"id":"https://openalex.org/keywords/binding-specificity","display_name":"binding specificity","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.9388516545295715},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.6927215456962585},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4625190496444702},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4117734432220459},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40482082962989807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4028416872024536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.327605277299881},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3035430610179901},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12969622015953064},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:cedar.wwu.edu:scholwk-1604","doi":null,"is_oa":false,"landing_page_url":"https://cedar.wwu.edu/scholwk/2019/2019_poster_presentations/79","pdf_url":null,"source":{"id":"https://openalex.org/S4377196384","display_name":"Western CEDAR (Western Washington University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52669646","host_organization_name":"Western Washington University","host_organization_lineage":["https://openalex.org/I52669646"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scholars Week","raw_type":"text"},{"id":"mag:2955182016","doi":null,"is_oa":false,"landing_page_url":"https://cedar.wwu.edu/scholwk/2019/2019_poster_presentations/79/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322617989","https://openalex.org/W4417535255","https://openalex.org/W2980104931","https://openalex.org/W3009392844","https://openalex.org/W2074570440","https://openalex.org/W7098624529","https://openalex.org/W4365791884","https://openalex.org/W2790587263","https://openalex.org/W2029440564","https://openalex.org/W2000251153"],"abstract_inverted_index":{"An":[0],"important":[1],"class":[2],"of":[3,11,28,39,46,50,83,97,113,132,140,160,183,214],"protein-protein":[4],"interactions":[5,33,245],"in":[6,36,77,87,229,240,247],"the":[7,44,81,94,110,137,141,157,201,209,248],"cell":[8],"involve":[9],"recognition":[10,45],"short":[12],"linear":[13],"motifs":[14,102],"(SLiMs)":[15],"or":[16,89],"peptides":[17,184],"which":[18],"often":[19],"have":[20],"a":[21,37,48,74,151,215],"relatively":[22],"weak":[23],"affinity":[24],"and":[25,31,61,100,185,224],"transient.":[26],"Dysregulation":[27],"SLiM-binding":[29,55],"domains":[30,117,198],"target":[32,98,200],"are":[34,103],"implicated":[35],"number":[38],"human":[40,142],"diseases.":[41],"Due":[42],"to":[43,66,79,190,242],"only":[47,106,119],"couple":[49],"amino":[51],"acid":[52],"positions":[53],"by":[54],"domains,":[56],"interaction":[57],"networks":[58,112,246],"greatly":[59],"overlap":[60],"specific":[62],"targeting":[63],"is":[64,122,238],"hard":[65],"achieve.":[67],"The":[68],"PDZ":[69,116,133,153,197,216],"domain":[70,217],"was":[71],"used":[72],"as":[73],"model":[75],"system":[76],"order":[78,241],"define":[80],"role":[82],"non-motif":[84,192,226,236],"selectivity":[85,193,227],"determinants":[86,194,228],"SLiM-":[88],"peptide-mediated":[90],"interactions.":[91],"They":[92],"recognize":[93],"extreme":[95],"C-terminus":[96],"proteins":[99],"binding":[101,111],"based":[104],"on":[105],"two":[107,125],"residues.":[108,177],"Dissecting":[109],"over":[114,150],"250":[115],"using":[118],"motif":[120,176],"preferences":[121],"impossible.":[123],"Likewise,":[124],"sequences":[126],"can":[127],"bind":[128],"drastically":[129],"different":[130],"numbers":[131],"domains.":[134],"For":[135],"example,":[136],"C-terminal":[138,158],"sequence":[139,159],"papillomavirus":[143],"E6":[144,203],"oncoprotein":[145],"(HPV16":[146],"E6)":[147],"interacts":[148,167],"with":[149,168],"dozen":[152],"domain-containing":[154],"proteins,":[155],"while":[156],"cystic":[161],"fibrosis":[162],"transmembrane":[163],"conductance":[164],"regulator":[165],"(CFTR)":[166],"less":[169],"than":[170],"five,":[171],"yet":[172],"both":[173],"contain":[174],"identical":[175],"We":[178,233],"reveal":[179],"that":[180,199,235],"single-residue":[181],"substitution":[182],"structural":[186],"biology":[187],"allow":[188],"us":[189],"determine":[191],"for":[195],"multiple":[196],"HPV16":[202],"oncoprotein.":[204],"In":[205],"addition,":[206],"we":[207],"present":[208],"first":[210],"known":[211],"crystal":[212],"structure":[213],"from":[218],"choanoflagellates,":[219],"our":[220],"closest":[221],"non-metazoan":[222],"ancestor,":[223],"describe":[225],"these":[230],"unique":[231],"organisms.":[232],"show":[234],"specificity":[237],"critical":[239],"characterize":[243],"SLiM":[244],"cell.":[249]},"counts_by_year":[],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2019-07-12T00:00:00"}