{"id":"https://openalex.org/W2955019986","doi":null,"title":"Towards novel antibacterials : Synthesis and identification of natural product inspired inhibitors of Chlamydia trachomatis and development of chemical probes targeting virulence of Pseudomonas aeruginosa","display_name":"Towards novel antibacterials : Synthesis and identification of natural product inspired inhibitors of Chlamydia trachomatis and development of chemical probes targeting virulence of Pseudomonas aeruginosa","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2955019986","mag":"2955019986"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-150970","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150970","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017023289","display_name":"Michael Saleeb","orcid":"https://orcid.org/0000-0003-2721-6074","observed_orcids":["https://orcid.org/0000-0003-2721-6074"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Saleeb","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2721-6074","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017023289"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.15860000252723694,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlamydia-trachomatis","display_name":"Chlamydia trachomatis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.968999981880188},{"id":"https://openalex.org/keywords/anti-virulence-agents","display_name":"anti-virulence agents","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hopeaphenol","display_name":"hopeaphenol","score":0.8690000176429749},{"id":"https://openalex.org/keywords/focused-compound-libraries","display_name":"focused compound libraries","score":0.722000002861023},{"id":"https://openalex.org/keywords/antichlamydial-activity","display_name":"antichlamydial activity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/type-iii-secretion-system","display_name":"type III secretion system","score":0.8500000238418579},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.6713489294052124},{"id":"https://openalex.org/C2777391075","wikidata":"https://www.wikidata.org/wiki/Q131065","display_name":"Chlamydia trachomatis","level":2,"score":0.6546645164489746},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6367610692977905},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5903094410896301},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.534968912601471},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.515949547290802},{"id":"https://openalex.org/C2776962539","wikidata":"https://www.wikidata.org/wiki/Q6472078","display_name":"Lagging","level":2,"score":0.4985973834991455},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.49180105328559875},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4754725992679596},{"id":"https://openalex.org/C2780122209","wikidata":"https://www.wikidata.org/wiki/Q153356","display_name":"Chlamydia","level":2,"score":0.45498859882354736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41918349266052246},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.27450159192085266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20746156573295593},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1961282193660736},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1020512580871582},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09203603863716125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09067714214324951},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08227583765983582},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-150970","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150970","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2955019986","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/record.jsf?pid=diva2:1240446&language=en","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-150970","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150970","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2771518252","https://openalex.org/W2765359739","https://openalex.org/W4409921707","https://openalex.org/W4378473194","https://openalex.org/W2035090605","https://openalex.org/W2774123554","https://openalex.org/W1693157855","https://openalex.org/W2557591025","https://openalex.org/W1952287394","https://openalex.org/W2890824084"],"abstract_inverted_index":{"Antibiotic":[0],"resistance":[1,205],"has":[2],"evolved":[3],"significantly":[4],"to":[5,12,35,46,154,219,226,238,261,347],"become":[6],"one":[7,170,271],"of":[8,19,65,118,140,163,167,171,213,235,246,273,305,325,341],"the":[9,17,29,161,172,183,228,233,236,243,255,267,284,338,345],"serious":[10],"threats":[11],"public":[13],"health":[14],"today.":[15],"Yet,":[16],"pipeline":[18],"new":[20],"antibiotics":[21],"is":[22,26,85,107,197,207,225],"drying":[23],"up":[24,292],"and":[25,53,100,126,143,190,222,280,298,320,336,344],"lagging":[27],"behind":[28],"challenging":[30],"needs.":[31],"As":[32],"a":[33,66,86,115,138,198,210],"contribution":[34],"this":[36,113,274],"recurrent":[37],"need":[38],"for":[39,134],"novel":[40,147,221,352],"antibacterials,":[41],"we":[42,276,313],"applied":[43],"multidisciplinary":[44],"strategies":[45,61],"identify":[47],"small-molecule":[48],"antibacterials":[49,224],"against":[50,56,79,97,182,283],"Chlamydia":[51,80],"trachomatis":[52],"antivirulence":[54,95,339],"agents":[55],"Pseudomonas":[57],"aeruginosa":[58,185,196,250,286],"infections.":[59,215],"These":[60],"included:":[62],"1.":[63],"Synthesis":[64],"focused":[67,116],"compounds":[68,120,149],"library":[69,117,130],"inspired":[70],"by":[71,76],"natural":[72,88],"product":[73,89],"scaffolds":[74],"followed":[75],"phenotypic":[77],"screening":[78,141,181],"trachomatis.":[81],"(Paper":[82,193],"I)":[83],"(-)-Hopeaphenol":[84],"polyphenol":[87],"that":[90,206],"was":[91,121,131,296,334],"identified":[92,157,281,321],"as":[93,351],"an":[94],"agent":[96],"Y.":[98],"pseudotuberculosis":[99],"P.":[101,184,195,249,285],"aeruginosa.":[102],"Hopeaphenol":[103],"core":[104],"scaffold,":[105],"2,3-diaryl-2,3-dihydrobenzofuran,":[106],"ubiquitous":[108],"in":[109,137,145,300],"polyphenolic":[110],"phytochemicals.":[111],"In":[112,270,310],"thesis,":[114,275],"forty-eight":[119],"synthesized":[122],"based":[123],"on":[124],"2,3-diarylbenzofuran":[125],"2,3-diaryl-2,3-":[127],"dihydrobenzofuran.":[128],"The":[129,156,330],"then":[132],"explored":[133],"antibacterial":[135],"properties":[136,340],"number":[139],"assays":[142],"resulted":[144,299],"five":[146,301],"antichlamydial":[148],"with":[150,202,209],"inhibition":[151],"potency":[152],"down":[153],"sub-micromolar.":[155],"molecules":[158,343],"also":[159],"inhibited":[160],"growth":[162],"different":[164],"clinical":[165,214],"presentations":[166],"C.":[168],"trachomatis,":[169],"most":[173],"common":[174],"sexually":[175],"transmitted":[176],"disease":[177],"worldwide.":[178],"2.":[179],"Target-based":[180],"virulence":[186,230,253],"factor":[187],"using":[188],"enzymatic":[189,278,308],"biophysical":[191,318],"assays.":[192],"II-IV)":[194],"Gram-negative":[199],"opportunistic":[200],"pathogen":[201],"remarkable":[203],"antibiotic":[204],"associated":[208],"wide":[211],"range":[212],"An":[216],"alternative":[217],"strategy":[218],"develop":[220],"selective":[223],"target":[227],"bacterial":[229],"factors,":[231],"i.e.":[232],"ability":[234],"bacteria":[237],"promote":[239],"disease,":[240],"thus":[241],"\u2018disarming\u2019":[242],"pathogens":[244],"instead":[245],"killing":[247],"them.":[248],"employs":[251],"its":[252],"factor,":[254],"type":[256],"III":[257],"secretion":[258],"system":[259],"(T3SS),":[260],"inject":[262],"toxins":[263],"(e.g.":[264],"ExoS)":[265],"into":[266],"eukaryotic":[268],"cytosol.":[269],"part":[272],"utilized":[277],"assay":[279,319],"inhibitors":[282,304],"T3S":[287,326],"toxin":[288],"(ExoS).":[289],"A":[290],"follow":[291],"structure-activity":[293],"relationship":[294],"analysis":[295,333],"established":[297,335],"(low":[302],"micromolar)":[303],"ExoS":[306],"ADP-ribosylation":[307],"activity.":[309],"another":[311],"part,":[312],"used":[314],"surface":[315],"plasmon":[316],"resonance":[317],"small":[322],"molecule":[323],"binders":[324],"translocation":[327],"protein":[328],"(PcrV).":[329],"primary":[331],"SAR":[332],"showed":[337],"these":[342],"potential":[346],"expand":[348],"them":[349],"further":[350],"antibacterials.":[353]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2019-07-12T00:00:00"}