{"id":"https://openalex.org/W2954986240","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct067","title":"Abstract CT067: A Phase I study of Fosbretabulin in combination with everolimus in neuroendocrine tumors (Grades 1-3) that have progressed after at least one prior regimen for metastatic disease","display_name":"Abstract CT067: A Phase I study of Fosbretabulin in combination with everolimus in neuroendocrine tumors (Grades 1-3) that have progressed after at least one prior regimen for metastatic disease","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2954986240","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct067","mag":"2954986240"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-ct067","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct067","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-ct067","pdf_url":null,"source":{"id":"https://openalex.org/S59378366","display_name":"Clinical Trials","issn_l":"1740-7745","issn":["1740-7745","1740-7753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Trials","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051388864","display_name":"Aman Chauhan","orcid":"https://orcid.org/0009-0003-0136-1983","observed_orcids":["https://orcid.org/0009-0003-0136-1983","https://orcid.org/0000-0002-4183-2116"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aman Chauhan","raw_affiliation_strings":["Division of Medical Oncology, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030064179","display_name":"Susanne M. Arnold","orcid":"https://orcid.org/0000-0001-6542-9551","observed_orcids":["https://orcid.org/0000-0001-6542-9551"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanne Arnold","raw_affiliation_strings":["Division of Medical Oncology, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075203835","display_name":"John C. Wu","orcid":"https://orcid.org/0000-0001-7990-7139","observed_orcids":["https://orcid.org/0000-0001-7990-7139"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Wu","raw_affiliation_strings":["Department of Biostatistics, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081279720","display_name":"Stacey A. Slone","orcid":"https://orcid.org/0000-0002-4355-7672","observed_orcids":["https://orcid.org/0000-0002-4355-7672"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Slone","raw_affiliation_strings":["Department of Biostatistics, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084235817","display_name":"Emily Van Meter Dressler","orcid":"https://orcid.org/0000-0002-6054-7839","observed_orcids":["https://orcid.org/0000-0002-6054-7839"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Dressler","raw_affiliation_strings":["Wake Forest School of Medicine, Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest School of Medicine, Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Heather Flynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Flynn","raw_affiliation_strings":["University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112664150","display_name":"Val R. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val Adams","raw_affiliation_strings":["College of Pharmacy, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023436882","display_name":"Heidi L. Weiss","orcid":"https://orcid.org/0009-0002-0980-7778","observed_orcids":["https://orcid.org/0009-0002-0980-7778"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi Weiss","raw_affiliation_strings":["Department of Biostatistics, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005448318","display_name":"Lowell Brian Anthony","orcid":"https://orcid.org/0000-0001-7348-7874","observed_orcids":["https://orcid.org/0000-0001-7348-7874"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lowell Anthony","raw_affiliation_strings":["Division of Medical Oncology, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"CT067","last_page":"CT067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.996999979019165},{"id":"https://openalex.org/keywords/gastroenteropancreatic-neuroendocrine-tumors","display_name":"gastroenteropancreatic neuroendocrine tumors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/vascular-disrupting-agents","display_name":"vascular disrupting agents","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7630000114440918},{"id":"https://openalex.org/keywords/recommended-phase-ii-dose","display_name":"recommended phase 2 dose","score":0.8050000071525574},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/metastatic-neuroendocrine-tumors","display_name":"metastatic neuroendocrine tumors","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.38999998569488525},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.8483558893203735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7131554484367371},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6936373114585876},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5451459288597107},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.5265058875083923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5092867612838745},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4835240840911865},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.43239736557006836},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2631375789642334}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-ct067","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct067","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-ct067","pdf_url":null,"source":{"id":"https://openalex.org/S59378366","display_name":"Clinical Trials","issn_l":"1740-7745","issn":["1740-7745","1740-7753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Trials","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2947085753","https://openalex.org/W2890170672","https://openalex.org/W2243071171","https://openalex.org/W3010499233","https://openalex.org/W2062917093","https://openalex.org/W2898206761","https://openalex.org/W4406869238","https://openalex.org/W2560364184","https://openalex.org/W1490001593","https://openalex.org/W2518021910"],"abstract_inverted_index":{"Background:":[0],"Based":[1],"on":[2,221],"the":[3,6,17,30,40,49,52,60,94,109,144,153,159,183,187,233,239,251,278,350,373,387,442],"SEER":[4],"database,":[5],"incidence":[7],"of":[8,39,51,66,96,158,161,186,264,357,415,441],"gastroenteropancreatic":[9],"neuroendocrine":[10,422],"tumors":[11,423],"(GEPNETs)":[12],"has":[13,74],"risen":[14],"six-fold":[15],"in":[16,29,63,81,119,165,270,293,321,417,421],"last":[18],"four":[19],"decades.":[20],"At":[21],"present,":[22],"more":[23],"than":[24],"150,000":[25],"GEPNET":[26,121],"patients":[27,122,235,295,318],"exist":[28],"United":[31],"States.":[32],"Fosbretabulin,":[33],"a":[34,64,78],"synthetic,":[35],"water-soluble,":[36],"phosphorylated":[37],"prodrug":[38],"natural":[41],"product":[42],"combretastatin":[43],"A4":[44],"(CA4P),":[45],"initially":[46],"isolated":[47],"from":[48],"bark":[50],"South":[53],"African":[54],"bush":[55],"willow,":[56],"Combretum":[57],"caffrum,":[58],"is":[59,90,277,386],"lead":[61],"compound":[62],"class":[65],"agents":[67,71],"termed":[68],"vascular":[69],"disrupting":[70],"(VDAs)":[72],"and":[73,84,105,116,163,205,301,314,332,360],"shown":[75],"activity":[76],"as":[77],"single":[79,127],"agent":[80],"ovarian":[82],"cancer":[83],"GEPNETs.":[85],"Everolimus,":[86],"an":[87],"mTOR":[88],"inhibitor,":[89],"FDA":[91],"approved":[92],"for":[93,176,226,435,445],"management":[95],"well-differentiated":[97],"NETs.":[98],"A":[99,362,411],"Phase":[100,111,412],"I":[101,131,413],"trial":[102,113],"combining":[103],"fosbretabulin":[104,164,276,383],"everolimus":[106,162,198,269,379,420],"to":[107,142,151,248,305,324,337,341],"determine":[108],"recommended":[110],"II":[112],"dose":[114,145,156,263],"(RP2D)":[115],"safety":[117,184],"data":[118],"metastatic":[120,177,436],"was":[123,150,209,244,335],"conducted.Method:":[124],"An":[125],"investigator-initiated,":[126],"center,":[128],"open-label,":[129],"phase":[130],"study":[132,306,414],"involving":[133],"GEPNETs":[134],"incorporated":[135],"partial":[136],"order":[137],"continual":[138],"reassessment":[139],"method":[140],"(PO-CRM)":[141],"define":[143],"escalation.":[146],"The":[147,261],"primary":[148],"objective":[149,180],"establish":[152],"maximum":[154],"tolerated":[155],"(MTD)":[157],"combination":[160,188,271,418],"NETs":[166],"that":[167,296,426],"have":[168,427],"progressed":[169,428],"after":[170,429],"at":[171,258,349,372,430],"least":[172,431],"one":[173,333,344,432],"prior":[174,433],"regimen":[175,434],"disease.":[178],"Secondary":[179],"included":[181],"identifying":[182],"profile":[185],"using":[189],"NCI":[190],"CTCAE4":[191],"reporting":[192],"criteria.":[193],"Patients":[194,223],"received":[195],"daily":[196,267,378],"oral":[197,268],"(2.5":[199],"mg,":[200,202,204],"5":[201,284,294],"7.5":[203],"10":[206,265],"mg).":[207],"Fosbretabulin":[208,416],"administered":[210],"IV":[211,275,384],"60":[212,381],"mg/m2":[213,382],"either":[214],"q3":[215],"weekly":[216,219,273,385],"or":[217,283],"q":[218,352],"based":[220],"PO-CRM.":[222],"were":[224,256,286,291],"treated":[225],"12":[227],"weeks":[228],"with":[229,250,272,365,419],"all":[230,366],"combinations.Results:":[231],"Of":[232],"17":[234],"enrolled,":[236],"16":[237],"completed":[238],"12-week":[240],"trial.":[241],"One":[242],"patient":[243,334,345],"not":[245],"evaluable":[246],"due":[247,323,340],"noncompliance":[249],"treatment":[252,322,339],"regimen.":[253],"No":[254,280],"DLTs":[255],"observed":[257],"day":[259],"21.":[260],"highest":[262],"mg":[266,376],"60mg/m2":[274],"RP2D.":[279,388],"grade":[281,325,367],"4":[282],"toxicities":[285,290,368],"noted.":[287],"Grade":[288],"3":[289,353],"seen":[292],"include":[297],"increased":[298],"abdominal":[299],"pain":[300],"hyperglycemia":[302],"(not":[303],"related":[304],"drug),":[307],"fatigue":[308],"(possibly":[309],"related),":[310],"decreased":[311],"lymphocyte":[312],"count":[313],"anemia":[315],"(related).":[316],"Several":[317],"had":[319,346],"delay":[320],"2":[326],"AE\u2019s":[327],"(GI":[328],"symptoms,":[329],"rash,":[330],"thrombocytopenia)":[331],"unable":[336],"complete":[338],"pneumonitis.":[342],"Only":[343],"radiologic":[347],"progression":[348],"first":[351],"monthly":[354],"CT":[355],"scan":[356],"chest,":[358],"abdomen,":[359],"pelvis.":[361],"detailed":[363],"table":[364],"will":[369],"be":[370],"presented":[371],"meeting.Conclusion:":[374],"Ten":[375],"PO":[377],"plus":[380],"ClinicalTrials.gov":[389],"Identifier:":[390],"NCT0301429Citation":[391],"Format:":[392],"Aman":[393],"Chauhan,":[394],"Susanne":[395],"Arnold,":[396],"John":[397],"Wu,":[398],"Stacey":[399],"Slone,":[400],"Emily":[401],"Dressler,":[402],"Heather":[403],"Flynn,":[404],"Val":[405],"Adams,":[406],"Heidi":[407],"Weiss,":[408],"Lowell":[409],"Anthony.":[410],"(Grades":[424],"1-3)":[425],"disease":[437],"[abstract].":[438],"In:":[439],"Proceedings":[440],"American":[443],"Association":[444],"Cancer":[446,460],"Research":[447],"Annual":[448],"Meeting":[449],"2019;":[450],"2019":[451],"Mar":[452],"29-Apr":[453],"3;":[454],"Atlanta,":[455],"GA.":[456],"Philadelphia":[457],"(PA):":[458],"AACR;":[459],"Res":[461],"2019;79(13":[462],"Suppl):Abstract":[463],"nr":[464],"CT067.":[465]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-07-12T00:00:00"}