{"id":"https://openalex.org/W2954715568","doi":"https://doi.org/10.1016/j.ctro.2019.06.008","title":"EGFR mutant locally advanced non-small cell lung cancer is at increased risk of brain metastasis","display_name":"EGFR mutant locally advanced non-small cell lung cancer is at increased risk of brain metastasis","publication_year":2019,"publication_date":"2019-06-27","ids":{"openalex":"https://openalex.org/W2954715568","doi":"https://doi.org/10.1016/j.ctro.2019.06.008","mag":"2954715568","pmid":"https://pubmed.ncbi.nlm.nih.gov/31341973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6612652"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctro.2019.06.008","doi":"https://doi.org/10.1016/j.ctro.2019.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctro.2019.06.008","pdf_url":"http://www.ctro.science/article/S2405630819300837/pdf","source":{"id":"https://openalex.org/S2898297225","display_name":"Clinical and Translational Radiation Oncology","issn_l":"2405-6308","issn":["2405-6308"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ctro.science/article/S2405630819300837/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018624284","display_name":"Devarati Mitra","orcid":"https://orcid.org/0000-0002-2225-164X","observed_orcids":["https://orcid.org/0000-0002-2225-164X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Devarati Mitra","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101831747","display_name":"Yu\u2010Hui Chen","orcid":"https://orcid.org/0000-0003-4292-698X","observed_orcids":["https://orcid.org/0000-0003-4292-698X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Hui Chen","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618621","display_name":"Richard Li","orcid":"https://orcid.org/0000-0002-9830-0970","observed_orcids":["https://orcid.org/0000-0002-9830-0970"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Li","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017973271","display_name":"Gretchen Hermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gretchen Hermann","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057173854","display_name":"Katelyn M. Atkins","orcid":"https://orcid.org/0000-0002-3165-4803","observed_orcids":["https://orcid.org/0000-0002-3165-4803"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Atkins","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":"https://orcid.org/0000-0002-3165-4803","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075890039","display_name":"David Kozono","orcid":"https://orcid.org/0000-0002-8916-396X","observed_orcids":["https://orcid.org/0000-0002-8916-396X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kozono","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106483495","display_name":"Elizabeth Healey Baldini","orcid":"https://orcid.org/0000-0003-3609-9834","observed_orcids":["https://orcid.org/0000-0003-3609-9834"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth H. Baldini","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051390263","display_name":"Ayal Aaron Aizer","orcid":"https://orcid.org/0000-0002-8941-188X","observed_orcids":["https://orcid.org/0000-0002-8941-188X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayal Aizer","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054361811","display_name":"Ugonma Nnenna Chukwueke","orcid":"https://orcid.org/0000-0003-0598-9535","observed_orcids":["https://orcid.org/0000-0003-0598-9535"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ugonma Chukwueke","raw_affiliation_strings":["Department of Neuro-Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064724289","display_name":"Raymond H. Mak","orcid":"https://orcid.org/0000-0002-8754-0565","observed_orcids":["https://orcid.org/0000-0002-8754-0565"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raymond H. Mak","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018624284","https://openalex.org/A5064724289"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"],"apc_list":{"value":560,"currency":"USD","value_usd":560},"apc_paid":{"value":560,"currency":"USD","value_usd":560},"fwci":2.3899,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.89071404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"18","issue":null,"first_page":"32","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.0851999968290329,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.984000027179718},{"id":"https://openalex.org/keywords/locally-advanced-nsclc","display_name":"locally advanced non-small cell lung cancer","score":0.9079999923706055},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.7390000224113464},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-genotype","display_name":"tumor genotype","score":0.7289999723434448},{"id":"https://openalex.org/keywords/competing-risk-analysis","display_name":"competing risk analysis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cumulative-incidence","display_name":"cumulative incidence","score":0.890999972820282},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.8684355616569519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.857551097869873},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7038717865943909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6739272475242615},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6472405195236206},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.583182692527771},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.501929521560669},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4943578243255615},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.42439964413642883},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3098788261413574},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.07334628701210022}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ctro.2019.06.008","doi":"https://doi.org/10.1016/j.ctro.2019.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctro.2019.06.008","pdf_url":"http://www.ctro.science/article/S2405630819300837/pdf","source":{"id":"https://openalex.org/S2898297225","display_name":"Clinical and Translational Radiation Oncology","issn_l":"2405-6308","issn":["2405-6308"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Radiation Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5603962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6612652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6612652","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6612652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Radiat Oncol","raw_type":"Text"},{"id":"pmid:31341973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31341973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational radiation oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:78f3c86b456a4bbabe964d207ef02d15","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/78f3c86b456a4bbabe964d207ef02d15","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Radiation Oncology, Vol 18, Iss , Pp 32-38 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ctro.2019.06.008","doi":"https://doi.org/10.1016/j.ctro.2019.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctro.2019.06.008","pdf_url":"http://www.ctro.science/article/S2405630819300837/pdf","source":{"id":"https://openalex.org/S2898297225","display_name":"Clinical and Translational Radiation Oncology","issn_l":"2405-6308","issn":["2405-6308"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Radiation Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2954715568.pdf","grobid_xml":"https://content.openalex.org/works/W2954715568.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1988717076","https://openalex.org/W1997601288","https://openalex.org/W2028315898","https://openalex.org/W2038981426","https://openalex.org/W2039202448","https://openalex.org/W2041835001","https://openalex.org/W2057209504","https://openalex.org/W2103043365","https://openalex.org/W2103134572","https://openalex.org/W2119331159","https://openalex.org/W2123406524","https://openalex.org/W2137119609","https://openalex.org/W2142850084","https://openalex.org/W2154996469","https://openalex.org/W2155073814","https://openalex.org/W2164514441","https://openalex.org/W2165459839","https://openalex.org/W2170874935","https://openalex.org/W2172010139","https://openalex.org/W2325642881","https://openalex.org/W2474049609","https://openalex.org/W2515905106","https://openalex.org/W2549236974","https://openalex.org/W2551013093","https://openalex.org/W2562373170","https://openalex.org/W2567746986","https://openalex.org/W2569782115","https://openalex.org/W2581511343","https://openalex.org/W2589049928","https://openalex.org/W2598659203","https://openalex.org/W2748695779","https://openalex.org/W2766679802","https://openalex.org/W2779968386","https://openalex.org/W2790824043","https://openalex.org/W2802952086","https://openalex.org/W2803453251","https://openalex.org/W2803545771","https://openalex.org/W2920467130"],"related_works":["https://openalex.org/W2325642881","https://openalex.org/W1978401308","https://openalex.org/W4410716339","https://openalex.org/W2767842975","https://openalex.org/W2494323406","https://openalex.org/W2733310910","https://openalex.org/W4280566123","https://openalex.org/W2616487303","https://openalex.org/W2946942312","https://openalex.org/W2123753884"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,58],"PURPOSE:":[2],"Small":[3],"studies":[4,28],"of":[5,23,41,96,108,138,160,181,212,222],"primarily":[6],"metastatic":[7],"non-small":[8],"cell":[9],"lung":[10],"cancer":[11],"(NSCLC)":[12],"have":[13,207],"suggested":[14],"an":[15],"association":[16],"between":[17],"EGFR":[18],"mutation":[19],"(EGFR+)":[20],"and":[21,62,84,94,115,120,189,195],"likelihood":[22,211],"brain":[24,42,80,97,139,163,182,214,237],"metastasis.":[25],"However,":[26],"these":[27],"are":[29],"confounded":[30],"by":[31],"follow-up":[32,79,125,164],"time":[33],"bias.":[34],"We":[35],"performed":[36,88],"a":[37,45,102,177,208],"competing":[38,103],"risk":[39,95,137],"analysis":[40],"metastasis":[43,140,183,215],"in":[44,112,141,157,184],"more":[46],"uniform":[47],"locally":[48],"advanced":[49],"NSCLC":[50],"(LA-NSCLC)":[51],"cohort":[52,145],"with":[53,66,99,110,136,162,204,236,243],"known":[54],"tumor":[55,69],"genotype.":[56],"MATERIALS":[57],"METHODS:":[59],"Between":[60],"2002":[61],"2014,":[63],"255":[64],"patients":[65,77,161,186],"LA-NSCLC":[67,206],"underwent":[68],"genotyping":[70],"for":[71],"EGFR,":[72,113],"ALK":[73,114],"and/or":[74,246],"KRAS":[75,116],"(180":[76],"had":[78],"imaging).":[81],"Cumulative":[82],"incidence":[83,180],"Fine-Gray":[85],"regression":[86],"were":[87,117],"on":[89],"clinical":[90],"variables":[91],"including":[92],"genotype":[93],"metastasis,":[98],"death":[100],"as":[101,154,156],"event.":[104],"RESULTS:":[105],"The":[106,123],"proportion":[107],"tumors":[109],"aberrations":[111],"17%,":[118],"4%":[119],"28%,":[121],"respectively.":[122],"median":[124],"was":[126,133],"68":[127],"months.":[128],"On":[129],"multivariate":[130],"analysis,":[131],"EGFR+":[132,185,205],"significantly":[134,209],"associated":[135],"the":[142,158],"full":[143],"patient":[144],"(HR":[146,166],"2.04,":[147],"95%":[148,168],"CI":[149,169],"1.22-3.39,":[150],"p":[151,171,199],"=":[152,172,200],"0.006)":[153],"well":[155],"subset":[159],"imaging":[165],"1.91.":[167],"1.17-3.13,":[170],"0.01).":[173],"This":[174,227],"translated":[175],"to":[176,239],"higher":[178,210],"cumulative":[179],"at":[187],"3":[188],"5":[190],"years":[191],"(33.3%":[192],"vs.":[193,197],"23.2":[194],"43.8%":[196],"24.2%,":[198],"0.006).":[201],"CONCLUSION:":[202],"Patients":[203],"developing":[213],"after":[216],"standard":[217],"combined":[218],"modality":[219],"therapy,":[220],"independent":[221],"their":[223],"longer":[224],"overall":[225],"survival.":[226],"high-risk":[228],"genotypic":[229],"subgroup":[230],"may":[231],"benefit":[232],"from":[233],"routine":[234],"surveillance":[235],"MRI":[238],"allow":[240],"early":[241],"salvage":[242],"targeted":[244],"systemic-":[245],"radiation-therapies.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-07-12T00:00:00"}
