{"id":"https://openalex.org/W2954636060","doi":null,"title":"Systematic Review of the Manifestations of Congenital Rubella Syndrome","display_name":"Systematic Review of the Manifestations of Congenital Rubella Syndrome","publication_year":2019,"publication_date":"2019-03-27","ids":{"openalex":"https://openalex.org/W2954636060","mag":"2954636060"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/40621358","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621358","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621358","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"review","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621358","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068019460","display_name":"Emily A. Simons","orcid":"https://orcid.org/0000-0002-6043-5052","observed_orcids":["https://orcid.org/0000-0002-6043-5052"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emily Simons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6043-5052","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068019460"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00952381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-rubella-syndrome","display_name":"congenital rubella syndrome","score":1.0},{"id":"https://openalex.org/keywords/maternal-rubella","display_name":"maternal rubella infection","score":0.8569999933242798},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.8289999961853027},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ocular-defects","display_name":"eye defects","score":0.6940000057220459},{"id":"https://openalex.org/keywords/disability-adjusted-life-years","display_name":"disability-adjusted life years","score":0.9459999799728394},{"id":"https://openalex.org/keywords/disability-burden","display_name":"disability burden","score":0.6159999966621399},{"id":"https://openalex.org/keywords/unvaccinated-population","display_name":"unvaccinated population","score":0.7990000247955322},{"id":"https://openalex.org/keywords/global-burden-of-disease","display_name":"global burden of disease","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2778814567","wikidata":"https://www.wikidata.org/wiki/Q155857","display_name":"Rubella","level":4,"score":0.6050146222114563},{"id":"https://openalex.org/C2776909254","wikidata":"https://www.wikidata.org/wiki/Q1724539","display_name":"Congenital rubella syndrome","level":5,"score":0.6001704931259155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5296494960784912},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.41733038425445557},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3795398473739624},{"id":"https://openalex.org/C2776438120","wikidata":"https://www.wikidata.org/wiki/Q79793","display_name":"Measles","level":3,"score":0.08986037969589233},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.06200554966926575}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/40621358","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621358","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621358","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:2954636060","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/40621358","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/40621358","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621358","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621358","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[{"id":"https://openalex.org/G6460517698","display_name":"INTEGRATED ECONOMIC, DYNAMIC DISEASE, RISK AND DECISION ANALYTIC","funder_award_id":"U66IP000519","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"}],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2954636060.pdf","grobid_xml":"https://content.openalex.org/works/W2954636060.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W138144936","https://openalex.org/W1247968195","https://openalex.org/W1431572321","https://openalex.org/W1494204496","https://openalex.org/W1501822307","https://openalex.org/W1526179459","https://openalex.org/W1546598478","https://openalex.org/W1555182204","https://openalex.org/W1570276418","https://openalex.org/W1583327662","https://openalex.org/W1617517836","https://openalex.org/W1744641194","https://openalex.org/W1803802834","https://openalex.org/W1823015675","https://openalex.org/W1972146003","https://openalex.org/W1978446630","https://openalex.org/W1983687065","https://openalex.org/W1990431894","https://openalex.org/W1991844388","https://openalex.org/W1995679247","https://openalex.org/W1996576434","https://openalex.org/W2002038815","https://openalex.org/W2011496335","https://openalex.org/W2013050910","https://openalex.org/W2013441353","https://openalex.org/W2016069471","https://openalex.org/W2022606200","https://openalex.org/W2023569938","https://openalex.org/W2024012830","https://openalex.org/W2027245362","https://openalex.org/W2029888713","https://openalex.org/W2031184801","https://openalex.org/W2033294314","https://openalex.org/W2034526230","https://openalex.org/W2037964927","https://openalex.org/W2040069832","https://openalex.org/W2052373110","https://openalex.org/W2054919518","https://openalex.org/W2057023719","https://openalex.org/W2060418828","https://openalex.org/W2060544791","https://openalex.org/W2061931028","https://openalex.org/W2064189073","https://openalex.org/W2067115539","https://openalex.org/W2071694136","https://openalex.org/W2076111115","https://openalex.org/W2076691514","https://openalex.org/W2077751044","https://openalex.org/W2077792528","https://openalex.org/W2079879244","https://openalex.org/W2086308620","https://openalex.org/W2087048446","https://openalex.org/W2088060289","https://openalex.org/W2089275284","https://openalex.org/W2093469271","https://openalex.org/W2108344016","https://openalex.org/W2114951886","https://openalex.org/W2115269123","https://openalex.org/W2116697352","https://openalex.org/W2124482763","https://openalex.org/W2128619120","https://openalex.org/W2133529940","https://openalex.org/W2134833483","https://openalex.org/W2134895227","https://openalex.org/W2137244859","https://openalex.org/W2154221599","https://openalex.org/W2154392344","https://openalex.org/W2160883633","https://openalex.org/W2252633254","https://openalex.org/W2288052656","https://openalex.org/W2328164920","https://openalex.org/W2336557563","https://openalex.org/W2339562853","https://openalex.org/W2409902468","https://openalex.org/W2413125479","https://openalex.org/W2415949044","https://openalex.org/W2420178706","https://openalex.org/W2490847455","https://openalex.org/W4230853509"],"related_works":["https://openalex.org/W1670884544","https://openalex.org/W2021169044","https://openalex.org/W2902057945","https://openalex.org/W1649303599","https://openalex.org/W2361111618","https://openalex.org/W2158969136","https://openalex.org/W7110981605","https://openalex.org/W2751939488","https://openalex.org/W3165816950","https://openalex.org/W2013050910"],"abstract_inverted_index":{"Congenital":[0],"rubella":[1,19,113],"syndrome":[2],"(CRS)":[3],"continues":[4],"to":[5,17,29,43,164,201,212],"cause":[6],"disability":[7,240,256],"among":[8],"unvaccinated":[9],"populations,":[10],"particularly":[11],"in":[12,22,68,148,158,219],"the":[13,35,45,57,74,116,122,128,133,143,159,165,229,243],"62":[14],"countries":[15,150,190,205,224],"yet":[16],"introduce":[18],"vaccine":[20,27],"and":[21,48,61,82,130,161,172,209,221,242,250],"immunized":[23],"populations":[24,89],"with":[25,41,70,102,156,228],"insufficient":[26],"coverage":[28],"prevent":[30],"transmission.":[31],"We":[32,54,95,126,177],"systematically":[33],"reviewed":[34],"literature":[36],"on":[37,73,99,233,247],"birth":[38],"outcomes":[39],"associated":[40],"CRS":[42,77,100,157,171,187,217],"estimate":[44],"duration,":[46],"severity,":[47],"frequency":[49,75],"of":[50,52,76,118,132,142,151,153,167,175,180,191,238,254],"combinations":[51],"morbidities.":[53],"searched":[55],"PubMed,":[56],"Science":[58],"Citation":[59],"Index,":[60],"references":[62],"from":[63,146,198],"relevant":[64],"articles":[65],"for":[66,79,170,189,203],"studies":[67,85,147],"English":[69],"primary":[71],"data":[72,98],"manifestations":[78],"\u226520":[80],"cases":[81,101],"identified":[83,155],"65":[84],"representing":[86],"66":[87],"study":[88],"that":[90],"met":[91],"our":[92],"inclusion":[93],"criteria.":[94],"abstracted":[96],"available":[97,134],"one":[103],"or":[104],"more":[105],"hearing,":[106],"heart,":[107],"and/or":[108],"eye":[109],"defects":[110],"following":[111],"maternal":[112],"infection":[114],"during":[115],"period":[117],"0-20":[119],"weeks":[120],"since":[121],"last":[123],"menstrual":[124],"period.":[125],"assessed":[127],"quality":[129],"weight":[131],"evidence":[135,144],"using":[136],"a":[137],"modified":[138],"GRADE":[139],"approach.":[140],"Most":[141],"originates":[145],"developed":[149,178],"cohorts":[152],"infants":[154],"1960s":[160],"1970s,":[162],"prior":[163],"development":[166],"standardized":[168],"definitions":[169],"widespread":[173],"use":[174],"vaccine.":[176],"estimates":[179,196],"undiscounted":[181],"disability-adjusted":[182],"life-years":[183],"(DALYs)":[184],"lost":[185,215],"per":[186,216],"case":[188,218],"different":[192],"income":[193],"levels.":[194],"The":[195],"ranged":[197],"approximately":[199,210],"26":[200],"38":[202],"high-income":[204],"assuming":[206,225],"optimal":[207],"treatment":[208],"29":[211],"39":[213],"DALYs":[214],"low-":[220],"lower":[222,230],"middle-income":[223],"minimal":[226],"treatment,":[227],"bound":[231,245],"based":[232,246],"2010":[234],"general":[235],"global":[236,252],"burden":[237,253],"disease":[239,255],"weights":[241],"upper":[244],"1990":[248],"age-specific":[249],"treatment-specific":[251],"weights.":[257]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2019-07-12T00:00:00"}