{"id":"https://openalex.org/W2954570175","doi":"https://doi.org/10.1097/01.hj.0000575368.59228.dd","title":"Intracochlear Steroid Delivery to Prevent Cisplatin-Dependent Hearing Loss","display_name":"Intracochlear Steroid Delivery to Prevent Cisplatin-Dependent Hearing Loss","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2954570175","doi":"https://doi.org/10.1097/01.hj.0000575368.59228.dd","mag":"2954570175"},"language":"en","primary_location":{"id":"doi:10.1097/01.hj.0000575368.59228.dd","doi":"https://doi.org/10.1097/01.hj.0000575368.59228.dd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hj.0000575368.59228.dd","pdf_url":null,"source":{"id":"https://openalex.org/S2764881414","display_name":"The Hearing Journal","issn_l":"0745-7472","issn":["0745-7472","2333-6218"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Hearing Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019949606","display_name":"Erik D. Pierstorff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147379","display_name":"O-Ray Pharma (United States)","ror":"https://ror.org/03gy7zk94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147379"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erik Pierstorff","raw_affiliation_strings":["Dr. Pierstorff'sresearch interests have focused on the intersection of the biotic and abiotic, spanning molecular and cell biology, gene therapy, nanomaterials, and drug delivery. For the past nine years at O-Ray Pharma, he has focused on integrating biology and biomedical engineering for the goal of drug development and sustained drug delivery for the treatment of hearing loss and other ear disorders"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Pierstorff'sresearch interests have focused on the intersection of the biotic and abiotic, spanning molecular and cell biology, gene therapy, nanomaterials, and drug delivery. For the past nine years at O-Ray Pharma, he has focused on integrating biology and biomedical engineering for the goal of drug development and sustained drug delivery for the treatment of hearing loss and other ear disorders","institution_ids":["https://openalex.org/I4210147379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019949606"],"corresponding_institution_ids":["https://openalex.org/I4210147379"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06726457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"7","first_page":"30,31","last_page":"30,31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin-ototoxicity","display_name":"cisplatin ototoxicity","score":0.968999981880188},{"id":"https://openalex.org/keywords/cisplatin-induced-hearing-loss","display_name":"cisplatin-induced hearing loss","score":0.9129999876022339},{"id":"https://openalex.org/keywords/intracochlear-drug-delivery","display_name":"intracochlear drug delivery","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fluticasone-propionate","display_name":"fluticasone propionate","score":0.8510000109672546},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5809999704360962},{"id":"https://openalex.org/keywords/otoprotection","display_name":"otoprotection","score":0.8759999871253967},{"id":"https://openalex.org/keywords/inner-ear-drug-delivery","display_name":"inner ear drug delivery","score":0.5770000219345093},{"id":"https://openalex.org/keywords/outer-hair-cells","display_name":"outer hair cells","score":0.671999990940094},{"id":"https://openalex.org/keywords/auditory-brainstem-response","display_name":"auditory brainstem response","score":0.7170000076293945},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.5059999823570251},{"id":"https://openalex.org/keywords/pediatric-cancer-patients","display_name":"pediatric cancer patients","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.9068793058395386},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.7661606073379517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7524629831314087},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.46287089586257935},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.4454207122325897},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.4357988238334656},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.35939162969589233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.313146710395813},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.11664572358131409}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.hj.0000575368.59228.dd","doi":"https://doi.org/10.1097/01.hj.0000575368.59228.dd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hj.0000575368.59228.dd","pdf_url":null,"source":{"id":"https://openalex.org/S2764881414","display_name":"The Hearing Journal","issn_l":"0745-7472","issn":["0745-7472","2333-6218"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Hearing Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1747250944","https://openalex.org/W2026040720","https://openalex.org/W2050292508","https://openalex.org/W2059998155","https://openalex.org/W2083888986","https://openalex.org/W2110043256","https://openalex.org/W2156234545","https://openalex.org/W2466806233"],"related_works":["https://openalex.org/W2802978377","https://openalex.org/W2888224333","https://openalex.org/W3209879222","https://openalex.org/W4396545609","https://openalex.org/W4224983146","https://openalex.org/W4415152858","https://openalex.org/W4409063781","https://openalex.org/W2923454124","https://openalex.org/W2325489171","https://openalex.org/W2599531942"],"abstract_inverted_index":{"As":[0],"cancer":[1,18,1051],"treatment":[2,222,439,1100],"continues":[3],"to":[4,74,87,97,112,126,175,323,365,380,386,456,475,493,538,543,606,636,641,783,816,822,895,965,1003,1036,1059],"advance,":[5],"more":[6,124,653,675,1095],"emphasis":[7],"has":[8,299,578],"been":[9,300,516],"placed":[10],"on":[11,197,204,1044],"improving":[12],"the":[13,52,56,63,99,104,109,127,151,163,171,282,303,316,329,342,381,387,401,417,421,426,443,461,471,476,480,487,498,505,519,525,544,556,565,570,585,590,615,647,698,704,711,718,727,740,744,750,756,759,771,779,786,801,808,811,846,863,872,884,933,956,966,972,1028,1045,1064,1067,1083,1099],"quality":[14,1046],"of":[15,17,44,58,65,78,130,153,170,289,305,319,331,389,440,442,479,489,507,522,551,559,587,595,611,632,656,682,701,707,717,739,753,758,778,848,865,891,958,975,990,1012,1023,1047,1049,1066,1087,1101],"life":[16,1048],"patients.":[19],"While":[20],"many":[21,485,1050],"chemotherapeutic":[22,67],"agents":[23,448,453],"are":[24,123,311,454,584,981,1056,1070],"effective,":[25],"they":[26,985],"may":[27,345,994],"also":[28,814],"come":[29],"with":[30,48,62,190,258,328,337,347,373,661,767,932],"serious":[31],"side":[32,557,1016],"effects":[33,129,558,1017],"that":[34,341,395,660,834,987,1082],"can":[35,137,145,161,397,563,604,670,1014,1039,1090],"have":[36,146,393,515,839,1040],"debilitating":[37],"consequences":[38],"during":[39],"and":[40,90,102,141,166,173,226,264,533,535,562,593,639,664,674,799,871,905,971,999,1030,1072,1094,1105],"following":[41,220,430,464,734,807,908],"a":[42,76,332,407,541,612,652,672,735,878,997,1041,1073,1092],"course":[43],"treatment.":[45],"An":[46],"area":[47,388],"increased":[49],"interest":[50],"over":[51],"past":[53],"decade":[54],"is":[55,95,156,321,340,449,622,651,831,1078],"prevention":[57,304],"hearing":[59,120,177,209,244,307,683,897,917,925,1006,1061,1103],"loss":[60,134,210,586,915,1104],"associated":[61],"administration":[64,339,364,576,1011],"platinum-based":[66],"drugs,":[68],"especially":[69,1053],"cisplatin.":[70],"Cisplatin,":[71],"commonly":[72],"used":[73,876],"treat":[75],"variety":[77],"solid":[79],"tumors,":[80],"acts":[81],"primarily":[82,113],"by":[83],"facilitating":[84],"DNA":[85],"damage":[86],"prevent":[88,416,1004,1021],"replication":[89],"induce":[91,896],"apoptosis.1":[92],"Unfortunately,":[93],"cisplatin":[94,154,203,221,242,338,348,374,396,418,768,780,892,909],"able":[96],"traverse":[98],"blood-labyrinthine":[100,472],"barrier":[101,478],"access":[103],"inner":[105,402,444,462,468,499,571,616,705,1107],"ear.":[106],"Once":[107,1063],"there,":[108],"drug":[110,298,491,542,575,613,668,802],"appears":[111],"attack":[114],"outer":[115],"hair":[116],"cells,":[117],"causing":[118],"permanent":[119],"loss.2-6":[121],"Children":[122],"susceptible":[125,1058],"ototoxic":[128],"cisplatin.7,":[131],"8":[132],"Hearing":[133,899],"in":[135,213,252,312,400,425,460,497,569,614,749,764,842,850,868,916,929,983,1027],"children":[136,1054],"impact":[138],"their":[139],"social":[140],"academic":[142],"progress,":[143],"which":[144,603],"long-term":[147,699],"effects.":[148],"However,":[149],"reducing":[150],"levels":[152,459,488,496,567,610,716],"administered":[155,202,378,560],"not":[157,371,625,952],"recommended,":[158],"as":[159,770,821,877],"this":[160,650,686,851,857],"reduce":[162,168,555,1015],"tumor":[164],"response":[165,183,921],"thus":[167],"control":[169],"disease":[172],"lead":[174,605],"reoccurrence.chemotheraphy,":[176],"loss,":[178],"cancerFigure":[179],"1:":[180],"Auditory":[181],"brainstem":[182,920],"(ABR)":[184],"thresholds.":[185],"Animals":[186,200],"were":[187,201,723,860,886],"unilaterally":[188],"implanted":[189,257,794,861,931],"intracochlear":[191,667,737,1010,1085],"controlled":[192,787],"release":[193,540,695,788,809],"fluticasone":[194,720,761,789,824,849,935,992],"propionate":[195,721],"micro-pellets":[196,259,696,790,859,993,1089],"Day":[198,205],"1.":[199],"14.":[206],"Statistically":[207,923],"significant":[208,250,914,924],"was":[211,247,635,762,782,853,875,900,927,940,951,963],"seen":[212],"No":[214],"Surgery":[215],"ears":[216,256,912,930],"(no":[217],"micro-pellet":[218,1068],"control)":[219],"between":[223,255,261],"day":[224,227,262,265],"14":[225,263],"28:":[228,266],"23.9":[229],"\u00b1":[230,235,268,273],"2.3":[231],"dB":[232,270],"vs.":[233,271],"40.7":[234],"2.5":[236],"dB;":[237],"P":[238,276],"\u2264":[239],"0.0001,":[240],"demonstrating":[241,279],"dependent":[243],"loss.":[245,308,684,898,1007,1062],"There":[246],"no":[248,297],"statistically":[249],"difference":[251],"ABR":[253],"threshold":[254],"(Implant)":[260],"25.6":[267],"1.3":[269],"25.0":[272],"3.1":[274],"dB,":[275],"\u2265":[277],"0.85,":[278],"otoprotection":[280],"from":[281,419,810,1018,1034],"micro-pellets.":[283,812,936],"Stars":[284],"indicate":[285],"statistical":[286,949,959],"significance.Table:":[287],"Comparison":[288],"Methods":[290],"for":[291,302,404,428,518,678,697,729,961,1098],"Inner":[292],"Ear":[293],"Drug":[294],"AdministrationAt":[295],"present,":[296],"approved":[301],"cisplatin-dependent":[306,828,1005,1060,1102],"Multiple":[309],"therapies":[310],"human":[313],"trials":[314],"but":[315,370,845],"clinical":[317],"success":[318],"these":[320,511,552,979,1088],"yet":[322],"be":[324,377,398,671,792,805,1091],"determined.":[325],"One":[326],"issue":[327],"use":[330,360],"systemic":[333,363,465,490,502,1019],"otoprotective":[334,343,356,840],"agent":[335,344,357],"concurrently":[336],"interfere":[346,372],"activity,":[349],"making":[350],"it":[351],"less":[352],"effective.":[353],"Therefore,":[354],"any":[355,411],"must":[358,414],"either":[359,415],"closely":[361],"timed":[362],"elicit":[366],"its":[367,384,579],"protective":[368],"effect":[369,1043],"activity":[375,385,757,803,841,1026],"or":[376,423],"directly":[379,645],"ear,":[382,572],"localizing":[383],"need.":[390],"Recent":[391],"studies":[392,980],"demonstrated":[394],"retained":[399,806],"ear":[403,422,427,445,463,469,500,574,617,706,867,874,1108],"months":[405,429,733],"after":[406],"single":[408,736],"administration.9":[409],"Thus,":[410,619],"effective":[412,676,1096],"otoprotectant":[413],"reaching":[420],"remain":[424],"administration.":[431,466,910],"GETTING":[432],"DRUGS":[433],"INTO":[434],"THE":[435],"INNER":[436],"EAR":[437],"The":[438,467,630,776,1008],"maladies":[441],"using":[446],"pharmaceutical":[447,680],"challenging.":[450],"Many":[451],"therapeutic":[452,458,495,566,1001],"unable":[455],"achieve":[457,494],"contains":[470],"barrier,":[473],"analogous":[474],"blood-brain":[477],"central":[481],"nervous":[482],"system.":[483],"In":[484,710,743,856],"cases,":[486],"needed":[492],"cause":[501],"toxicity,":[503],"limiting":[504],"practicality":[506],"dosing.":[508],"To":[509,685],"circumvent":[510],"problems,":[512],"multiple":[513,691],"techniques":[514],"developed":[517],"local":[520],"delivery":[521,669,700],"drugs":[523,561,588],"into":[524,646,703,726,795,862,996],"middle":[526,545,573],"ear.10-19":[527],"These":[528],"include":[529],"intratympanic":[530],"injections,":[531],"micropumps":[532],"wicks,":[534],"depot":[536],"systems":[537],"slowly":[539],"ear/round":[546],"window":[547],"niche.":[548],"Although":[549,649,978],"all":[550],"methods":[553,638],"generally":[554],"enhance":[564],"achieved":[568],"still":[577],"shortcomings.20,":[580],"21":[581],"Most":[582],"notable":[583],"down":[589],"Eustachian":[591],"tube":[592],"variability":[594,974],"patient":[596,1035],"anatomy":[597],"(bony":[598],"protrusions,":[599],"false":[600],"membranes,":[601],"etc.),":[602],"having":[607],"highly":[608],"variable":[609],"fluid.":[618],"accurate":[620],"dosing":[621,1033],"difficult,":[623],"if":[624,785,800],"impossible.":[626],"INTRACOCHLEAR":[627],"DRUG":[628],"DELIVERY":[629],"goal":[631,777],"our":[633],"group":[634],"develop":[637],"technologies":[640],"safely":[642,724,793],"administer":[643],"therapeutics":[644],"cochlea.":[648],"invasive":[654,1075],"route":[655],"administration,":[657,904,1020],"we":[658,688,1080],"believe":[659,955,1081],"enhanced":[662],"technology":[663],"surgical":[665,1076],"techniques,":[666],"safe":[673,998,1093],"method":[677,1097],"delivering":[679],"interventions":[681],"end,":[687],"recently":[689,747],"published":[690,748],"reports":[692],"highlighting":[693],"extended":[694],"steroids":[702,1013],"guinea":[708,765,796],"pigs.":[709],"first":[712],"study,":[713,858],"very":[714],"consistent":[715,1032],"steroid":[719],"(fluticasone)":[722],"delivered":[725],"perilymph":[728],"at":[730],"least":[731],"three":[732],"implantation":[738,989,1086],"controlled-release":[741,934,991],"micro-pellets.22":[742],"follow-up":[745],"report":[746],"International":[751],"Journal":[752],"Pediatric":[754],"Otorhinolaryngology,23":[755],"released":[760],"tested":[763],"pigs,":[766],"ototoxicity":[769],"outcome":[772],"measure.":[773],"STUDY":[774],"HIGHLIGHTS":[775],"study":[781],"test":[784],"could":[791,804,825],"pig":[797],"cochleae":[798,864],"We":[813,954],"wanted":[815],"perform":[817],"an":[818,888],"initial":[819],"assessment":[820],"whether":[823],"protect":[826],"against":[827],"ototoxicity.":[829],"It":[830],"well":[832],"known":[833],"other":[835,1106],"corticosteroids":[836],"(i.e.,":[837],"dexamethasone)":[838],"animal":[843],"models,":[844],"effectiveness":[847],"scenario":[852],"previously":[854],"untested.":[855],"one":[866],"healthy":[869],"animals,":[870],"contralateral":[873],"non-implanted":[879],"control.":[880],"After":[881],"two":[882,906],"weeks,":[883],"animals":[885],"given":[887],"intraperitoneal":[889],"injection":[890],"sufficient":[893],"enough":[894],"assessed":[901],"pre-surgery,":[902],"pre-cisplatin":[903],"weeks":[907],"Non-implanted":[911],"showed":[913],"via":[918,942],"auditory":[919],"(ABR).":[922],"preservation":[926],"observed":[928,941],"A":[937],"similar":[938],"trend":[939],"distortion":[943],"product":[944],"otoacoustic":[945],"emissions":[946],"(DPOAEs),":[947],"though":[948],"significance":[950,960],"achieved.":[953],"lack":[957],"DPOAEs":[962],"due":[964],"study's":[967],"small":[968],"sample":[969],"size":[970],"higher":[973],"DPOAE":[976],"measurements.":[977],"preliminary":[982],"nature,":[984],"suggest":[986],"intra-cochlear":[988],"evolve":[995],"viable":[1000],"option":[1002],"direct":[1009,1084],"interference":[1022],"cisplatin's":[1024],"anti-cancer":[1025],"body,":[1029],"provide":[1031],"patient.":[1037],"This":[1038],"profound":[1042],"patients,":[1052],"who":[1055],"particularly":[1057],"safety":[1065],"components":[1069],"confirmed":[1071],"minimally":[1074],"technique":[1077],"developed,":[1079],"disorders.":[1109]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-07-12T00:00:00"}
