{"id":"https://openalex.org/W2954534864","doi":null,"title":"Quantitative proteome analysis of oral tongue squamous cell carcinoma by laser capture microdissection, stable isotope labeling and liquid chromatography-mass spectrometry.","display_name":"Quantitative proteome analysis of oral tongue squamous cell carcinoma by laser capture microdissection, stable isotope labeling and liquid chromatography-mass spectrometry.","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2954534864","mag":"2954534864"},"language":"en","primary_location":{"id":"mag:2954534864","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/65/9_Supplement/93.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027299217","display_name":"Shen Hu","orcid":"https://orcid.org/0000-0001-9488-0376","observed_orcids":["https://orcid.org/0000-0001-9488-0376"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shen Hu","raw_affiliation_strings":["UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA"],"raw_orcid":"https://orcid.org/0000-0001-9488-0376","affiliations":[{"raw_affiliation_string":"UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049065273","display_name":"Xiaofeng C. Zhou","orcid":"https://orcid.org/0000-0002-4047-6228","observed_orcids":["https://orcid.org/0000-0002-4047-6228"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Zhou","raw_affiliation_strings":["UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA"],"raw_orcid":"https://orcid.org/0000-0002-4047-6228","affiliations":[{"raw_affiliation_string":"UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069655890","display_name":"Bao-Lin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bao-Lin Huang","raw_affiliation_strings":["UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003299197","display_name":"Joseph A. Loo","orcid":"https://orcid.org/0000-0001-9989-1437","observed_orcids":["https://orcid.org/0000-0001-9989-1437"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Loo","raw_affiliation_strings":["UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA"],"raw_orcid":"https://orcid.org/0000-0001-9989-1437","affiliations":[{"raw_affiliation_string":"UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087543035","display_name":"David T. Wong","orcid":"https://orcid.org/0000-0002-0290-2206","observed_orcids":["https://orcid.org/0000-0002-0290-2206"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Wong","raw_affiliation_strings":["UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA"],"raw_orcid":"https://orcid.org/0000-0002-0290-2206","affiliations":[{"raw_affiliation_string":"UCLA School of Dentistry, Los Angeles, CA and UCLA Mass Spec and Proteomics Center, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.28357845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"65","issue":null,"first_page":"93","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-tongue-squamous-cell-carcinoma","display_name":"oral tongue squamous cell carcinoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/quantitative-proteomics","display_name":"quantitative proteomics","score":0.7850000262260437},{"id":"https://openalex.org/keywords/laser-capture-microdissection","display_name":"laser capture microdissection","score":0.8479999899864197},{"id":"https://openalex.org/keywords/stable-isotope-labeling","display_name":"stable isotope labeling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/itraq","display_name":"iTRAQ","score":0.9150000214576721},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.902999997138977},{"id":"https://openalex.org/keywords/tumor-associated-proteins","display_name":"tumor-associated proteins","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cell-cycle-proteins","display_name":"cell cycle proteins","score":0.9309999942779541},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.9129999876022339},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.877976655960083},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7491766214370728},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.593127429485321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5824238061904907},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5624821186065674},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5345375537872314},{"id":"https://openalex.org/C11242284","wikidata":"https://www.wikidata.org/wiki/Q4293202","display_name":"Microdissection","level":3,"score":0.5231834053993225},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47662341594696045},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4584400951862335},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4402182698249817},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42989444732666016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34287166595458984},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.31397536396980286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31085556745529175},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17602071166038513},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06737568974494934},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2954534864","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/65/9_Supplement/93.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977651481","https://openalex.org/W2087586988","https://openalex.org/W1879882968","https://openalex.org/W7220420765","https://openalex.org/W2051143564","https://openalex.org/W2351542550","https://openalex.org/W2351399546","https://openalex.org/W3036427329","https://openalex.org/W3145508063","https://openalex.org/W1998102655"],"abstract_inverted_index":{"400":[0],"Quantitative":[2],"proteome":[3],"analysis":[4],"of":[5,27,30,41,104,133,177],"tongue":[6,128],"squamous":[7],"cell":[8,146],"carcinoma":[9],"was":[10],"performed":[11],"by":[12,93,182],"using":[13,47],"laser":[14],"capture":[15],"microdissection":[16],"(LCM)":[17],"and":[18,57,68,80,90,100,119,186],"mass":[19],"spectrometry.":[20],"LCM":[21],"allowed":[22],"for":[23,97,157],"the":[24,168],"one-step":[25],"procurement":[26],"homogeneous":[28],"populations":[29],"normal/tumor":[31],"epithelial":[32],"cells":[33,44],"from":[34],"tissue":[35],"sections.":[36],"The":[37,72],"protein":[38,63,98],"expression":[39,138],"profiles":[40],"dissected":[42],"normal/cancer":[43,149],"were":[45,65,75,87,107,140],"examined":[46,154],"a":[48],"quantitative":[49],"proteomics":[50],"approach":[51],"based":[52],"on":[53],"stable":[54],"isotope":[55],"labeling":[56],"liquid":[58],"chromatography-mass":[59],"spectrometry":[60],"(LC-MS).":[61],"Both":[62,84],"extracts":[64],"reduced,":[66],"alkylated":[67],"digested":[69],"with":[70,77],"trypsin.":[71],"resulting":[73],"peptides":[74,86],"labeled":[76,85],"iTRAQ":[78],"114":[79],"117":[81],"reagents,":[82],"respectively.":[83],"then":[88],"combined":[89],"analyzed":[91],"simultaneously":[92],"nanoflow":[94],"LC-QTOF":[95],"MS":[96],"identification":[99],"quantitation.":[101],"A":[102,131],"total":[103],"115":[105],"proteins":[106,125,134,158,166],"found":[108,141],"to":[109,142,155,170],"be":[110,143,171],"differentially":[111,162],"expressed,":[112],"including":[113],"37":[114],"up-regulated":[115],"(1.2-3":[116],"fold":[117,123],"change)":[118,124],"78":[120],"down-regulated":[121],"(1.2-4":[122],"in":[126],"human":[127],"cancer":[129],"tissue.":[130],"number":[132],"altered":[135],"at":[136],"their":[137],"levels":[139],"tumor-":[144],"or":[145],"cycle-associated.":[147],"Additional":[148],"subjects":[150],"are":[151,160],"currently":[152],"being":[153],"search":[156],"that":[159],"significantly":[161],"expressed.":[163],"These":[164],"tumor-related":[165],"hold":[167],"potential":[169],"diagnostic":[172],"biomarkers":[173],"and/or":[174],"therapeutic":[175],"targets":[176],"this":[178],"specific":[179],"cancer.":[180],"Supported":[181],"PHS":[183],"grants":[184],"RO1-DE15970":[185],"UO1-":[187],"DE016275.":[188]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2019-07-12T00:00:00"}
