{"id":"https://openalex.org/W2954520245","doi":"https://doi.org/10.1158/1538-7445.am2019-lb-065","title":"Abstract LB-065: A high quality neoantigen fitness model cooperates with T lymphocyte infiltrates to identify glioblastoma patients with the longest survival","display_name":"Abstract LB-065: A high quality neoantigen fitness model cooperates with T lymphocyte infiltrates to identify glioblastoma patients with the longest survival","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2954520245","doi":"https://doi.org/10.1158/1538-7445.am2019-lb-065","mag":"2954520245"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-lb-065","doi":"https://doi.org/10.1158/1538-7445.am2019-lb-065","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-lb-065","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100640288","display_name":"Jing Zhang","orcid":"https://orcid.org/0000-0003-2265-565X","observed_orcids":["https://orcid.org/0000-0003-2265-565X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Zhang","raw_affiliation_strings":["1Columbia Univ., New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia Univ., New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090470125","display_name":"Francesca Pia Caruso","orcid":"https://orcid.org/0000-0002-2206-1459","observed_orcids":["https://orcid.org/0000-0002-2206-1459"]},"institutions":[{"id":"https://openalex.org/I16337185","display_name":"University of Sannio","ror":"https://ror.org/04vc81p87","country_code":"IT","type":"education","lineage":["https://openalex.org/I16337185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca P. Caruso","raw_affiliation_strings":["2Universita' degli Studi del Sannio, Benevento, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Universita' degli Studi del Sannio, Benevento, Italy;","institution_ids":["https://openalex.org/I16337185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069767881","display_name":"Jason K. Sa","orcid":"https://orcid.org/0000-0002-3251-5004","observed_orcids":["https://orcid.org/0000-0002-3251-5004"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jason K. Sa","raw_affiliation_strings":["3Samsung Medical Center, Seoul, Republic of Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Samsung Medical Center, Seoul, Republic of Korea;","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070388321","display_name":"Sune F. L. Justesen","orcid":"https://orcid.org/0000-0002-3039-2178","observed_orcids":["https://orcid.org/0000-0002-3039-2178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sune Justesen","raw_affiliation_strings":["4Immunitrack Aps, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Immunitrack Aps, Copenhagen, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018929039","display_name":"Do\u2010Hyun Nam","orcid":"https://orcid.org/0000-0003-3053-644X","observed_orcids":["https://orcid.org/0000-0003-3053-644X"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do-Hyun Nam","raw_affiliation_strings":["3Samsung Medical Center, Seoul, Republic of Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Samsung Medical Center, Seoul, Republic of Korea;","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066080208","display_name":"Peter A. Sims","orcid":"https://orcid.org/0000-0002-3921-4837","observed_orcids":["https://orcid.org/0000-0002-3921-4837"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Sims","raw_affiliation_strings":["1Columbia Univ., New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia Univ., New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085527072","display_name":"Michele Ceccarelli","orcid":"https://orcid.org/0000-0002-4702-6617","observed_orcids":["https://orcid.org/0000-0002-4702-6617"]},"institutions":[{"id":"https://openalex.org/I16337185","display_name":"University of Sannio","ror":"https://ror.org/04vc81p87","country_code":"IT","type":"education","lineage":["https://openalex.org/I16337185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Ceccarelli","raw_affiliation_strings":["2Universita' degli Studi del Sannio, Benevento, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Universita' degli Studi del Sannio, Benevento, Italy;","institution_ids":["https://openalex.org/I16337185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053349450","display_name":"Anna Lasorella","orcid":"https://orcid.org/0000-0002-1839-5421","observed_orcids":["https://orcid.org/0000-0002-1839-5421"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Lasorella","raw_affiliation_strings":["1Columbia Univ., New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia Univ., New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078024735","display_name":"Antonio Iavarone","orcid":"https://orcid.org/0000-0002-0683-4634","observed_orcids":["https://orcid.org/0000-0002-0683-4634"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Iavarone","raw_affiliation_strings":["1Columbia Univ., New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia Univ., New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"LB","last_page":"065"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.49950000643730164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.49950000643730164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.4860999882221222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.9049999713897705},{"id":"https://openalex.org/keywords/patient-survival-prediction","display_name":"patient survival prediction","score":0.6119999885559082},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.7379999756813049},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.6669999957084656},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6238089203834534},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5903140902519226},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5795556306838989},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5204998850822449},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5191863775253296},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.513340175151825},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47398367524147034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41483891010284424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3970675468444824},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3827401399612427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2947513461112976}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-lb-065","doi":"https://doi.org/10.1158/1538-7445.am2019-lb-065","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-lb-065","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2941709580","https://openalex.org/W3186955049","https://openalex.org/W7140645228","https://openalex.org/W4303437774","https://openalex.org/W4390422147","https://openalex.org/W4245820246","https://openalex.org/W2959500507","https://openalex.org/W4415940841","https://openalex.org/W7162545841","https://openalex.org/W3010265110"],"abstract_inverted_index":{"Abstract":[0],"Malignant":[1],"glioma":[2],"(glioblastoma,":[3],"GBM)":[4],"is":[5],"a":[6,24,69,106,125],"lethal":[7],"cancer":[8],"resistant":[9],"to":[10,30,205],"multimodality":[11],"therapeutic":[12],"approaches.":[13],"A":[14,194],"high":[15,77,195],"burden":[16,123],"of":[17,39,76,101,108,132,140,169,216],"tumor-specific":[18],"mutant":[19],"peptides":[20],"(neoantigens)":[21],"correlates":[22],"with":[23,91,98,111,201,209],"more":[25,92],"favorable":[26,93],"prognosis":[27],"and":[28,41,62,67,156,166],"response":[29],"immunotherapies":[31],"in":[32,47,80],"selected":[33],"solid":[34],"tumors":[35,49],"but":[36],"the":[37,57,74,112,129,149,210,217],"role":[38],"neoantigens":[40,61,79],"how":[42],"they":[43],"impact":[44],"clinical":[45,94],"outcome":[46,95],"most":[48],"including":[50],"GBM":[51,89,109,141,144,170],"remains":[52],"unclear.":[53],"Here,":[54],"we":[55],"exploited":[56],"similarity":[58],"between":[59],"tumor":[60,99,121],"infectious":[63],"disease-derived":[64],"immune":[65],"epitopes":[66],"applied":[68],"neoantigen":[70,84,122,150,197],"fitness":[71,86,198],"model":[72,87,127,152,199],"for":[73,164,220],"identification":[75],"quality":[78,85,151,196],"human":[81],"GBM.":[82],"The":[83,143],"stratified":[88],"patients":[90,110,208],"and,":[96],"together":[97],"infiltration":[100],"CD8":[102,133],"T":[103,134,202],"lymphocytes,":[104],"identified":[105],"subgroup":[107,145],"longest":[113,211],"survival,":[114],"thus":[115],"exhibiting":[116],"optimal":[117],"performance.":[118],"Conversely,":[119],"neither":[120],"from":[124,148],"quantity":[126],"nor":[128],"isolated":[130],"enrichment":[131],"lymphocytes":[135],"could":[136],"predict":[137],"better":[138],"survival":[139,212],"patients.":[142,171],"that":[146,159],"emerged":[147],"displays":[153],"distinct":[154],"genomic":[155],"transcriptomic":[157],"features":[158],"should":[160],"guide":[161],"patient":[162],"stratification":[163],"immunotherapy":[165],"maximal":[167],"benefit":[168],"Citation":[172],"Format:":[173],"Jing":[174],"Zhang,":[175],"Francesca":[176],"P.":[177],"Caruso,":[178],"Jason":[179],"K.":[180],"Sa,":[181],"Sune":[182],"Justesen,":[183],"Do-Hyun":[184],"Nam,":[185],"Peter":[186],"Sims,":[187],"Michele":[188],"Ceccarelli,":[189],"Anna":[190],"Lasorella,":[191],"Antonio":[192],"Iavarone.":[193],"cooperates":[200],"lymphocyte":[203],"infiltrates":[204],"identify":[206],"glioblastoma":[207],"[abstract].":[213],"In:":[214],"Proceedings":[215],"American":[218],"Association":[219],"Cancer":[221,235],"Research":[222],"Annual":[223],"Meeting":[224],"2019;":[225],"2019":[226],"Mar":[227],"29-Apr":[228],"3;":[229],"Atlanta,":[230],"GA.":[231],"Philadelphia":[232],"(PA):":[233],"AACR;":[234],"Res":[236],"2019;79(13":[237],"Suppl):Abstract":[238],"nr":[239],"LB-065.":[240]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-12T00:00:00"}
