{"id":"https://openalex.org/W2954469253","doi":"https://doi.org/10.1016/j.hlc.2019.06.453","title":"Eukaryotic Elongation Factor 2 Kinase (eEF2k) Regulates Cholesterol Uptake by Macrophages via CD36 Scavenger Receptor Expression","display_name":"Eukaryotic Elongation Factor 2 Kinase (eEF2k) Regulates Cholesterol Uptake by Macrophages via CD36 Scavenger Receptor Expression","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2954469253","doi":"https://doi.org/10.1016/j.hlc.2019.06.453","mag":"2954469253"},"language":"en","primary_location":{"id":"doi:10.1016/j.hlc.2019.06.453","doi":"https://doi.org/10.1016/j.hlc.2019.06.453","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.hlc.2019.06.453","pdf_url":null,"source":{"id":"https://openalex.org/S119123570","display_name":"Heart Lung and Circulation","issn_l":"1443-9506","issn":["1443-9506","1444-2892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart, Lung and Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103236811","display_name":"Sanuja Fernando","orcid":"https://orcid.org/0000-0002-4766-2250","observed_orcids":["https://orcid.org/0000-0002-4766-2250"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"S. Fernando","raw_affiliation_strings":["SAHMRI, Adelaide, Australia","The University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"The University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066016421","display_name":"Nisha Schwarz","orcid":"https://orcid.org/0000-0003-1551-3645","observed_orcids":["https://orcid.org/0000-0003-1551-3645"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"N. Schwarz","raw_affiliation_strings":["SAHMRI, Adelaide, Australia","The University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"The University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017183758","display_name":"Lauren Sandeman","orcid":"https://orcid.org/0000-0001-7721-6879","observed_orcids":["https://orcid.org/0000-0001-7721-6879"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"L. Sandeman","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053591320","display_name":"T. Skoumbourdis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"T. Skoumbourdis","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007071008","display_name":"J. Zareh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. Zareh","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066596302","display_name":"A. Williamson","orcid":"https://orcid.org/0009-0000-7016-7859","observed_orcids":["https://orcid.org/0009-0000-7016-7859"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. Williamson","raw_affiliation_strings":["SAHMRI, Adelaide, Australia","The University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"The University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055522361","display_name":"Catherine G. Dimasi","orcid":"https://orcid.org/0000-0001-9907-2909","observed_orcids":["https://orcid.org/0000-0001-9907-2909"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"C. Dimasi","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052106992","display_name":"Deborah Toledo\u2010Flores","orcid":"https://orcid.org/0000-0003-1899-0914","observed_orcids":["https://orcid.org/0000-0003-1899-0914"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D. Toledo","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108027515","display_name":"Joanne T. M. Tan","orcid":"https://orcid.org/0000-0003-1875-4882","observed_orcids":["https://orcid.org/0000-0003-1875-4882"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. Tan","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076994136","display_name":"B. Diartolo B","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"B. Diartolo B","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085190525","display_name":"Christina A. Bursill","orcid":"https://orcid.org/0000-0002-0682-8760","observed_orcids":["https://orcid.org/0000-0002-0682-8760","https://orcid.org/0000-0003-1087-7781"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"C. Bursill","raw_affiliation_strings":["SAHMRI, Adelaide, Australia","The University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"The University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055849986","display_name":"Stephen James Nicholls","orcid":"https://orcid.org/0000-0002-9668-4368","observed_orcids":["https://orcid.org/0000-0002-9668-4368"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. Nicholls","raw_affiliation_strings":["SAHMRI, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030513468","display_name":"Christopher G. Proud","orcid":"https://orcid.org/0000-0003-0704-6442","observed_orcids":["https://orcid.org/0000-0003-0704-6442"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"C. Proud","raw_affiliation_strings":["SAHMRI, Adelaide, Australia","The University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"The University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026826649","display_name":"Peter Psaltis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P. Psaltis","raw_affiliation_strings":["SAHMRI, Adelaide, Australia","The University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAHMRI, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"The University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103236811"],"corresponding_institution_ids":["https://openalex.org/I4210137740","https://openalex.org/I5681781"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05248227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":null,"first_page":"S329","last_page":"S329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.427700012922287,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eef2k","display_name":"eEF2K","score":0.847000002861023},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.7540000081062317},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cholesterol-absorption","display_name":"cholesterol absorption","score":0.9129999876022339},{"id":"https://openalex.org/keywords/foam-cell-formation","display_name":"foam cell formation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.8650000095367432},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/scavenger-receptors","display_name":"scavenger receptors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.4909999966621399},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.5740000009536743},{"id":"https://openalex.org/keywords/atherogenic-diet","display_name":"atherogenic diet","score":0.7630000114440918},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.7089999914169312},{"id":"https://openalex.org/keywords/protein-synthesis-regulation","display_name":"protein synthesis regulation","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.875680685043335},{"id":"https://openalex.org/C2777895019","wikidata":"https://www.wikidata.org/wiki/Q1425962","display_name":"Foam cell","level":4,"score":0.7922859787940979},{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.6403951644897461},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46289175748825073},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4612381160259247},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4235076308250427},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.42114585638046265},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4207339286804199},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4181116223335266},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3288535177707672},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2635881304740906},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25945568084716797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2567102313041687},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2545974850654602},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23942211270332336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2376573085784912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22290244698524475}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.hlc.2019.06.453","doi":"https://doi.org/10.1016/j.hlc.2019.06.453","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.hlc.2019.06.453","pdf_url":null,"source":{"id":"https://openalex.org/S119123570","display_name":"Heart Lung and Circulation","issn_l":"1443-9506","issn":["1443-9506","1444-2892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart, Lung and Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4206437782","https://openalex.org/W3098054060","https://openalex.org/W2013710108","https://openalex.org/W2043789282","https://openalex.org/W1981000063","https://openalex.org/W2091442843","https://openalex.org/W4313386702","https://openalex.org/W2336225960","https://openalex.org/W2399565026","https://openalex.org/W4293073555"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2019-07-12T00:00:00"}