{"id":"https://openalex.org/W2954460587","doi":"https://doi.org/10.1038/s41598-019-45551-y","title":"CD163+ immune cell infiltrates and presence of CD54+ microvessels are prognostic markers for patients with embryonal rhabdomyosarcoma","display_name":"CD163+ immune cell infiltrates and presence of CD54+ microvessels are prognostic markers for patients with embryonal rhabdomyosarcoma","publication_year":2019,"publication_date":"2019-06-25","ids":{"openalex":"https://openalex.org/W2954460587","doi":"https://doi.org/10.1038/s41598-019-45551-y","mag":"2954460587","pmid":"https://pubmed.ncbi.nlm.nih.gov/31239476","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6592899"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-45551-y","doi":"https://doi.org/10.1038/s41598-019-45551-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-45551-y","pdf_url":"https://www.nature.com/articles/s41598-019-45551-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-45551-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073483894","display_name":"Jakob Nikolas Kather","orcid":"https://orcid.org/0000-0002-3730-5348","observed_orcids":["https://orcid.org/0000-0002-3730-5348"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jakob Nikolas Kather","raw_affiliation_strings":["Applied Tumor Immunity, German Cancer Research Center, Heidelberg, Germany","Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Tumor Immunity, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063514685","display_name":"Christian H\u00f6rner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian H\u00f6rner","raw_affiliation_strings":["Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018126915","display_name":"Cleo\u2010Aron Weis","orcid":"https://orcid.org/0000-0002-1831-3406","observed_orcids":["https://orcid.org/0000-0002-1831-3406"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cleo-Aron Weis","raw_affiliation_strings":["Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102461657","display_name":"Thiha Aung","orcid":"https://orcid.org/0009-0005-0591-3567","observed_orcids":["https://orcid.org/0009-0005-0591-3567","https://orcid.org/0000-0002-5896-3817"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thiha Aung","raw_affiliation_strings":["Center of Plastic-, Hand- and Reconstructive Surgery, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Plastic-, Hand- and Reconstructive Surgery, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091832008","display_name":"Christian Vokuhl","orcid":"https://orcid.org/0000-0002-4138-4536","observed_orcids":["https://orcid.org/0000-0002-4138-4536"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Vokuhl","raw_affiliation_strings":["Institute of Pathology, Paidopathology, University Medical Center Kiel, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Paidopathology, University Medical Center Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014209447","display_name":"Christel Wei\u00df","orcid":"https://orcid.org/0000-0002-8692-5690","observed_orcids":["https://orcid.org/0000-0002-8692-5690"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christel Weiss","raw_affiliation_strings":["Department of Medical Statistics and Biomathematics, University Medical Centre Mannheim, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics and Biomathematics, University Medical Centre Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002688480","display_name":"Monika Scheer","orcid":"https://orcid.org/0000-0002-0665-6268","observed_orcids":["https://orcid.org/0000-0002-0665-6268"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Scheer","raw_affiliation_strings":["Pediatrics 5 (Oncology, Hematology, Immunology), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics 5 (Oncology, Hematology, Immunology), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034981822","display_name":"Alexander Marx","orcid":"https://orcid.org/0000-0001-9722-2483","observed_orcids":["https://orcid.org/0000-0001-9722-2483"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Marx","raw_affiliation_strings":["Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9722-2483","affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039665228","display_name":"Katja Simon\u2010Keller","orcid":"https://orcid.org/0000-0003-2340-8765","observed_orcids":["https://orcid.org/0000-0003-2340-8765"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Katja Simon-Keller","raw_affiliation_strings":["Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany. katja.simon-keller@medma.uni-heidelberg.de","Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2340-8765","affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany. katja.simon-keller@medma.uni-heidelberg.de","institution_ids":["https://openalex.org/I4210156450"]},{"raw_affiliation_string":"Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5039665228"],"corresponding_institution_ids":["https://openalex.org/I4210156450"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":3.0329,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.93214958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"9211","last_page":"9211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryonal-rhabdomyosarcoma","display_name":"embryonal rhabdomyosarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alveolar-rhabdomyosarcoma","display_name":"alveolar rhabdomyosarcoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cd163-macrophages","display_name":"CD163+ macrophages","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6890000104904175},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.8960000276565552},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.503000020980835},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"digital pathology","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2775858924","wikidata":"https://www.wikidata.org/wiki/Q18034009","display_name":"CD163","level":4,"score":0.6760913133621216},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.6465646028518677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6427200436592102},{"id":"https://openalex.org/C2777176876","wikidata":"https://www.wikidata.org/wiki/Q5370233","display_name":"Embryonal rhabdomyosarcoma","level":4,"score":0.5564777255058289},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48818713426589966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46780943870544434},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44702908396720886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4256688952445984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3654717206954956},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.334493488073349},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.1739751100540161},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12830087542533875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11102378368377686},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.10561177134513855}],"mesh":[{"descriptor_ui":"D000098902","descriptor_name":"CD163 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015214","descriptor_name":"Antigens, Differentiation, Myelomonocytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018233","descriptor_name":"Rhabdomyosarcoma, Embryonal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018233","descriptor_name":"Rhabdomyosarcoma, Embryonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018233","descriptor_name":"Rhabdomyosarcoma, Embryonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018233","descriptor_name":"Rhabdomyosarcoma, Embryonal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-019-45551-y","doi":"https://doi.org/10.1038/s41598-019-45551-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-45551-y","pdf_url":"https://www.nature.com/articles/s41598-019-45551-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6592899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6592899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31239476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31239476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c796a9e781c840a7a416281e38ea0b21","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c796a9e781c840a7a416281e38ea0b21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)","raw_type":"article"},{"id":"pmh:oai:epub.uni-regensburg.de:48550","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/48550/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-45551-y","doi":"https://doi.org/10.1038/s41598-019-45551-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-45551-y","pdf_url":"https://www.nature.com/articles/s41598-019-45551-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2954460587.pdf","grobid_xml":"https://content.openalex.org/works/W2954460587.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1504229479","https://openalex.org/W1755371994","https://openalex.org/W1939738412","https://openalex.org/W1954282217","https://openalex.org/W1965030776","https://openalex.org/W1972209822","https://openalex.org/W1990963334","https://openalex.org/W2007252198","https://openalex.org/W2014399831","https://openalex.org/W2018310400","https://openalex.org/W2049491375","https://openalex.org/W2049553585","https://openalex.org/W2050139225","https://openalex.org/W2056956799","https://openalex.org/W2064629866","https://openalex.org/W2066671159","https://openalex.org/W2084942636","https://openalex.org/W2109197651","https://openalex.org/W2127736279","https://openalex.org/W2152061559","https://openalex.org/W2168249395","https://openalex.org/W2171524684","https://openalex.org/W2332570123","https://openalex.org/W2337150359","https://openalex.org/W2346121781","https://openalex.org/W2366882338","https://openalex.org/W2562844176","https://openalex.org/W2578528809","https://openalex.org/W2590978913","https://openalex.org/W2599811342","https://openalex.org/W2605630275","https://openalex.org/W2605830629","https://openalex.org/W2606495925","https://openalex.org/W2611458549","https://openalex.org/W2622499649","https://openalex.org/W2624782256","https://openalex.org/W2725295224","https://openalex.org/W2727744877","https://openalex.org/W2735904407","https://openalex.org/W2755261245","https://openalex.org/W2755469841","https://openalex.org/W2762797139","https://openalex.org/W2765468373","https://openalex.org/W2767966995","https://openalex.org/W2773804840","https://openalex.org/W2774766781","https://openalex.org/W2775369717","https://openalex.org/W2775901287","https://openalex.org/W2776567451","https://openalex.org/W2786718111","https://openalex.org/W2788602025","https://openalex.org/W2790536428","https://openalex.org/W2791554826","https://openalex.org/W2793293870","https://openalex.org/W2794897270","https://openalex.org/W2800862488","https://openalex.org/W2806832126","https://openalex.org/W2809898200","https://openalex.org/W2885139325","https://openalex.org/W2889205611","https://openalex.org/W2892047621","https://openalex.org/W2892995292","https://openalex.org/W2898416788","https://openalex.org/W2952481429"],"related_works":["https://openalex.org/W4388090250","https://openalex.org/W4405124634","https://openalex.org/W4393096248","https://openalex.org/W4384831060","https://openalex.org/W3019967466","https://openalex.org/W7130644820","https://openalex.org/W2135057281","https://openalex.org/W2074526746","https://openalex.org/W3126849063","https://openalex.org/W6990826933"],"abstract_inverted_index":{"Rhabdomyosarcomas":[0],"(RMS)":[1],"are":[2],"rare":[3,192],"and":[4,45,91,138,158,163],"often":[5,151],"lethal":[6],"diseases.":[7],"It":[8],"is":[9,24],"assumed":[10],"that":[11,88],"the":[12,30,59,71,116,175],"tumor":[13,72,119,128],"microenvironment":[14,73],"(TME)":[15],"of":[16,29,41,54,66,94,107,118,174,178,194],"RMS":[17,42,179],"exerts":[18],"an":[19,75],"immunosuppressive":[20],"function,":[21],"but":[22,114],"there":[23],"currently":[25],"no":[26],"systematic":[27,168],"analysis":[28,53,169],"immune":[31,56,68,96,108,135,176],"cells":[32,57,69,97],"infiltrating":[33,67,120],"sarcoma":[34],"tissue.":[35],"Focusing":[36],"on":[37],"two":[38],"common":[39],"types":[40],"(alveolar":[43],"[RMA]":[44],"embryonal":[46],"[RME]),":[47],"we":[48],"performed":[49,62],"a":[50,63,81,104,171],"comprehensive":[51,172],"immunohistochemical":[52],"tumor-infiltrating":[55,95],"in":[58,70,153,156],"TME.":[60],"We":[61,86],"qualitative":[64],"estimation":[65],"by":[74],"experienced":[76],"pathologist":[77],"as":[78,80,143,145],"well":[79,144],"quantitative":[82],"digital":[83],"pathology":[84],"analysis.":[85],"found":[87],"(1)":[89],"manual":[90],"automatic":[92],"quantification":[93],"were":[98,149],"consistent;":[99],"(2)":[100],"RME":[101,154],"tumors":[102,113],"showed":[103],"higher":[105],"degree":[106],"cell":[109,136],"infiltration":[110,137],"than":[111,155],"RMA":[112,157],"(3)":[115],"number":[117],"lymphocytes":[121],"was":[122],"low":[123],"compared":[124],"to":[125,182],"other":[126],"solid":[127],"types;":[129],"(4)":[130],"microvascular":[131],"density":[132],"correlated":[133,159],"with":[134,160],"(5)":[139],"CD163":[140],"positive":[141,147],"macrophages":[142],"CD54":[146],"microvessels":[148],"more":[150],"detected":[152],"patient":[161],"overall":[162],"event":[164],"free":[165],"survival.":[166],"Our":[167],"provides":[170],"view":[173],"landscape":[177],"which":[180],"needs":[181],"be":[183],"taken":[184],"into":[185],"account":[186],"for":[187,190],"developing":[188],"immunotherapies":[189],"this":[191],"type":[193],"cancer.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-12T00:00:00"}
