{"id":"https://openalex.org/W2954442972","doi":"https://doi.org/10.1158/1538-7445.am2019-4273","title":"Abstract 4273: Inhibition of autophagy increases HNSCC sensitivity to cancer therapies","display_name":"Abstract 4273: Inhibition of autophagy increases HNSCC sensitivity to cancer therapies","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2954442972","doi":"https://doi.org/10.1158/1538-7445.am2019-4273","mag":"2954442972"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-4273","doi":"https://doi.org/10.1158/1538-7445.am2019-4273","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4273","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036728233","display_name":"Yong-Syu Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong-Syu Lee","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052995393","display_name":"Justin H. Skiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Skiba","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077119235","display_name":"Jaimee Kubatzke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaimee Kubatzke","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109331991","display_name":"Kwangok P. Nickel","orcid":"https://orcid.org/0000-0003-0263-128X","observed_orcids":["https://orcid.org/0000-0003-0263-128X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwangok P. Nickel","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073175528","display_name":"Randall J. Kimple","orcid":"https://orcid.org/0000-0001-8336-8000","observed_orcids":["https://orcid.org/0000-0001-8336-8000"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall Kimple","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"4273","last_page":"4273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy-inhibition","display_name":"autophagy inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.8059999942779541},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9629999995231628},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9620000123977661},{"id":"https://openalex.org/keywords/laptm4b","display_name":"LAPTM4B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sbi-0206965","display_name":"SBI-0206965","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.6380000114440918},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.8009999990463257},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.4690000116825104},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8107677698135376},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.7619166374206543},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6694412231445312},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.6026415824890137},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5984801650047302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49326199293136597},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4862426817417145},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44867774844169617},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.42415738105773926},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3768526315689087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32442769408226013},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30195310711860657},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17279651761054993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15995705127716064},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.09236863255500793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-4273","doi":"https://doi.org/10.1158/1538-7445.am2019-4273","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4273","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162678080","https://openalex.org/W2916546224","https://openalex.org/W2886690271","https://openalex.org/W3011781943","https://openalex.org/W4282960610","https://openalex.org/W2485989205","https://openalex.org/W3209954526","https://openalex.org/W2007052769","https://openalex.org/W2041156021","https://openalex.org/W4298171731"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Radiation":[2,113],"and":[3,14,46,57,70,92,103,146,186,197,207,212,237,280,291],"EGFR-targeted":[4],"therapies":[5,188,338],"are":[6],"commonly":[7],"used":[8,106,151,178],"in":[9,31,55,95,166,189,240,289,293,295],"the":[10,65,72,109,167,181,218,233,343],"treatment":[11,253,267],"of":[12,28,67,101,125,156,183,205,235,243,277,283,304,331,342],"head":[13,56],"neck":[15,58],"squamous":[16],"cell":[17,97,159,164,244,287],"carcinoma":[18],"(HNSCC).":[19],"These":[20,299],"treatments":[21],"fail":[22],"to":[23,107,152,179,265,311,314,336],"control":[24,256],"a":[25,32,50,83,117,122,229,247,308],"significant":[26],"number":[27],"cancers":[29],"resulting":[30],"5-year":[33],"survival":[34,160,231,245,288],"rate":[35,124],"that":[36,43,302],"remains":[37],"around":[38],"40-50%.":[39],"We":[40],"have":[41],"shown":[42],"both":[44,195,278],"cetuximab":[45,196,262],"radiation":[47,198,238,260],"induce":[48],"autophagy,":[49],"pro-survival":[51],"cellular":[52],"stress":[53],"response,":[54],"cancer.":[59],"In":[60,250],"this":[61],"study,":[62],"we":[63],"examine":[64],"consequence":[66],"autophagy":[68,157,184,200,210,272,284,305,332],"inhibition":[69,155,303],"investigate":[71],"molecular":[73],"mechanism":[74],"underlying":[75],"therapy-induced":[76],"autophagy.":[77],"Methods:":[78],"Autophagy":[79],"was":[80,114,138,177],"assessed":[81,216],"using":[82,116,134,174,217,226],"nano-Luc":[84,219],"LC3":[85],"reporter":[86,220],"(Promega),":[87],"immunofluorescence":[88],"for":[89,346],"LC3,":[90],"p62,":[91],"acridine":[93],"orange":[94],"HNSCC":[96,313,334],"lines.":[98],"RNAi":[99],"knockdown":[100],"EGFR":[102,206,279],"LAPTM4B":[104,208],"were":[105,150,224],"test":[108,180],"involved":[110],"signaling":[111],"molecules.":[112],"delivered":[115,139],"RS225":[118],"cabinet":[119],"irradiator":[120],"at":[121],"dose":[123,130],"approximately":[126],"3":[127],"Gy/min":[128],"with":[129,259],"validation":[131],"by":[132,201],"TLD":[133],"custom":[135],"phantoms.":[136],"Cetuximab":[137],"via":[140],"intraperitoneal":[141],"injection.":[142],"Vps34":[143],"inhibitor":[144,148],"SAR405":[145,236,252],"ULK1":[147],"SBI-0206965":[149],"determine":[153],"whether":[154],"reduces":[158],"or":[161,261],"represses":[162],"cancer":[163,337],"growth":[165],"clonogenic":[168,230],"assay.":[169,221],"A":[170],"flank":[171],"xenograft":[172],"model":[173],"A253":[175],"cells":[176],"combination":[182,234],"inhibitors":[185],"current":[187],"vivo.":[190],"Results:":[191],"As":[192],"previously":[193],"shown,":[194],"induced":[199,271],"two":[202],"times.":[203],"Knockdown":[204],"decreased":[209,286,294],"(62.5%":[211],"65%,":[213],"respectively)":[214],"when":[215,257,263],"Similar":[222],"results":[223,300],"seen":[225],"IF.":[227],"Using":[228],"assay,":[232],"resulted":[239,285,292],"complete":[241],"loss":[242],"suggesting":[246],"radiosensitizing":[248],"effect.":[249],"vivo,":[251],"improved":[254],"tumor":[255,297],"combined":[258],"compared":[264],"either":[266],"alone.":[268],"Conclusions:":[269],"Therapy":[270],"is":[273],"dependent":[274],"upon":[275],"expression":[276],"LAPTM4B.":[281],"Inhibition":[282,330],"vitro":[290],"vivo":[296],"growth.":[298],"suggest":[301],"may":[306],"be":[307],"viable":[309],"approach":[310],"sensitize":[312],"anti-cancer":[315],"treatments.":[316],"Citation":[317],"Format:":[318],"Yong-Syu":[319],"Lee,":[320],"Justin":[321],"Skiba,":[322],"Jaimee":[323],"Kubatzke,":[324],"Kwangok":[325],"P.":[326],"Nickel,":[327],"Randall":[328],"Kimple.":[329],"increases":[333],"sensitivity":[335],"[abstract].":[339],"In:":[340],"Proceedings":[341],"American":[344],"Association":[345],"Cancer":[347,361],"Research":[348],"Annual":[349],"Meeting":[350],"2019;":[351],"2019":[352],"Mar":[353],"29-Apr":[354],"3;":[355],"Atlanta,":[356],"GA.":[357],"Philadelphia":[358],"(PA):":[359],"AACR;":[360],"Res":[362],"2019;79(13":[363],"Suppl):Abstract":[364],"nr":[365],"4273.":[366]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2019-07-12T00:00:00"}
