{"id":"https://openalex.org/W2954420119","doi":"https://doi.org/10.1158/1538-7445.sabcs18-457","title":"Abstract 457: HER2, AR protein expression and chromosomal instability in circulating tumor cells (CTCs) of metastatic breast cancer (MBC) patients (pts)","display_name":"Abstract 457: HER2, AR protein expression and chromosomal instability in circulating tumor cells (CTCs) of metastatic breast cancer (MBC) patients (pts)","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2954420119","doi":"https://doi.org/10.1158/1538-7445.sabcs18-457","mag":"2954420119"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-457","doi":"https://doi.org/10.1158/1538-7445.sabcs18-457","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-457","pdf_url":null,"source":{"id":"https://openalex.org/S4306506411","display_name":"Clinical Research (Excluding Clinical Trials)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Research (Excluding Clinical Trials)","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054661940","display_name":"Priscilla Ontiveros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priscilla Ontiveros","raw_affiliation_strings":["Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016747277","display_name":"Connie Landaverde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connie Landaverde","raw_affiliation_strings":["Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083426638","display_name":"Maren K. Levin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maren K. Levin","raw_affiliation_strings":["Baylor Scott & White Research Institute, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Scott & White Research Institute, Dallas, TX","institution_ids":["https://openalex.org/I4405274104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020138275","display_name":"Sarah Hippely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Hippely","raw_affiliation_strings":["Baylor Scott & White Research Institute, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Scott & White Research Institute, Dallas, TX","institution_ids":["https://openalex.org/I4405274104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112098169","display_name":"Mark Andrew Landers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Landers","raw_affiliation_strings":["Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692705","display_name":"Yipeng Wang","orcid":"https://orcid.org/0000-0001-9769-9839","observed_orcids":["https://orcid.org/0000-0001-9769-9839"]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yipeng Wang","raw_affiliation_strings":["Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022442590","display_name":"Ryan Vance Dittamore","orcid":"https://orcid.org/0000-0003-2281-3232","observed_orcids":["https://orcid.org/0000-0003-2281-3232"]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Dittamore","raw_affiliation_strings":["Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071432873","display_name":"Joyce O\u2019Shaughnessy","orcid":"https://orcid.org/0000-0002-2955-5523","observed_orcids":["https://orcid.org/0000-0002-2955-5523","https://orcid.org/0000-0001-6764-2807"]},"institutions":[{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce A. O'Shaughnessy","raw_affiliation_strings":["Baylor Scott & White Research Institute, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Scott & White Research Institute, Dallas, TX","institution_ids":["https://openalex.org/I4405274104"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"457","last_page":"457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/her2-expression","display_name":"HER2 expression","score":0.847000002861023},{"id":"https://openalex.org/keywords/androgen-receptor-expression","display_name":"androgen receptor expression","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":1.0},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.8769999742507935},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6420000195503235},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.800000011920929},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.8669999837875366},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8389999866485596},{"id":"https://openalex.org/keywords/single-cell-whole-genome-sequencing","display_name":"single-cell whole-genome sequencing","score":0.7960000038146973},{"id":"https://openalex.org/keywords/subclonal-heterogeneity","display_name":"subclonal heterogeneity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.8311961889266968},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.7855706810951233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5645779371261597},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5461229085922241},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5441282391548157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5250306725502014},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.4772186875343323},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.4665892422199249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40456992387771606},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39304620027542114},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3279370963573456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3246191740036011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2996346652507782},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13604041934013367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08537888526916504}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-457","doi":"https://doi.org/10.1158/1538-7445.sabcs18-457","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-457","pdf_url":null,"source":{"id":"https://openalex.org/S4306506411","display_name":"Clinical Research (Excluding Clinical Trials)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Research (Excluding Clinical Trials)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2943901884","https://openalex.org/W2757819986","https://openalex.org/W4220854896","https://openalex.org/W2984197055","https://openalex.org/W2100778529","https://openalex.org/W2254532131","https://openalex.org/W1506491886","https://openalex.org/W2476361402","https://openalex.org/W7117111997","https://openalex.org/W2912830583"],"abstract_inverted_index":{"Background:":[0],"Upregulation":[1],"of":[2,15,30,89,147,157,165,219,234,258,309,354,364],"HER2":[3,77,116,197],"and":[4,8,21,40,78,83,92,105,117,150,184,190,207,221,251,272,296,346],"AR":[5,79,122,208,295,343],"protein":[6,344],"expression,":[7],"increase":[9],"in":[10,51,194,283,349],"chromosomal":[11,85,259,297,347],"instability,":[12],"are":[13,22,37,281],"mechanisms":[14],"acquired":[16,97],"resistance":[17,318],"to":[18,42,48,140,243],"endocrine":[19],"therapy,":[20],"being":[23],"investigated":[24],"as":[25,316],"treatment-guiding":[26],"biomarkers.":[27],"However,":[28],"measurement":[29],"these":[31,235,310],"biomarkers":[32,292,311],"requires":[33],"metastatic":[34,54,107,355],"biopsies,":[35],"which":[36,44],"costly,":[38],"invasive,":[39],"prone":[41],"under-sampling":[43],"precludes":[45],"their":[46],"utility":[47],"guide":[49,301],"treatment":[50],"late":[52],"stage":[53],"pts.":[55,110],"A":[56],"CTC-based":[57],"test":[58],"could":[59,300],"expand":[60],"the":[61,65,124,273,365],"clinical":[62],"utility.":[63],"Using":[64],"Epic":[66,125],"Sciences":[67],"platform,":[68],"MBC":[69,285,313],"blood":[70],"samples":[71,95,112,230],"were":[72,96,113,119,269,275],"characterized":[73],"for":[74,115,121,320,368],"CTC":[75,84,126,278,290],"prevalence,":[76],"expression":[80,198,209,233,345],"on":[81,134,199,210,312],"CTCs,":[82,161],"instability":[86,298,348],"at":[87,171,179,237],"time":[88],"disease":[90,238,288],"progression.Material":[91],"methods:":[93],"Blood":[94],"from":[98,137],"127":[99],"total":[100],"pts":[101,139,158,286],"with":[102,162,247,277],"HR+/HER2-,":[103],"HR-/HER2+":[104],"TNBC":[106],"breast":[108,356],"cancer":[109,357],"114":[111],"analyzed":[114,120],"110":[118],"using":[123],"Platform.":[127],"Single-cell":[128],"whole":[129],"genome":[130],"sequencing":[131],"was":[132],"performed":[133],"157":[135],"CTCs":[136,192,201,212,223,246,280,315],"19":[138],"assess":[141],"large":[142],"scale":[143],"transitions":[144],"(a":[145],"surrogate":[146],"chromosome":[148],"instability)":[149],"gene":[151],"copy":[152],"number":[153],"alterations.Results:":[154],"87/114":[155],"(76.3%)":[156],"had":[159,170,178,187,224,255],"detectable":[160],"a":[163,317],"median":[164],"1.1":[166],"CTC/mL.":[167],"17/114":[168],"(14.9%)":[169],"least":[172,180],"one":[173,181],"HER2(+)":[174,191],"CTC,":[175,183],"21/110":[176],"(19.1%)":[177],"AR(+)":[182,189],"10/110":[185],"(9%)":[186],"both":[188],"detected":[193,282],"technical":[195],"replicates.":[196],"individual":[200,211],"showed":[202,213,231],"distinctive":[203],"cytoplasmic":[204],"membrane":[205],"staining,":[206],"frequent":[214],"nuclear":[215,249],"localization.":[216],"The":[217,304],"majority":[218],"HER2+":[220],"AR+":[222],"high":[225],"cytokeratin":[226],"expression.":[227],"Most":[228],"pt":[229],"heterogeneous":[232],"markers":[236],"progression":[239],"indicating":[240],"subclonal":[241],"sensitivity":[242],"targeted":[244,321],"therapies.":[245],"larger":[248],"area":[250],"higher":[252,256],"N/C":[253],"ratio":[254],"frequency":[257],"instability.":[260],"ERBB2,":[261],"FGFR1":[262],"gain,":[263],"PTEN,":[264],"CDH1,":[265],"BRCA1,":[266],"BRCA2":[267],"loss":[268],"frequently":[270],"observed":[271],"prevalence":[274],"associated":[276],"phenotypes.Conclusions:":[279],"most":[284],"upon":[287],"progression.":[289],"based":[291],"assessing":[293],"HER2,":[294,342],"status":[299],"therapy":[302],"selection.":[303],"results":[305],"warrant":[306],"prospective":[307],"evaluation":[308],"pts\u2019":[314],"marker":[319],"therapies.Citation":[322],"Format:":[323],"Priscilla":[324],"Ontiveros,":[325],"Connie":[326],"Landaverde,":[327],"Maren":[328],"K.":[329],"Levin,":[330],"Sarah":[331],"Hippely,":[332],"Mark":[333],"Landers,":[334],"Yipeng":[335],"Wang,":[336],"Ryan":[337],"Dittamore,":[338],"Joyce":[339],"A.":[340],"O'Shaughnessy.":[341],"circulating":[350],"tumor":[351],"cells":[352],"(CTCs)":[353],"(MBC)":[358],"patients":[359],"(pts)":[360],"[abstract].":[361],"In:":[362],"Proceedings":[363],"American":[366],"Association":[367],"Cancer":[369,383],"Research":[370],"Annual":[371],"Meeting":[372],"2019;":[373],"2019":[374],"Mar":[375],"29-Apr":[376],"3;":[377],"Atlanta,":[378],"GA.":[379],"Philadelphia":[380],"(PA):":[381],"AACR;":[382],"Res":[384],"2019;79(13":[385],"Suppl):Abstract":[386],"nr":[387],"457.":[388]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-07-12T00:00:00"}