{"id":"https://openalex.org/W2954058581","doi":"https://doi.org/10.1158/1538-7445.am2019-2117","title":"Abstract 2117: Different sensitivities of four protein tyrosine kinase inhibitors towards drug-resistant RET mutations","display_name":"Abstract 2117: Different sensitivities of four protein tyrosine kinase inhibitors towards drug-resistant RET mutations","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2954058581","doi":"https://doi.org/10.1158/1538-7445.am2019-2117","mag":"2954058581"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-2117","doi":"https://doi.org/10.1158/1538-7445.am2019-2117","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-2117","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100362324","display_name":"Xuan Liu","orcid":"https://orcid.org/0000-0002-7356-7898","observed_orcids":["https://orcid.org/0000-0002-7356-7898"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuan Liu","raw_affiliation_strings":["1University of Oklahoma Health Sciences Center, Oklahoma City, OK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center, Oklahoma City, OK;","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101693822","display_name":"Tao Shen","orcid":"https://orcid.org/0009-0009-3463-8567","observed_orcids":["https://orcid.org/0009-0009-3463-8567"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Shen","raw_affiliation_strings":["1University of Oklahoma Health Sciences Center, Oklahoma City, OK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center, Oklahoma City, OK;","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007711727","display_name":"Qingling Huang","orcid":"https://orcid.org/0000-0002-0538-8249","observed_orcids":["https://orcid.org/0000-0002-0538-8249"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingling Huang","raw_affiliation_strings":["2H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Teng Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teng Peng","raw_affiliation_strings":["3University of South Florida, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of South Florida, Tampa, FL;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074720413","display_name":"Frank Hilberg","orcid":"https://orcid.org/0000-0001-8925-7336","observed_orcids":["https://orcid.org/0000-0001-8925-7336"]},"institutions":[{"id":"https://openalex.org/I4210119669","display_name":"Boehringer Ingelheim (Austria)","ror":"https://ror.org/026vtvm28","country_code":"AT","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210119669"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Frank Hilberg","raw_affiliation_strings":["4Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria","institution_ids":["https://openalex.org/I4210119669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034454888","display_name":"Jianfeng Cai","orcid":"https://orcid.org/0000-0003-3106-3306","observed_orcids":["https://orcid.org/0000-0003-3106-3306"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianfeng Cai","raw_affiliation_strings":["3University of South Florida, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of South Florida, Tampa, FL;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055253170","display_name":"Blaine H. M. Mooers","orcid":"https://orcid.org/0000-0001-8181-8987","observed_orcids":["https://orcid.org/0000-0001-8181-8987"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaine H. Mooers","raw_affiliation_strings":["1University of Oklahoma Health Sciences Center, Oklahoma City, OK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center, Oklahoma City, OK;","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014705936","display_name":"Jie Wu","orcid":"https://orcid.org/0000-0002-2864-1606","observed_orcids":["https://orcid.org/0000-0002-2864-1606"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Wu","raw_affiliation_strings":["1University of Oklahoma Health Sciences Center, Oklahoma City, OK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center, Oklahoma City, OK;","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"2117","last_page":"2117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ret-mutations","display_name":"RET mutations","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cabozantinib","display_name":"cabozantinib","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vandetanib","display_name":"vandetanib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nintedanib","display_name":"nintedanib","score":1.0},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2780333294","wikidata":"https://www.wikidata.org/wiki/Q7914515","display_name":"Vandetanib","level":4,"score":0.9639252424240112},{"id":"https://openalex.org/C2781064419","wikidata":"https://www.wikidata.org/wiki/Q795057","display_name":"Cabozantinib","level":3,"score":0.7754944562911987},{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.6966613531112671},{"id":"https://openalex.org/C2780120053","wikidata":"https://www.wikidata.org/wiki/Q3493538","display_name":"Medullary thyroid cancer","level":4,"score":0.6696720719337463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5684974789619446},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5478678345680237},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.5117495059967041},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5059494376182556},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4984719753265381},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49226394295692444},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.47770431637763977},{"id":"https://openalex.org/C2780171596","wikidata":"https://www.wikidata.org/wiki/Q15149723","display_name":"Nintedanib","level":4,"score":0.46732842922210693},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28746652603149414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24545767903327942},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.2125525176525116},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.20035287737846375},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.13222342729568481},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09811070561408997},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.047253161668777466},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.0},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-2117","doi":"https://doi.org/10.1158/1538-7445.am2019-2117","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-2117","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2808147817","https://openalex.org/W2978208408","https://openalex.org/W2467135960","https://openalex.org/W2479797442","https://openalex.org/W2886486611","https://openalex.org/W2953717512","https://openalex.org/W1975396905","https://openalex.org/W3092435798","https://openalex.org/W4394699743","https://openalex.org/W2755024705"],"abstract_inverted_index":{"Abstract":[0],"The":[1,140,226],"RET":[2,71,95,259,317],"protein":[3,311],"tyrosine":[4,38,312],"kinase":[5,39,313],"(PTK)":[6],"is":[7,28,102,272],"a":[8,29,137,173,181,240],"clinically":[9],"validated":[10],"target":[11],"of":[12,31,82,86,88,131,158,167,195,242,246,251,309,322],"therapy":[13,36],"in":[14,24,34,104,176,184,248,274],"non-small":[15],"cell":[16],"lung":[17],"cancer":[18,35],"(NSCLC)":[19],"and":[20,61,97,123,148,163,169,197,215,222,236,277],"thyroid":[21,106],"cancer.":[22],"Mutations":[23],"the":[25,54,98,115,129,154,159,164,191,219,243,284,323],"targeted":[26],"PTKs":[27],"mechanism":[30],"drug":[32],"resistance":[33,145],"with":[37,67,190],"inhibitors":[40,314],"(TKIs).":[41],"Mutation-sensitive":[42],"secondary":[43],"drugs":[44],"have":[45,256],"been":[46],"used":[47],"successfully":[48],"to":[49,53,80,120,146,180,201,233,283],"overcome":[50],"acquired":[51],"drug-resistance":[52],"first":[55],"line":[56],"TKIs.":[57,84,269,287],"Cabozantinib,":[58],"lenvatinib,":[59,122],"vandetanib,":[60,185],"nintedanib":[62,155,170,200,211,247,271],"are":[63,281],"FDA-approved":[64],"multikinase":[65],"TKIs":[66,91],"anti-RET":[68,268],"activity.":[69],"Using":[70],"kinase-dependent":[72],"BaF3/KIF5B-RET":[73],"cells,":[74],"we":[75,208,255],"isolated":[76,135],"thirteen":[77],"mutations":[78,260,318],"resistant":[79,119,232,282],"one":[81],"these":[83,89,93],"Cross-analysis":[85],"sensitivities":[87,308],"four":[90,267,310],"on":[92],"drug-resistant":[94,316],"mutants":[96,279],"RETM918T":[99,116,276],"mutant,":[100],"which":[101,178],"found":[103],"medullary":[105],"carcinoma,":[107],"revealed":[108],"different":[109,263],"TKI":[110],"resistance-sensitivity":[111,264],"profiles.":[112],"In":[113],"particular,":[114],"mutant":[117],"was":[118,134,231],"cabozantinib,":[121],"vandetanib":[124,168],"but":[125,150],"did":[126,151],"not":[127,152],"affect":[128,153],"potency":[130],"nintedanib.":[132],"RETL881V":[133,141,230,278],"as":[136],"vandetanib-resistant":[138],"mutation.":[139],"mutation":[142],"also":[143],"induced":[144],"cabozantinib":[147],"lenvatinib":[149],"sensitivity.":[156],"Examination":[157],"RET-vandetanib":[160],"co-crystal":[161],"structure":[162],"chemical":[165],"structures":[166],"suggested":[171],"that":[172,229,261,280],"phenyl":[174,220,244],"group":[175,183,221,245],"nintedanib,":[177],"corresponds":[179],"methoxy":[182],"may":[186],"form":[187],"hydrophobic":[188],"interaction":[189],"shorter":[192],"side":[193],"chain":[194],"Val881":[196],"thus":[198],"allows":[199],"inhibit":[202],"RETL881V.":[203,252],"To":[204],"test":[205],"this":[206],"possibility,":[207],"synthesized":[209],"two":[210],"analogs":[212],"(Compound":[213],"1":[214,235],"Compound":[216,234,237],"2)":[217],"without":[218],"tested":[223],"their":[224],"activities.":[225],"data":[227],"showed":[228],"2,":[238],"supporting":[239],"role":[241],"mediating":[249],"inhibition":[250],"Taken":[253],"together,":[254],"identified":[257],"13":[258],"display":[262],"profiles":[265],"against":[266],"Moreover,":[270],"effective":[273],"inhibiting":[275],"other":[285],"three":[286],"Citation":[288],"Format:":[289],"Xuan":[290],"Liu,":[291],"Tao":[292],"Shen,":[293],"Qingling":[294],"Huang,":[295],"Teng":[296],"Peng,":[297],"Frank":[298],"Hilberg,":[299],"Jianfeng":[300],"Cai,":[301],"Blaine":[302],"H.":[303],"Mooers,":[304],"Jie":[305],"Wu.":[306],"Different":[307],"towards":[315],"[abstract].":[319],"In:":[320],"Proceedings":[321],"American":[324],"Association":[325],"for":[326],"Cancer":[327,341],"Research":[328],"Annual":[329],"Meeting":[330],"2019;":[331],"2019":[332],"Mar":[333],"29-Apr":[334],"3;":[335],"Atlanta,":[336],"GA.":[337],"Philadelphia":[338],"(PA):":[339],"AACR;":[340],"Res":[342],"2019;79(13":[343],"Suppl):Abstract":[344],"nr":[345],"2117.":[346]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2019-07-12T00:00:00"}
