{"id":"https://openalex.org/W2954035219","doi":"https://doi.org/10.11575/prism/34963","title":"Synergy of anti-leukemic effects between anti-thymocyte globulin, busulfan, and fludarabine","display_name":"Synergy of anti-leukemic effects between anti-thymocyte globulin, busulfan, and fludarabine","publication_year":2017,"publication_date":"2017-11-30","ids":{"openalex":"https://openalex.org/W2954035219","doi":"https://doi.org/10.11575/prism/34963","mag":"2954035219"},"language":"en","primary_location":{"id":"pmh:doi:10.11575/prism/34963","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/109341","pdf_url":"https://ucalgary.scholaris.ca/bitstreams/19fac431-b09b-4095-8c60-3f7f772807e4/download","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference poster"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ucalgary.scholaris.ca/bitstreams/19fac431-b09b-4095-8c60-3f7f772807e4/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110399009","display_name":"Lucy Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang, Lucy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051379710","display_name":"Rosy Dabas","orcid":"https://orcid.org/0000-0002-6662-4153","observed_orcids":["https://orcid.org/0000-0002-6662-4153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dabas, Rosy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084879148","display_name":"Jan Storek","orcid":"https://orcid.org/0000-0002-7884-9122","observed_orcids":["https://orcid.org/0000-0002-7884-9122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Storek, Jan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32697418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.8930000066757202},{"id":"https://openalex.org/keywords/busulfan","display_name":"busulfan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":1.0},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/leukemia-cell-death","display_name":"leukemia cell death","score":0.7490000128746033},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.47999998927116394},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8259999752044678},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2780611847","wikidata":"https://www.wikidata.org/wiki/Q348922","display_name":"Busulfan","level":4,"score":0.8248661160469055},{"id":"https://openalex.org/C2780882860","wikidata":"https://www.wikidata.org/wiki/Q584065","display_name":"Anti-thymocyte globulin","level":3,"score":0.8215512037277222},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.737909197807312},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.4461134076118469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4111787676811218},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3426649868488312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25281813740730286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24835485219955444},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.20854702591896057},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.18357357382774353},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13635259866714478},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.13175228238105774}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:doi:10.11575/prism/34963","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/109341","pdf_url":"https://ucalgary.scholaris.ca/bitstreams/19fac431-b09b-4095-8c60-3f7f772807e4/download","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference poster"},{"id":"pmh:oai:ucalgary.scholaris.ca:1880/109341","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/109341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402261","display_name":"Libraries and Cultural Resources (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference poster"},{"id":"doi:10.11575/prism/34963","doi":"https://doi.org/10.11575/prism/34963","is_oa":true,"landing_page_url":"https://doi.org/10.11575/prism/34963","pdf_url":null,"source":{"id":"https://openalex.org/S4306402261","display_name":"Libraries and Cultural Resources (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"},{"id":"mag:2954035219","doi":null,"is_oa":false,"landing_page_url":"https://prism.ucalgary.ca/handle/1880/109341","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:doi:10.11575/prism/34963","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/109341","pdf_url":"https://ucalgary.scholaris.ca/bitstreams/19fac431-b09b-4095-8c60-3f7f772807e4/download","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference poster"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2954035219.pdf","grobid_xml":"https://content.openalex.org/works/W2954035219.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2259831675","https://openalex.org/W2358315628","https://openalex.org/W2887103131","https://openalex.org/W2047019299","https://openalex.org/W2549796089","https://openalex.org/W2974043578","https://openalex.org/W2581469447","https://openalex.org/W1853603843","https://openalex.org/W2766208928","https://openalex.org/W2789783043"],"abstract_inverted_index":{"Antithymocyte":[0],"Globulin":[1],"(ATG)":[2],"is":[3],"an":[4],"anti-GvHD":[5],"(Graft":[6],"versus":[7],"Host":[8],"Disease)":[9],"drug":[10],"that":[11,116],"has":[12],"recently":[13],"been":[14],"shown":[15],"to":[16,27,37,54,57,84,134,180,217,220,223],"have":[17],"anti-leukemic":[18],"effects.":[19,233],"In":[20,127],"Alberta,":[21],"Busulfan":[22,80,148,203],"and":[23,81,112,202],"Fludarabine":[24,82],"are":[25],"used":[26,111],"treat":[28],"acute":[29,94],"myeloid":[30,95],"leukemia.":[31],"However,":[32,153],"both":[33],"drugs":[34,208],"also":[35],"lead":[36],"the":[38,44,125,130,155,158,163,181,206],"death":[39,99,138,227],"of":[40,72,79,129,145,157],"healthy":[41],"cells":[42,106,118],"within":[43],"body,":[45],"especially":[46],"with":[47,68,76,142,147,151,154,228],"increased":[48,136],"doses.":[49],"It":[50],"would":[51],"be":[52,135,178,210],"beneficial":[53],"study":[55],"ways":[56],"maintain":[58],"their":[59,63,86],"effects":[60,87],"while":[61],"decreasing":[62],"toxicity,":[64],"such":[65],"as":[66],"synergy":[67,198],"ATG.":[69],"Different":[70],"concentrations":[71,78,187],"ATG":[73,146,150,201],"were":[74,110,172],"combined":[75,113],"different":[77],"separately":[83],"test":[85,140],"on":[88],"pre-conditioned":[89],"leukemia":[90,96],"cell":[91,137,226],"samples":[92],"from":[93,107],"patients.":[97],"Cell":[98],"was":[100,165],"quantified":[101],"using":[102],"flow":[103],"cytometry.":[104],"The":[105],"five":[108],"patients":[109],"into":[114],"graphs":[115],"compared":[117],"dyed":[119],"by":[120],"7AAD":[121],"(dead":[122],"cells)":[123],"between":[124,200],"drugs.":[126],"some":[128],"combinations,":[131],"there":[132,171],"appeared":[133],"in":[139,190,213],"tubes":[141],"a":[143],"combination":[144],"or":[149,204],"Fludarabine.":[152],"use":[156],"Wilcoxon":[159],"Matched":[160],"Pairs":[161],"Test,":[162],"difference":[164],"deemed":[166],"not":[167,188],"significant.":[168],"Even":[169],"though":[170],"no":[173],"significant":[174],"differences,":[175],"it":[176],"could":[177,193],"due":[179],"low":[182],"sample":[183],"size.":[184],"Furthermore,":[185],"other":[186],"tested":[189],"this":[191],"experiment":[192],"yield":[194],"better":[195],"results.":[196],"If":[197],"exists":[199],"Fludarabine,":[205],"two":[207],"should":[209],"moved":[211],"up":[212],"patients\u2019":[214],"conditioning":[215],"schedules":[216],"allow":[218],"synergism":[219],"occur,":[221],"leading":[222],"more":[224],"cancer":[225],"less":[229],"risk":[230],"for":[231],"side":[232]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-07-12T00:00:00"}