{"id":"https://openalex.org/W2953852067","doi":"https://doi.org/10.21873/cgp.20131","title":"STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary\u2013Mucinous Carcinoma of the Transverse Colon","display_name":"STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary\u2013Mucinous Carcinoma of the Transverse Colon","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2953852067","doi":"https://doi.org/10.21873/cgp.20131","mag":"2953852067","pmid":"https://pubmed.ncbi.nlm.nih.gov/31243107","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6609257"},"language":"en","primary_location":{"id":"doi:10.21873/cgp.20131","doi":"https://doi.org/10.21873/cgp.20131","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cgp.20131","pdf_url":"http://cgp.iiarjournals.org/content/16/4/267.full.pdf","source":{"id":"https://openalex.org/S4210194588","display_name":"Cancer Genomics & Proteomics","issn_l":"1109-6535","issn":["1109-6535","1790-6245"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genomics - Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://cgp.iiarjournals.org/content/16/4/267.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"MOHAMMAD SHAHID","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MOHAMMAD SHAHID","raw_affiliation_strings":["Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416778","display_name":"Dapeng Wang","orcid":"https://orcid.org/0000-0002-5746-4987","observed_orcids":["https://orcid.org/0000-0002-5746-4987"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAPENG WANG","raw_affiliation_strings":["Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044340098","display_name":"James Joseph Saller","orcid":"https://orcid.org/0000-0001-5040-4482","observed_orcids":["https://orcid.org/0000-0001-5040-4482"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES SALLER","raw_affiliation_strings":["Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009890017","display_name":"Elena Ryzhova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ELENA RYZHOVA","raw_affiliation_strings":["Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055965341","display_name":"Dahui Qin","orcid":"https://orcid.org/0000-0001-9618-5836","observed_orcids":["https://orcid.org/0000-0001-9618-5836"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAHUI QIN","raw_affiliation_strings":["Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080487628","display_name":"Anthony M. Magliocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANTHONY MAGLIOCCO","raw_affiliation_strings":["Moffitt Morsani Advanced Diagnostic Laboratories, H. Lee Moffitt Cancer and Research Institute, Tampa, FL, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Morsani Advanced Diagnostic Laboratories, H. Lee Moffitt Cancer and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076324164","display_name":"Domenico Coppola","orcid":"https://orcid.org/0000-0001-9090-1205","observed_orcids":["https://orcid.org/0000-0001-9090-1205","https://orcid.org/0009-0008-3540-2014"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210096898","display_name":"Florida Digestive Health Specialists","ror":"https://ror.org/00tvc4894","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096898"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DOMENICO COPPOLA","raw_affiliation_strings":["Department of Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","Department of Pathology, Florida Digestive Health Specialists, Bradenton, FL, U.S.A","Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A. domenico.coppola@fdhs.com","Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Pathology, Florida Digestive Health Specialists, Bradenton, FL, U.S.A","institution_ids":["https://openalex.org/I4210096898"]},{"raw_affiliation_string":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A. domenico.coppola@fdhs.com","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08854688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"16","issue":"4","first_page":"267","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stk11","display_name":"STK11","score":0.7850000262260437},{"id":"https://openalex.org/keywords/medullary-carcinoma","display_name":"medullary carcinoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mucinous-carcinoma","display_name":"mucinous carcinoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/transverse-colon-cancer","display_name":"transverse colon cancer","score":0.7730000019073486},{"id":"https://openalex.org/keywords/microsatellite-instability-high","display_name":"microsatellite instability-high","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.9549999833106995},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/novel-mutations","display_name":"novel mutations","score":0.5550000071525574},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.8268821239471436},{"id":"https://openalex.org/C2777874381","wikidata":"https://www.wikidata.org/wiki/Q6931137","display_name":"Mucinous carcinoma","level":4,"score":0.667350709438324},{"id":"https://openalex.org/C2777807078","wikidata":"https://www.wikidata.org/wiki/Q2619732","display_name":"Transverse colon","level":2,"score":0.6141786575317383},{"id":"https://openalex.org/C2777983448","wikidata":"https://www.wikidata.org/wiki/Q2745322","display_name":"STK11","level":5,"score":0.6057443618774414},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5974416136741638},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.532788097858429},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5321463942527771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5012509822845459},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4394654333591461},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42781805992126465},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.42455270886421204},{"id":"https://openalex.org/C2909866369","wikidata":"https://www.wikidata.org/wiki/Q18557126","display_name":"Mucinous Tumor","level":3,"score":0.4236152172088623},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3495626747608185},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2841669023036957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27730420231819153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2722000181674957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13079240918159485},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.1044030487537384},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.061699628829956055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.055351585149765015},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.0},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002288","descriptor_name":"Adenocarcinoma, Mucinous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044684","descriptor_name":"Colon, Transverse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.21873/cgp.20131","doi":"https://doi.org/10.21873/cgp.20131","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cgp.20131","pdf_url":"http://cgp.iiarjournals.org/content/16/4/267.full.pdf","source":{"id":"https://openalex.org/S4210194588","display_name":"Cancer Genomics & Proteomics","issn_l":"1109-6535","issn":["1109-6535","1790-6245"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genomics - Proteomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6609257","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6609257","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genomics Proteomics","raw_type":"Text"},{"id":"pmid:31243107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31243107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genomics & proteomics","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.21873/cgp.20131","doi":"https://doi.org/10.21873/cgp.20131","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cgp.20131","pdf_url":"http://cgp.iiarjournals.org/content/16/4/267.full.pdf","source":{"id":"https://openalex.org/S4210194588","display_name":"Cancer Genomics & Proteomics","issn_l":"1109-6535","issn":["1109-6535","1790-6245"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genomics - Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G362094","display_name":null,"funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320311073","funder_display_name":"Moffitt Cancer Center"},{"id":"https://openalex.org/G4551976579","display_name":null,"funder_award_id":"CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8135003176","display_name":null,"funder_award_id":"CA076292","funder_id":"https://openalex.org/F4320311073","funder_display_name":"Moffitt Cancer Center"},{"id":"https://openalex.org/G9000876523","display_name":"Moffitt Cancer Center Support Grant","funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953852067.pdf","grobid_xml":"https://content.openalex.org/works/W2953852067.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1548511028","https://openalex.org/W1663153674","https://openalex.org/W1889393210","https://openalex.org/W1892915455","https://openalex.org/W1969637146","https://openalex.org/W2011995257","https://openalex.org/W2055732173","https://openalex.org/W2101297236","https://openalex.org/W2125147268","https://openalex.org/W2239917694","https://openalex.org/W2272438203","https://openalex.org/W2317512076","https://openalex.org/W2588338171","https://openalex.org/W2592982749","https://openalex.org/W2804452586","https://openalex.org/W2805885226"],"related_works":["https://openalex.org/W4415569137","https://openalex.org/W3096826690","https://openalex.org/W2062515547","https://openalex.org/W4413938684","https://openalex.org/W1988905988","https://openalex.org/W4212819972","https://openalex.org/W3030542504","https://openalex.org/W4403044510","https://openalex.org/W2745084366","https://openalex.org/W2125147268"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"To":[1],"report":[2,110],"a":[3,23,50,81,111],"case":[4,35],"of":[5,26,33,55,66,77,119],"mixed":[6],"medullary/mucinous":[7],"adenocarcinoma":[8],"with":[9,22,52,122],"unusual":[10],"mutational":[11],"gene":[12],"profile.":[13],"PATIENTS":[14],"AND":[15],"METHODS:":[16],"A":[17],"79-year-old":[18],"female":[19],"was":[20,87],"diagnosed":[21],"colorectal":[24,60],"carcinoma":[25,118],"the":[27,64,74,91,95,120],"transverse":[28],"colon.":[29],"The":[30,46],"diagnostic":[31],"work-up":[32],"this":[34,78],"included":[36],"thorough":[37],"clinicopathological":[38,47],"evaluation,":[39],"immunohistochemistry":[40],"and":[41,58,97,104],"next":[42],"generation":[43],"Sequencing.":[44],"RESULTS:":[45],"evaluation":[48],"showed":[49,72],"tumor":[51,79],"morphological":[53],"features":[54],"both":[56],"medullary":[57,75,96,117],"mucinous":[59,92,98,125],"carcinoma.":[61],"Immunohistochemistry":[62],"revealed":[63],"loss":[65],"DNA":[67],"mismatch":[68],"repair":[69],"proteins.":[70],"NGS":[71],"that":[73],"component":[76],"had":[80,101],"novel":[82,112],"STK11":[83,114],"p.G270W":[84],"mutation,":[85],"which":[86],"not":[88],"present":[89],"in":[90,116],"component.":[93,126],"Both":[94],"components":[99],"also":[100],"BRAF":[102],"V600E":[103],"AKT1":[105],"(pE17K)":[106],"mutations.":[107],"CONCLUSION:":[108],"We":[109],"mutation":[113],"(p.G270W),":[115],"colon":[121],"an":[123],"associated":[124]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-12T00:00:00"}
