{"id":"https://openalex.org/W2953844638","doi":"https://doi.org/10.1016/j.ekir.2019.05.135","title":"SAT-107 BONE MARROW STROMAL CELL ANTIGEN-1 MEDIATES ACUTE KIDNEY INJURY AND KIDNEY FIBROSIS","display_name":"SAT-107 BONE MARROW STROMAL CELL ANTIGEN-1 MEDIATES ACUTE KIDNEY INJURY AND KIDNEY FIBROSIS","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2953844638","doi":"https://doi.org/10.1016/j.ekir.2019.05.135","mag":"2953844638"},"language":"en","primary_location":{"id":"doi:10.1016/j.ekir.2019.05.135","doi":"https://doi.org/10.1016/j.ekir.2019.05.135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2019.05.135","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ekir.2019.05.135","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062629520","display_name":"Tomoo Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. INOUE","raw_affiliation_strings":["The University of Tokyo, CKD pathophysiology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo, CKD pathophysiology, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031957363","display_name":"Jin Yao","orcid":"https://orcid.org/0000-0002-3053-8245","observed_orcids":["https://orcid.org/0000-0002-3053-8245"]},"institutions":[{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Yao","raw_affiliation_strings":["University of Virginia, Nephrology, Charlottesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Nephrology, Charlottesville, USA","institution_ids":["https://openalex.org/I4210134211","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101526218","display_name":"Lu Huang","orcid":"https://orcid.org/0000-0002-2546-2493","observed_orcids":["https://orcid.org/0000-0002-2546-2493"]},"institutions":[{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Huang","raw_affiliation_strings":["University of Virginia, Nephrology, Charlottesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Nephrology, Charlottesville, USA","institution_ids":["https://openalex.org/I4210134211","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017888514","display_name":"Diane L. Rosin","orcid":"https://orcid.org/0000-0003-0187-5717","observed_orcids":["https://orcid.org/0000-0003-0187-5717"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Rosin","raw_affiliation_strings":["University of Virginia, Nephrology, Charlottesvile, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Nephrology, Charlottesvile, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Ishihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Ishihara","raw_affiliation_strings":["Kawasaki Medical School, Immunology, Kurashiki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kawasaki Medical School, Immunology, Kurashiki, Japan","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035573141","display_name":"Reiko Inagi","orcid":"https://orcid.org/0000-0001-7032-7736","observed_orcids":["https://orcid.org/0000-0001-7032-7736"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Inagi","raw_affiliation_strings":["The University of Tokyo, CKD pathophysiology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo, CKD pathophysiology, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036113498","display_name":"Masaomi Nangaku","orcid":"https://orcid.org/0000-0001-7401-2934","observed_orcids":["https://orcid.org/0000-0001-7401-2934"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Nangaku","raw_affiliation_strings":["The University of Tokyo, Nephrology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo, Nephrology, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Wada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287250","display_name":"Isotope Science Center, The University of Tokyo","ror":"https://ror.org/04jggjp59","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287250","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Wada","raw_affiliation_strings":["The University of Tokyo, Isotope Science Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo, Isotope Science Center, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287250","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043847672","display_name":"Mark Douglas Okusa","orcid":"https://orcid.org/0000-0002-0801-0532","observed_orcids":["https://orcid.org/0000-0002-0801-0532"]},"institutions":[{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Okusa","raw_affiliation_strings":["University of Virginia, Nephrology, Charlottesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Nephrology, Charlottesville, USA","institution_ids":["https://openalex.org/I4210134211","https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2625,"currency":"USD","value_usd":2625},"apc_paid":{"value":2625,"currency":"USD","value_usd":2625},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"7","first_page":"S50","last_page":"S51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.11079999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.10949999839067459,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100a10","display_name":"S100A10","score":0.6389999985694885},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9470000267028809},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sphingosine-kinase-2","display_name":"sphingosine kinase 2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":0.9700000286102295},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7527999877929688},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6791003346443176},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6273093223571777},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.578977108001709},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5595725774765015},{"id":"https://openalex.org/C2777550365","wikidata":"https://www.wikidata.org/wiki/Q14913834","display_name":"Sphingosine kinase 1","level":5,"score":0.5555449724197388},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.46837908029556274},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.4348362684249878},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.4250320494174957},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37348368763923645},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3723474144935608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2257501482963562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1648678183555603},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08836555480957031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05456942319869995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ekir.2019.05.135","doi":"https://doi.org/10.1016/j.ekir.2019.05.135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2019.05.135","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ekir.2019.05.135","doi":"https://doi.org/10.1016/j.ekir.2019.05.135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2019.05.135","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4301398281","https://openalex.org/W4396998229","https://openalex.org/W2539691454","https://openalex.org/W2890188297","https://openalex.org/W4396995218","https://openalex.org/W2967693628","https://openalex.org/W2033179866","https://openalex.org/W4253911553","https://openalex.org/W2744403052","https://openalex.org/W2981785373"],"abstract_inverted_index":{"Interstitial":[0],"fibrosis":[1,15,36,103],"is":[2,47,57,63,96],"a":[3],"final":[4],"common":[5],"pathway":[6],"following":[7],"organ":[8],"injury":[9,41],"and":[10,55,69,78],"therapies":[11],"that":[12,16,28],"focus":[13],"on":[14],"delay":[17],"or":[18],"reverse":[19],"progressive":[20],"renal":[21],"failure":[22],"are":[23],"limited.":[24],"Previously":[25],"we":[26],"showed":[27],"sphingosine":[29,51],"kinase":[30,52],"2-deficient":[31],"mice":[32],"(SphK2KO)":[33],"develop":[34],"less":[35],"after":[37],"unilateral":[38],"kidney":[39,102],"ischemia-reperfusion":[40],"(IRI).":[42],"Sphingosine":[43],"1-phosphate":[44],"(S1P),":[45],"which":[46,83],"produced":[48,71],"by":[49,72],"two":[50],"isoforms":[53],"(SphK1":[54],"SphK2),":[56],"involved":[58],"in":[59,66],"diverse":[60],"functions.":[61],"SphK2":[62,73],"primarily":[64],"located":[65],"the":[67],"nucleus":[68],"S1P":[70],"inhibits":[74],"histone":[75,80],"deacetylase":[76],"(HDAC)":[77],"changes":[79],"acetylation":[81],"status,":[82],"can":[84],"lead":[85],"to":[86,97],"altered":[87],"target":[88],"gene":[89],"expression.":[90],"The":[91],"aim":[92],"of":[93,101],"this":[94],"study":[95],"elucidate":[98],"new":[99],"mechanisms":[100],"through":[104],"epigenetic":[105],"changes.":[106]},"counts_by_year":[],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2019-07-12T00:00:00"}
