{"id":"https://openalex.org/W2953739498","doi":"https://doi.org/10.3233/jad-190046","title":"Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer\u2019s Disease Cerebrospinal Fluid Biomarker Levels","display_name":"Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer\u2019s Disease Cerebrospinal Fluid Biomarker Levels","publication_year":2019,"publication_date":"2019-06-06","ids":{"openalex":"https://openalex.org/W2953739498","doi":"https://doi.org/10.3233/jad-190046","mag":"2953739498","pmid":"https://pubmed.ncbi.nlm.nih.gov/31177219"},"language":"en","primary_location":{"id":"doi:10.3233/jad-190046","doi":"https://doi.org/10.3233/jad-190046","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-190046","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad190046?id=journal-of-alzheimers-disease%2Fjad190046","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad190046?id=journal-of-alzheimers-disease%2Fjad190046","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047661125","display_name":"Adri\u00e0 Tort\u2010Merino","orcid":"https://orcid.org/0000-0002-5646-0482","observed_orcids":["https://orcid.org/0000-0002-5646-0482"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adri\u00e0 Tort-Merino","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019739387","display_name":"Jaume Olives","orcid":"https://orcid.org/0000-0003-1961-4830","observed_orcids":["https://orcid.org/0000-0003-1961-4830"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jaume Olives","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045063998","display_name":"Mar\u00eda Le\u00f3n","orcid":"https://orcid.org/0000-0003-2303-3035","observed_orcids":["https://orcid.org/0000-0003-2303-3035"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Le\u00f3n","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044955864","display_name":"Claudia Pe\u00f1aloza","orcid":"https://orcid.org/0000-0003-1200-5936","observed_orcids":["https://orcid.org/0000-0003-1200-5936"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Claudia Pe\u00f1aloza","raw_affiliation_strings":["Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020314167","display_name":"Natalia Valech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Natalia Valech","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026994260","display_name":"Miguel Santos\u2010Santos","orcid":"https://orcid.org/0000-0003-1567-617X","observed_orcids":["https://orcid.org/0000-0003-1567-617X"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel A. Santos-Santos","raw_affiliation_strings":["Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051269661","display_name":"Estela C\u00e0mara","orcid":"https://orcid.org/0000-0002-3879-0496","observed_orcids":["https://orcid.org/0000-0002-3879-0496"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Estela C\u00e0mara","raw_affiliation_strings":["Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076799586","display_name":"Petra Gr\u00f6nholm-Nyman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Petra Gr\u00f6nholm-Nyman","raw_affiliation_strings":["Department of Psychology, \u00c5bo Akademi University, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, \u00c5bo Akademi University, Turku, Finland","institution_ids":["https://openalex.org/I130217899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050002274","display_name":"Pablo Mart\u00ednez\u2010Lage","orcid":"https://orcid.org/0000-0001-5404-9967","observed_orcids":["https://orcid.org/0000-0001-5404-9967"]},"institutions":[{"id":"https://openalex.org/I4210152675","display_name":"Fundacion CITA Alzheimer","ror":"https://ror.org/041c71a74","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210152675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Mart\u00ednez-Lage","raw_affiliation_strings":["Neurolog\u00eda, Fundaci\u00f3n CITA-Alzh\u00e9imer Fundazioa, Centro de Investigaci\u00f3n y Terapias Avanzadas, San Sebasti\u00e1n, Guip\u00fazcoa, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurolog\u00eda, Fundaci\u00f3n CITA-Alzh\u00e9imer Fundazioa, Centro de Investigaci\u00f3n y Terapias Avanzadas, San Sebasti\u00e1n, Guip\u00fazcoa, Espa\u00f1a","institution_ids":["https://openalex.org/I4210152675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010797490","display_name":"Juan Fortea","orcid":"https://orcid.org/0000-0002-1340-638X","observed_orcids":["https://orcid.org/0000-0002-1340-638X"]},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Fortea","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain","Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau and Institute of Biomedical Research, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210115082"]},{"raw_affiliation_string":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau and Institute of Biomedical Research, Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740","https://openalex.org/I4387155026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036068671","display_name":"Jos\u00e9 Lu\u00eds Molinuevo","orcid":"https://orcid.org/0000-0003-0485-6001","observed_orcids":["https://orcid.org/0000-0003-0485-6001"]},"institutions":[{"id":"https://openalex.org/I4210107429","display_name":"Pasqual Maragall Foundation","ror":"https://ror.org/01nry9c15","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210107429"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128274","display_name":"Barcelona\u03b2eta Brain Research Center","ror":"https://ror.org/03k4wdb90","country_code":"ES","type":"facility","lineage":["https://openalex.org/I170486558","https://openalex.org/I4210107429","https://openalex.org/I4210128274"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 L. Molinuevo","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain","institution_ids":["https://openalex.org/I4210107429","https://openalex.org/I4210128274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047159861","display_name":"Raquel S\u00e1nchez\u2010Valle","orcid":"https://orcid.org/0000-0001-7750-896X","observed_orcids":["https://orcid.org/0000-0001-7750-896X"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel S\u00e1nchez-Valle","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006329075","display_name":"Matti Laine","orcid":"https://orcid.org/0000-0003-4529-4965","observed_orcids":["https://orcid.org/0000-0003-4529-4965"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Matti Laine","raw_affiliation_strings":["Department of Psychology, \u00c5bo Akademi University, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, \u00c5bo Akademi University, Turku, Finland","institution_ids":["https://openalex.org/I130217899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037124206","display_name":"Antoni Rodr\u00edguez\u2010Fornells","orcid":"https://orcid.org/0000-0002-3249-6931","observed_orcids":["https://orcid.org/0000-0002-3249-6931"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antoni Rodr\u00edguez-Fornells","raw_affiliation_strings":["Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain","Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain","Department of Cognition, Development and Education Psychology, University of Barcelona, L\u2019Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]},{"raw_affiliation_string":"Department of Cognition, Development and Education Psychology, University of Barcelona, L\u2019Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027089756","display_name":"Lorena Rami","orcid":"https://orcid.org/0000-0002-7411-1921","observed_orcids":["https://orcid.org/0000-0002-7411-1921"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Lorena Rami","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5027089756"],"corresponding_institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"],"apc_list":null,"apc_paid":null,"fwci":1.3184,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78604829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"70","issue":"1","first_page":"211","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.8360949754714966},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7931272387504578},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5888921022415161},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5161157846450806},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5122739672660828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48686450719833374},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3903310298919678},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3820072412490845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31406721472740173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10798788070678711},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-190046","doi":"https://doi.org/10.3233/jad-190046","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-190046","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad190046?id=journal-of-alzheimers-disease%2Fjad190046","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},{"id":"pmid:31177219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31177219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/175417","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2445/175417","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Cognici\u00f3, Desenvolupament i Psicologia de l'Educaci\u00f3)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/716bff1f-ef60-4a9d-971e-0d98ca04c459","doi":null,"is_oa":false,"landing_page_url":"https://content.iospress.com/articles/journal-of-alzheimers-disease/jad190046","pdf_url":null,"source":{"id":"https://openalex.org/S4406923060","display_name":"\u00c5bo Akademi University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tort-Merino, A, Olives, J, Le\u00f3n, M, Pe\u00f1aloza, C, Valech, N, Santos-Santos, MA, C\u00e0mara, E, Gr\u00f6nholm-Nyman, P, Martinez-Lage, P, Fortea, J, Molinuevo, JL, S\u00e0nchez-Valle, R, Laine, M, Rodr\u00edguez-Fornells, A & Rami, L 2019, 'Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels', Journal of Alzheimer's Disease, vol. 70, no. 1, pp. 211\u2013225. https://doi.org/10.3233/JAD-190046","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3233/jad-190046","doi":"https://doi.org/10.3233/jad-190046","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-190046","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad190046?id=journal-of-alzheimers-disease%2Fjad190046","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2582485871","display_name":"Efectos de la p\u00e9rdida de peso mediante dieta mediterr\u00e1nea hipocal\u00f3rica y aumento de la actividad f\u00edsica sobre la cognici\u00f3n y la estructura y funci\u00f3n cerebrales determinados por resonancia magn\u00e9tica funcional en individuos obesos con s\u00edndrome metab\u00f3lico","funder_award_id":"PI14/00563","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3559709381","display_name":null,"funder_award_id":"PI14/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4193446334","display_name":null,"funder_award_id":"2013-2016","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953739498.pdf","grobid_xml":"https://content.openalex.org/works/W2953739498.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W611723161","https://openalex.org/W1666194336","https://openalex.org/W1684937978","https://openalex.org/W1705785002","https://openalex.org/W1706219887","https://openalex.org/W1814695138","https://openalex.org/W1847168837","https://openalex.org/W1902875872","https://openalex.org/W1905973631","https://openalex.org/W1939543393","https://openalex.org/W1967823816","https://openalex.org/W1971503708","https://openalex.org/W1986788796","https://openalex.org/W1986951455","https://openalex.org/W1987081043","https://openalex.org/W1990313607","https://openalex.org/W1992939348","https://openalex.org/W1996642546","https://openalex.org/W2002555348","https://openalex.org/W2014897730","https://openalex.org/W2033085283","https://openalex.org/W2036814508","https://openalex.org/W2037665248","https://openalex.org/W2048378108","https://openalex.org/W2048505725","https://openalex.org/W2051949306","https://openalex.org/W2052742260","https://openalex.org/W2057739090","https://openalex.org/W2061358809","https://openalex.org/W2067975928","https://openalex.org/W2074274706","https://openalex.org/W2075675743","https://openalex.org/W2079009347","https://openalex.org/W2081164888","https://openalex.org/W2085550866","https://openalex.org/W2093132963","https://openalex.org/W2097531156","https://openalex.org/W2099797739","https://openalex.org/W2102554143","https://openalex.org/W2113708991","https://openalex.org/W2114815865","https://openalex.org/W2118421222","https://openalex.org/W2119117410","https://openalex.org/W2120357670","https://openalex.org/W2126900474","https://openalex.org/W2137333905","https://openalex.org/W2140928605","https://openalex.org/W2144907160","https://openalex.org/W2145336227","https://openalex.org/W2153071923","https://openalex.org/W2153299035","https://openalex.org/W2155298532","https://openalex.org/W2161360439","https://openalex.org/W2258646945","https://openalex.org/W2551101903","https://openalex.org/W2611494546","https://openalex.org/W2613167232","https://openalex.org/W2626001339","https://openalex.org/W2763301808","https://openalex.org/W2791142298","https://openalex.org/W2798054687","https://openalex.org/W2800799167","https://openalex.org/W2807443525","https://openalex.org/W2811293288","https://openalex.org/W2883021501","https://openalex.org/W2886478721","https://openalex.org/W2949466265","https://openalex.org/W4230920194","https://openalex.org/W4233953021","https://openalex.org/W4246615189","https://openalex.org/W4251404648","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2075675743","https://openalex.org/W3020923599","https://openalex.org/W1982884883","https://openalex.org/W2258646945","https://openalex.org/W2763301808","https://openalex.org/W4283717411","https://openalex.org/W2032122310","https://openalex.org/W2765379446","https://openalex.org/W3199609242","https://openalex.org/W4380884100"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,134],"investigated":[2],"a":[3,31,50,95,102,221,265],"sample":[4],"of":[5,110,143,263,267],"cognitively":[6,66],"healthy":[7,279],"subjects":[8,71,113],"with":[9,60,171,193,199,273],"normal":[10,69],"Alzheimer's":[11],"disease":[12],"(AD)":[13],"cerebrospinal":[14],"fluid":[15],"(CSF)":[16],"biomarker":[17,51],"levels":[18],"to":[19,25,47,53,140,216,256],"identify":[20,141],"the":[21,77,87,108,112,240,261,274],"earliest":[22,275],"variables":[23],"related":[24,52,215,272],"longitudinal":[26,61,153,167,241],"memory":[27,37,62,168,276],"changes.":[28,243],"OBJECTIVE:":[29],"Employing":[30],"new":[32],"highly":[33],"demanding":[34],"learning":[35],"and":[36,67,76,81,92,125,152,166,185,226,232,252],"test":[38],"(the":[39],"Ancient":[40],"Farming":[41],"Equipment":[42],"Test;":[43],"AFE-T),":[44],"we":[45],"aimed":[46],"investigate":[48],"whether":[49],"neurodegeneration":[54],"(i.e.,":[55],"CSF":[56,164],"tau)":[57],"was":[58,98,160],"associated":[59],"decline.":[63],"METHODS:":[64],"Thirty-two":[65],"biologically":[68],"(CBN)":[70],"underwent":[72],"MRI,":[73],"neuropsychological":[74],"assessment,":[75],"AFE-T":[78,172,212],"at":[79,230],"baseline":[80,151],"18":[82],"months":[83],"later.":[84],"To":[85],"explore":[86,107],"relationship":[88],"between":[89,163,191],"cognitive":[90,154,242,257],"performance":[91,213],"relevant":[93],"factors,":[94],"linear":[96],"model":[97],"set":[99],"up.":[100],"For":[101],"secondary":[103],"analysis":[104],"that":[105,147,211,233],"further":[106,186],"effect":[109],"tau,":[111,264],"were":[114],"divided":[115],"into":[116],"CBN-Tau\u2193":[117],"(tau":[118,127],"<":[119,177,183,206],"228.64":[120,129],"pg/ml;":[121,130],"n":[122,131],"=":[123,132,174,180,203],"16)":[124],"CBN-Tau\u2191":[126],">":[128],"16).":[133],"also":[135],"performed":[136],"voxel-based":[137],"morphometry":[138],"(VBM)":[139],"regions":[142],"grey":[144,217],"matter":[145,218],"volume":[146,219],"would":[148],"predict":[149],"both":[150],"performance.":[155],"RESULTS:":[156],"Our":[157],"main":[158],"finding":[159],"an":[161,194],"association":[162],"tau":[165,201],"decline":[169,196],"measured":[170],"(B":[173],"-0.17,":[175],"p":[176,182,205],"0.05;":[178],"r":[179],"-0.414;":[181],"0.01),":[184],"analyses":[187],"showed":[188],"different":[189],"evolvement":[190],"subgroups,":[192],"accelerated":[195],"in":[197,220,278],"individuals":[198],"higher":[200],"(F(1,31)":[202],"8.37;":[204],"0.01).":[207],"VBM":[208],"results":[209],"suggested":[210],"is":[214],"medial":[222],"temporal,":[223],"middle":[224],"frontal,":[225],"posterior":[227],"cerebellar":[228],"network":[229],"baseline,":[231],"there":[234],"are":[235],"strategic":[236],"brain":[237],"areas":[238],"driving":[239],"CONCLUSIONS:":[244],"The":[245],"present":[246],"findings":[247],"provide":[248],"evidence":[249],"for":[250],"structural":[251],"biological":[253],"markers":[254],"linked":[255],"aging":[258],"by":[259],"highlighting":[260],"role":[262],"marker":[266],"neurodegeneration,":[268],"which":[269],"can":[270],"be":[271],"changes":[277],"subjects.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-07-12T00:00:00"}
