{"id":"https://openalex.org/W2953548995","doi":"https://doi.org/10.1101/690966","title":"Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in diffuse intrinsic pontine glioma (DIPG)","display_name":"Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in diffuse intrinsic pontine glioma (DIPG)","publication_year":2019,"publication_date":"2019-07-02","ids":{"openalex":"https://openalex.org/W2953548995","doi":"https://doi.org/10.1101/690966","mag":"2953548995"},"language":"en","primary_location":{"id":"doi:10.1101/690966","doi":"https://doi.org/10.1101/690966","is_oa":true,"landing_page_url":"https://doi.org/10.1101/690966","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/02/690966.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/02/690966.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076064163","display_name":"Cavan P. Bailey","orcid":"https://orcid.org/0000-0003-2334-2612","observed_orcids":["https://orcid.org/0000-0003-2334-2612"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cavan P. Bailey","raw_affiliation_strings":["Center for Cancer Epigenetics, MD Anderson Cancer Center, Houston, TX","Department of Pediatrics \u2013 Research and Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, Houston, TX","The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-2334-2612","affiliations":[{"raw_affiliation_string":"Center for Cancer Epigenetics, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Pediatrics \u2013 Research and Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110610399","display_name":"Megan M. Romero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan M. Romero","raw_affiliation_strings":["Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089189433","display_name":"Oren Josh Becher","orcid":"https://orcid.org/0000-0003-4016-8492","observed_orcids":["https://orcid.org/0000-0003-4016-8492"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oren J. Becher","raw_affiliation_strings":["Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, IL"],"raw_orcid":"https://orcid.org/0000-0003-4016-8492","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022800990","display_name":"Michelle Monje","orcid":"https://orcid.org/0000-0002-3547-237X","observed_orcids":["https://orcid.org/0000-0002-3547-237X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Monje","raw_affiliation_strings":["Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA"],"raw_orcid":"https://orcid.org/0000-0002-3547-237X","affiliations":[{"raw_affiliation_string":"Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019752519","display_name":"Dean Anthony Lee","orcid":"https://orcid.org/0000-0001-6693-5392","observed_orcids":["https://orcid.org/0000-0001-6693-5392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dean A. Lee","raw_affiliation_strings":["Department of Pediatrics, Nationwide Children\u2019s and the Ohio State Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0001-6693-5392","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nationwide Children\u2019s and the Ohio State Comprehensive Cancer Center, Columbus, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051182441","display_name":"Linghua Wang","orcid":"https://orcid.org/0000-0001-9380-0266","observed_orcids":["https://orcid.org/0000-0001-9380-0266","https://orcid.org/0000-0003-3117-1390"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linghua Wang","raw_affiliation_strings":["Department of Genomic Medicine, MD Anderson Cancer Center, Houston, TX","The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0001-9380-0266","affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013157173","display_name":"Joya Chandra","orcid":"https://orcid.org/0000-0002-2077-9715","observed_orcids":["https://orcid.org/0000-0002-2077-9715"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joya Chandra","raw_affiliation_strings":["Center for Cancer Epigenetics, MD Anderson Cancer Center, Houston, TX","Department of Pediatrics \u2013 Research and Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, Houston, TX","The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-2077-9715","affiliations":[{"raw_affiliation_string":"Center for Cancer Epigenetics, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Pediatrics \u2013 Research and Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013157173"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-intrinsic-pontine-glioma","display_name":"diffuse intrinsic pontine glioma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lsd1","display_name":"LSD1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/lsd1-inhibitors","display_name":"LSD1 inhibitors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pediatric-high-grade-glioma","display_name":"pediatric high-grade glioma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/immune-related-gene-signature","display_name":"immune-related gene signature","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nk-cell-infiltration","display_name":"NK cell infiltration","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immunosensitization","display_name":"immunosensitization","score":0.6480000019073486},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6541619300842285},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6414874792098999},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6034843921661377},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5787769556045532},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5513203740119934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5010397434234619},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4713703393936157},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.4359099566936493},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4225502610206604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2872331142425537},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.24706947803497314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2342205047607422},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18726763129234314},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09697359800338745},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09485399723052979}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/690966","doi":"https://doi.org/10.1101/690966","is_oa":true,"landing_page_url":"https://doi.org/10.1101/690966","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/02/690966.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/690966","doi":"https://doi.org/10.1101/690966","is_oa":true,"landing_page_url":"https://doi.org/10.1101/690966","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/02/690966.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G293715275","display_name":null,"funder_award_id":"P30-CA-016672","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G5686491264","display_name":"Preclinical evaluation of a novel combinatory epigenetics based therapy for glioblastoma","funder_award_id":"R21NS093387","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904906","display_name":"SPORE in Brain Cancer","funder_award_id":"P50CA127001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306814","display_name":"Rose Foundation for Communities and the Environment","ror":"https://ror.org/0145pgy59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953548995.pdf","grobid_xml":"https://content.openalex.org/works/W2953548995.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1560814177","https://openalex.org/W1603797292","https://openalex.org/W1985987855","https://openalex.org/W1990260147","https://openalex.org/W1995105508","https://openalex.org/W2015850802","https://openalex.org/W2021334649","https://openalex.org/W2022930470","https://openalex.org/W2051921450","https://openalex.org/W2102156431","https://openalex.org/W2158233796","https://openalex.org/W2192976324","https://openalex.org/W2366536035","https://openalex.org/W2416176993","https://openalex.org/W2416368103","https://openalex.org/W2432147558","https://openalex.org/W2474402643","https://openalex.org/W2555694983","https://openalex.org/W2592743985","https://openalex.org/W2593014410","https://openalex.org/W2613790813","https://openalex.org/W2738161330","https://openalex.org/W2738678436","https://openalex.org/W2750168879","https://openalex.org/W2751187578","https://openalex.org/W2770704851","https://openalex.org/W2771352624","https://openalex.org/W2771438132","https://openalex.org/W2772664652","https://openalex.org/W2773406691","https://openalex.org/W2784214891","https://openalex.org/W2788202982","https://openalex.org/W2788969237","https://openalex.org/W2789346374","https://openalex.org/W2790186911","https://openalex.org/W2790751347","https://openalex.org/W2794180511","https://openalex.org/W2800219125","https://openalex.org/W2803003012","https://openalex.org/W2803040262","https://openalex.org/W2806906871","https://openalex.org/W2809146677","https://openalex.org/W2809237949","https://openalex.org/W2883888248","https://openalex.org/W2885441485","https://openalex.org/W2889354357","https://openalex.org/W2901704338","https://openalex.org/W2902849275","https://openalex.org/W2905692147","https://openalex.org/W2909571824","https://openalex.org/W2917456162"],"related_works":["https://openalex.org/W3011468031","https://openalex.org/W3110858817","https://openalex.org/W2809296574","https://openalex.org/W2617280761","https://openalex.org/W2942107453","https://openalex.org/W4309014277","https://openalex.org/W2980438467","https://openalex.org/W2899853730","https://openalex.org/W4404236635","https://openalex.org/W4399787477"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Diffuse":[2],"intrinsic":[3],"pontine":[4],"glioma":[5,74,140,274],"(DIPG)":[6],"is":[7,184,239,260,293,333,347,369],"an":[8,124,234,328],"incurable":[9],"pediatric":[10,46,72,272,308],"brain":[11,309],"tumor.":[12],"Mutations":[13],"in":[14,45,57,98,130,160,219,263,271,302,335,351,419],"the":[15,61,216,290,294,355,383,397],"H3":[16],"histone":[17],"tail":[18],"(H3.1/3.3-K27M)":[19],"are":[20,192,198,207,228],"a":[21,246,303,415,427],"feature":[22],"of":[23,33,38,63,82,114,154,164,178,289,300,307,316,341,349,357,367,377,386,393,400,404,411],"DIPG,":[24,58],"potentially":[25],"rendering":[26],"them":[27],"therapeutically":[28],"sensitive":[29],"to":[30,79,110,186,200,209,297],"small-molecule":[31],"inhibition":[32,37,224,254,277,299,388,413],"chromatin":[34],"modifiers.":[35],"Pharmacological":[36],"lysine":[39],"specific":[40],"demethylase-1":[41],"(LSD1)":[42],"shows":[43],"promise":[44],"cancers":[47],"such":[48],"as":[49,414],"Ewing\u2019s":[50],"sarcoma,":[51],"but":[52],"has":[53],"not":[54,214],"been":[55],"investigated":[56],"which":[59],"was":[60,96,128,158],"aim":[62],"our":[64,407],"study.":[65],"Methods":[66],"Patient-derived":[67],"DIPG":[68,99,131,161,165,220,283,324,336,368],"cell":[69,94,243,280,365,391,423],"lines":[70,132],"and":[71,89,105,116,123,162,212,232,326,381,402,429],"high-grade":[73,139,273],"(pHGG)":[75],"datasets":[76],"were":[77,108],"used":[78,109],"evaluate":[80,298],"effects":[81],"several":[83,134,256,317],"LSD1":[84,103,136,156,196,205,223,253,276,301,362,372,387,412],"inhibitors":[85,104,157,168,197,206,227,340],"on":[86,118],"selective":[87,314],"cytotoxicity":[88,95,122,281,315,392],"immune":[90,112,235,329,344],"gene":[91,126,150,217,236,267,330,345,379],"expression.":[92],"Immune":[93],"assessed":[97],"cells":[100,202,211,337],"treated":[101],"with":[102,166,241,284,354,421],"informatics":[106],"platforms":[107],"determine":[111],"infiltration":[113,183],"pHGG":[115],"impact":[117],"survival.":[119],"Results":[120],"Selective":[121],"immunogenic":[125],"signature":[127,218,237,268,331,346,360],"established":[129],"using":[133,147,225,255],"clinically-relevant":[135],"inhibitors.":[137],"Pediatric":[138],"patient":[141,179,187,322],"sequencing":[142],"data":[143,180],"demonstrated":[144],"survival":[145,188,270],"benefit":[146],"this":[148,359,378],"LSD1-dependent":[149],"signature.":[151],"On-target":[152],"binding":[153],"catalytic":[155,226,339],"confirmed":[159,181],"pre-treatment":[163],"these":[167],"increased":[169],"lysis":[170],"by":[171,338,371],"natural":[172],"killer":[173],"(NK)":[174],"cells.":[175,221,395],"CIBERSORT":[176],"analysis":[177],"NK":[182,201,210,242,279,364,390,422],"beneficial":[185],"while":[189,203],"CD8":[190],"T-cells":[191],"negatively":[193],"prognostic.":[194],"Catalytic":[195],"non-perturbing":[199],"scaffolding":[204],"toxic":[208],"do":[213],"induce":[215],"Conclusions":[222],"both":[229],"selectively":[230,261],"cytotoxic":[231,262],"promote":[233],"that":[238,332],"associated":[240],"killing,":[244],"representing":[245],"therapeutic":[247],"opportunity":[248],"for":[249],"pHGG.":[250],"Key":[251],"points":[252],"clinically":[257,318],"relevant":[258,319],"compounds":[259,320],"DIPG.":[264,311],"An":[265],"LSD1-controlled":[266],"predicts":[269],"patients.":[275],"enhances":[278],"against":[282,321],"correlative":[285],"genetic":[286],"biomarkers.":[287],"Importance":[288],"study":[291,296],"This":[292,343],"first":[295,384],"uniformly":[304],"lethal":[305],"type":[306],"tumor:":[310],"We":[312],"demonstrate":[313],"derived":[323],"cells,":[325],"identify":[327],"upregulated":[334],"LSD1.":[342],"predictive":[348],"prognosis":[350,399],"pHGG,":[352],"consistent":[353],"rationale":[356],"promoting":[358,389],"through":[361],"inhibition.":[363],"killing":[366],"enhanced":[370],"inhibition,":[373],"providing":[374],"functional":[375],"confirmation":[376],"signature,":[380],"represents":[382],"report":[385],"cancer":[394],"Given":[396],"poor":[398],"pHGGs":[401],"lack":[403],"effective":[405],"treatments,":[406],"results":[408],"suggest":[409],"use":[410],"single":[416],"agent":[417],"or":[418],"combination":[420],"therapy":[424],"may":[425],"be":[426],"safe":[428],"efficacious":[430],"strategy.":[431]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-07-12T00:00:00"}
