{"id":"https://openalex.org/W2953536588","doi":"https://doi.org/10.3389/fendo.2019.00401","title":"Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries","display_name":"Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries","publication_year":2019,"publication_date":"2019-06-25","ids":{"openalex":"https://openalex.org/W2953536588","doi":"https://doi.org/10.3389/fendo.2019.00401","mag":"2953536588","pmid":"https://pubmed.ncbi.nlm.nih.gov/31293518","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6603095"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2019.00401","doi":"https://doi.org/10.3389/fendo.2019.00401","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2019.00401","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00401/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00401/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110680555","display_name":"Adair Rodr\u00edguez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-5760-744X","observed_orcids":["https://orcid.org/0000-0002-5760-744X"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Adair Rodr\u00edguez-Rodr\u00edguez","raw_affiliation_strings":["Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067468641","display_name":"Iv\u00e1n Lazcano","orcid":"https://orcid.org/0000-0002-3971-3628","observed_orcids":["https://orcid.org/0000-0002-3971-3628"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Lazcano","raw_affiliation_strings":["Departamento de Neurobiolog\u00eda Celular y Molecular, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Juriquilla, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Neurobiolog\u00eda Celular y Molecular, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Juriquilla, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065668445","display_name":"Edith S\u00e1nchez\u2010Jaramillo","orcid":"https://orcid.org/0000-0002-5560-2645","observed_orcids":["https://orcid.org/0000-0002-5560-2645"]},"institutions":[{"id":"https://openalex.org/I4210154708","display_name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz","ror":"https://ror.org/05qjm2261","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210154708"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Edith S\u00e1nchez-Jaramillo","raw_affiliation_strings":["Laboratorio de Neuroendocrinolog\u00eda Molecular, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Neuroendocrinolog\u00eda Molecular, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210154708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111194929","display_name":"Rosa Mar\u00eda Uribe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rosa Mar\u00eda Uribe","raw_affiliation_strings":["Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090724641","display_name":"Lorraine Jaimes-Hoy","orcid":"https://orcid.org/0000-0002-0937-6077","observed_orcids":["https://orcid.org/0000-0002-0937-6077"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Lorraine Jaimes-Hoy","raw_affiliation_strings":["Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037661087","display_name":"Patricia Joseph\u2010Bravo","orcid":"https://orcid.org/0000-0003-4794-6816","observed_orcids":["https://orcid.org/0000-0003-4794-6816"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Patricia Joseph-Bravo","raw_affiliation_strings":["Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031126052","display_name":"Jean\u2010Louis Charli","orcid":"https://orcid.org/0000-0002-3021-0688","observed_orcids":["https://orcid.org/0000-0002-3021-0688"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Jean-Louis Charli","raw_affiliation_strings":["Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031126052"],"corresponding_institution_ids":["https://openalex.org/I8961855"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.871,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.64731183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"401","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tanycytes","display_name":"tanycytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9909999966621399},{"id":"https://openalex.org/keywords/median-eminence","display_name":"median eminence","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-thyroid-axis","display_name":"hypothalamic-pituitary-thyroid axis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.6930000185966492},{"id":"https://openalex.org/keywords/type-2-deiodinase","display_name":"type 2 deiodinase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"negative feedback","score":0.49300000071525574},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C2779067335","wikidata":"https://www.wikidata.org/wiki/Q1337712","display_name":"Median eminence","level":3,"score":0.8814743757247925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7812121510505676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7696644067764282},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.7010974884033203},{"id":"https://openalex.org/C2778417266","wikidata":"https://www.wikidata.org/wiki/Q24781273","display_name":"Deiodinase","level":4,"score":0.6719229221343994},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.5611556172370911},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.5166540741920471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49891018867492676},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.48764172196388245},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.4831818640232086},{"id":"https://openalex.org/C113214860","wikidata":"https://www.wikidata.org/wiki/Q1703635","display_name":"Hypothalamic\u2013pituitary\u2013thyroid axis","level":4,"score":0.4481462836265564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32165372371673584},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.2253367006778717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14987286925315857},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2019.00401","doi":"https://doi.org/10.3389/fendo.2019.00401","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2019.00401","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00401/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6603095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6603095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:31293518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31293518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:877bf3abed974e57809a4bfadc6ffbd3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/877bf3abed974e57809a4bfadc6ffbd3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2019.00401","doi":"https://doi.org/10.3389/fendo.2019.00401","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2019.00401","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00401/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G128196911","display_name":null,"funder_award_id":"IN204316","funder_id":"https://openalex.org/F4320335100","funder_display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico"},{"id":"https://openalex.org/G3281497707","display_name":null,"funder_award_id":"CB154931","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G5488239083","display_name":null,"funder_award_id":"PN562","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G6275561212","display_name":null,"funder_award_id":"CB284883","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G8898182390","display_name":null,"funder_award_id":"PAPIIT IN204316","funder_id":"https://openalex.org/F4320335100","funder_display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico"},{"id":"https://openalex.org/G8903762108","display_name":null,"funder_award_id":"CB254960","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"}],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953536588.pdf","grobid_xml":"https://content.openalex.org/works/W2953536588.grobid-xml"},"referenced_works_count":194,"referenced_works":["https://openalex.org/W104726253","https://openalex.org/W131118871","https://openalex.org/W200530305","https://openalex.org/W639584013","https://openalex.org/W995713276","https://openalex.org/W1587655743","https://openalex.org/W1600609658","https://openalex.org/W1616436068","https://openalex.org/W1703087551","https://openalex.org/W1839779564","https://openalex.org/W1897148950","https://openalex.org/W1941456052","https://openalex.org/W1963559704","https://openalex.org/W1966171994","https://openalex.org/W1966176326","https://openalex.org/W1966522739","https://openalex.org/W1966791415","https://openalex.org/W1966824338","https://openalex.org/W1968329147","https://openalex.org/W1972473911","https://openalex.org/W1975062397","https://openalex.org/W1975442007","https://openalex.org/W1975557150","https://openalex.org/W1978695159","https://openalex.org/W1979009439","https://openalex.org/W1980127660","https://openalex.org/W1982747139","https://openalex.org/W1983666444","https://openalex.org/W1984202851","https://openalex.org/W1987450218","https://openalex.org/W1988377203","https://openalex.org/W1991454487","https://openalex.org/W1992268803","https://openalex.org/W1992304191","https://openalex.org/W1993031478","https://openalex.org/W1995993817","https://openalex.org/W1997494318","https://openalex.org/W2000321746","https://openalex.org/W2000570774","https://openalex.org/W2002099673","https://openalex.org/W2002154622","https://openalex.org/W2002389632","https://openalex.org/W2005359107","https://openalex.org/W2005744729","https://openalex.org/W2006340543","https://openalex.org/W2006755265","https://openalex.org/W2006889378","https://openalex.org/W2007697011","https://openalex.org/W2008043546","https://openalex.org/W2008804576","https://openalex.org/W2011301426","https://openalex.org/W2012721631","https://openalex.org/W2014543820","https://openalex.org/W2019223615","https://openalex.org/W2020378174","https://openalex.org/W2021313833","https://openalex.org/W2021410366","https://openalex.org/W2022726058","https://openalex.org/W2024794762","https://openalex.org/W2026027052","https://openalex.org/W2028423755","https://openalex.org/W2029160783","https://openalex.org/W2029592985","https://openalex.org/W2031632319","https://openalex.org/W2031929672","https://openalex.org/W2033553696","https://openalex.org/W2036659686","https://openalex.org/W2037382253","https://openalex.org/W2037412834","https://openalex.org/W2038334005","https://openalex.org/W2038678383","https://openalex.org/W2038993022","https://openalex.org/W2039840980","https://openalex.org/W2043371470","https://openalex.org/W2045703150","https://openalex.org/W2046037386","https://openalex.org/W2046152275","https://openalex.org/W2046337839","https://openalex.org/W2046492969","https://openalex.org/W2046694106","https://openalex.org/W2047024738","https://openalex.org/W2048400736","https://openalex.org/W2052021580","https://openalex.org/W2052481625","https://openalex.org/W2052948801","https://openalex.org/W2055877450","https://openalex.org/W2057348494","https://openalex.org/W2057774710","https://openalex.org/W2057808752","https://openalex.org/W2061005803","https://openalex.org/W2061660689","https://openalex.org/W2062347722","https://openalex.org/W2065234128","https://openalex.org/W2067703245","https://openalex.org/W2068597583","https://openalex.org/W2068672685","https://openalex.org/W2069003539","https://openalex.org/W2070170063","https://openalex.org/W2070995469","https://openalex.org/W2074081460","https://openalex.org/W2075141289","https://openalex.org/W2076777516","https://openalex.org/W2076824236","https://openalex.org/W2078230942","https://openalex.org/W2078697459","https://openalex.org/W2080153847","https://openalex.org/W2083657371","https://openalex.org/W2083858558","https://openalex.org/W2085205986","https://openalex.org/W2086004438","https://openalex.org/W2087087304","https://openalex.org/W2088120727","https://openalex.org/W2088666612","https://openalex.org/W2089105953","https://openalex.org/W2089843950","https://openalex.org/W2090278129","https://openalex.org/W2090420969","https://openalex.org/W2092694916","https://openalex.org/W2093997127","https://openalex.org/W2097440306","https://openalex.org/W2101123075","https://openalex.org/W2102129489","https://openalex.org/W2102611661","https://openalex.org/W2106237215","https://openalex.org/W2106664880","https://openalex.org/W2111536564","https://openalex.org/W2111792865","https://openalex.org/W2111814389","https://openalex.org/W2112647438","https://openalex.org/W2114793335","https://openalex.org/W2121637377","https://openalex.org/W2121662324","https://openalex.org/W2123353710","https://openalex.org/W2123491442","https://openalex.org/W2125333644","https://openalex.org/W2127275626","https://openalex.org/W2128112362","https://openalex.org/W2135480836","https://openalex.org/W2136488101","https://openalex.org/W2136655542","https://openalex.org/W2141532080","https://openalex.org/W2142524436","https://openalex.org/W2144441182","https://openalex.org/W2148247134","https://openalex.org/W2159171051","https://openalex.org/W2159882692","https://openalex.org/W2160881604","https://openalex.org/W2162716270","https://openalex.org/W2164169013","https://openalex.org/W2164577763","https://openalex.org/W2164884566","https://openalex.org/W2165995911","https://openalex.org/W2168197605","https://openalex.org/W2171513174","https://openalex.org/W2201239534","https://openalex.org/W2247962318","https://openalex.org/W2252303002","https://openalex.org/W2256418959","https://openalex.org/W2260524887","https://openalex.org/W2357991904","https://openalex.org/W2406620525","https://openalex.org/W2409823926","https://openalex.org/W2412634097","https://openalex.org/W2416920775","https://openalex.org/W2462538637","https://openalex.org/W2485216328","https://openalex.org/W2496006906","https://openalex.org/W2505094455","https://openalex.org/W2508836614","https://openalex.org/W2557571313","https://openalex.org/W2570474222","https://openalex.org/W2571106728","https://openalex.org/W2578897403","https://openalex.org/W2585988261","https://openalex.org/W2586421092","https://openalex.org/W2601723752","https://openalex.org/W2625840978","https://openalex.org/W2733043123","https://openalex.org/W2739407595","https://openalex.org/W2751252080","https://openalex.org/W2759765784","https://openalex.org/W2766326437","https://openalex.org/W2790193528","https://openalex.org/W2889449597","https://openalex.org/W2895636463","https://openalex.org/W2901439761","https://openalex.org/W2914978827","https://openalex.org/W2944059047","https://openalex.org/W2944223163","https://openalex.org/W4239204613","https://openalex.org/W4242457804","https://openalex.org/W4249313273","https://openalex.org/W4249925242","https://openalex.org/W6720746809"],"related_works":["https://openalex.org/W3141011709","https://openalex.org/W2996416790","https://openalex.org/W2944545183","https://openalex.org/W1967123676","https://openalex.org/W1979869334","https://openalex.org/W2508836614","https://openalex.org/W2320549413","https://openalex.org/W7117456706","https://openalex.org/W2791370634","https://openalex.org/W1839779564"],"abstract_inverted_index":{"Central":[0],"and":[1,9,27,43,46,50,90,96,130,157,167,176,226,257,278,333,342],"peripheral":[2],"mechanisms":[3],"that":[4,105],"modulate":[5,31],"energy":[6,12,18,220],"intake,":[7],"partition":[8],"expenditure":[10,19],"determine":[11],"homeostasis.":[13],"Thyroid":[14],"hormones":[15],"(TH)":[16],"regulate":[17,223],"through":[20],"the":[21,39,61,65,73,77,107,110,113,118,170,174,180,189,197,224,231,258,265,301,305,313,318,331],"control":[22,284,292,335],"of":[23,60,64,76,109,117,124,132,142,161,173,199,228,240,252,260,290,293,304,315,336],"basal":[24,266],"metabolic":[25],"rate":[26],"thermogenesis;":[28],"they":[29],"also":[30,222,245],"food":[32],"intake.":[33],"TH":[34,212],"concentrations":[35],"are":[36,153],"regulated":[37],"by":[38,44,155,208,296],"hypothalamus-pituitary-thyroid":[40],"(HPT)":[41],"axis,":[42],"transport":[45],"metabolism":[47,131],"in":[48,86,127,169,219,230,300,346],"blood":[49],"target":[51],"tissues.":[52],"In":[53,321],"mammals,":[54],"hypophysiotropic":[55],"thyrotropin-releasing":[56],"hormone":[57],"(TRH)":[58],"neurons":[59],"paraventricular":[62],"nucleus":[63],"hypothalamus":[66,111,120],"integrate":[67],"energy-related":[68,238],"information.":[69],"They":[70],"project":[71],"to":[72,179,211,269,282],"external":[74,171,302],"zone":[75],"median":[78,306],"eminence":[79],"(ME),":[80],"a":[81,102,122,140,235,326],"brain":[82],"circumventricular":[83],"organ":[84],"rich":[85],"neuron":[87],"terminal":[88],"varicosities":[89,166],"buttons,":[91],"tanycytes,":[92],"other":[93],"glial":[94],"cells":[95],"capillaries.":[97,182,271,320],"These":[98,272],"capillary":[99],"vessels":[100],"form":[101],"portal":[103,202,319,340],"system":[104],"links":[106],"base":[108],"with":[112,164,264,275],"anterior":[114],"pituitary.":[115],"Tanycytes":[116,151],"medio-basal":[119],"express":[121,188,246],"repertoire":[123],"proteins":[125],"involved":[126],"transport,":[128],"sensing,":[129],"TH;":[133],"among":[134],"them":[135],"is":[136,205],"type":[137,184],"2":[138,185],"deiodinase,":[139,186],"source":[141],"3,3',5-triiodo-L-thyronine":[143],"necessary":[144],"for":[145,237,330],"negative":[146,213],"feedback":[147,214],"on":[148,215,254],"TRH":[149,165,200,253,294,316,337],"neurons.":[150],"subtypes":[152],"distinguished":[154],"position":[156],"phenotype.":[158],"The":[159],"end-feet":[160,262,273],"\u03b22-tanycytes":[162,187,234,244,323],"intermingle":[163],"terminals":[168],"layer":[172,303],"ME":[175,181,270,276],"terminate":[177],"close":[178],"Besides":[183],"TRH-degrading":[190],"ectoenzyme":[191],"(TRH-DE);":[192],"this":[193],"enzyme":[194],"likely":[195],"controls":[196],"amount":[198],"entering":[201],"vessels.":[203],"TRH-DE":[204,229,255,279],"rapidly":[206],"upregulated":[207],"TH,":[209],"contributing":[210],"HPT":[216,241,285,343],"axis.":[217],"Alterations":[218],"balance":[221],"expression":[225],"activity":[227,256],"ME,":[232],"making":[233],"hub":[236],"regulation":[239,345],"axis":[242,286,344],"activity.":[243,287],"TRH-R1,":[247],"which":[248],"mediates":[249],"positive":[250],"effects":[251],"size":[259],"\u03b22-tanycyte":[261],"contacts":[263],"lamina":[267],"adjacent":[268],"associations":[274],"capillaries,":[277],"activity,":[280],"appear":[281,324],"coordinately":[283],"Thus,":[288],"down-stream":[289],"neuronal":[291],"release":[295],"action":[297],"potentials":[298],"arrival":[299],"eminence,":[307],"imbricated":[308],"intercellular":[309],"processes":[310],"may":[311],"coordinate":[312],"flux":[314,338],"into":[317,339],"conclusion,":[322],"as":[325],"critical":[327],"cellular":[328],"element":[329],"somatic":[332],"post-secretory":[334],"vessels,":[341],"mammals.":[347]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-07-12T00:00:00"}