{"id":"https://openalex.org/W29534569","doi":"https://doi.org/10.7936/k7mp5175","title":"Engineering Biosensors for Short-chain Alcohols","display_name":"Engineering Biosensors for Short-chain Alcohols","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W29534569","doi":"https://doi.org/10.7936/k7mp5175","mag":"29534569"},"language":"en","primary_location":{"id":"pmh:oai:openscholarship.wustl.edu:eng_etds-1011","doi":null,"is_oa":true,"landing_page_url":"https://openscholarship.wustl.edu/eng_etds/10","pdf_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1011&context=eng_etds","source":{"id":"https://openalex.org/S4377196400","display_name":"Open Scholarship Institutional Repository (Washington University in St. Louis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"McKelvey School of Engineering Theses & Dissertations","raw_type":"text"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1011&context=eng_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062534695","display_name":"Yu Xia","orcid":"https://orcid.org/0000-0001-8694-9900","observed_orcids":["https://orcid.org/0000-0001-8694-9900"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xia, Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062534695"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00110411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/short-chain-alcohols","display_name":"short-chain alcohols","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biofuels","display_name":"biofuels","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.8999999761581421},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/synthetic-gene-circuits","display_name":"synthetic gene circuits","score":0.972000002861023},{"id":"https://openalex.org/keywords/strain-screening","display_name":"strain screening","score":0.7670000195503235},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.8610000014305115},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C199185054","wikidata":"https://www.wikidata.org/wiki/Q552299","display_name":"Chain (unit)","level":2,"score":0.4841247498989105},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.41359743475914},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35830020904541016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34380030632019043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18093180656433105},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08007225394248962},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:openscholarship.wustl.edu:eng_etds-1011","doi":null,"is_oa":true,"landing_page_url":"https://openscholarship.wustl.edu/eng_etds/10","pdf_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1011&context=eng_etds","source":{"id":"https://openalex.org/S4377196400","display_name":"Open Scholarship Institutional Repository (Washington University in St. Louis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"McKelvey School of Engineering Theses & Dissertations","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.674.691","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.674.691","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://openscholarship.wustl.edu/cgi/viewcontent.cgi?article%3D1011%26context%3Deng_etds","raw_type":"text"},{"id":"mag:29534569","doi":null,"is_oa":false,"landing_page_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1011&context=eng_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.7936/k7mp5175","doi":"https://doi.org/10.7936/k7mp5175","is_oa":true,"landing_page_url":"https://doi.org/10.7936/k7mp5175","pdf_url":null,"source":{"id":"https://openalex.org/S7407053377","display_name":"Washington University in St. Louis Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:openscholarship.wustl.edu:eng_etds-1011","doi":null,"is_oa":true,"landing_page_url":"https://openscholarship.wustl.edu/eng_etds/10","pdf_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1011&context=eng_etds","source":{"id":"https://openalex.org/S4377196400","display_name":"Open Scholarship Institutional Repository (Washington University in St. Louis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"McKelvey School of Engineering Theses & Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.75,"display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W29534569.pdf","grobid_xml":"https://content.openalex.org/works/W29534569.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1540505601","https://openalex.org/W1969350272","https://openalex.org/W1972549326","https://openalex.org/W1975276775","https://openalex.org/W1976037543","https://openalex.org/W1978119727","https://openalex.org/W1978579085","https://openalex.org/W1990902952","https://openalex.org/W2027113296","https://openalex.org/W2027576577","https://openalex.org/W2032619610","https://openalex.org/W2041404237","https://openalex.org/W2043105926","https://openalex.org/W2055304344","https://openalex.org/W2073265884","https://openalex.org/W2081484203","https://openalex.org/W2082398508","https://openalex.org/W2086802511","https://openalex.org/W2095836360","https://openalex.org/W2102850224","https://openalex.org/W2112083325","https://openalex.org/W2112906241","https://openalex.org/W2121806138","https://openalex.org/W2123985266","https://openalex.org/W2124078475","https://openalex.org/W2124977728","https://openalex.org/W2131350482","https://openalex.org/W2132828256","https://openalex.org/W2136305830","https://openalex.org/W2145674897","https://openalex.org/W2146308594","https://openalex.org/W2164189687","https://openalex.org/W2166939578","https://openalex.org/W2169989540"],"related_works":["https://openalex.org/W4392912940","https://openalex.org/W2711078472","https://openalex.org/W2538539874","https://openalex.org/W3213406240","https://openalex.org/W7117316900","https://openalex.org/W7167176937","https://openalex.org/W7132860874","https://openalex.org/W2556376536","https://openalex.org/W3094909566","https://openalex.org/W3042402241"],"abstract_inverted_index":{"Biofuel":[0],"is":[1,58,67,127],"a":[2,64,77,83,162],"promising":[3],"substitute":[4],"for":[5,39,165],"fossil":[6],"fuel":[7,33,48,142],"and":[8,42,103,144,153,173],"the":[9,19,32,47,110,117,122,174],"research":[10,152],"of":[11,31,46,79,121],"biofuel":[12],"production":[13,34,49,155],"has":[14],"been":[15,25],"extensively":[16],"conducted":[17],"during":[18],"recent":[20,175],"years.":[21],"Great":[22],"efforts":[23],"have":[24],"made":[26],"to":[27,69,96,105,113,128,139],"create":[28,129],"many":[29],"types":[30],"hosts.":[35],"However,":[36],"effective":[37],"approaches":[38],"high":[40,43],"specificity":[41],"throughput":[44],"screening":[45,147],"strains":[50],"are":[51,90],"still":[52],"lacking.":[53],"The":[54,134],"cellular":[55,170],"stress":[56,171],"response":[57,172],"one":[59],"universal":[60],"defense":[61],"mechanism":[62],"when":[63,82],"microbial":[65],"cell":[66,84],"exposed":[68],"an":[70],"unfavorable":[71],"substance":[72],"or":[73,115],"environment.":[74],"It":[75],"triggers":[76],"series":[78],"downstream":[80],"responses":[81],"senses":[85],"certain":[86],"chemicals.":[87],"Transcriptional":[88],"factors":[89],"widely":[91],"used":[92],"in":[93,124,149,177],"living":[94],"organisms":[95],"regulate":[97],"gene":[98],"expression.":[99],"They":[100],"can":[101,136],"recognize":[102],"bind":[104],"specific":[106,141],"DNA":[107,118],"sequences":[108],"on":[109,169],"promoter":[111],"region":[112],"repress":[114],"activate":[116],"transcription.":[119],"One":[120],"applications":[123],"actual":[125],"practice":[126],"biosensors":[130,135],"using":[131],"these":[132],"mechanisms.":[133],"be":[137],"designed":[138],"detect":[140],"molecules":[143],"become":[145],"useful":[146],"tools":[148],"metabolic":[150],"engineering":[151],"industrial":[154],"area.":[156],"In":[157],"this":[158],"study,":[159],"I":[160],"demonstrated":[161],"novel":[163],"method":[164],"biosensor":[166],"design":[167],"based":[168],"developments":[176],"genetic":[178],"circuits.":[179]},"counts_by_year":[],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2016-06-24T00:00:00"}