{"id":"https://openalex.org/W2953410366","doi":"https://doi.org/10.1093/annonc/mdz155.304","title":"K-Ras mutation in liquid biopsy and tumor tissue correlation in patients with pancreatic cancer","display_name":"K-Ras mutation in liquid biopsy and tumor tissue correlation in patients with pancreatic cancer","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2953410366","doi":"https://doi.org/10.1093/annonc/mdz155.304","mag":"2953410366"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdz155.304","doi":"https://doi.org/10.1093/annonc/mdz155.304","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdz155.304","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(19)30820-8/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annalsofoncology.org/article/S0923-7534(19)30820-8/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"E. Perdomo Zaldivar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Perdomo Zaldivar","raw_affiliation_strings":["Hospital Universitario Reina Sofia, C\u00f3rdoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Reina Sofia, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001663589","display_name":"Elizabeth Inga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Inga","raw_affiliation_strings":["Hospital Universitario Reina Sofia, Cordoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Reina Sofia, Cordoba, Spain","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110616990","display_name":"T. Cano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"T. Cano","raw_affiliation_strings":["Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047169390","display_name":"M. G\u00f3mez","orcid":"https://orcid.org/0009-0004-3191-6879","observed_orcids":["https://orcid.org/0009-0004-3191-6879"]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. G\u00f3mez","raw_affiliation_strings":["H. Reina Sofia, C\u00f3rdoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Reina Sofia, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103857066","display_name":"M. Toledano Fonseca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093628","display_name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba","ror":"https://ror.org/00j9b6f88","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210093628"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Toledano Fonseca","raw_affiliation_strings":["Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, Cordoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, Cordoba, Spain","institution_ids":["https://openalex.org/I4210093628"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Saavedra Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"G. Saavedra Garcia","raw_affiliation_strings":["Hospital Universitario Reina Sofia, Cordoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Reina Sofia, Cordoba, Spain","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070649891","display_name":"B. Rodriguez Alonso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B. Rodriguez Alonso","raw_affiliation_strings":["Hospital Universitario Reina Sofia, Cordoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Reina Sofia, Cordoba, Spain","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102145135","display_name":"Ros\u00e1rio Alonso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Rodriguez Alonso","raw_affiliation_strings":["Hospital Universitario Reina Sofia, Cordoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Reina Sofia, Cordoba, Spain","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058755562","display_name":"Antonio Rodr\u00edguez\u2010Ariza","orcid":"https://orcid.org/0000-0001-5304-5745","observed_orcids":["https://orcid.org/0000-0001-5304-5745"]},"institutions":[{"id":"https://openalex.org/I4210093628","display_name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba","ror":"https://ror.org/00j9b6f88","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210093628"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Rodriguez Ariza","raw_affiliation_strings":["Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, Cordoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, Cordoba, Spain","institution_ids":["https://openalex.org/I4210093628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068189051","display_name":"Enrique Aranda","orcid":"https://orcid.org/0000-0002-5471-2842","observed_orcids":["https://orcid.org/0000-0002-5471-2842"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210093628","display_name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba","ror":"https://ror.org/00j9b6f88","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210093628"]},{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Aranda","raw_affiliation_strings":["IMIBIC, Reina Sof\u00eda Hospital, University of C\u00f3rdoba, CIBERONC, Instituto de Salud Carlos III, C\u00f3rdoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMIBIC, Reina Sof\u00eda Hospital, University of C\u00f3rdoba, CIBERONC, Instituto de Salud Carlos III, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210093628","https://openalex.org/I4210123675","https://openalex.org/I4210158561","https://openalex.org/I53110688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":null,"fwci":0.0749,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.32479627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"30","issue":null,"first_page":"iv84","last_page":"iv84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.2232999950647354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.859000027179718},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8539999723434448},{"id":"https://openalex.org/keywords/non-invasive-cancer-diagnosis","display_name":"non-invasive cancer diagnosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.7139999866485596},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.896385669708252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8258476257324219},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.7652862071990967},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7183700203895569},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.6529240012168884},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5690953135490417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5671192407608032},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5398565530776978},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4990968704223633},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.48933976888656616},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4725354015827179},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.43771788477897644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37854862213134766},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32341307401657104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15506556630134583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1010972261428833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0832345187664032}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/annonc/mdz155.304","doi":"https://doi.org/10.1093/annonc/mdz155.304","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdz155.304","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(19)30820-8/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdz155.304","doi":"https://doi.org/10.1093/annonc/mdz155.304","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdz155.304","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(19)30820-8/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953410366.pdf","grobid_xml":"https://content.openalex.org/works/W2953410366.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1945319061","https://openalex.org/W3041299573","https://openalex.org/W3170930677","https://openalex.org/W2982809161","https://openalex.org/W2516846277","https://openalex.org/W2207038926","https://openalex.org/W2565133985","https://openalex.org/W2997653870","https://openalex.org/W2147243980","https://openalex.org/W4229841980"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-07-12T00:00:00"}