{"id":"https://openalex.org/W2953183258","doi":null,"title":"Regulation of B cell metabolic activation, germinal center responses and autoimmunity by Tandem PH domain-containing proteins","display_name":"Regulation of B cell metabolic activation, germinal center responses and autoimmunity by Tandem PH domain-containing proteins","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2953183258","mag":"2953183258"},"language":"en","primary_location":{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/32486","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1993/32486","pdf_url":"http://hdl.handle.net/1993/32486","source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1993/32486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048766391","display_name":"Nipun Jayachandran","orcid":"https://orcid.org/0000-0001-9205-8119","observed_orcids":["https://orcid.org/0000-0001-9205-8119"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nipun Jayachandran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9205-8119","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048766391"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06279999762773514,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transabdominal-preperitoneal-repair","display_name":"transabdominal preperitoneal repair","score":0.7329999804496765},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pi-3-4-p2","display_name":"PI(3,4)P2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/b-cell-metabolism","display_name":"B cell metabolism","score":0.7570000290870667},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.746999979019165},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lupus","display_name":"lupus","score":0.7720000147819519},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7379999756813049},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7409999966621399},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.5329999923706055},{"id":"https://openalex.org/keywords/mixed-bone-marrow-chimeras","display_name":"mixed bone marrow chimeras","score":0.6349999904632568},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.6930000185966492},{"id":"https://openalex.org/keywords/anti-dsdna-antibodies","display_name":"anti-dsDNA antibodies","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.8066571354866028},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6054343581199646},{"id":"https://openalex.org/C2777814067","wikidata":"https://www.wikidata.org/wiki/Q1752317","display_name":"Tandem","level":2,"score":0.5687510371208191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46145451068878174},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4471856355667114},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4192940294742584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3471144437789917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34115880727767944},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33986014127731323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3321409225463867},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.27222955226898193},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13396978378295898},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12587550282478333},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07928505539894104},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/32486","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1993/32486","pdf_url":"http://hdl.handle.net/1993/32486","source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"mag:2953183258","doi":null,"is_oa":false,"landing_page_url":"https://mspace.lib.umanitoba.ca/xmlui/handle/1993/32486","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/32486","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1993/32486","pdf_url":"http://hdl.handle.net/1993/32486","source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953183258.pdf","grobid_xml":"https://content.openalex.org/works/W2953183258.grobid-xml"},"referenced_works_count":287,"referenced_works":["https://openalex.org/W27857866","https://openalex.org/W60759546","https://openalex.org/W1481419339","https://openalex.org/W1484813060","https://openalex.org/W1487018400","https://openalex.org/W1495912824","https://openalex.org/W1518329800","https://openalex.org/W1520327324","https://openalex.org/W1521412087","https://openalex.org/W1525933301","https://openalex.org/W1534635237","https://openalex.org/W1536070820","https://openalex.org/W1543903698","https://openalex.org/W1547450219","https://openalex.org/W1554840117","https://openalex.org/W1557923725","https://openalex.org/W1561493617","https://openalex.org/W1563300801","https://openalex.org/W1564765245","https://openalex.org/W1568122112","https://openalex.org/W1592624601","https://openalex.org/W1617435269","https://openalex.org/W1666780611","https://openalex.org/W1667541874","https://openalex.org/W1726858145","https://openalex.org/W1780630048","https://openalex.org/W1781833168","https://openalex.org/W1786913179","https://openalex.org/W1798290921","https://openalex.org/W1801771134","https://openalex.org/W1820319724","https://openalex.org/W1847270645","https://openalex.org/W1867136150","https://openalex.org/W1893843472","https://openalex.org/W1906388760","https://openalex.org/W1913270944","https://openalex.org/W1920115643","https://openalex.org/W1923661714","https://openalex.org/W1926727282","https://openalex.org/W1938716777","https://openalex.org/W1940555945","https://openalex.org/W1944753949","https://openalex.org/W1959856035","https://openalex.org/W1963778872","https://openalex.org/W1965503707","https://openalex.org/W1966851529","https://openalex.org/W1966949480","https://openalex.org/W1967850547","https://openalex.org/W1968332969","https://openalex.org/W1969140398","https://openalex.org/W1972564604","https://openalex.org/W1973201987","https://openalex.org/W1973274031","https://openalex.org/W1973837499","https://openalex.org/W1974951139","https://openalex.org/W1976046500","https://openalex.org/W1976274898","https://openalex.org/W1977237743","https://openalex.org/W1977489066","https://openalex.org/W1978153385","https://openalex.org/W1978432163","https://openalex.org/W1981003679","https://openalex.org/W1982070877","https://openalex.org/W1982158297","https://openalex.org/W1983395516","https://openalex.org/W1983940041","https://openalex.org/W1984020924","https://openalex.org/W1985094563","https://openalex.org/W1988190549","https://openalex.org/W1989134497","https://openalex.org/W1989279522","https://openalex.org/W1990297263","https://openalex.org/W1991430024","https://openalex.org/W1992250154","https://openalex.org/W1992387294","https://openalex.org/W1993192840","https://openalex.org/W1995025510","https://openalex.org/W1997105134","https://openalex.org/W2002043709","https://openalex.org/W2004756723","https://openalex.org/W2005118791","https://openalex.org/W2005478135","https://openalex.org/W2007661731","https://openalex.org/W2007886976","https://openalex.org/W2007910255","https://openalex.org/W2007950400","https://openalex.org/W2008065206","https://openalex.org/W2008423767","https://openalex.org/W2009381057","https://openalex.org/W2010394923","https://openalex.org/W2010736123","https://openalex.org/W2011443550","https://openalex.org/W2011444435","https://openalex.org/W2011557149","https://openalex.org/W2012741632","https://openalex.org/W2012751406","https://openalex.org/W2014058353","https://openalex.org/W2014113929","https://openalex.org/W2014956545","https://openalex.org/W2016054852","https://openalex.org/W2016121277","https://openalex.org/W2016156008","https://openalex.org/W2016190951","https://openalex.org/W2016318369","https://openalex.org/W2016441216","https://openalex.org/W2016591994","https://openalex.org/W2017390384","https://openalex.org/W2017433337","https://openalex.org/W2019169142","https://openalex.org/W2019383774","https://openalex.org/W2019743324","https://openalex.org/W2020603414","https://openalex.org/W2021012077","https://openalex.org/W2021257197","https://openalex.org/W2021525259","https://openalex.org/W2021652030","https://openalex.org/W2022012352","https://openalex.org/W2023668073","https://openalex.org/W2025234369","https://openalex.org/W2025315496","https://openalex.org/W2025786205","https://openalex.org/W2027632198","https://openalex.org/W2027705428","https://openalex.org/W2027781307","https://openalex.org/W2029957805","https://openalex.org/W2030612164","https://openalex.org/W2031622194","https://openalex.org/W2032348735","https://openalex.org/W2034360108","https://openalex.org/W2034408745","https://openalex.org/W2035237509","https://openalex.org/W2036217549","https://openalex.org/W2036524475","https://openalex.org/W2038041677","https://openalex.org/W2039220817","https://openalex.org/W2041572974","https://openalex.org/W2042797177","https://openalex.org/W2044005459","https://openalex.org/W2044725781","https://openalex.org/W2046696423","https://openalex.org/W2046976278","https://openalex.org/W2048596844","https://openalex.org/W2052059548","https://openalex.org/W2052401940","https://openalex.org/W2053772964","https://openalex.org/W2054526083","https://openalex.org/W2056037428","https://openalex.org/W2056703680","https://openalex.org/W2056807976","https://openalex.org/W2057728325","https://openalex.org/W2058924545","https://openalex.org/W2059509768","https://openalex.org/W2060071841","https://openalex.org/W2060407329","https://openalex.org/W2061586163","https://openalex.org/W2061976026","https://openalex.org/W2063693187","https://openalex.org/W2064378988","https://openalex.org/W2066489069","https://openalex.org/W2067874044","https://openalex.org/W2068012172","https://openalex.org/W2068427129","https://openalex.org/W2068616810","https://openalex.org/W2069047496","https://openalex.org/W2069501059","https://openalex.org/W2069545269","https://openalex.org/W2069590838","https://openalex.org/W2070012169","https://openalex.org/W2070359556","https://openalex.org/W2071368241","https://openalex.org/W2071380288","https://openalex.org/W2074873270","https://openalex.org/W2075036714","https://openalex.org/W2075175827","https://openalex.org/W2075191309","https://openalex.org/W2076104117","https://openalex.org/W2076198413","https://openalex.org/W2076265532","https://openalex.org/W2076743305","https://openalex.org/W2076820280","https://openalex.org/W2077236851","https://openalex.org/W2078495995","https://openalex.org/W2078657089","https://openalex.org/W2078702573","https://openalex.org/W2078948501","https://openalex.org/W2079232338","https://openalex.org/W2079763590","https://openalex.org/W2079980036","https://openalex.org/W2079999658","https://openalex.org/W2080032941","https://openalex.org/W2080231208","https://openalex.org/W2080282132","https://openalex.org/W2081064697","https://openalex.org/W2082450387","https://openalex.org/W2082869698","https://openalex.org/W2083592023","https://openalex.org/W2087653208","https://openalex.org/W2090669047","https://openalex.org/W2093577878","https://openalex.org/W2094068658","https://openalex.org/W2095096783","https://openalex.org/W2095434093","https://openalex.org/W2096196471","https://openalex.org/W2097259163","https://openalex.org/W2099443640","https://openalex.org/W2099616702","https://openalex.org/W2100034730","https://openalex.org/W2101572834","https://openalex.org/W2102771576","https://openalex.org/W2105198579","https://openalex.org/W2106134589","https://openalex.org/W2107104928","https://openalex.org/W2110311209","https://openalex.org/W2110948560","https://openalex.org/W2111803354","https://openalex.org/W2112305018","https://openalex.org/W2113932056","https://openalex.org/W2115035007","https://openalex.org/W2115375944","https://openalex.org/W2116458521","https://openalex.org/W2117309266","https://openalex.org/W2117355775","https://openalex.org/W2117386173","https://openalex.org/W2118128813","https://openalex.org/W2119151792","https://openalex.org/W2123130879","https://openalex.org/W2123247601","https://openalex.org/W2124472991","https://openalex.org/W2125479390","https://openalex.org/W2125521670","https://openalex.org/W2126464081","https://openalex.org/W2127132484","https://openalex.org/W2128771042","https://openalex.org/W2132785929","https://openalex.org/W2133063407","https://openalex.org/W2133496311","https://openalex.org/W2134295150","https://openalex.org/W2134451223","https://openalex.org/W2134544592","https://openalex.org/W2135458863","https://openalex.org/W2136149088","https://openalex.org/W2137268127","https://openalex.org/W2138302399","https://openalex.org/W2138483765","https://openalex.org/W2139466117","https://openalex.org/W2140489687","https://openalex.org/W2141329234","https://openalex.org/W2141934750","https://openalex.org/W2142839893","https://openalex.org/W2145481590","https://openalex.org/W2146791037","https://openalex.org/W2147246240","https://openalex.org/W2147449671","https://openalex.org/W2149965740","https://openalex.org/W2151655407","https://openalex.org/W2154581565","https://openalex.org/W2156116884","https://openalex.org/W2156180689","https://openalex.org/W2157023326","https://openalex.org/W2157296603","https://openalex.org/W2157739158","https://openalex.org/W2158381180","https://openalex.org/W2159114783","https://openalex.org/W2161016426","https://openalex.org/W2163577434","https://openalex.org/W2163690533","https://openalex.org/W2165023381","https://openalex.org/W2165451672","https://openalex.org/W2165470016","https://openalex.org/W2166586954","https://openalex.org/W2167403404","https://openalex.org/W2167692982","https://openalex.org/W2168330194","https://openalex.org/W2168443986","https://openalex.org/W2168721537","https://openalex.org/W2178214143","https://openalex.org/W2182386412","https://openalex.org/W2239291357","https://openalex.org/W2241669093","https://openalex.org/W2344829769","https://openalex.org/W2404997321","https://openalex.org/W2416666529","https://openalex.org/W2482434238","https://openalex.org/W2507936899","https://openalex.org/W2513070161","https://openalex.org/W2590316543","https://openalex.org/W4253030770"],"related_works":["https://openalex.org/W2549755339","https://openalex.org/W1482977728","https://openalex.org/W2806439974","https://openalex.org/W1587113887","https://openalex.org/W4313387485","https://openalex.org/W2780016707","https://openalex.org/W2793639665","https://openalex.org/W7161628339","https://openalex.org/W4230581980","https://openalex.org/W2312344731"],"abstract_inverted_index":{"Regulation":[0],"of":[1,20,63,110,155,166,176,187,220,249,253,300,313,327],"PI3K":[2,24,69,104,231,270,318],"signaling":[3,211,232,319],"is":[4,65,214],"critical":[5],"for":[6],"B":[7,28,116,209,227,239,262,322,334],"cells":[8,240,273],"to":[9,53,56,90,97,100,137,173,216,320,342],"generate":[10],"an":[11,162],"effective":[12],"adaptive":[13],"immune":[14],"response":[15],"and":[16,22,40,148,223,236,257,285,305,337],"prevent":[17],"the":[18,54,61,101,108,140,153,156,174,185,190,218,298],"development":[19,175,219],"autoimmunity":[21],"malignancy.":[23],"pathway":[25],"activated":[26],"upon":[27,103,233],"cell":[29,117,210,228,263,323,335],"antigen":[30],"receptor":[31],"(BCR)":[32],"crosslinking":[33,235],"generates":[34],"membrane":[35,55,102],"phosphoinositide":[36],"such":[37],"as":[38,158],"PI(3,4,5)P3":[39,64],"PI(3,4)P2":[41,71,91,114,316],"which":[42,87],"are":[43,74,84],"lipid":[44],"second":[45],"messenger":[46],"molecules":[47],"that":[48,133,171,206,244,311],"recruit":[49],"various":[50],"effector":[51],"proteins":[52,82,86],"mediate":[57],"downstream":[58],"signaling.":[59,271],"Although":[60],"role":[62,109],"extensively":[66],"studied":[67],"in":[68,115,123,164,179,195,247,282,288,292,332],"signaling,":[70,118],"dependent":[72],"mechanisms":[73],"not":[75],"well":[76],"understood.":[77],"Tandem":[78],"PH":[79,95,131],"domain":[80,96],"containing":[81],"(TAPPs)":[83],"adapter":[85],"strictly":[88],"bind":[89],"via":[92],"its":[93],"C-terminal":[94,130],"get":[98],"recruited":[99],"activation.":[105,325],"To":[106],"investigate":[107],"TAPPs":[111,314],"interacting":[112],"with":[113,139,169,297,315],"studies":[119],"were":[120,266],"carried":[121],"out":[122],"mice":[124,182,277,296],"bearing":[125],"targeted":[126],"mutations":[127],"within":[128,152],"their":[129,135],"domains":[132],"disrupt":[134],"ability":[136],"interact":[138],"membrane.":[141],"These":[142],"animals":[143],"developed":[144],"splenomegaly,":[145],"antinuclear":[146],"antibodies":[147,168],"showed":[149,205,229],"IgG":[150],"deposition":[151],"glomeruli":[154],"kidney":[157],"they":[159],"age.":[160],"Additionally,":[161],"increase":[163,246,281],"titre":[165],"anti-dsDNA":[167],"age":[170],"corresponds":[172],"chronic":[177,221,303,333],"GC":[178,191,304],"TAPP":[180,198,207,225,260,275,294],"KI":[181,199,208,226,261,276,295],"together":[183],"resembles":[184],"characteristics":[186],"lupus.":[188],"Disrupting":[189],"reversed":[192,267,302],"autoantibody":[193,343],"production":[194],"these":[196,308],"aging":[197,293],"mice.The":[200],"mixed":[201],"bone":[202],"chimera":[203],"approach":[204],"defect":[212],"alone":[213],"sufficient":[215],"drive":[217],"GCs":[222],"autoimmunity.":[224,306],"enhanced":[230,251],"BCR":[234],"exhibited":[237,241,278],"hyperresponsiveness.These":[238],"metabolic":[242,324],"abnormalities":[243],"include":[245],"rate":[248],"glycolysis,":[250,301],"expression":[252,287],"glucose":[254,283],"transporter":[255],"(GLUT1)":[256],"elevated":[258],"glucose.":[259],"intrinsic":[264],"defects":[265],"by":[268],"blocking":[269],"GCB":[272],"from":[274],"a":[279],"significant":[280],"uptake":[284],"GLUT1":[286],"vivo.":[289],"Targeting":[290],"glycolysis":[291],"inhibitor":[299],"Together":[307],"findings":[309],"suggest":[310],"interaction":[312],"regulates":[317],"attenuate":[321],"Disruption":[326],"this":[328],"regulatory":[329],"circuit":[330],"results":[331],"activation":[336],"germinal":[338],"center":[339],"responses,":[340],"leading":[341],"production.":[344]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}
