{"id":"https://openalex.org/W2953061967","doi":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","title":"PB1768 PREDICTIVE FACTORS OF SEVERE BLEEDING IN ACUTE PROMYELOCYTIC LEUKEMIA","display_name":"PB1768 PREDICTIVE FACTORS OF SEVERE BLEEDING IN ACUTE PROMYELOCYTIC LEUKEMIA","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2953061967","doi":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","mag":"2953061967"},"language":"en","primary_location":{"id":"doi:10.1097/01.hs9.0000565580.66253.aa","doi":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077316652","display_name":"Ardak N. Zhumagaliyeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135680","display_name":"Semey Medical University","ror":"https://ror.org/03kg5qh91","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210135680"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"A. Zhumagaliyeva","raw_affiliation_strings":["Hospital Therapy, Semey Medical University, Semey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Therapy, Semey Medical University, Semey","institution_ids":["https://openalex.org/I4210135680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036239301","display_name":"M. Nazilova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10232997","display_name":"L. N. Gumilyov Eurasian National University","ror":"https://ror.org/0242cby63","country_code":"KZ","type":"education","lineage":["https://openalex.org/I10232997"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"M. Nazilova","raw_affiliation_strings":["Eurasian National University, Astana, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eurasian National University, Astana, Kazakhstan","institution_ids":["https://openalex.org/I10232997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052037594","display_name":"A.B. Karakanova","orcid":"https://orcid.org/0009-0008-2218-9082","observed_orcids":["https://orcid.org/0009-0008-2218-9082"]},"institutions":[{"id":"https://openalex.org/I4210135680","display_name":"Semey Medical University","ror":"https://ror.org/03kg5qh91","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210135680"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"A. Karakanova","raw_affiliation_strings":["Hospital Therapy, Semey Medical University, Semey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Therapy, Semey Medical University, Semey","institution_ids":["https://openalex.org/I4210135680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053909565","display_name":"E. Idrissova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135680","display_name":"Semey Medical University","ror":"https://ror.org/03kg5qh91","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210135680"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"E. Idrissova","raw_affiliation_strings":["Hospital Therapy, Semey Medical University, Semey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Therapy, Semey Medical University, Semey","institution_ids":["https://openalex.org/I4210135680"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032469716","display_name":"G. Demenova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135680","display_name":"Semey Medical University","ror":"https://ror.org/03kg5qh91","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210135680"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"G. Demenova","raw_affiliation_strings":["Hospital Therapy, Semey Medical University, Semey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Therapy, Semey Medical University, Semey","institution_ids":["https://openalex.org/I4210135680"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2480,"currency":"USD","value_usd":2480},"apc_paid":{"value":2480,"currency":"USD","value_usd":2480},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"S1","first_page":"812","last_page":"812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.6959999799728394},{"id":"https://openalex.org/keywords/hemorrhage-risk-factors","display_name":"hemorrhage risk factors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9229999780654907},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/coagulation-index","display_name":"coagulation indices","score":0.5740000009536743},{"id":"https://openalex.org/keywords/early-mortality","display_name":"early mortality","score":0.5450000166893005},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/prothrombin-time","display_name":"prothrombin time","score":0.6200000047683716},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.9664086103439331},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6028107404708862},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.5454918742179871},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.5361084938049316},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5360190272331238},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.4999406337738037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45228904485702515},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44500166177749634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.444824755191803},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.4380629360675812},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.42479342222213745},{"id":"https://openalex.org/C167752854","wikidata":"https://www.wikidata.org/wiki/Q220677","display_name":"Chromosome 17 (human)","level":4,"score":0.4216892719268799},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.4064749479293823},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.402563214302063},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38779741525650024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3724454641342163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36650627851486206},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.2528943717479706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21652477979660034},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19209718704223633},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16783136129379272}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.hs9.0000565580.66253.aa","doi":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1097/01.hs9.0000565580.66253.aa","doi":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000565580.66253.aa","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2282180365","https://openalex.org/W2113072859","https://openalex.org/W2761438321","https://openalex.org/W2339873546","https://openalex.org/W4412103759","https://openalex.org/W2182801504","https://openalex.org/W4417050738","https://openalex.org/W78907138","https://openalex.org/W4243860697","https://openalex.org/W4283394501"],"abstract_inverted_index":{"Background:":[0],"Acute":[1],"promyelocytic":[2,33,108],"leukemia":[3,109],"(APL)":[4,110],"is":[5,52],"identified":[6],"by":[7,96,205,237],"the":[8,14,32,40,75,82,98,139,177,271,277,304,309,317,330,368,389,403,415,497],"predomination":[9],"of":[10,63,69,81,100,117,129,142,165,182,186,188,207,216,233,248,266,274,282,332,367,411,419,448,500],"abnormal":[11,101],"promyelocytes":[12,299],"in":[13,27,67,104,209,221,303,316,342,377,383,392,402,422,463,469,483,503],"bone":[15,296,322],"marrow":[16,297,323],"(BM)":[17],"and":[18,39,73,150,158,184,190,194,243,245,250,295,329,337,350,371,444,477],"a":[19,28,162,210],"specific":[20],"chromosomal":[21,58],"translocation":[22,59],"\u2013":[23,25],"t(15;17)":[24,57,208],"resulting":[26],"fusion":[29],"transcript":[30,51],"between":[31,147,345],"(PML)":[34],"gene":[35,46],"on":[36,47,176],"chromosome":[37,48],"15":[38],"retinoic":[41],"acid":[42],"receptor":[43],"alpha":[44],"(RAR\u03b1)":[45],"17;":[49],"this":[50,423],"known":[53],"as":[54,257,339,341],"PML\u2013RAR\u03b1.":[55],"The":[56,79,170,229,280,364],"can":[60],"cause":[61,262,273,418,499],"hyperexpression":[62],"tissue":[64],"factor":[65],"(TF)":[66],"cells":[68],"patients":[70,105,131,346,378,393,426,453,464,504],"with":[71,106,120,134,161,347,352,379,385,394,436,454,465,471,507],"APL":[72,121,135,171,234],"render":[74],"patient":[76],"hypercoagulable.":[77],"Aims:":[78],"objective":[80],"current":[83],"study":[84],"was":[85,203,235,255,270,397],"to":[86,260,308,400,430,452],"assure":[87],"more":[88,428,440,461],"appropriate":[89],"therapeutic":[90],"strategies":[91],"for":[92,239],"reducing":[93],"severe":[94,485],"hemorrhaging":[95],"assessing":[97],"recovery":[99,365],"coagulation":[102],"indexes":[103],"acute":[107],"during":[111,124,276,361],"induction":[112,278,362,420,475],"therapy.":[113,363],"Methods:":[114],"Retrospective":[115],"analyses":[116],"newly":[118,132,505],"diagnosed":[119,133,506],"were":[122,136,174,300,313,374,414,427],"performed":[123],"initial":[125],"treatment.":[126,412],"A":[127,200],"total":[128],"23":[130],"treated":[137],"at":[138],"Hematology":[140],"department":[141],"Emergency":[143],"Hospital":[144],"(Semey,":[145],"Kazakhstan),":[146],"April":[148],"2008":[149],"January":[151],"2019.":[152],"This":[153],"cohort":[154],"included":[155],"9":[156],"males":[157],"14":[159],"females":[160],"median":[163],"age":[164],"41":[166],"years":[167],"(range:":[168],"12\u201375).":[169],"diagnostic":[172],"criteria":[173],"based":[175],"World":[178],"Health":[179],"Organization":[180],"Classification":[181],"Tumors\u2013Pathology":[183],"Genetics":[185],"Tumors":[187],"Hematopoietic":[189],"Lymphoid":[191],"Tissues":[192],"(2008)":[193],"French\u2013American\u2013British":[195],"classification":[196],"systems":[197],"(1976)":[198],"criteria.":[199],"molecular":[201],"diagnosis":[202,232],"confirmed":[204],"identification":[206],"cytogenetic":[211],"analysis":[212],"and/or":[213],"positive":[214],"detection":[215],"PML\u2013RAR\u03b1":[217],"using":[218],"either":[219],"fluorescence":[220],"situ":[222],"hybridization":[223],"or":[224],"reverse":[225],"transcription\u2010polymerase":[226],"chain":[227],"reaction.":[228],"immune":[230],"phenotype":[231],"established":[236],"positivity":[238],"CD33,":[240],"CD9,":[241],"CD13,":[242],"CD117,":[244],"low":[246,492],"expression":[247],"HLA\u2010DR":[249],"CD34.":[251],"Early":[252],"death":[253,258,275,421],"(ED)":[254],"defined":[256],"due":[259],"any":[261],"within":[263],"30":[264],"days":[265],"diagnosi":[267],"Results:":[268],"Hemorrhage":[269],"principal":[272],"period.":[279],"values":[281,373],"white":[283,318],"blood":[284,319,478],"cell":[285,320],"count,":[286,321,328],"lactate":[287,333],"dehydrogenase,":[288,334],"prothrombin":[289],"time":[290,360],"(PT),":[291],"fibrinogen":[292],"(Fbg),":[293],"hemoglobin,":[294],"leukemic":[298,324],"significantly":[301,357,375,460],"different":[302],"high\u2010risk":[305],"group":[306,406],"compared":[307,451],"low/intermediate\u2010risk":[310],"groups.":[311],"There":[312],"significant":[314],"differences":[315],"promyelocytes,":[325],"platelet":[326],"(PLT)":[327],"levels":[331],"d\u2010dimer,":[335],"PT,":[336,370],"Fbg,":[338],"well":[340],"FLT3\u2010ITD":[343,449],"mutations":[344,450],"major":[348,380,395,437,466],"bleeding":[349,381,396,405,433,438,467,486,502],"those":[351,384,470],"minor":[353,386,404,455,472],"bleeding.":[354,387,456,473],"Hemostatic":[355,457],"variables":[356,458],"improved":[358],"over":[359],"times":[366],"PLT,":[369],"Fbg":[372],"slower":[376],"than":[382,468],"Particularly,":[388],"PLT":[390,493],"level":[391],"not":[398],"similar":[399],"that":[401,491],"until":[407],"after":[408],"4":[409],"weeks":[410],"Hemorrhages":[413],"most":[416],"common":[417],"study.":[424],"High\u2010risk":[425],"prone":[429],"serious":[431],"clinical":[432],"symptoms.":[434],"Patients":[435],"had":[439],"rapid":[441],"proliferation":[442],"characteristics":[443],"an":[445],"increased":[446],"incidence":[447],"recovered":[459],"slowly":[462],"Active":[474],"therapy":[476],"product":[479],"infusion":[480],"are":[481],"efficient":[482],"preventing":[484],"Summary/Conclusion:":[487],"Our":[488],"results":[489],"suggested":[490],"count":[494],"might":[495],"be":[496],"leading":[498],"fatal":[501],"APL.":[508]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-06-27T00:00:00"}
